Research

Publications

Below you can find a list of our published research.

6125 results

Cited 18 times since 2001 (0.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 85, Issue 4, 1 1 2001, Pages 458-462 Increased risk for ischaemic events is related to combined RAS polymorphism. van Geel PP, Pinto YM, Zwinderman AH, Henning RH, van Boven AJ, Jukema JW, Bruschke AV, Kastelein JJ, van Gilst WH

Objective: To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis. Design: Prospective defined substudy of the lipid lowering regression trial (REGRESS). Setting: University hospital. Patients: 885 male patients with stable coronary artery disease. Main outcome me... Abstract

Cited 6 times since 2001 (0.3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 71, Issue 4, 1 1 2001, Pages 1382-1383 Implantation of cardioverter device in young children: the perirenal approach. Hazekamp MG, Blom NA, Schoof PH, Schalij MJ, Dion RA

Placement of Implantable cardioverter devices in young children is complicated because of the relatively large size and heavy weight of these devices. A technique is described where the device is implanted in the left perirenal space while an endovascular lead is used instead of an epicardial patch electrode. Abstract

Cited 4 times since 2001 (0.2 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 85, Issue 4, 1 1 2001, Pages 746-747 Factor VII polymorphisms and myocardial infarction: what is special in Italians? REGRESS study group. Regression Growth Evaluation Statin Study. Nederhand RJ, de Maat MP, Jukema JW, Regression Growth Evaluation Statin Study group

Abstract

Cited 70 times since 2001 (2.9 per year) source: EuropePMC

Circulation, Volume 103, Issue 13, 1 1 2001, Pages 1778-1786 Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Delsing DJ, Offerman EH, van Duyvenvoorde W, van Der Boom H, de Wit EC, Gijbels MJ, van Der Laarse A, Jukema JW, Havekes LM, Princen HM

Background: The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. Methods and results: Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimibe mixed into the diet. The HC diet resulted in a plasma cholesterol concentration of 18.7+/-2.6 mmol/L. Addition of avasimibe lowered plasma cholesterol by 56% to 8.1+/-1.2 mmol/... Abstract

Cited 22 times since 2001 (0.9 per year) source: EuropePMC

Gene therapy, Volume 8, Issue 7, 1 1 2001, Pages 534-541 In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI. Lamfers ML, Lardenoye JH, de Vries MR, Aalders MC, Engelse MA, Grimbergen JM, van Hinsbergh VW, Quax PH

Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled proteolytic degradation of extracellular matrix surrounding the cell. Plasmin is a major contributor to this process by degrading various matrix proteins directly, or indirectly by activating matrix metalloproteinases. This makes it an attractive target for inhibition by gene transfer. An adenoviral vector, Ad.ATF.BPTI, was constructed encoding... Abstract

Cited 170 times since 2001 (7.1 per year) source: EuropePMC

Circulation, Volume 103, Issue 9, 1 1 2001, Pages 1198-1205 Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HO, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J, Kastelein JJ, Hayden MR

Background: Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 (ABCA1) as the major gene underlying the HDL deficiency associated with reduced cholesterol efflux. Mutations within the ABCA1 gene are associated with decreased HDL-C, increased triglycerides, and an increased risk of CAD. However, the extent to which common variation within this gene influences plasma lipid levels an... Abstract

Cited 17 times since 2001 (0.7 per year) source: EuropePMC

The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), Volume 45, Issue 1, 1 1 2001, Pages 108-114 Perfusion and functional abnormalities outside the septal region in patients with left bundle branch block assessed with gated SPECT. Bavelaar-Croon CD, Wahba FF, Van Hecke MV, Atsma DE, Stokkel MP, Pauwels EK, Van der Wall EE

Background: The presence of a left bundle branch block (LBBB) pattern on the electrocardiogram may frequently lead to perfusion defects in the septum not necessarily due to ischemic heart disease, but probably due to abnormal septal wall motion. The introduction of gated single photon emission computed tomography (SPECT) allows the evaluation of myocardial perfusion and function in one study. Accordingly, we analysed perfusion and function and the relation between perfusion and regional function... Abstract

Cited 13 times since 2001 (0.5 per year) source: EuropePMC

Analytical biochemistry, Volume 290, Issue 2, 1 1 2001, Pages 283-291 Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer. Havenga MJ, van Dam B, Groot BS, Grimbergen JM, Valerio D, Bout A, Quax PH

Nitric oxide (NO) is involved in the regulation of SMC proliferation during intimal hyperplasia as has been shown by the inhibitory effect on intimal hyperplasia of adenovirus-mediated ceNOS overexpression in injured arteries in pig. Good assays to quantify the NO-producing enzymes, i.e., NO synthases (NOS), are essential to analyze the mechanism of action of NO in this process. We have developed novel flow cytometric assays for the simultaneous detection of NOS-3 protein, using NOS-3 specific a... Abstract

