Research

Publications

Below you can find a list of our published research.

7429 results

Cited 15 times since 2015 (1.5 per year) source: EuropePMC

European heart journal, Volume 36, Issue 31, 16 3 2015, Pages 2079-2086 Secundum atrial septal defect is associated with reduced survival in adult men. Kuijpers JM, van der Bom T, van Riel AC, Meijboom FJ, van Dijk AP, Pieper PG, Vliegen HW, Waskowsky WM, Oomen T, Zomer AC, Wagenaar LJ, Heesen WF, Roos-Hesselink JW, Zwinderman AH, Mulder BJ, Bouma BJ

Aims: The identification of sex differences in the prognosis of adults with a secundum atrial septal defect (ASD2) could help tailor their clinical management, as it has in other cardiovascular diseases. We investigated whether disparity between the sexes exists in long-term outcome of adult ASD2 patients. Methods and results: Patients with ASD2 classified as the primary defect were selected from the Dutch national registry of adult congenital heart disease. Survival stratified by sex was compar... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Journal of electrocardiology, Volume 48, Issue 4, 15 3 2015, Pages 490-497 Intra-individual ECG changes over 25 years: How long can elective ECGs be used as reference for acute ischemia detection? De Jongh MC, Ter Haar CC, Man S, Treskes RW, Maan AC, Schalij MJ, Swenne CA

Background: The guidelines advocate, in patients with chest pain, comparison of the acute ECG with a previously made, non-ischemic ECG that serves as a reference, to corroborate the working diagnosis of acute coronary syndrome (ACS). Our approach of this serial comparison is to compute the differences between the ST vectors at the J point and 60 ms thereafter (∆ST(J+0), ∆ST(J+60)) and between the ventricular gradient (VG) vectors (∆VG). In the current study, we investigate if reference ECGs rema... Abstract

Cited 80 times since 2015 (8.1 per year) source: EuropePMC

Molecular psychiatry, Volume 21, Issue 2, 14 2 2015, Pages 189-197 GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ, Schmidt CO, Mather KA, Chouraki V, Sun Q, Resnick SM, Rose LM, Oldmeadow C, Stewart M, Smith BH, Gudnason V, Yang Q, Mirza SS, Jukema JW, deJager PL, Harris TB, Liewald DC, Amin N, Coker LH, Stegle O, Lopez OL, Schmidt R, Teumer A, Ford I, Karbalai N, Becker JT, Jonsdottir MK, Au R, Fehrmann R, Herms S, Nalls M, Zhao W, Turner ST, Yaffe K, Lohman K, van Swieten JC, Kardia S, Knopman DS, Meeks WM, Heiss G, Holliday EG, Schofield PW, Tanaka T, Stott DJ, Wang J, Ridker P, Gow AJ, Pattie A, Starr JM, Hocking LJ, Armstrong NJ, McLachlan S, Shulman JM, Pilling LC, Eiriksdottir G, Scott RJ, Kochan NA, Palotie A, Hsieh YC, Eriksson JG, Penman A, Gottesman RF, Oostra BA, Yu L, DeStefano AL, Beiser A, Garcia M, Rotter JI, Nöthen MM, Hofman A, Slagboom PE, Westendorp R, Buckley

To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time... Abstract

Cited 92 times since 2015 (9.3 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 100, Issue 6, 9 2 2015, Pages 2181-2191 Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis. Chaker L, Baumgartner C, den Elzen WP, Ikram MA, Blum MR, Collet TH, Bakker SJ, Dehghan A, Drechsler C, Luben RN, Hofman A, Portegies ML, Medici M, Iervasi G, Stott DJ, Ford I, Bremner A, Wanner C, Ferrucci L, Newman AB, Dullaart RP, Sgarbi JA, Ceresini G, Maciel RM, Westendorp RG, Jukema JW, Imaizumi M, Franklyn JA, Bauer DC, Walsh JP, Razvi S, Khaw KT, Cappola AR, Völzke H, Franco OH, Gussekloo J, Rodondi N, Peeters RP, Thyroid Studies Collaboration

