Research

Publications

Below you can find a list of our published research.

7154 results

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

The American journal of cardiology, Volume 113, Issue 11, 15 3 2014, Pages 1782-1787 Comparison by computed tomographic angiography-the presence and extent of coronary arterial atherosclerosis in South Asians versus Caucasians with diabetes mellitus. Roos CJ, Kharagjitsingh AV, Jukema JW, Bax JJ, Scholte AJ

South Asians in the Western world have a high prevalence of diabetes mellitus (DM) and an increased risk of coronary artery disease (CAD) and mortality compared with Caucasians. CAD in asymptomatic South Asian patients with type 2 DM has not been investigated. The aim of this observational cohort study was to investigate CAD in asymptomatic South Asian patients with type 2 DM and to compare with matched Caucasian patients. A total of 120 asymptomatic South Asian patients with type 2 DM and match... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

European journal of clinical nutrition, Volume 68, Issue 5, 12 2 2014, Pages 635-637 Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women. Klop B, van de Geijn GJ, Birnie E, Njo TL, Janssen HW, Jansen HG, Jukema JW, Elte JW, Castro Cabezas M

Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was... Abstract

Cited 65 times since 2014 (5.9 per year) source: EuropePMC

Journal of the American Society of Nephrology : JASN, Volume 25, Issue 8, 7 1 2014, Pages 1710-1722 Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity. Bijkerk R, van Solingen C, de Boer HC, van der Pol P, Khairoun M, de Bruin RG, van Oeveren-Rietdijk AM, Lievers E, Schlagwein N, van Gijlswijk DJ, Roeten MK, Neshati Z, de Vries AA, Rodijk M, Pike-Overzet K, van den Berg YW, van der Veer EP, Versteeg HH, Reinders ME, Staal FJ, van Kooten C, Rabelink TJ, van Zonneveld AJ

Ischemia/reperfusion injury (IRI) is a central phenomenon in kidney transplantation and AKI. Integrity of the renal peritubular capillary network is an important limiting factor in the recovery from IRI. MicroRNA-126 (miR-126) facilitates vascular regeneration by functioning as an angiomiR and by modulating mobilization of hematopoietic stem/progenitor cells. We hypothesized that overexpression of miR-126 in the hematopoietic compartment could protect the kidney against IRI via preservation of m... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, Volume 199, 5 1 2014, Pages 23-29 Effects of fly ash and boric acid on Y2O3-stabilized tetragonal ZrO2 dispersed with MgAl2O4: An experimental study on rat subcutaneous tissue. Ergun G, Guru M, Egilmez F, Cekic-Nagas I, Yilmaz D

The aim of this study was to evaluate the subcutaneous tissue reaction around zirconia-based materials. Forty-eight male Wistar Albino rats were used in this study. Disk-shaped (1mm height and 5mm diameter) samples composed of 67% spinel (MgAl2O4), 27% tetragonal zirconia polycrystal, 4% (m/m) fly ash and 2% (m/m) boric acid were inserted into dorsal muscles of rats. After 1, 4, 8 and 16 weeks, the animals were sacrificed and zirconia materials were removed with the surrounding tissue. Tissue se... Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

Heart rhythm, Volume 11, Issue 6, 4 1 2014, Pages 1031-1039 Endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy? The role of 12-lead ECG criteria in clinical practice. Piers SR, Silva Mde R, Kapel GF, Trines SA, Schalij MJ, Zeppenfeld K

Background: Specific 12-lead ECG criteria have been reported to predict an epicardial site of origin (SoO) of induced ventricular tachycardias (VTs) in left ventricular nonischemic cardiomyopathy. Objective: The purpose of this study was to (1) determine the value of ECG criteria to predict an epicardial SoO of clinically documented VTs, (2) analyze the effect of VT cycle length (CL) and antiarrhythmic drugs on the accuracy of ECG criteria, and (3) assess interobserver variability. Methods: In 3... Abstract

Cited 22 times since 2014 (2 per year) source: Scopus

British journal of anaesthesia, Volume 112, Issue 6, 3 1 2014, Pages 1005-1014 Cardiospecific sevoflurane treatment quenches inflammation but does not attenuate myocardial cell damage markers: a proof-of-concept study in patients undergoing mitral valve repair. Kortekaas KA, van der Baan A, Aarts LP, Palmen M, Cobbaert CM, Verhagen JC, Engbers FH, Klautz RJ, Lindeman JH

Background: Inflammation is considered a key mediator of complications after cardiac surgery. Sevoflurane has been shown to quench inflammation and to provide cardioprotection in preclinical studies. Clinical studies using sevoflurane confirm this effect on inflammation but do not consistently show clinical benefits. This paradox may indicate that the contribution of inflammation to postoperative sequalae is less than commonly thought or that systemic doses are too low in their local concentrati... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

Journal of chromatography. A, Volume 1338, 2 1 2014, Pages 111-116 Accurate quantitation of pentaerythritol tetranitrate and its degradation products using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Brust H, van Asten A, Koeberg M, Dalmolen J, van der Heijden A, Schoenmakers P

