Research

Publications

Below you can find a list of our published research.

6190 results

Cited 14 times since 2013 (1.2 per year) source: EuropePMC

Journal of African earth sciences (Oxford, England : 1994), Volume 86, 1 1 2013, Pages 65-106 Orogen styles in the East African Orogen: A review of the Neoproterozoic to Cambrian tectonic evolution. Fritz H, Abdelsalam M, Ali KA, Bingen B, Collins AS, Fowler AR, Ghebreab W, Hauzenberger CA, Johnson PR, Kusky TM, Macey P, Muhongo S, Stern RJ, Viola G

The East African Orogen, extending from southern Israel, Sinai and Jordan in the north to Mozambique and Madagascar in the south, is the world́s largest Neoproterozoic to Cambrian orogenic complex. It comprises a collage of individual oceanic domains and continental fragments between the Archean Sahara-Congo-Kalahari Cratons in the west and Neoproterozoic India in the east. Orogen consolidation was achieved during distinct phases of orogeny between ∼850 and 550 Ma. The northern part of the oroge... Abstract

Cited 53 times since 2013 (4.6 per year) source: EuropePMC

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume 33, Issue 4, 29 5 2013, Pages 479-490 Determinants of virulence of influenza A virus. Schrauwen EJ, de Graaf M, Herfst S, Rimmelzwaan GF, Osterhaus AD, Fouchier RA

Influenza A viruses cause yearly seasonal epidemics and occasional global pandemics in humans. In the last century, four human influenza A virus pandemics have occurred. Occasionally, influenza A viruses that circulate in other species cross the species barrier and infect humans. Virus reassortment (i.e. mixing of gene segments of multiple viruses) and the accumulation of mutations contribute to the emergence of new influenza A virus variants. Fortunately, most of these variants do not have the... Abstract

Cited 6 times since 2013 (0.5 per year) source: EuropePMC

Heart and vessels, Volume 29, Issue 5, 27 4 2013, Pages 619-628 Prognostic implications of left ventricular regional function heterogeneity assessed with two-dimensional speckle tracking in patients with ST-segment elevation myocardial infarction and depressed left ventricular ejection fraction. Hoogslag GE, Thijssen J, Höke U, Boden H, Antoni ML, Debonnaire P, Haeck ML, Holman ER, Bax JJ, Ajmone Marsan N, Schalij MJ, Delgado V

The aim of the current study was to evaluate the prognostic implications of myocardial tissue heterogeneity assessed with two-dimensional speckle-tracking echocardiography in patients three months after first ST-segment elevation myocardial infarction (STEMI) with left ventricular ejection fraction (LVEF) ≤35 %. For this purpose, a total of 79 patients with first STEMI and LVEF ≤35 % at three months postinfarction were evaluated. Based on left ventricular (LV) speckle-tracking longitudinal strai... Abstract

Cited 7 times since 2013 (0.6 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 18, Issue 1, 26 4 2013, Pages 33-37 Primary closure using Redon drains for the treatment of post-sternotomy mediastinitis. Vos RJ, van Putte BP, Sonker U, Kloppenburg GT

Objectives: Post-sternotomy mediastinitis is a severe complication of open heart surgery resulting in prolonged hospital stay and increased mortality. Vacuum-assisted closure is commonly used as treatment for post-sternotomy mediastinitis, but has some disadvantages. Primary closure over high vacuum suction Redon drains previously has shown to be an alternative approach with promising results. We report our short- and long-term results of Redon therapy-treated mediastinitis. Methods: We performe... Abstract

American heart journal, Volume 166, Issue 5, 24 4 2013, Pages e43 Reply to letter to the editor by Koza et al. Kooiman J, le Haen PA, Gezgin G, de Vries JP, Boersma D, Brulez HF, Sijpkens YW, van der Molen AJ, Cannegieter SC, Hamming JF, Huisman MV

Abstract

Cited 29 times since 2013 (2.5 per year) source: EuropePMC

Circulation, Volume 128, Issue 25, 24 4 2013, Pages 2732-2744 Atrium-specific Kir3.x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans. Bingen BO, Neshati Z, Askar SF, Kazbanov IV, Ypey DL, Panfilov AV, Schalij MJ, de Vries AA, Pijnappels DA

Background: Atrial fibrillation is the most common cardiac arrhythmia. Ventricular proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium-specific Kir3.x channels, which generate a constitutively active current (I(K,ACh-c)) after atrial remodeling, might circumvent this problem. However, it is unknown whether and how I(K,ACh-c) contributes to atrial fibrillation induction, dynamics, and termination. Therefore, we investigated the effects of I(K,ACh-c) blockade... Abstract

Cited 61 times since 2013 (5.2 per year) source: EuropePMC

The American journal of cardiology, Volume 112, Issue 12, 21 3 2013, Pages 1867-1872 Outcome after ST elevation myocardial infarction in patients with cancer treated with primary percutaneous coronary intervention. Velders MA, Boden H, Hofma SH, Osanto S, van der Hoeven BL, Heestermans AA, Cannegieter SC, Jukema JW, Umans VA, Schalij MJ, van Boven AJ

