Research

Publications

Below you can find a list of our published research.

6139 results

Cited 53 times since 2017 (7 per year) source: EuropePMC

Disease models & mechanisms, Volume 10, Issue 9, 1 1 2017, Pages 1039-1059 Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies. Brandão KO, Tabel VA, Atsma DE, Mummery CL, Davis RP

It is now a decade since human induced pluripotent stem cells (hiPSCs) were first described. The reprogramming of adult somatic cells to a pluripotent state has become a robust technology that has revolutionised our ability to study human diseases. Crucially, these cells capture all the genetic aspects of the patient from which they were derived. Combined with advances in generating the different cell types present in the human heart, this has opened up new avenues to study cardiac disease in hu... Abstract

Cited 13 times since 2017 (1.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 25, Issue 12, 1 1 2017, Pages 675-681 A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects. van der Linde IHM, Hiemstra YL, Bökenkamp R, van Mil AM, Breuning MH, Ruivenkamp C, Ten Broeke SW, Veldkamp RF, van Waning JI, van Slegtenhorst MA, van Spaendonck-Zwarts KY, Lekanne Deprez RH, Herkert JC, Boven L, van der Zwaag PA, Jongbloed JDH, Bootsma M, Barge-Schaapveld DQCM

Background: Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects. Methods: In this study, we describe a mutation in the MYH7 gene, c. 5754C > G; p. (Asn1918Lys), present in 15 probands and 65 family members. Results: Of the 80 carriers (age range 0-88 years), 46 (57.5%) had cardiomyopathy (mainly dilated cardiomyopathy (DCM)) and seven (8.8%) had a congenital heart defect. Childhood onset of cardiomyop... Abstract

Cited 16 times since 2017 (2.1 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 10, Issue 9, 1 1 2017, Pages e005987 Bicuspid Aortic Valve: What to Image in Patients Considered for Transcatheter Aortic Valve Replacement? Kong WKF, Delgado V, Bax JJ

Abstract

JAMA cardiology, Volume 2, Issue 9, 1 1 2017, Pages 1047-1048 Bicuspid Aortopathy-Reply. Delgado V, Kong WKF, Bax JJ

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Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 25, Issue 9, 1 1 2017, Pages 490-497 Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score. Montero-Cabezas JM, Karalis I, Wolterbeek R, Kraaijeveld AO, Hoefer IE, Pasterkamp G, Pijls NH, Doevendans PA, Walterberger J, Kuiper J, van Zonneveld AJ, Jukema JW

Background: We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with know... Abstract

Heart (British Cardiac Society), Volume 104, Issue 4, 1 1 2017, Pages 332-339 Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography. Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E

Objective: We investigated the impact of cardiac presynaptic norepinephrine recycling in patients with long-QT syndrome (LQTS) using positron emission tomography (PET) with 11C-meta-hydroxyephedrine ([11C]mHED-PET). Methods: [11C]mHED-PET was performed in 25 patients with LQTS (LQT1: n=14; LQT2: n=11) and 20 healthy controls and correlated with clinical parameters. [11C]mHED-PET images were analysed for global and regional retention indices (RI) and washout rates (WO) reflecting dynamic paramete... Abstract

Cited 19 times since 2017 (2.5 per year) source: EuropePMC

Scientific reports, Volume 7, Issue 1, 31 5 2017, Pages 10269 Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure. Bezhaeva T, Wong C, de Vries MR, van der Veer EP, van Alem CMA, Que I, Lalai RA, van Zonneveld AJ, Rotmans JI, Quax PHA

Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cel... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

European radiology, Volume 28, Issue 2, 30 5 2017, Pages 844-850 Accurate late gadolinium enhancement prediction by early T1- based quantitative synthetic mapping. van Dijk R, Kuijpers D, Kaandorp TAM, van Dijkman PRM, Vliegenthart R, van der Harst P, Oudkerk M

Objectives: Early synthetic gadolinium enhancement (ESGE) imaging from post-contrast T1 mapping after adenosine stress-perfusion cardiac magnetic resonance (CMR) was compared to conventional late gadolinium enhancement (LGE) imaging for assessing myocardial scar. Methods: Two hundred fourteen consecutive patients suspected of myocardial ischaemia were referred for stress-perfusion CMR. Myocardial infarct volume was quantified on a per-subsegment basis in both synthetic (2-3 min post-gadolinium)... Abstract