After an explosion of pentaerythritol tetranitrate (PETN), its degradation products pentaerythritol trinitrate (PETriN), dinitrate (PEDiN) and mononitrate (PEMN) were detected using liquid chromatography-atmospheric-pressure chemical-ionization-mass spectrometry (LC-APCI-MS). Discrimination between post-explosion and naturally degraded PETN could be achieved based on the relative amounts of the degradation products. This information can be used as evidence when investigating a possible relations... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Veterinary microbiology, Volume 170, Issue 3-4, 2 1 2014, Pages 266-277 Phylogeny of Spanish swine influenza viruses isolated from respiratory disease outbreaks and evolution of swine influenza virus within an endemically infected farm. Martín-Valls GE, Simon-Grifé M, van Boheemen S, de Graaf M, Bestebroer TM, Busquets N, Martín M, Casal J, Fouchier RA, Mateu E

In the present study, outbreaks of respiratory disease were investigated for the presence of swine influenza virus (SIV). In 14 cases the circulating SIV strains were isolated, fully sequenced and compared with other known SIVs. The viruses causing the outbreaks belonged to the H1N1 (including human pandemic H1N1), H3N2 and H1N2 subtypes. In 11/14 cases the phylogenetic analyses indicated the occurrence of probable reassortment events. In the second part of the study, the genetic evolution of H1... Abstract

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, Volume 24 Suppl 1, 1 1 2014, Pages S46-7 An unusual location for cellular schwannoma. Golge UH, Komurcu E, Yilmaz D

Schwannomas are solitary benign tumours derived from peripheral nerve sheath that are difficult to diagnose using imaging only. Diagnoses are commonly confirmed with conventional surgical resection. Small proportion of cases are formed by cellular schwannoma usually seen at paravertebral, pelvic, retroperitoneal, or mediastinal location. This patient had a 3 x 2 cm hard mass at the dorsal side of proximal phalanx of the right third toe. Bone destruction was seen on radiography and MR imaging. Cu... Abstract

Cited 116 times since 2014 (10.5 per year) source: EuropePMC

JAMA, Volume 311, Issue 12, 1 1 2014, Pages 1225-1233 Glycated hemoglobin measurement and prediction of cardiovascular disease. Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundström J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gómez-de-la-Cámara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Björkelund C, Blazer DG, Wassertheil-Smoller S, Onat A, Marín Ibañez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett-Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh J

Importance: The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain. Objective: To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. Design, setting, and participants: Analysis of individual-participant data available from 73 prospective studies involving 294,998 participants without a known history o... Abstract

Cited 64 times since 2014 (5.8 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 147, Issue 6, 28 4 2014, Pages 1783-1789 Outcomes of slide tracheoplasty in 101 children: a 17-year single-center experience. Butler CR, Speggiorin S, Rijnberg FM, Roebuck DJ, Muthialu N, Hewitt RJ, Elliott MJ

Objective: Our study describes the results from surgical slide tracheoplasty (STP) in children with long segment tracheal stenosis. Methods: Demographic and preoperative conditions, operative details, and outcome measures, including the need for endoscopic airway intervention and mortality, were collected for children undergoing STP between February 1995 and December 2012. Results: One hundred one patients (median age, 5.8 months; range, 5 days-15 years) underwent STP. Seventy-two patients (71.3... Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Volume 29, Issue 5, 27 4 2014, Pages 1029-1036 A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography. Kooiman J, Sijpkens YW, de Vries JP, Brulez HF, Hamming JF, van der Molen AJ, Aarts NJ, Cannegieter SC, Putter H, Swarts R, van den Hout WB, Rabelink TJ, Huisman MV

Background: Guidelines recommend saline hydration for prophylaxis of contrast-induced acute kidney injury (CI-AKI) in patients with chronic kidney disease (CKD) undergoing intravenous contrast media-enhanced CT (CE-CT). The safety and efficacy of a brief hydration protocol using sodium bicarbonate in this population is unknown. We analysed whether 1-h sodium bicarbonate hydration prior to CE-CT is non-inferior to saline hydration prior to and after CE-CT in CKD patients. Methods: We performed an... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

Cardiovascular research, Volume 102, Issue 2, 27 4 2014, Pages 224-231 Interaction between myofibroblasts and stem cells in the fibrotic heart: balancing between deterioration and regeneration. Ramkisoensing AA, de Vries AA, Atsma DE, Schalij MJ, Pijnappels DA

Signalling between the various cell types in the heart has been investigated for decades. However, relatively little is known about the interplay between the cardiac fibroblasts and myofibroblasts, which help to maintain myocardial tissue structure and function, and resident cardiac or extracardiac stem cells involved in tissue homeostasis and repair. Much of our knowledge about these interactions is derived from experimental animal models, especially those of myocardial infarction and stem cell... Abstract

