Research

Publications

Below you can find a list of our published research.

7241 results

PloS one, Volume 18, Issue 12, 19 3 2023, Pages e0292645 Differences in the gut microbiota between Gurkhas and soldiers of British origin. Troth TD, McInnes RS, Dunn SJ, Mirza J, Whittaker AH, Goodchild SA, Loman NJ, Harding SV, van Schaik W

Previous work indicated that the incidence of travellers' diarrhoea (TD) is higher in soldiers of British origin, when compared to soldiers of Nepalese descent (Gurkhas). We hypothesise that the composition of the gut microbiota may be a contributing factor in the risk of developing TD in soldiers of British origin. This study aimed to characterise the gut microbial composition of Gurkha and non-Gurkha soldiers of the British Army. Recruitment of 38 soldiers (n = 22 Gurkhas, n = 16 non-Gurk... Abstract

Cited 3 times since 2023 (2 per year) source: EuropePMC

European journal of heart failure, Volume 26, Issue 1, 18 3 2023, Pages 87-102 Proteomic prediction of incident heart failure and its main subtypes. Emilsson V, Jonsson BG, Austin TR, Gudmundsdottir V, Axelsson GT, Frick EA, Jonmundsson T, Steindorsdottir AE, Loureiro J, Brody JA, Aspelund T, Launer LJ, Thorgeirsson G, Kortekaas KA, Lindeman JH, Orth AP, Lamb JR, Psaty BM, Kizer JR, Jennings LL, Gudnason V

Aim: To examine the ability of serum proteins in predicting future heart failure (HF) events, including HF with reduced or preserved ejection fraction (HFrEF or HFpEF), in relation to event time, and with or without considering established HF-associated clinical variables. Methods and results: In the prospective population-based Age, Gene/Environment Susceptibility Reykjavik Study (AGES-RS), 440 individuals developed HF after their first visit with a median follow-up of 5.45 years. Among them, 1... Abstract

BMJ open, Volume 13, Issue 12, 18 3 2023, Pages e064335 New methodology to assess the excess burden of antibiotic resistance using country-specific parameters: a case study regarding <i>E. coli</i> urinary tract infections. Godijk NG, McDonald SA, Altorf-van der Kuil W, Schoffelen AF, Franz E, Bootsma MCJ

Objectives: Antimicrobial resistant (AMR) infections are a major public health problem and the burden on population level is not yet clear. We developed a method to calculate the excess burden of resistance which uses country-specific parameter estimates and surveillance data to compare the mortality and morbidity due to resistant infection against a counterfactual (the expected burden if infection was antimicrobial susceptible). We illustrate this approach by estimating the excess burden for AM... Abstract

Computer methods and programs in biomedicine, Volume 244, 17 3 2023, Pages 107984 Quantification of the intrinsic neural plexus of the heart - The missing link in histological tissue analysis. Chen HS, Voortman LM, van Munsteren JC, Wisse LJ, deRuiter MC, Zeppenfeld K, Jongbloed MRM

Background and objective: The heart is under strict regulation of the autonomic nervous system, during which, in a healthy state, the effects of sympathetic and parasympathetic branches are balanced. In recent years, there has been increasing interest in pathological remodeling and outgrowth of cardiac autonomic nerves in relation to arrhythmogenesis. However, the small size of the cardiac nerves in relatively large tissues renders research using histological quantification of these nerves extre... Abstract

Cited 4 times since 2023 (2.7 per year) source: EuropePMC

Journal of thrombosis and haemostasis : JTH, Volume 22, Issue 4, 15 3 2023, Pages 936-950 A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment. Gallego-Fabrega C, Temprano-Sagrera G, Cárcel-Márquez J, Muiño E, Cullell N, Lledós M, Llucià-Carol L, Martin-Campos JM, Sobrino T, Castillo J, Millán M, Muñoz-Narbona L, López-Cancio E, Ribó M, Alvarez-Sabin J, Jiménez-Conde J, Roquer J, Tur S, Obach V, Arenillas JF, Segura T, Serrano-Heras G, Marti-Fabregas J, Freijo-Guerrero M, Moniche F, Castellanos MDM, Morrison AC, Smith NL, de Vries PS, Fernández-Cadenas I, Sabater-Lleal M, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Spanish Stroke Genetic Consortium