Cited 12 times since 2017 (1.6 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 11, 30 5 2017, Pages 2008-2016 Usefulness of the CRT-SCORE for Shared Decision Making in Cardiac Resynchronization Therapy in Patients With a Left Ventricular Ejection Fraction of ≤35. Höke U, Mertens B, Khidir MJH, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N

Individualized estimation of prognosis after cardiac resynchronization therapy (CRT) remains challenging. Our aim was to develop a multiparametric prognostic risk score (CRT-SCORE) that could be used for patient-specific clinical shared decision making about CRT implantation. The CRT-SCORE was derived from an ongoing CRT registry, including 1,053 consecutive patients (age 67 ± 10 years, 76% male). Using preimplantation variables, 100 multiple imputed datasets were generated for model calibration... Abstract

Cited 15 times since 2017 (2 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 11, 30 5 2017, Pages 2065-2072 Influence of Aging on Level and Layer-Specific Left Ventricular Longitudinal Strain in Subjects Without Structural Heart Disease. Abou R, Leung M, Khidir MJH, Wolterbeek R, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V

Values for level- (apical, mid, and basal) and layer-based (endocardial, mid-myocardial, and epicardial) left ventricular (LV) longitudinal strain across age are scarce. The present study evaluates the effect of aging on level- and layer-specific LV longitudinal strain in subjects without structural heart disease. A total of 408 subjects (mean age 58 years [range 16 to 91]; 49% men) were evaluated retrospectively. Subjects were divided into equal groups based on age and gender. Subjects with evi... Abstract

Cited 13 times since 2017 (1.7 per year) source: EuropePMC

Trials, Volume 18, Issue 1, 29 5 2017, Pages 402 Mobile phones in cryptogenic strOke patients Bringing sIngle Lead ECGs for Atrial Fibrillation detection (MOBILE-AF): study protocol for a randomised controlled trial. Treskes RW, Gielen W, Wermer MJ, Grauss RW, van Alem AP, Dehnavi RA, Kirchhof CJ, van der Velde ET, Maan AC, Wolterbeek R, Overbeek OM, Schalij MJ, Trines SA

Background: Recently published randomised clinical trials indicate that prolonged electrocardiom (ECG) monitoring might enhance the detection of paroxysmal atrial fibrillation (AF) in cryptogenic stroke or transient ischaemic attack (TIA) patients. A device that might be suitable for prolonged ECG monitoring is a smartphone-compatible ECG device (Kardia Mobile, Alivecor, San Francisco, CA, USA) that allows the patient to record a single-lead ECG without the presence of trained health care staff.... Abstract

Cited 8 times since 2017 (1.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 25, Issue 3, 28 4 2017, Pages 860-871 Invasive assessment of coronary artery disease. Pyxaras SA, Wijns W, Reiber JHC, Bax JJ

Coronary artery disease is associated to high mortality and morbidity rates and an accurate diagnostic assessment during heart catheterization has a fundamental role in prognostic stratification and treatment choices. Coronary angiography has been integrated by intravascular imaging modalities, namely intravascular ultrasound and optical coherence tomography, which allow the precise quantification of the atherosclerotic burden of coronary arteries. The hemodynamic relevance of a given coronary s... Abstract

Cited 30 times since 2017 (4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 104, Issue 7, 28 4 2017, Pages 574-580 Factors associated with coronary artery disease and stroke in adults with congenital heart disease. Bokma JP, Zegstroo I, Kuijpers JM, Konings TC, van Kimmenade RRJ, van Melle JP, Kiès P, Mulder BJM, Bouma BJ

Objective: To determine factors associated with coronary artery disease (CAD) and ischaemic stroke in ageing adult congenital heart disease (ACHD) patients. Methods: We performed a multicentre case-control study, using data from the national CONgenital CORvitia (CONCOR) registry to identify ACHD patients within five participating centres. Patients with CAD were matched (1:2 ratio) with ACHD patients without CAD on age, CHD defect group and gender. Patients with ischaemic stroke (or transient isc... Abstract

