6190 results
Cited 21 times since 2013 (1.8 per year)
source: EuropePMC
Journal of medical genetics,
Volume 51, Issue 2, 16 3 2013, Pages 122-131
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.
Oei L, Hsu YH, Styrkarsdottir U, Eussen BH, de Klein A, Peters MJ, Halldorsson B, Liu CT, Alonso N, Kaptoge SK, Thorleifsson G, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Kruk M, Lewis JR, Patel MS, Scollen S, Svensson O, Trompet S, van Schoor NM, Zhu K, Buckley BM, Cooper C, Ford I, Goltzman D, González-Macías J, Langdahl BL, Leslie WD, Lips P, Lorenc RS, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Slagboom PE, Garcia-Ibarbia C, Ingvarsson T, Johannsdottir H, Luben R, Medina-Gómez C, Arp P, Nandakumar K, Palsson ST, Sigurdsson G, van Meurs JB, Zhou Y, Hofman A, Jukema JW, Pols HA, Prince RL, Cupples LA, Marshall CR, Pinto D, Sato D, Scherer SW, Reeve J, Thorsteinsdottir U, Karasik D, Richards JB, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F, Estrada K
Background: Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk. Aim: To identify CNVs associated with osteoporotic bone fracture risk. Method: We performed a genome-wide CNV association study in 5178 individuals from a prospective cohort in the Netherlands, inclu...
Abstract
Cited 12 times since 2013 (1.1 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 55, Issue 1, 12 2 2013, Pages 50-57
Additional diagnostic value of integrated analysis of cardiac CTA and SPECT MPI using the SMARTVis system in patients with suspected coronary artery disease.
Kirişli HA, Gupta V, Shahzad R, Al Younis I, Dharampal A, Geuns RJ, Scholte AJ, de Graaf MA, Joemai RM, Nieman K, van Vliet L, van Walsum T, Lelieveldt B, Niessen WJ
Unlabelled: CT angiography (CTA) and SPECT myocardial perfusion imaging (MPI) are complementary imaging techniques to assess coronary artery disease (CAD). Spatial integration and combined visualization of SPECT MPI and CTA data may facilitate correlation of myocardial perfusion defects and subtending coronary arteries and thus offer additional diagnostic value over either stand-alone or side-by-side interpretation of the respective datasets from the 2 modalities. In this study, we investigated...
Abstract
Cited 56 times since 2013 (4.9 per year)
source: EuropePMC
International journal of cancer,
Volume 134, Issue 11, 12 2 2013, Pages 2663-2673
Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody.
van Driel PB, van der Vorst JR, Verbeek FP, Oliveira S, Snoeks TJ, Keereweer S, Chan B, Boonstra MC, Frangioni JV, van Bergen en Henegouwen PM, Vahrmeijer AL, Lowik CW
Intraoperative near-infrared (NIR) fluorescence imaging is a technology with high potential to provide the surgeon with real-time visualization of tumors during surgery. Our study explores the feasibility for clinical translation of an epidermal growth factor receptor (EGFR)-targeting nanobody for intraoperative imaging and resection of orthotopic tongue tumors and cervical lymph node metastases. The anti-EGFR nanobody 7D12 and the negative control nanobody R2 were conjugated to the NIR fluoroph...
Abstract
Cited 4 times since 2013 (0.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 113, Issue 5, 12 2 2013, Pages 772-778
Prognostic value of aortic and mitral valve calcium detected by contrast cardiac computed tomography angiography in patients with suspicion of coronary artery disease.
Kamperidis V, de Graaf MA, Broersen A, Ahmed W, Sianos G, Delgado V, Dijkstra J, Bax JJ, Scholte AJ
Aortic valve calcium (VC) detected on noncontrast cardiac computed tomography angiography (CCTA) is known to be associated with all-cause mortality in asymptomatic and primary prevention population. However, the clinical significance of aortic and mitral VC remains unknown in symptomatic patients with suspected coronary artery disease (CAD). The aim of the present study was to assess whether aortic and mitral VC is independently associated with cardiac events and all-cause mortality in symptomat...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
Urology,
Volume 83, Issue 2, 9 2 2013, Pages 508.e7-12
The effect of intracavernosal avanafil, a newer phosphodiesterase-5 inhibitor, on neonatal type 2 diabetic rats with erectile dysfunction.