The simultaneous occurrence of cancer and coronary heart disease is increasing in the Western world. Nevertheless, the influence of cancer on ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) has not been investigated extensively. This multicenter registry included patients with STEMI treated with primary PCI from 2006 to 2009. Patients were stratified according to history of cancer, and primary focus lay on all-cause and cardiac mortalities... Abstract

Cited 20 times since 2013 (1.7 per year) source: EuropePMC

PloS one, Volume 8, Issue 9, 19 3 2013, Pages e75573 Erythrocyte-bound apolipoprotein B in relation to atherosclerosis, serum lipids and ABO blood group. Klop B, van de Geijn GJ, Bovenberg SA, van der Meulen N, Elte JW, Birnie E, Njo TL, Janssen HW, van Miltenburg A, Jukema JW, Cabezas MC

Introduction: Erythrocytes carry apolipoprotein B on their membrane, but the determining factors of erythrocyte-bound apolipoprotein B (ery-apoB) are unknown. We aimed to explore the determinants of ery-apoB to gain more insight into potential mechanisms. Methods: Subjects with and without CVD were included (N = 398). Ery-apoB was measured on fresh whole blood samples using flow cytometry. Subjects with ery-apoB levels ≤ 0.20 a.u. were considered deficient. Carotid intima media thickness (CIMT)... Abstract

Cited 63 times since 2013 (5.4 per year) source: EuropePMC

PloS one, Volume 8, Issue 9, 16 3 2013, Pages e74083 BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. Boon MR, van den Berg SA, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC

Background/aims: Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity upon cold exposure. Recently, Bone Morphogenetic Protein 7 (BMP7) was identified as an inducer of BAT differentiation. We aimed to elucidate the role of sympathetic activation in the effect of BMP7 o... Abstract

Cited 12 times since 2013 (1 per year) source: EuropePMC

Journal of surgical education, Volume 71, Issue 2, 14 2 2013, Pages 222-228 Quality of life of surgical oncology residents and fellows across Europe. Mordant P, Deneuve S, Rivera C, Carrabin N, Mieog JS, Malyshev N, Van Der Vorst JR, Audisio RA, French Association of Young Surgical Oncologists (AJCO), European Society of Surgical Oncology Young Surgeons and Alumni Club (EYSAC)

Background: Data are currently lacking regarding the quality of life of surgical oncology (SO) trainees. We sought to assess the training conditions and quality of life of SO residents and fellows across Europe. Material and methods: Members of the European Society for Surgical Oncology were invited to complete a Web-based survey that included a questionnaire specifically designed for SO trainees. Demographics, timing, and incentive to choose for SO, quality of life, and symptoms of fatigue, sle... Abstract

Cited 16 times since 2013 (1.4 per year) source: Scopus

The American journal of cardiology, Volume 112, Issue 11, 13 2 2013, Pages 1800-1806 Multidetector row computed tomography parameters associated with paravalvular regurgitation after transcatheter aortic valve implantation. Katsanos S, Ewe SH, Debonnaire P, van der Kley F, de Weger A, Palmen M, Scholte AJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Multidetector row computed tomographic (MDCT) assessment of aortic annulus dimensions and frame position and deployment have been associated with paravalvular aortic regurgitation (PAVR) after transcatheter aortic valve implantation (TAVI). The present evaluation investigated the (pre- and postprocedure) MDCT associates of PAVR ≥2+. In total, 123 patients referred for TAVI underwent clinical evaluation, transthoracic echocardiography, and pre- and post-TAVI MDCT. Pre-TAVI MDCT measurements of th... Abstract

Cited 87 times since 2013 (7.5 per year) source: EuropePMC

Circulation, Volume 128, Issue 21, 13 2 2013, Pages 2289-2295 Initial human feasibility of infusion needle catheter ablation for refractory ventricular tachycardia. Sapp JL, Beeckler C, Pike R, Parkash R, Gray CJ, Zeppenfeld K, Kuriachan V, Stevenson WG

Background: Ablation of ventricular tachycardia (VT) is sometimes unsuccessful when ablation lesions are of insufficient depth to reach arrhythmogenic substrate. We report the initial experience with the use of a catheter with an extendable/retractable irrigated needle at the tip capable of intramyocardial mapping and ablation. Methods and results: Sequential consenting patients with recurrent VT underwent ablation with the use of a needle-tipped catheter. At target sites, the needle was advance... Abstract

Cited 95 times since 2013 (8.2 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 5, 13 2 2013, Pages 875-883 Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy: implications for the ablation strategy. Piers SR, Tao Q, van Huls van Taxis CF, Schalij MJ, van der Geest RJ, Zeppenfeld K