Cited 12 times since 2001 (0.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 71, Issue 2, 1 1 2001, Pages 601-7; discussion 607-8 Outcome and follow-up of aortic valve replacement with the freestyle stentless bioprosthesis. Kappetein AP, Braun J, Baur LH, Prat A, Peels K, Hazekamp MG, Schoof PH, Huysmans HA

Background: The aim of this study was to determine the morbidity, mortality, and hemodynamics after implantation of the Freestyle stentless bioprosthesis in the aortic position. Methods: A total of 280 patients were operated on from June 1993 to July 1999 as part of a multicenter investigation. Factors influencing hospital mortality and long-term survival were assessed by logistic regression and Cox proportional hazards analysis. Patients were evaluated postoperatively at discharge, at 3 to 6 mo... Abstract

Cited 40 times since 2001 (1.7 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 21, Issue 2, 1 1 2001, Pages 118-122 Quality of life in patients with intermittent claudication using the World Health Organisation (WHO) questionnaire. Breek JC, Hamming JF, De Vries J, Aquarius AE, van Berge Henegouwen DP

Objective: to assess quality of life (QOL) in patients with intermittent claudication. Design: a prospective, open study. Material and method: one hundred and fifty-one consecutive claudicants (100 men, 51 women), and 161 healthy controls (70 men and 91 women) completed an adapted version of the World Health Organisation Quality of Life Assessment Instrument-100. Results: patients scored significantly worse on the domains Physical health and Level of independence, as well as on the facets Pain a... Abstract

Cited 21 times since 2001 (0.9 per year) source: EuropePMC

Pflugers Archiv : European journal of physiology, Volume 441, Issue 5, 1 1 2001, Pages 717-724 Within-subject electrocardiographic differences at equal heart rates: role of the autonomic nervous system. Frederiks J, Swenne CA, Kors JA, van Herpen G, Maan AC, Levert JV, Schalij MJ, Bruschke AV

Various combinations of sympathetic and vagal tone can yield the same heart rate, while ventricular electrophysiology differs. To demonstrate this in humans, we studied healthy volunteers in the sitting position with horizontal legs. First, heart rate was increased by lowering the legs to 60 degrees and back. Thereafter, heart rate was increased by handgrip. In each subject, a leg-lowering angle was selected at which heart rate matched best with heart rate in the third handgrip minute. Thirteen... Abstract

Cited 26 times since 2001 (1.1 per year) source: EuropePMC

Radiology, Volume 218, Issue 2, 1 1 2001, Pages 540-547 Improved MR flow mapping in coronary artery bypass grafts during adenosine-induced stress. Langerak SE, Kunz P, Vliegen HW, Lamb HJ, Jukema JW, van Der Wall EE, de Roos A

Purpose: To validate a recently developed fast high-temporal-resolution magnetic resonance (MR) flow sequence and use it to assess coronary artery bypass graft function during pharmacologic stress. Materials and methods: Aortic and internal mammary artery flow was measured in 11 healthy volunteers by using conventional cine gradient-echo imaging as a reference standard method and turbo-field echo-planar imaging (TFEPI). By using TFEPI, breath-hold flow mapping with a spatial and temporal resolut... Abstract

Cited 35 times since 2001 (1.4 per year) source: EuropePMC

European journal of immunology, Volume 31, Issue 1, 1 1 2001, Pages 146-155 Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer. van der Burg SH, de Cock K, Menon AG, Franken KL, Palmen M, Redeker A, Drijfhout J, Kuppen PJ, van de Velde C, Erdile L, Tollenaar RA, Melief CJ, Offringa R

Colorectal carcinoma is commonly associated with mutation and overexpression of p53, making this antigen a potential target for immune intervention. We analyzed humoral and proliferative immunity against p53 in the blood of patients with resected primary colorectal cancer. The majority of these patients displayed anti-p53 T helper (Th) immunity in the absence of measurable p53 specific antibody levels. The Th responses were long-lasting since they could be detected up to several years after rese... Abstract

Cited 33 times since 2001 (1.4 per year) source: EuropePMC

Circulation, Volume 103, Issue 4, 1 1 2001, Pages 562-569 Adenoviral expression of a urokinase receptor-targeted protease inhibitor inhibits neointima formation in murine and human blood vessels. Quax PH, Lamfers ML, Lardenoye JH, Grimbergen JM, de Vries MR, Slomp J, de Ruiter MC, Kockx MM, Verheijen JH, van Hinsbergh VW

Background: Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid protein designed to inhibit the activity of cell surface-bound plasmin, which cannot be inhibited by its natural inhibitors, such as alpha(2)-antiplasmin.... Abstract