Yilmaz D, Bayatli N, Un O, Kadowitz PJ, Sikka SC, Gur S
Objective: To determine the effect of avanafil, a novel phosphodiesterase-5 inhibitor, on the treatment of erectile dysfunction associated with type 2 diabetes mellitus (T2DM). Methods: In 2-day-old rats, T2DM was induced by single intraperitoneal injection of 90 mg/kg of streptozotocin (STZ; i.p.). Erectile responses were evaluated after 10 weeks on intracavernosal injection of avanafil (1 μM) to anesthetized rats and data expressed as intracavernosal pressure (ICP)/mean arterial pressure and t...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 40, Issue 3, 4 1 2013, Pages 373-378
The prognostic value of plasma Δ-copeptin levels in patients with isolated traumatic brain injury.
Cavus UY, Yildirim S, Gurer B, Dibek K, Yilmaz D, Ozturk G, Buyukcam F, Sonmez E
Purpose: Traumatic brain injury (TBI) is one of the most common causes of death among trauma patients. Earlier prediction of possible poor neurological outcomes, even upon admission to the emergency department, may help to guide treatment. The aim of this prospective study was to assess the predictive value of plasma copeptin levels for early morbidity and mortality in patients with isolated TBI. Methods: This prospective study comprised 53 patients who were admitted to the emergency department...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 1, 3 1 2013, Pages 1-2
Abstracts, articles, citations.
Bax JJ, Delgado V
Abstract
Cited 31 times since 2013 (2.7 per year)
source: EuropePMC
Journal of dairy science,
Volume 97, Issue 2, 2 1 2013, Pages 715-730
Exploring the value of routinely collected herd data for estimating dairy cattle welfare.
de Vries M, Bokkers EA, van Schaik G, Engel B, Dijkstra T, de Boer IJ
Routine on-farm assessment of dairy cattle welfare is time consuming and, therefore, expensive. A promising strategy to assess dairy cattle welfare more efficiently is to estimate the level of animal welfare based on herd data available in national databases. Our aim was to explore the value of routine herd data (RHD) for estimating dairy cattle welfare at the herd level. From November 2009 through March 2010, 7 trained observers collected data for 41 welfare indicators in a selected sample of 1...
Abstract
Cited 4 times since 2013 (0.4 per year)
source: EuropePMC
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 22, Issue 4, 1 1 2013, Pages 213-222
The Use of Intra-aortic Balloon Pump in a Real-World Setting: A Comparison between Survivors and Nonsurvivors from Acute Coronary Syndrome Treated with IABP. The Jakarta Acute Coronary Syndrome Registry.
Dharma S, Dakota I, Firdaus I, Wardeh AJ, Jukema JW
Real-world data on acute coronary syndrome (ACS) patients who received intra-aortic balloon pump (IABP) support are limited. The objective of this study was to evaluate the characteristics of ACS patients who received IABP support from a real-world ACS registry. Patients with ACS (N = 121) who received IABP support were enrolled. Characteristics of survivors and nonsurvivors were compared at 30 days. Mortality rate of patients with ACS who received IABP was 47%. The survivors (N = 64) had less o...
Abstract
Cited 116 times since 2013 (10.2 per year)
source: EuropePMC
Annals of internal medicine,
Volume 159, Issue 12, 1 1 2013, Pages 815-823
Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial.
Meijer CA, Stijnen T, Wasser MN, Hamming JF, van Bockel JH, Lindeman JH, Pharmaceutical Aneurysm Stabilisation Trial Study Group
Background: Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. Objective: To test whether doxycycline inhibits AAA progression in humans. Design: Randomized, placebo-controlled, double-blind trial. (Dutch Trial Registry: NTR 1345) SETTING: 14 Dutch hospitals. Patients: 286 patients with small AAAs between October 2008 and June 2011. Intervention: Daily d...