Objective: The objective was to determine the risk of stroke associated with subclinical hypothyroidism. Data sources and study selection: Published prospective cohort studies were identified through a systematic search through November 2013 without restrictions in several databases. Unpublished studies were identified through the Thyroid Studies Collaboration. We collected individual participant data on thyroid function and stroke outcome. Euthyroidism was defined as TSH levels of 0.45-4.49 mIU... Abstract

Cited 19 times since 2015 (1.9 per year) source: EuropePMC

Open heart, Volume 2, Issue 1, 8 2 2015, Pages e000237 Prosthetic aortic valve selection: current patient experience, preferences and knowledge. Korteland NM, Bras FJ, van Hout FM, Kluin J, Klautz RJ, Bogers AJ, Takkenberg JJ

Objective: Current clinical practice guidelines advocate shared decision-making (SDM) in prosthetic valve selection. This study assesses among adult patients accepted for aortic valve replacement (AVR): (1) experience with current clinical decision-making regarding prosthetic valve selection, (2) preferences for SDM and risk presentation and (3) prosthetic valve knowledge and numeracy. Methods: In a prospective multicentre cohort study, AVR patients were surveyed preoperatively and 3 months post... Abstract

Cited 31 times since 2015 (3.1 per year) source: EuropePMC

International journal of epidemiology, Volume 44, Issue 2, 7 1 2015, Pages 604-612 LDL cholesterol still a problem in old age? A Mendelian randomization study. Postmus I, Deelen J, Sedaghat S, Trompet S, de Craen AJ, Heijmans BT, Franco OH, Hofman A, Dehghan A, Slagboom PE, Westendorp RG, Jukema JW

Background: Observational studies in older subjects have shown no or inverse associations between cholesterol levels and mortality. However, in old age plasma low-density lipoprotein cholesterol (LDL-C) may not reflect the lifetime level due to reverse causality, and hence the risk may be underestimated. In the current study, we used an LDL genetic risk score (GRS) to overcome this problem. Methods: A weighted GRS was created using 51 single nucleotide polymorphisms associated with LDL-C levels.... Abstract

Cited 6 times since 2015 (0.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 2, 7 1 2015, Pages 538-44; discussion 544-5 A single-centre 37-year experience with reoperation after primary repair of atrioventricular septal defect. Sojak V, Kooij M, Yazdanbakhsh A, Koolbergen DR, Bruggemans EF, Hazekamp MG

Objectives: To evaluate our experience with patients reoperated after primary repair of atrioventricular septal defect (AVSD) and identify predictors of poor outcome. Methods: Between 1976 and 2014, 69 patients were reoperated after primary repair of partial (n = 28), intermediate (n = 15) or complete (n = 26) AVSD. Results: Median age at first reoperation was 62.4 (range, 1.6-845) months, median interval to first reoperation was 22.3 (range, 0.2-598) months. Main indications for first reoperati... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 42, Issue 5, 7 1 2015, Pages 1297-1304 High-temporal velocity-encoded MRI for the assessment of left ventricular inflow propagation velocity: Comparison with color M-mode echocardiography. Calkoen EE, Marsan NA, Bax JJ, van den Boogaard PJ, Roest AA, de Roos A, Westenberg JJ

Purpose: To develop an alternative method for Vp-assessment using high-temporal velocity-encoded magnetic resonance imaging (VE-MRI). Left ventricular (LV) inflow propagation velocity (Vp) is considered a useful parameter in the complex assessment of LV diastolic function and is measured by Color M-mode echocardiography. Materials and methods: A total of 43 patients diagnosed with ischemic heart failure (61 ± 11 years) and 22 healthy volunteers (29 ± 13 years) underwent Color M-mode echocardiogr... Abstract

Cited 34 times since 2015 (3.4 per year) source: Scopus

JACC. Cardiovascular interventions, Volume 8, Issue 5, 1 1 2015, Pages 670-677 Surgical sutureless and transcatheter aortic valves: hemodynamic performance and clinical outcomes in propensity score-matched high-risk populations with severe aortic stenosis. Kamperidis V, van Rosendael PJ, de Weger A, Katsanos S, Regeer M, van der Kley F, Mertens B, Sianos G, Ajmone Marsan N, Bax JJ, Delgado V

