6173 results
American heart journal,
Volume 282, 9 2 2025, Pages 134-145
Increased prevalence of coronary atherosclerosis in cancer survivors: A retrospective matched cross-sectional study with coronary CT angiography.
Polomski EAS, Heemelaar JC, de Ronde MES, Al Jaff AAM, Mertens BJA, van Dijkman PRM, Jukema JW, Antoni ML
Background: Cancer and cancer treatment may accelerate the development of cardiovascular disease. With the improved prognosis of cancer survivors, cardiovascular events are increasing in this patient group. However, it is unknown whether the prevalence of coronary atherosclerosis is increased in patients with a history of cancer. This study aims to evaluate the prevalence and severity of coronary atherosclerosis in different age groups of cancer survivors compared to matched controls. Methods: C...
Abstract
Pharmacological research,
Volume 212, 9 2 2025, Pages 107575
GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study.
Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR, Genomic Investigation of Statin Therapy Consortium (GIST)
Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 100...
Abstract
JACC. Advances,
Volume 4, Issue 2, 8 2 2025, Pages 101535
Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER.
Choi SH, Young R, Koyama S, Jukema JW, Trompet S, Ford I, Natarajan P, Peloso GM
Abstract
Langenbeck's archives of surgery,
Volume 410, Issue 1, 8 2 2025, Pages 28
Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.
Tange FP, Peul RC, van den Hoven P, Koning S, Kruiswijk MW, Faber RA, Verduijn PS, van Rijswijk CSP, Galema HA, Hilling DE, van Dijk SPJ, van Ginhoven TM, Keereweer S, Mureau MAM, Feitsma EA, Noltes ME, Kruijff S, Driessen C, Achiam MP, Schepers A, van Schaik J, Mieog JSD, Vahrmeijer AL, Hamming JF, van der Vorst JR
Purpose: Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital tissue perfusion across target tissues using this imaging modality. Methods: Data from five prospective study cohorts conducted in three Dutch academic medical centres between December 2018 and June 2023 was included. Quantitative ana...
Abstract
PloS one,
Volume 20, Issue 1, 8 2 2025, Pages e0313916
Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs.
Jean-Joseph H, Kortekaas K, Range F, Kotrschal K
A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support, both at the behavioural and physiological levels. We combined behavioural observations with heart rate parameters (i.e., HR and heart rate variability, HRV) in equally raised and housed wolves and dogs to assess the responses to food offered in the vicinity of a potential stressor (an unknown spinn...
Abstract
Pediatric cardiology,
6 1 2025
Printed Models for Better Prediction of Surgery in Patients with Double Outlet Right Ventricle.
Hoogerbeets SF, Roest AAW, Valverde I, Gomez-Ciriza G, Kroft L, Hazekamp MG
The complex and variable anatomy of complex double outlet right ventricle makes it imperative to understand the spatial anatomic structures to determine whether it is feasible to repair the anomaly in a biventricular or univentricular fashion. Biventricular repair should be aimed for but is not always feasible. Choosing the correct surgical technique is of great importance in surgical planning of biventricular repair. Conventional imaging is typically insufficient to predict feasibility and tech...
Abstract
Cited 1 times since 2025 (3.4 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 56, 3 1 2025, Pages 101595
Epicardial fat tissue, a hidden enemy against the early recovery of left ventricular systolic function after transcatheter aortic valve implantation.
Anwar HS, Lopez Santi P, Algowhary M, Abdelmegid MAF, Helmy HA, Jukema JW, Ajmone Marsan N, Van Der Kley F
Background: Epicardial fat tissue (EFT) is an active organ that can affect cardiac function and structure through endocrine, paracrine, and proinflammatory mechanisms. We hypothesized that greater thickness of EFT may harm the recovery of left ventricular (LV) systolic function in patients with severe aortic stenosis (AS) and reduced LV ejection fraction (EF ≤ 50 %) undergoing transcatheter aortic valve implantation (TAVI). Methods: A sixty six patients with severe AS and 20 % ≥ LVEF ≤ 50 % who...