Background: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient's prognosis. Objectives: To investigate the association between genetically determined natural hemostatic factors' levels and increased risk of HT after r-tPA treatment.... Abstract

PHAGE (New Rochelle, N.Y.), Volume 4, Issue 4, 14 2 2023, Pages 159-164 Genome Sequence and Characterization of Coliphage Môr Ffagbaw. Thomas NE, Ugokwe NI, Kinsella A, Galyov E, van Schaik W, Joyce N, Nobrega FL, Millard A, Wilkinson RC

Background: The quality of coastal waters around the United Kingdom is an area of increasing concern following sewer overflow, where wastewater is discharged into the environment. Coliphages, viruses that infect coliform bacteria, are associated with water quality in aquatic systems, yet remain largely uncharacterized at the genomic level. Materials and methods: Phage môr ffagbaw was isolated from seawater against Escherichia coli by enrichment and plaque assays. Whole genome sequencing, transmi... Abstract

Cited 1 times since 2023 (0.7 per year) source: EuropePMC

Journal of cardiology, Volume 84, Issue 2, 14 2 2023, Pages 86-92 Mitral regurgitation in atrial fibrillation: Is a simple repair enough to tackle a complex problem? Tomšič A, Meucci MC, de Jong AR, Braun J, Marsan NA, Klautz RJM, Palmen M

Background: Clinical and echocardiographic results of valve repair for mitral regurgitation in the setting of atrial fibrillation are poorly studied. Methods: Between January 2008 and December 2020, 89 patients underwent valve repair for mitral regurgitation in the setting of atrial fibrillation. Clinical and echocardiographic follow-up data were collected and studied. The primary composite endpoint consisted of all-cause mortality or hospitalization for heart failure. Results: Valve repair with... Abstract

Cited 2 times since 2023 (1.3 per year) source: EuropePMC

Cancers, Volume 15, Issue 24, 13 2 2023, Pages 5831 Relation between Coronary Artery Calcium Score and Cardiovascular Events in Hodgkin Lymphoma Survivors: A Cross-Sectional Matched Cohort Study. Polomski EAS, Heemelaar JC, de Graaf MA, Krol ADG, Louwerens M, Stöger JL, van Dijkman PRM, Schalij MJ, Jukema JW, Antoni ML

Background: Thoracic radiotherapy is one of the corner stones of HL treatment, but it is associated with increased risk of cardiovascular events. As HL is often diagnosed at a young age, long-term follow-up including screening for coronary artery disease (CAD) is recommended. Objectives: This study aims to evaluate the presence of coronary artery calcium score (CACS) in relation to cardiovascular events in HL patients treated with thoracic radiotherapy compared to a non-cancer control group. Met... Abstract

Cited 2 times since 2023 (1.3 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 103, Issue 2, 13 2 2023, Pages 308-316 Balloon atrial septostomy for transposition of the great arteries: Safety and experience with the Z-5 balloon catheter. Weeda JA, Bokenkamp-Gramann R, Straver BB, Rammeloo L, Hahurij ND, Bertels RA, Haak MC, Te Pas AB, Hazekamp MG, Blom NA, van der Palen RLF

Background: Balloon atrial septostomy (BAS) is an emergent and essential cardiac intervention to enhance intercirculatory mixing at atrial level in deoxygenated patients diagnosed with transposition of the great arteries (TGA) and restrictive foramen ovale. The recent recall of several BAS catheters and the changes in the European legal framework for medical devices (MDR 2017/745), has led to an overall scarcity of BAS catheters and raised questions about the use, safety, and experience of the r... Abstract

Cited 1 times since 2023 (0.7 per year) source: EuropePMC

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 50, Issue 2, 12 2 2023, Pages 107317 Consensus conference statement on fluorescence-guided surgery (FGS) ESSO course on fluorescence-guided surgery. van Dam MA, Bijlstra OD, Faber RA, Warmerdam MI, Achiam MP, Boni L, Cahill RA, Chand M, Diana M, Gioux S, Kruijff S, Van der Vorst JR, Rosenthal RJ, Polom K, Vahrmeijer AL, Mieog JSD