Objectives: In propensity score-matched patients with severe aortic stenosis treated with surgical aortic valve replacement (AVR) with the 3f Enable sutureless prosthesis (Medtronic, Minneapolis, Minnesota) or transcatheter aortic valve replacement (TAVR), the hemodynamic performance of both valves and mid-term survival of patients were evaluated. Background: Data on hemodynamic performance of surgical sutureless bioprostheses in high operative risk patients with aortic stenosis are scarce. Meth... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 10, Issue 12, 1 1 2015, Pages 1488-1492 How should I treat recurrent concomitant para-ring and valvular mitral regurgitation after surgical mitral valve repair in a high-risk patient? van Rosendael P, van der Kley F, Martina B, Palmen M, Delgado V, Schillinger W, von Bardeleben RS, Yeo KK, Ho KW, Jack Tan WC

Abstract

European heart journal, Volume 36, Issue 14, 1 1 2015, Pages 832-833 The first European Congress on e-Cardiology & e-Health. Bruining N, van der Velde ET, Saner H

Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

World journal for pediatric & congenital heart surgery, Volume 6, Issue 2, 1 1 2015, Pages 298-300 Isolated right subclavian artery with interrupted aortic arch, ventricular septal defect, and left ventricular outflow tract obstruction. Te Hoven AS, Clur SA, Andreu JP, Hazekamp MG

We present two cases of isolated right subclavian artery from the right pulmonary artery (PA) associated with interrupted aortic arch, ventricular septal defect, left ventricular outflow tract obstruction, and 22q11 microdeletion. Both patients were successfully managed with bilateral PA banding initially followed by a modified Yasui operation. Isolation of the subclavian artery is rare but should always be taken into account, especially when bilateral PA banding is considered. The banding must... Abstract

Cited 22 times since 2015 (2.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 10, 31 5 2015, Pages 794-799 Severe tricuspid regurgitation is predictive for adverse events in tetralogy of Fallot. Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Hazekamp MG, Koolbergen DR, Groenink M, Mulder BJ, Bouma BJ

Objective: Patients with surgically repaired tetralogy of Fallot (rTOF) may develop functional tricuspid regurgitation (TR) due to annulus dilation. Guidelines suggest pulmonary valve replacement (PVR) in patients with rTOF with progressive TR, but data on clinical outcomes are lacking. Our objective was to determine whether TR was predictive for adverse events after PVR. Methods: In this retrospective, multicenter cohort study, patients with rTOF who had undergone PVR after preoperative echocar... Abstract

Cited 12 times since 2015 (1.2 per year) source: EuropePMC

International journal of cardiology, Volume 187, 28 4 2015, Pages 559-561 Heart rate variability, but not heart rate, is associated with handgrip strength and mortality in older Africans at very low cardiovascular risk: A population-based study. Koopman JJ, van Bodegom D, Maan AC, Li Z, Ziem JB, Westendorp RG, Jukema JW

Abstract

Cited 33 times since 2015 (3.3 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 26, Issue 5, 27 4 2015, Pages 547-555 QRS Fragmentation and QTc Duration Relate to Malignant Ventricular Tachyarrhythmias and Sudden Cardiac Death in Patients with Hypertrophic Cardiomyopathy. Debonnaire P, Katsanos S, Joyce E, VAN DEN Brink OV, Atsma DE, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Background: QRS fragmentation (fQRS) and prolonged QTc interval on surface ECG are prognostic in various cardiomyopathies other than hypertrophic cardiomyopathy (HCM). The association between fQRS and prolonged QTc duration with occurrence of ventricular tachyarrhythmias or sudden cardiac death (VTA/SCD) in patients with HCM was explored. Methods and results: One hundred and ninety-five clinical HCM patients were studied. QTc duration was derived applying Bazett's formula; fQRS was defined... Abstract