Background: There are limited data on typical arrhythmogenic substrates and associated ventricular tachycardias (VT) in patients with nonischemic cardiomyopathy. The substrate location may have implications for the ablation strategy. Methods and results: Nineteen consecutive patients with nonischemic cardiomyopathy (age 58±14 years, 79% men, left ventricular ejection fraction 41±11%) who underwent contrast-enhanced MRI and VT ablation were included. On the basis of 3-dimensional contrast-enhance... Abstract

Cited 28 times since 2013 (2.4 per year) source: EuropePMC

Journal of the American Society of Nephrology : JASN, Volume 24, Issue 12, 12 2 2013, Pages 2105-2117 Common variants in Mendelian kidney disease genes and their association with renal function. Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A, Rao M, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra BA, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Döring A, Wichmann HE, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG,

Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidne... Abstract

Cited 22 times since 2013 (1.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 147, Issue 5, 12 2 2013, Pages 1561-1567 Left and right ventricular performance after arterial switch operation. Klitsie LM, Roest AA, Kuipers IM, Hazekamp MG, Blom NA, Ten Harkel AD

Objective: Recent descriptions of decreased exercise capacity 10 to 15 years after arterial switch operation (ASO) suggest subclinical hemodynamic restrictions. Persistent impairment of ventricular performance following ASO may add to this. We aimed to characterize the time course of changes in biventricular performance within the first year following ASO. Methods: We prospectively included 26 patients with transposition of the great arteries undergoing ASO and 20 age-matched controls. Left and... Abstract

Cited 41 times since 2013 (3.5 per year) source: EuropePMC

The American journal of pathology, Volume 183, Issue 4, 10 2 2013, Pages 1137-1143 Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans. van Riel D, Leijten LME, de Graaf M, Siegers JY, Short KR, Spronken MIJ, Schrauwen EJA, Fouchier RAM, Osterhaus ADME, Kuiken T

Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential... Abstract

Cited 6 times since 2013 (0.5 per year) source: EuropePMC

International journal of cardiology, Volume 169, Issue 3, 10 2 2013, Pages 190-195 The wealth of nations and the dissemination of cardiovascular research. Winnik S, Speer T, Raptis DA, Walker JH, Hasun M, Clavien PA, Komajda M, Bax JJ, Tendera M, Fox K, Van de Werf F, Mundow C, Lüscher TF, Ruschitzka F, Nallamothu BK, Matter CM

Background: This study aimed at understanding whether investigators from less wealthy countries were at a disadvantage in disseminating their research, after accounting for potential differences in research quality and infrastructure. Methods and results: In this bibliometric analysis a representative random selection of 10% (n=1002 studies) of all abstracts submitted to the European Society of Cardiology (ESC) congress 2006 was followed for publication and citation from September 2006 to Decemb... Abstract

Cited 18 times since 2013 (1.5 per year) source: EuropePMC

International journal of cardiology, Volume 169, Issue 2, 8 2 2013, Pages 139-144 Postoperative arrhythmias in adults with congenital heart disease: incidence and risk factors. Koyak Z, Achterbergh RC, de Groot JR, Berger F, Koolbergen DR, Bouma BJ, Lagrand WK, Hazekamp MG, Blom NA, Mulder BJ

Background: Little is known about the clinical impact of arrhythmias after surgery for congenital heart disease (CHD) in adults. Therefore, we investigated the prevalence of in-hospital arrhythmias after CHD surgery and their impact on clinical outcome. Methods: This was a multicenter retrospective study and included adults who underwent congenital cardiac surgery between January 2009 and December 2011. Clinical events were defined as all cause mortality, heart failure (HF) requiring medical tre... Abstract

Cited 42 times since 2013 (3.6 per year) source: EuropePMC

International journal of cardiology, Volume 169, Issue 3, 7 1 2013, Pages 183-189 A cornerstone of heart failure treatment is not effective in experimental right ventricular failure. Borgdorff MA, Bartelds B, Dickinson MG, Steendijk P, Berger RM

Background: Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure treatment) is effective in RV failure. We investigated the effects of combination treatment of aldosterone-blocker eplerenone+angiotensin II receptor blocker losartan (Ep/Lo) on RV... Abstract

Cited 14 times since 2013 (1.2 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 64, 5 1 2013, Pages 51-58 C57BL/6 NK cell gene complex is crucially involved in vascular remodeling. de Vries MR, Seghers L, van Bergen J, Peters HA, de Jong RC, Hamming JF, Toes RE, van Hinsbergh VW, Quax PH

Objective: NK cells are known to be involved in cardiovascular disease processes. One of these processes, vascular remodeling, may strongly differ between individuals and mouse strains such as the C57BL/6 and BALB/c. Moreover, C57BL/6 and BALB/c mice vary in immune responses and in the composition of their Natural Killer gene Complex (NKC). Here we study the role of NK cells, and in particular the C57BL/6 NKC in vascular remodeling and intimal hyperplasia formation. Methods and results: C57BL/6,... Abstract