Background: Fluorescence-guided surgery (FGS) has emerged as an innovative technique with promising applications in various surgical specialties. However, clinical implementation is hampered by limited availability of evidence-based reference work supporting the translation towards standard-of-care use in surgical practice. Therefore, we developed a consensus statement on current applications of FGS. Methods: During an international FGS course, participants anonymously voted on 36 statements. Co... Abstract

Cited 2 times since 2023 (1.3 per year) source: EuropePMC

Cell reports methods, Volume 3, Issue 12, 11 2 2023, Pages 100671 Opto-electronic feedback control of membrane potential for real-time control of action potentials. Ördög B, De Coster T, Dekker SO, Bart CI, Zhang J, Boink GJJ, Bax WH, Deng S, den Ouden BL, de Vries AAF, Pijnappels DA

To unlock new research possibilities by acquiring control of action potential (AP) morphologies in excitable cells, we developed an opto-electronic feedback loop-based system integrating cellular electrophysiology, real-time computing, and optogenetic approaches and applied it to monolayers of heart muscle cells. This allowed accurate restoration and preservation of cardiac AP morphologies in the presence of electrical perturbations of different origin in an unsupervised, self-regulatory manner,... Abstract

Cited 4 times since 2023 (2.6 per year) source: EuropePMC

Annals of medicine, Volume 55, Issue 2, 8 2 2023, Pages 2283195 Cardiac sympathetic hyperinnervation after myocardial infarction: a systematic review and qualitative analysis. Chen HS, van Roon L, Schoones J, Zeppenfeld K, DeRuiter MC, Jongbloed MRM

Background: Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with arrhythmogenesis and sudden cardiac death. The characteristics of cardiac sympathetic hyperinnervation remain underexposed. Objective: To provide a systematic review on cardiac sympathetic hyperinnervation after MI, taking into account: (1) definition, experimental model and quantification method and (2) location, amount and timing, in order to obtain an overview of current knowledge and to expos... Abstract

Cited 7 times since 2023 (4.6 per year) source: EuropePMC

Nature reviews. Disease primers, Volume 9, Issue 1, 7 1 2023, Pages 70 Degenerative mitral regurgitation. Delgado V, Ajmone Marsan N, Bonow RO, Hahn RT, Norris RA, Zühlke L, Borger MA

Degenerative mitral regurgitation is a major threat to public health and affects at least 24 million people worldwide, with an estimated 0.88 million disability-adjusted life years and 34,000 deaths in 2019. Improving access to diagnostic testing and to timely curative therapies such as surgical mitral valve repair will improve the outcomes of many individuals. Imaging such as echocardiography and cardiac magnetic resonance allow accurate diagnosis and have provided new insights for a better def... Abstract

Cardiology and therapy, Volume 13, Issue 1, 7 1 2023, Pages 103-116 Automatic Quantification of Local Plaque Thickness Differences as Assessed by Serial Coronary Computed Tomography Angiography Using Scan-Quality-Based Vessel-Specific Thresholds. van Driest FY, Broersen A, van der Geest RJ, Wouter Jukema J, Scholte AJHA, Dijkstra J

Introduction: The use of serial coronary computed tomography angiography (CCTA) allows for the early assessment of coronary plaque progression, a crucial factor in averting major adverse cardiac events (MACEs). Traditionally, serial CCTA is assessed using anatomical landmarks to match baseline and follow-up scans. Recently, a tool has been developed that allows for the automatic quantification of local plaque thickness differences in serial CCTA utilizing plaque contour delineation. The aim of t... Abstract

Cited 5 times since 2023 (3.3 per year) source: EuropePMC

Behavioral ecology and sociobiology, Volume 77, Issue 12, 6 1 2023, Pages 134 Reproductive success of Bornean orangutan males: scattered in time but clustered in space. van Noordwijk MA, LaBarge LR, Kunz JA, Marzec AM, Spillmann B, Ackermann C, Rianti P, Vogel ER, Atmoko SSU, Kruetzen M, van Schaik CP

Abstract: The social and mating systems of orangutans, one of our closest relatives, remain poorly understood. Orangutans (Pongo spp.) are highly sexually dimorphic and females are philopatric and maintain individual, but overlapping home ranges, whereas males disperse, are non-territorial and wide-ranging, and show bimaturism, with many years between reaching sexual maturity and attaining full secondary sexual characteristics (including cheek pads (flanges) and emitting long calls). We report o... Abstract

