Research

Publications

Below you can find a list of our published research.

6190 results

Cited 7 times since 2013 (0.6 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 20 3 2013 The role of exercise echocardiography in the management of mitral valve disease. Jansen R, Kracht PA, Cramer MJ, Tietge WJ, van Herwerden LA, Klautz RJ, Kluin J, Chamuleau SA

Purpose: Exercise echocardiography can assess the dynamic component of mitral valve (MV) disease and may therefore be helpful for the clinical decision-making by the heart team. The purpose of this study is to determine the role of exercise echocardiography in the management of disproportionately symptomatic or otherwise atypical patients with mitral regurgitation (MR) and stenosis (MS) in clinical practice. Methods: Data of 14 MR and 14 MS patients, including echocardiograms at rest, were prese... Abstract

Cited 71 times since 2013 (6.1 per year) source: EuropePMC

Circulation research, Volume 113, Issue 9, 20 3 2013, Pages 1065-1075 Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype. van der Veer EP, de Bruin RG, Kraaijeveld AO, de Vries MR, Bot I, Pera T, Segers FM, Trompet S, van Gils JM, Roeten MK, Beckers CM, van Santbrink PJ, Janssen A, van Solingen C, Swildens J, de Boer HC, Peters EA, Bijkerk R, Rousch M, Doop M, Kuiper J, Schalij MJ, van der Wal AC, Richard S, van Berkel TJ, Pickering JG, Hiemstra PS, Goumans MJ, Rabelink TJ, de Vries AA, Quax PH, Jukema JW, Biessen EA, van Zonneveld AJ

Rationale: RNA-binding proteins are critical post-transcriptional regulators of RNA and can influence pre-mRNA splicing, RNA localization, and stability. The RNA-binding protein Quaking (QKI) is essential for embryonic blood vessel development. However, the role of QKI in the adult vasculature, and in particular in vascular smooth muscle cells (VSMCs), is currently unknown. Objective: We sought to determine the role of QKI in regulating adult VSMC function and plasticity. Methods and results: We... Abstract

Cited 22 times since 2013 (1.9 per year) source: EuropePMC

Diabetes care, Volume 36, Issue 10, 15 3 2013, Pages 3054-3061 Stratified patient-centered care in type 2 diabetes: a cluster-randomized, controlled clinical trial of effectiveness and cost-effectiveness. Slingerland AS, Herman WH, Redekop WK, Dijkstra RF, Jukema JW, Niessen LW

Objective: Diabetes treatment should be effective and cost-effective. HbA1c-associated complications are costly. Would patient-centered care be more (cost-) effective if it was targeted to patients within specific HbA1c ranges? Research design and methods: This prospective, cluster-randomized, controlled trial involved 13 hospitals (clusters) in the Netherlands and 506 patients with type 2 diabetes randomized to patient-centered (n=237) or usual care (controls) (n=269). Primary outcomes were cha... Abstract

Cited 16 times since 2013 (1.4 per year) source: EuropePMC

The American journal of cardiology, Volume 112, Issue 10, 14 2 2013, Pages 1533-1539 In-hospital major bleeding and its clinical relevance in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Boden H, Velders MA, van der Hoeven BL, Cannegieter SC, Schalij MJ

Advances in antithrombotic therapy for ST elevation myocardial infarction (STEMI) enhance the risk of bleeding. Therefore, the incidence, determinants, and prognostic implications of in-hospital major bleeding after primary percutaneous coronary intervention for STEMI were investigated. In 963 consecutive patients, the incidence of bleeding was evaluated according to commonly used classifications including Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with E... Abstract

Cited 52 times since 2013 (4.4 per year) source: EuropePMC

Virus research, Volume 178, Issue 1, 13 2 2013, Pages 15-20 Transmission of influenza A/H5N1 viruses in mammals. Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of fac... Abstract

Cited 47 times since 2013 (4 per year) source: EuropePMC

Journal of dairy science, Volume 96, Issue 10, 9 2 2013, Pages 6264-6273 Evaluating results of the Welfare Quality multi-criteria evaluation model for classification of dairy cattle welfare at the herd level. de Vries M, Bokkers EA, van Schaik G, Botreau R, Engel B, Dijkstra T, de Boer IJ

The Welfare Quality multi-criteria evaluation (WQ-ME) model aggregates scores of single welfare measures into an overall assessment for the level of animal welfare in dairy herds. It assigns herds to 4 welfare classes: unacceptable, acceptable, enhanced, or excellent. The aim of this study was to demonstrate the relative importance of single welfare measures for WQ-ME classification of a selected sample of Dutch dairy herds. Seven trained observers quantified 63 welfare measures of the Welfare Q... Abstract