Cited 234 times since 2015 (23.5 per year) source: EuropePMC

Circulation. Cardiovascular genetics, Volume 8, Issue 3, 27 4 2015, Pages 437-446 Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members. Groeneweg JA, Bhonsale A, James CA, te Riele AS, Dooijes D, Tichnell C, Murray B, Wiesfeld AC, Sawant AC, Kassamali B, Atsma DE, Volders PG, de Groot NM, de Boer K, Zimmerman SL, Kamel IR, van der Heijden JF, Russell SD, Jan Cramer M, Tedford RJ, Doevendans PA, van Veen TA, Tandri H, Wilde AA, Judge DP, van Tintelen JP, Hauer RN, Calkins H

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a progressive cardiomyopathy. We aimed to define long-term outcome in a transatlantic cohort of 1001 individuals. Methods and results: Clinical and genetic characteristics and follow-up data of ARVD/C index-patients (n=439, fulfilling of 2010 criteria in all) and family members (n=562) were assessed. Mutations were identified in 276 index-patients (63%). Index-patients presented predominantly with sustained ventric... Abstract

Cited 55 times since 2015 (5.5 per year) source: EuropePMC

Journal of the American Heart Association, Volume 4, Issue 4, 26 4 2015, Pages e001403 A change in inflammatory footprint precedes plaque instability: a systematic evaluation of cellular aspects of the adaptive immune response in human atherosclerosis. van Dijk RA, Duinisveld AJ, Schaapherder AF, Mulder-Stapel A, Hamming JF, Kuiper J, de Boer OJ, van der Wal AC, Kolodgie FD, Virmani R, Lindeman JH

Background: Experimental studies characterize adaptive immune response as a critical factor in the progression and complications of atherosclerosis. Yet, it is unclear whether these observations translate to the human situation. This study systematically evaluates cellular components of the adaptive immune response in a biobank of human aortas covering the full spectrum of atherosclerotic disease. Methods and results: A systematic analysis was performed on 114 well-characterized perirenal aortic... Abstract

Cited 22 times since 2015 (2.2 per year) source: EuropePMC

The American journal of cardiology, Volume 115, Issue 12, 24 4 2015, Pages 1726-1732 Timing of staged percutaneous coronary intervention before transcatheter aortic valve implantation. van Rosendael PJ, van der Kley F, Kamperidis V, Katsanos S, Al Amri I, Regeer M, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V

Significant coronary artery disease is highly prevalent in patients who underwent transcatheter aortic valve implantation (TAVI). Timing of staged percutaneous coronary intervention (PCI) in TAVI candidates remains debated. The present study assessed the impact of timing of the staged PCI on TAVI outcomes. Ninety-six patients (age 81 ± 5 years, 57% men) who had undergone staged PCI within 1 year before TAVI were included. The population was dichotomized according to the median time elapsed betwe... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Journal of cardiac failure, Volume 21, Issue 7, 18 3 2015, Pages 601-607 The Post-Myocardial Infarction Pacing Remodeling Prevention Therapy (PRomPT) Trial: Design and Rationale. Chung ES, Fischer TM, Kueffer F, Anand IS, Bax JJ, Gold MR, Gorman RC, Theres H, Udelson JE, Stancak B, Svendsen JH, Stone GW, Leon A

Background: Despite considerable improvements in the medical management of patients with myocardial infarction (MI), patients with large MI still have substantial risk of developing heart failure. In the early post-MI setting, implantable cardioverter defibrillators have reduced arrhythmic deaths but have no impact on overall mortality. Therefore, additional interventions are required to further reduce the overall morbidity and mortality of patients with large MI. Methods: The Pacing Remodeling... Abstract

Cited 14 times since 2015 (1.4 per year) source: EuropePMC

International journal of cardiology, Volume 186, 11 2 2015, Pages 315-320 Weighing the risks: Thrombotic and bleeding events in adults with atrial arrhythmias and congenital heart disease. Heidendael JF, Bokma JP, de Groot JR, Koolbergen DR, Mulder BJ, Bouma BJ

Introduction: Atrial arrhythmias are associated to thromboembolism and anticoagulant treatment is installed according to risk profile. This study aimed to assess the rate of thrombotic events and major bleedings in adults with congenital heart disease (CHD) and atrial arrhythmias, as well as to determine the predictive value of specific clinical features and two risk scores for thromboembolism and bleeding. Methods and results: In this retrospective study, a total of 229 adult CHD patients with... Abstract