Cited 31 times since 2014 (2.8 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 34, Issue 5, 27 4 2014, Pages 1093-1101 Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Huang J, Huffman JE, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Bis JC, Ikram MA, Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, CARDIoGRAM Consortium, Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Specto

Objective: Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases. We conducted a meta-analysis of genome-wide association studies to identify novel correlates of circulating levels of tPA. Approach and results: Fourteen cohort studies with tPA measures (N=... Abstract

Cited 43 times since 2014 (3.9 per year) source: EuropePMC

American heart journal, Volume 167, Issue 5, 26 4 2014, Pages 666-673 Prognosis of elderly patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention in 2001 to 2011: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) registry. Velders MA, James SK, Libungan B, Sarno G, Fröbert O, Carlsson J, Schalij MJ, Albertsson P, Lagerqvist B

Background: Elderly patients constitute a growing part of the population presenting with ST-elevation myocardial infarction (STEMI). The use of primary percutaneous coronary intervention (PCI) in this high-risk population remains poorly investigated. Methods: Using the Swedish Coronary Angiography and Angioplasty Registry (SCAAR), we identified consecutive patients with STEMI 80 years or older undergoing primary PCI during a 10-year period. Temporal trends in care and 1-year prognosis were inves... Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 46, Issue 3, 23 4 2014, Pages 474-9; discussion 479 Reoperation for neoaortic root pathology after the arterial switch operation. Koolbergen DR, Manshanden JS, Yazdanbakhsh AP, Bouma BJ, Blom NA, de Mol BA, Mulder BJ, Hazekamp MG

Objectives: To evaluate incidence and results of surgical intervention for neoaortic root pathology following arterial switch operation (ASO) for transposition of the great arteries (TGA). Methods: Between April 1996 and August 2013, 12 patients underwent reoperation for neoaortic root dilatation (ARD) and/or neoaortic valve regurgitation (AR). Maximal aortic sinus and annulus diameter Z-scores were recorded. Original diagnoses were TGA/IVS (6), TGA/ventricular septal defect (VSD) (4) and Taussi... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

TheScientificWorldJournal, Volume 2014, 23 4 2014, Pages 531324 Echocardiographic assessment of embryonic and fetal mouse heart development: a focus on haemodynamics and morphology. Hahurij ND, Calkoen EE, Jongbloed MR, Roest AA, Gittenberger-de Groot AC, Poelmann RE, De Ruiter MC, van Munsteren CJ, Steendijk P, Blom NA

Background: Heart development is a complex process, and abnormal development may result in congenital heart disease (CHD). Currently, studies on animal models mainly focus on cardiac morphology and the availability of hemodynamic data, especially of the right heart half, is limited. Here we aimed to assess the morphological and hemodynamic parameters of normal developing mouse embryos/fetuses by using a high-frequency ultrasound system. Methods: A timed breeding program was initiated with a WT m... Abstract

Cited 65 times since 2014 (5.9 per year) source: EuropePMC

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 40, Issue 7, 22 4 2014, Pages 850-858 Real-time intraoperative detection of breast cancer using near-infrared fluorescence imaging and Methylene Blue. Tummers QR, Verbeek FP, Schaafsma BE, Boonstra MC, van der Vorst JR, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: Despite recent developments in preoperative breast cancer imaging, intraoperative localization of tumor tissue can be challenging, resulting in tumor-positive resection margins during breast conserving surgery. Based on certain physicochemical similarities between Technetium((99m)Tc)-sestamibi (MIBI), an SPECT radiodiagnostic with a sensitivity of 83-90% to detect breast cancer preoperatively, and the near-infrared (NIR) fluorophore Methylene Blue (MB), we hypothesized that MB might... Abstract

Cited 10 times since 2014 (0.9 per year) source: EuropePMC

PloS one, Volume 9, Issue 2, 21 3 2014, Pages e88984 Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis. Willems S, van der Velden D, Quax PH, de Borst GJ, de Vries JP, Moll FL, Kuiper J, Toes RE, de Jager SC, de Kleijn DP, Hoefer IE, Pasterkamp G, Bot I

Background: Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activate mast cells during the progression and destabilization of atherosclerotic lesions remain unidentified. Mast cells can be activated by immunoglobulins and in the present study, we aimed to... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 47, Issue 5, 20 3 2014, Pages 479-486 Differences in mortality, risk factors, and complications after open and endovascular repair of ruptured abdominal aortic aneurysms. von Meijenfeldt GC, Ultee KH, Eefting D, Hoeks SE, ten Raa S, Rouwet EV, Hendriks JM, Verhagen HJ, Bastos Goncalves FM

Objective/background: Endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysm (rAAA) has faced resistance owing to the marginal evidence of benefit over open surgical repair (OSR). This study aims to determine the impact of treatment modality on early mortality after rAAA, and to assess differences in postoperative complications and long-term survival. Methods: Patients treated between January 2000 and June 2013 were identified. The primary endpoint was early mortality. Second... Abstract