Cited 7 times since 2013 (0.6 per year) source: EuropePMC

PloS one, Volume 8, Issue 8, 9 2 2013, Pages e70676 Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. Verschuren JJ, Trompet S, Sampietro ML, Heijmans BT, Koch W, Kastrati A, Houwing-Duistermaat JJ, Slagboom PE, Quax PH, Jukema JW

Background: Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition. Methods: The GENetic DEterm... Abstract

Cited 154 times since 2013 (13.1 per year) source: EuropePMC

Nature, Volume 501, Issue 7468, 7 1 2013, Pages 560-563 Limited airborne transmission of H7N9 influenza A virus between ferrets. Richard M, Schrauwen EJ, de Graaf M, Bestebroer TM, Spronken MI, van Boheemen S, de Meulder D, Lexmond P, Linster M, Herfst S, Smith DJ, van den Brand JM, Burke DF, Kuiken T, Rimmelzwaan GF, Osterhaus AD, Fouchier RA

Wild waterfowl form the main reservoir of influenza A viruses, from which transmission occurs directly or indirectly to various secondary hosts, including humans. Direct avian-to-human transmission has been observed for viruses of subtypes A(H5N1), A(H7N2), A(H7N3), A(H7N7), A(H9N2) and A(H10N7) upon human exposure to poultry, but a lack of sustained human-to-human transmission has prevented these viruses from causing new pandemics. Recently, avian A(H7N9) viruses were transmitted to humans, cau... Abstract

Cited 170 times since 2013 (14.5 per year) source: EuropePMC

Epigenetics & chromatin, Volume 6, Issue 1, 6 1 2013, Pages 26 Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Slieker RC, Bos SD, Goeman JJ, Bovée JV, Talens RP, van der Breggen R, Suchiman HE, Lameijer EW, Putter H, van den Akker EB, Zhang Y, Jukema JW, Slagboom PE, Meulenbelt I, Heijmans BT

Background: DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study design and focus there still is no consensus as to the annotation of genomic regions predominantly involved in tissue-specific methylation. We used a new algorithm to identify and annotate tissue-specific differentially methylated regions (tDMRs) from Illumina 450k chip data for... Abstract

Journal of molecular and cellular cardiology, Volume 63, 2 1 2013, Pages 118-121 Mediators of inflammation after cardiac ischemia: the role of invariant natural killer T (iNKT) cells. Arslan F

Abstract

Cited 5 times since 2013 (0.4 per year) source: EuropePMC

Cardiovascular & hematological disorders drug targets, Volume 13, Issue 2, 1 1 2013, Pages 111-122 Anti-apoptotic serpins as therapeutics in cardiovascular diseases. Kuiper J, Quax PH, Bot I

Acute cardiovascular syndromes such as myocardial infarction and stroke are a major cause of death in the Western society and are generally caused by rupture of an atherosclerotic plaque. Treatment of atherosclerosis, the main underlying cause of acute cardiovascular syndromes, is still inadequate for most of the patients. Therefore, there is a need for new therapeutic strategies in addition to the existing lipid-lowering drugs such as statins. Lipid accumulation, inflammation and matrix degrada... Abstract

Cited 46 times since 2013 (3.9 per year) source: EuropePMC

Lancet (London, England), Volume 382, Issue 9892, 1 1 2013, Pages 644-657 Future treatment strategies in ST-segment elevation myocardial infarction. Windecker S, Bax JJ, Myat A, Stone GW, Marber MS

Over the past five decades, management of acute ST-segment elevation myocardial infarction (STEMI) has evolved substantially. Current treatment encompasses a systematic chain of network activation, antithrombotic drugs, and rapid instigation of mechanical reperfusion, although pharmacoinvasive strategies remain relevant. Secondary prevention with drugs and lifestyle modifications completes the contemporary management package. Despite a tangible improvement in outcomes, STEMI remains a frequent c... Abstract

Cited 78 times since 2013 (6.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 62, Issue 21, 31 5 2013, Pages 1966-1976 Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EPA, Li M, Leusink M, Trompet S, Verschuren JJW, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, van 't Hooft F, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Mateo Leach I, Breitling LP, Brenner H, Thiery J, Dallmeier D, Franco-Cereceda A, Boer JMA, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day INM, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der

Objectives: This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease. Background: Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA2 inhibitor (varespladib) was stopped prematurely for lack of efficacy. Methods: We conducted a Mendelian randomization meta-anal... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