Abstract
Cited 26 times since 2013 (2.3 per year)
source: Scopus
International journal of behavioral medicine,
Volume 20, Issue 4, 1 1 2013, Pages 582-589
Changes in illness perceptions and quality of life during participation in cardiac rehabilitation.
Janssen V, De Gucht V, van Exel H, Maes S
Background: The beliefs patients hold about their disease and corresponding treatment have been shown to predict recovery in cardiac patients. Purpose: However, it is not known to what extent these beliefs change during participation in cardiac rehabilitation and whether this is related to psychological indicators of outcome. Method: Illness perceptions and health-related quality of life (HRQOL) were measured upon entry to (T0) and completion of (T1) a 3-month outpatient cardiac rehabilitation p...
Abstract
Cited 12 times since 2013 (1.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 12, 1 1 2013, Pages 540-544
What do cardiologists know about the effects of cardiovascular agents on sexual function? A survey among Dutch cardiologists. Part I.
Nicolai MP, Liem SS, Both S, Pelger RC, Putter H, Schalij MJ, Elzevier HW
Introduction: Several cardiovascular agents, such as diuretics and β-blockers, can negatively affect sexual function, leading to noncompliance with therapy. Others such as angiotensin II receptor blockers (ARBs) can improve patients' sexual function. Aims: We aimed to gain insight into cardiologists' knowledge about the effects of cardiovascular drugs on sexual function and whether they take this knowledge into account when prescribing drugs. Methods: An anonymous questionnaire was mai...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
European journal of emergency medicine : official journal of the European Society for Emergency Medicine,
Volume 20, Issue 6, 1 1 2013, Pages 402-407
EEG as a part of the decision-making process in the emergency department.
Yigit O, Eray O, Mihci E, Yilmaz D, Eray B, Özkaynak S
Study objective: Although electroencephalography (EEG) is a useful diagnostic tool for patients with a suspected seizure, its value in informing the acute care of patients in the emergency department (ED) remains unclear. The aim of this study is to determine the effects of EEG results on subsequent patient management in or from the ED. Materials and methods: This prospective observational study was carried out in the ED of a tertiary-care university hospital. All patients presenting to the ED w...
Abstract
Cited 22 times since 2013 (1.9 per year)
source: EuropePMC
Critical care medicine,
Volume 41, Issue 12, 1 1 2013, Pages e401-10
Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia.
Schwarzl M, Seiler S, Wallner M, von Lewinski D, Huber S, Maechler H, Steendijk P, Zelzer S, Truschnig-Wilders M, Obermayer-Pietsch B, Lueger A, Pieske BM, Post H
Objective: We tested whether mild hypothermia impacts on circulatory and respiratory dysfunction during experimental endotoxemia. Design: Randomized controlled prospective experimental study. Setting: Large animal facility, Medical University of Graz, Austria. Subjects: Thirteen anesthetized and mechanically ventilated pigs. Interventions: Lipopolysaccharide was administered for 4 hours. With the beginning of lipopolysaccharide infusion, animals were assigned to either normothermia (38°C, n = 7)...
Abstract
Cited 87 times since 2013 (7.6 per year)
source: EuropePMC
Mediators of inflammation,
Volume 2013, 30 5 2013, Pages 206039
Danger signals in the initiation of the inflammatory response after myocardial infarction.
de Haan JJ, Smeets MB, Pasterkamp G, Arslan F
During myocardial infarction, sterile inflammation occurs. The danger model is a solid theoretic framework that explains this inflammation as danger associated molecular patterns activate the immune system. The innate immune system can sense danger signals through different pathogen recognition receptors (PRR) such as toll-like receptors, nod-like receptors and receptors for advanced glycation endproducts. Activation of a PRR results in the production of cytokines and the recruitment of leukocyt...