Cited 14 times since 2017 (1.9 per year) source: EuropePMC

Scientific reports, Volume 7, Issue 1, 23 4 2017, Pages 9193 Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload. Wang JW, Fontes MSC, Wang X, Chong SY, Kessler EL, Zhang YN, de Haan JJ, Arslan F, de Jager SCA, Timmers L, van Veen TAB, Lam CSP, Kleijn DPV

An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic pressure overload is unclear. We sought to evaluate the role of TLR2 in cardiac hypertrophy, fibrosis and dysfunction in sustained pressure overload. We induced pressure overload via transverse aortic constriction (TAC) in TLR2-/- and wild type (WT) mice, and followed temporal changes over 8 weeks. Despite similar increases in heart weight, left... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 104, Issue 6, 16 3 2017, Pages 454-455 Surgical treatment of Marfan syndrome and related disorders is all about dealing with uncertainties. Groenink M, Koolbergen DR

Abstract

Cited 5 times since 2017 (0.7 per year) source: EuropePMC

Journal of clinical lipidology, Volume 11, Issue 6, 8 2 2017, Pages 1407-1414 Low levels of apolipoprotein-CII in normotriglyceridemic patients with very premature coronary artery disease: Observations from the MISSION! Intervention study. Hermans MPJ, Bodde MC, Jukema JW, Schalij MJ, van der Laarse A, Cobbaert CM

Background: While the overall acute myocardial infarction rates declined in women and men, premature acute myocardial infarction rates remained stable in men and increased in women. Objective: The purpose of this study was to assess whether baseline apolipoprotein (apo) levels, clinical characteristics, and follow-up of patients with very premature coronary artery disease (CAD) could provide novel clues for the identification of high-risk individuals. Methods: Apos were measured with a validated... Abstract

Cited 5 times since 2017 (0.7 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 13, Issue 5, 4 1 2017, Pages e564-e571 Call-to-balloon time dashboard in patients with ST-segment elevation myocardial infarction results in significant improvement in the logistic chain. Hermans MPJ, Velders MA, Smeekes M, Drexhage OS, Hautvast RWM, Ytsma T, Schalij MJ, Umans VAWM

Aims: Timely reperfusion with primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI) patients is associated with superior clinical outcomes. Aiming to reduce ischaemic time, an innovative system for home-to-hospital (H2H) time monitoring was implemented, which enabled real-time evaluation of ischaemic time intervals, regular feedback and improvements in the logistic chain. The objective of this study was to assess the results after implementation... Abstract

Cited 46 times since 2017 (6 per year) source: EuropePMC

The EMBO journal, Volume 36, Issue 18, 4 1 2017, Pages 2726-2741 Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie AF, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret JC, Schepers A, Julien E

Among other targets, the protein lysine methyltransferase PR-Set7 induces histone H4 lysine 20 monomethylation (H4K20me1), which is the substrate for further methylation by the Suv4-20h methyltransferase. Although these enzymes have been implicated in control of replication origins, the specific contribution of H4K20 methylation to DNA replication remains unclear. Here, we show that H4K20 mutation in mammalian cells, unlike in Drosophila, partially impairs S-phase progression and protects from D... Abstract

Cited 6 times since 2017 (0.8 per year) source: EuropePMC

Current opinion in lipidology, Volume 28, Issue 4, 1 1 2017, Pages 361-366 Increasing HDL-C levels with medication: current perspectives. Smit RA, Jukema JW, Trompet S

Purpose of review: To date, observational studies have repeatedly demonstrated an inverse association between HDL cholesterol (HDL-C) levels and cardiovascular outcomes. Although the efficacy of established HDL-modifying treatment strategies have been examined in multiple large-scale phase III trials, findings from these experimental studies conflict with the hypothesis that HDL-C levels are atheroprotective. In this review, we describe the trial evidence to date, and attempt to place these resu... Abstract

Cited 25 times since 2017 (3.3 per year) source: EuropePMC

Cell reports, Volume 20, Issue 8, 1 1 2017, Pages 1978-1990 Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC

There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary for maintaining long-term graft persistence. To model this alloimmunity, humanized mice engrafted with human hematopoietic and immune cells could prove to be useful. In this study, an in-depth analysis of graft-infiltrating human lymphocytes and splenocy... Abstract