Resuscitation, Volume 84, Issue 11, 30 5 2013, Pages 1530-1535 Association between angiographic culprit lesion and out-of-hospital cardiac arrest in ST-elevation myocardial infarction patients. Velders MA, van Boven N, Boden H, van der Hoeven BL, Heestermans AA, Jukema JW, de Jonge E, Kuiper MA, van Boven AJ, Hofma SH, Schalij MJ, Umans VA

Background: Factors related to the occurrence of out-of-hospital cardiac arrest (OHCA) in ST-elevation myocardial infarction (STEMI) are still poorly understood. The current study sought to compare STEMI patients presenting with and without OHCA to identify angiographic factors related to OHCA. Methods: This multicenter registry consisted of consecutive STEMI patients, including OHCA patients with return-of-spontaneous circulation. Patients were treated with primary percutaneous coronary interve... Abstract

Cited 4 times since 2013 (0.3 per year) source: EuropePMC

PloS one, Volume 8, Issue 7, 29 5 2013, Pages e69796 Connectivity between migrating and landlocked populations of a diadromous fish species investigated using otolith microchemistry. Tulp I, Keller M, Navez J, Winter HV, de Graaf M, Baeyens W

Smelt Osmerus eperlanus has two different life history strategies in The Netherlands. The migrating population inhabits the Wadden Sea and spawns in freshwater areas. After the closure of the Afsluitdijk in 1932, part of the smelt population became landlocked. The fresh water smelt population has been in severe decline since 1990, and has strongly negatively impacted the numbers of piscivorous water birds relying on smelt as their main prey. The lakes that were formed after the dike closure, IJs... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

BMJ case reports, Volume 2013, 29 5 2013, Pages bcr2013010219 An unusual cause of constipation in a 72-year-old man with a rising creatinine. Pimenta D, Yilmaz D, Grossman R, Soin B

Abstract

Cited 112 times since 2013 (9.5 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 347, 29 5 2013, Pages f4600 Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study. Sabayan B, Wijsman LW, Foster-Dingley JC, Stott DJ, Ford I, Buckley BM, Sattar N, Jukema JW, van Osch MJ, van der Grond J, van Buchem MA, Westendorp RG, de Craen AJ, Mooijaart SP

Objective: To investigate the association between visit-to-visit variability in blood pressure and cognitive function in old age (>70 years). Design: Prospective cohort study. Setting: PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) study, a collaboration between centres in Ireland, Scotland, and the Netherlands. Participants: 5461 participants, mean age 75.3 years, who were at risk of cardiovascular disease. Blood pressure was measured every three months during an average o... Abstract

Cited 6 times since 2013 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 8, 27 4 2013, Pages 1829-1837 Association of atherosclerosis in the descending thoracic aorta with coronary artery disease on multi detector row computed tomography coronary angiography in patients with suspected coronary artery disease. Roos CJ, Witkowska AJ, de Graaf MA, Veltman CE, Delgado V, de Grooth GJ, Jukema JW, Bax JJ, Scholte AJ

The association between atherosclerosis in the descending thoracic aorta (DTA) visualized on computed tomography coronary angiography (CTA) and coronary artery disease (CAD) has not been extensively explored. Therefore, a comprehensive analysis of DTA atherosclerosis on CTA was performed and the association of DTA atherosclerosis with CAD was evaluated in patients with suspected CAD. A total of 344 patients (54 ± 12 years, 54% men) with suspected CAD underwent CTA. CTA were classified based on C... Abstract

Cited 671 times since 2013 (57 per year) source: EuropePMC

Nature reviews. Clinical oncology, Volume 10, Issue 9, 23 4 2013, Pages 507-518 Image-guided cancer surgery using near-infrared fluorescence. Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV

Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster, better and less expensively than current standards. Optical imaging that exploits invisible near-infrared (NIR) fluorescent light (700-900 nm) has the potential to improve cancer surgery outcomes, minimize the time patients are under anaesthesia and lower health-care costs largely by way of its improved contrast and depth of tissue penetration relative to visible light. Accordingly, the past few years have wi... Abstract

Cited 29 times since 2013 (2.5 per year) source: EuropePMC

Seminars in fetal & neonatal medicine, Volume 18, Issue 5, 22 4 2013, Pages 237-244 Embryology of the heart and its impact on understanding fetal and neonatal heart disease. Gittenberger-de Groot AC, Bartelings MM, Poelmann RE, Haak MC, Jongbloed MR

Heart development is a complex process during which the heart needs to transform from a single tube towards a fully septated heart with four chambers and a separated outflow tract. Several major events contribute to this process, that largely overlap in time. Abnormal heart development results in congenital heart disease, which has an estimated incidence of 1% of liveborn children. Eighty percent of cases of congenital heart disease are considered to have a multifactoral developmental background... Abstract