Abstract
Cited 12 times since 2013 (1 per year)
source: EuropePMC
Arrhythmia & electrophysiology review,
Volume 2, Issue 2, 29 5 2013, Pages 128-134
Imaging-guided Ventricular Tachycardia Ablation.
Piers SR, Zeppenfeld K
Over the past decades important advances have been made in the field of ventricular tachycardia (VT) ablation, and as a result, VT ablation is now more widely being performed. The identification of ablation target sites still relies on electroanatomical substrate mapping, which is time-consuming, hampered by the intramural location of some scars and limited by epicardial fat. The potential of various imaging modalities to overcome these limitations have stimulated clinical electrophysiologists t...
Abstract
Cited 15 times since 2013 (1.3 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 47, Issue 2, 27 4 2013, Pages 183-190
Acute coronary syndrome with a totally occluded culprit artery: relation of the ST injury vector with ST-elevation and non-ST elevation ECGs.
Man S, Rahmattulla C, Maan AC, van der Putten NH, Dijk WA, van Zwet EW, van der Wall EE, Schalij MJ, Gorgels AP, Swenne CA
Background: In acute coronary syndrome (ACS), ST-segment elevation (STE), often associated with a completely occluded culprit artery, is an important ECG criterion for primary percutaneous coronary intervention (PCI). However, several studies showed that in ACS a completely occluded culprit artery can also occur with a non-ST-elevation (NSTE) ECG. In order to elucidate reasons for this discrepancy we examined ST injury vector orientation and magnitude in ACS patients with and without STE, all ad...
Abstract
Cited 19 times since 2013 (1.7 per year)
source: EuropePMC
Thyroid : official journal of the American Thyroid Association,
Volume 24, Issue 2, 13 2 2013, Pages 208-214
Subclinical thyroid dysfunction and functional capacity among elderly.
Virgini VS, Wijsman LW, Rodondi N, Bauer DC, Kearney PM, Gussekloo J, den Elzen WP, Jukema JW, Westendorp RG, Ford I, Stott DJ, Mooijaart SP, PROSPER Study Group
Background: Subclinical thyroid dysfunction is common among older people and has been associated with decreased functional capacity but with conflicting data. The aim of this study was to assess the association between subclinical thyroid dysfunction and functional capacity in an elderly population. Methods: We included 5182 participants with a mean age of 75.2 years from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Self-reported functional capacity was assessed using t...
Abstract
Cited 99 times since 2013 (8.6 per year)
source: EuropePMC
The lancet. Diabetes & endocrinology,
Volume 2, Issue 3, 12 2 2013, Pages 210-217
Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study.
Bakker LE, Boon MR, van der Linden RA, Arias-Bouda LP, van Klinken JB, Smit F, Verberne HJ, Jukema JW, Tamsma JT, Havekes LM, van Marken Lichtenbelt WD, Jazet IM, Rensen PC
Background: Individuals of south Asian origin have a very high risk of developing type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity of brown adipose tissue (BAT), which is thought to have a role in energy metabolism by combusting fatty acids and glucose to produce heat and might contribute to the difference in incidence of type 2 diabetes between ethnic groups. Methods: We enrolled Dutch nationals with south Asian ancestry and matched Caucasian participants a...
Abstract
Cited 46 times since 2013 (4 per year)
source: EuropePMC
Psychological research,
Volume 78, Issue 6, 8 2 2013, Pages 878-891
Optimal training design for procedural motor skills: a review and application to laparoscopic surgery.
Spruit EN, Band GP, Hamming JF, Ridderinkhof KR
This literature review covers the choices to consider in training complex procedural, perceptual and motor skills. In particular, we focus on laparoscopic surgery. An overview is provided of important training factors modulating the acquisition, durability, transfer, and efficiency of trained skills. We summarize empirical studies and their theoretical background on the topic of training complex cognitive and motor skills that are pertinent to proficiency in laparoscopic surgery. The overview pe...
Abstract