Cited 3 times since 2023 (2 per year) source: EuropePMC

Medical education online, Volume 29, Issue 1, 5 1 2023, Pages 2289262 Tips for developing a coaching program in medical education. Miller-Kuhlmann R, Sasnal M, Gold CA, Nassar AK, Korndorffer JR, Van Schaik S, Marmor A, Williams S, Blankenburg R, Rassbach CE

This article provides structure to developing, implementing, and evaluating a successful coaching program that effectively meets the needs of learners. We highlight the benefits of coaching in medical education and recognize that many educators desiring to build coaching programs seek resources to guide this process. We align 12 tips with Kern's Six Steps for Curriculum Development and integrate theoretical frameworks from the literature to inform the process. Our tips include defining the... Abstract

Cited 1 times since 2023 (0.7 per year) source: EuropePMC

Healthcare (Basel, Switzerland), Volume 11, Issue 23, 4 1 2023, Pages 3099 Measurement of Three-Dimensional Back Shape of Normal Adults Using a Novel Three-Dimensional Imaging Mobile Surface Topography System (MSTS): An Intra- and Inter-Rater Reliability Study. Kandasamy G, Bettany-Saltikov J, Van Schaik P

Postural and spinal deformities are major contributing factors to musculoskeletal (MSK) disorders. Posture screening and assessment can help to identify early morphological deformities, thereby preventing progression and reducing or correcting them with effective treatments. The study evaluates both intra- and inter-repeatability of using a mobile structured light sensor with a structured light pattern for building an accurate 3D human model and its use in postural screening. 16 young males (age... Abstract

Cited 6 times since 2023 (3.9 per year) source: EuropePMC

Journal of medical Internet research, Volume 25, 4 1 2023, Pages e48461 Guide Development for eHealth Interventions Targeting People With a Low Socioeconomic Position: Participatory Design Approach. Faber JS, Al-Dhahir I, Kraal JJ, Breeman LD, van den Berg-Emons RJG, Reijnders T, van Dijk S, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM

Background: People with a low socioeconomic position (SEP) are less likely to benefit from eHealth interventions, exacerbating social health inequalities. Professionals developing eHealth interventions for this group face numerous challenges. A comprehensive guide to support these professionals in their work could mitigate these inequalities. Objective: We aimed to develop a web-based guide to support professionals in the development, adaptation, evaluation, and implementation of eHealth interve... Abstract

Cited 2 times since 2023 (1.3 per year) source: EuropePMC

International journal of surgery (London, England), Volume 109, Issue 12, 1 1 2023, Pages 4057-4061 Predictors for postoperative cranial nerve complications in carotid body tumor resection: a retrospective cohort study. Alimohamad H, Yilmaz D, Marang-van de Mheen PJ, Jansen J, Hamming JF, Schepers A

Introduction: Carotid body tumors (CBTs) are slow-growing benign tumors. Therefore, surgical resection is considered in case of tumor growth. The timing of surgery is of the utmost importance as the risk of iatrogenic surgical complications increases when resecting larger tumors, whereas on the other hand, resections for asymptomatic small CBT should be prevented. The primary aim of this study was to identify which tumor size or dimension is most accurate to predict nerve injury in patients unde... Abstract

Aorta (Stamford, Conn.), Volume 11, Issue 6, 1 1 2023, Pages 191-197 The Prevalence of Coronary Artery Disease in Bicuspid Aortic Valve Patients: An Overview of the Literature. Dolmaci OB, Hilhorst TL, Malekzadeh A, Mertens BJA, Klautz RJM, Poelmann RE, Grewal N

The prevalence of coronary artery disease (CAD) in bicuspid aortic valve (BAV) patients is a debatable topic. Several studies have indicated that BAV patients have a lower prevalence of CAD compared with patients with a tricuspid aortic valve (TAV), but the effects of age and gender have not always been considered. This systematic review provides an overview of articles which report on CAD in BAV and TAV patients. Searches were executed in April 2021 and January 2022 according to the PRISMA (Pre... Abstract