Cited 6 times since 2001 (0.2 per year) source: EuropePMC

Early human development, Volume 60, Issue 3, 1 1 2001, Pages 159-170 Inhibition of nitric oxide synthesis following severe hypoxia-ischemia restores autoregulation of cerebral blood flow in newborn lambs. Dorrepaal CA, Steendijk P, Baan J, van Bel F

Birth asphyxia impairs the autoregulatory ability of the cerebral blood flow. Inappropriate synthesis of vasodilatory nitric oxide may be important in this respect. We investigated if nitric oxide synthesis inhibition by N(omega)-nitro-L-arginine (NLA) could restore cerebral autoregulation after severe hypoxia-ischemia (HI). HI was induced in 15 newborn lambs. Cerebral blood flow (carotid artery blood flow [ml/min]: Qcar) and mean aortic blood pressure [mmHg]: MABP) were measured over a 30 min p... Abstract

Cited 23 times since 2001 (1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 8, Issue 1, 1 1 2001, Pages 10-18 Comparison of left ventricular function at rest and post-stress in patients with myocardial infarction: Evaluation with gated SPECT. Bavelaar-Croon CD, America YG, Atsma DE, Dibbets-Schneider P, Zwinderman AH, Stokkel MP, Pauwels EK, van der Wall EE

Background: Quantitative electrocardiogram-gated single photon emission computed tomography (SPECT) myocardial imaging (QGS) is a means of providing functional information about the left ventricle and myocardial perfusion. However, the functional information derived 30 minutes post-stress may be different from the left ventricular (LV) function determined at rest. This study determined whether LV function post-stress would be different from LV function at rest in patients with an earlier myocard... Abstract

Cited 9 times since 2001 (0.4 per year) source: EuropePMC

Nuclear medicine communications, Volume 22, Issue 1, 1 1 2001, Pages 45-55 The additive value of gated SPET myocardial perfusion imaging in patients with known and suspected coronary artery disease. Bavelaar-Croon CD, Atsma DE, van der Wall EE, Dibbets-Schneider P, Zwinderman AH, Pauwels EK

In myocardial perfusion scintigraphy, the clinical significance of fixed defects presents some difficulty. In this study, we evaluated whether additional information on left ventricular function assessed by quantitative gated single-photon emission computed tomography (gated SPET) would increase the diagnostic yield of the study in such patients. We studied 55 patients with a previous myocardial infarction and 20 patients without a previous myocardial infarction using gated SPET 99Tc(m)-tetrofos... Abstract

Cited 17 times since 2001 (0.7 per year) source: EuropePMC

Journal of biomechanics, Volume 34, Issue 1, 1 1 2001, Pages 41-50 Predicting systolic and diastolic aortic blood pressure and stroke volume in the intact sheep. Segers P, Steendijk P, Stergiopulos N, Westerhof N

We developed a mathematical model describing the interaction between the heart and the arterial system. The model was constructed and tested on basis of invasive hemodynamic data in six sheep. Data from a first group of three animals (49 cardiac cycles) were used to assess a template time-varying elastance curve for the left ventricle, while the baseline steady-state data of a second group of three animals were used to assess reference cardiac and arterial parameters in sheep. The model is fully... Abstract

Cited 15 times since 2001 (0.6 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 280, Issue 1, 1 1 2001, Pages H392-400 Enhanced systolic function of the right ventricle during respiratory distress syndrome in newborn lambs. De Vroomen M, Steendijk P, Lopes Cardozo RH, Brouwers HH, Van Bel F, Baan J

Respiratory distress syndrome (RDS) causes pulmonary hypertension. It is often suggested that this increased afterload for the right ventricle (RV) might lead to cardiac dysfunction. To examine this, we studied biventricular function in an experimental model. RDS was induced by lung lavages in seven newborn lambs. Five additional lambs served as controls. Cardiac function was quantified by indexes derived from end-systolic pressure-volume relations obtained by pressure-conductance catheters. Aft... Abstract

Cited 8 times since 2000 (0.3 per year) source: EuropePMC

Cardiovascular research, Volume 48, Issue 3, 1 1 2000, Pages 455-463 A new approach to determine parallel conductance for left ventricular volume measurements. Kornet L, Schreuder JJ, van der Velde ET, Baan J, Jansen JR

Objectives: To determine absolute ventricular volume with the conductance catheter technique, the electrical conductance of tissues and fluids (parallel conductance) around the ventricle should be determined precisely. Methods: A new objective method to estimate parallel conductance based on analysis of the dilution curve of hypertonic saline was investigated. The parallel conductances obtained with the new method (G(a)(p)) were compared to those obtained with the conventional method (G(l)(p)).... Abstract