Abstract
JAMA dermatology,
Volume 161, Issue 1, 1 1 2025, Pages 12-21
Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis.
van der Rijst LP, Kamphuis E, Schuttelaar MLA, Hurmuz R, Seyger MMB, Caron AGM, Zuithoff NPA, Nguyen NT, Kamsteeg M, de Bruin-Weller MS, Pasmans SGMA, Middelkamp-Hup MA, de Graaf M
Importance: Dupilumab, methotrexate (MTX), and cyclosporine A (CsA) are valuable treatment options for pediatric patients with refractory moderate to severe atopic dermatitis (AD). Yet, comparative data on these treatments in pediatric patients are scarce. Objective: To evaluate drug survival of dupilumab, MTX, and CsA, and identify associated predictors in a multicenter daily practice cohort study of pediatric patients with AD. Design, setting, and participants: This multicenter daily practice...
Abstract
Digital health,
Volume 11, 1 1 2025, Pages 20552076241288724
Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers.
van den Brink WJ, Oosterman JE, Smid DJ, de Vries HJ, Atsma DE, Overeem S, Wopereis S
Digital biomarkers are quantifiable and objective indicators of a person's physiological function, behavioral state or treatment response, that can be captured using connected sensor technologies such as wearable devices and mobile apps. We envision that continuous and 24-h monitoring of the underlying physiological and behavioral processes through digital biomarkers can enhance early diagnostics, disease management, and self-care of cardiometabolic diseases. Cardiometabolic diseases, which...
Abstract
Journal of the Society for Cardiovascular Angiography & Interventions,
Volume 4, Issue 2, 31 5 2025, Pages 102492
Navigating Treble Clef Aorta: A Challenge for Transfemoral Transcatheter Aortic Valve Replacement-A Case Report.
Anwar HS, Montero-Cabezas JM, Van Der Kley F
Transcatheter aortic valve replacement (TAVR) has emerged as a widely approved intervention for managing severe aortic stenosis. As the number of patients undergoing TAVR continues to rise, certain cases present unique challenges, particularly in relation to vascular access. This report highlights a case of successful transfemoral TAVR performed in a patient with an exceptionally tortuous and elongated aortic arch, characterized by significant curvature reminiscent of the treble clef musical sym...
Abstract
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
26 4 2024, Pages 15266028241309267
Diagnostic Performance of the Maximal Systolic Acceleration for Detecting a Significant Stenosis in the Aortoiliac and Popliteal Pathway: A Retrospective Cohort Study.
Willems SA, Dolfing SG, van Wissen RC, van der Meer RW, van Schaik J, van der Vorst JR, Schepers A, Hamming JF, Brouwers JJWM
Introduction: Identifying peripheral arterial disease (PAD) remains challenging with currently used bedside tests. The maximal systolic acceleration (ACCmax) is a promising noninvasive parameter measured by duplex ultrasonography and reflects the arterial perfusion proximal to its measurement point. The principal aim of this study was to analyze the diagnostic accuracy of the ACCmax for detecting significant stenosis in different arterial segments, which could be useful in clinical decision-maki...
Abstract
EBioMedicine,
Volume 111, 25 4 2024, Pages 105518
Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools.
Kokkorakis M, Folkertsma P, Anagnostakis F, Sirotin N, Agarwal M, Shantouf R, Henning RH, Pijl H, Wolffenbuttel BHR, Bax JJ, Atsma DE, Castela Forte J, Mantzoros CS, van Dam S
Background: Coronary artery disease (CAD) comprises one of the leading causes of morbidity and mortality both in the European population and globally. All established clinical risk stratification scores and models require blood lipids and physical measurements. The latest reports of the European Commission suggest that attracting health professionals to collect these data can be challenging, both from a logistic and cost perspective, which limits the usefulness of established models and makes th...
Abstract
Cited 2 times since 2024 (6.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 111, Issue 2, 23 4 2024, Pages 62-68
Evolving use and clinical outcomes of coronary intravascular lithotripsy: insights from an international, multicentre registry.
van Oort MJH, Al Amri I, Bingen BO, Oliveri F, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) is increasingly used for treatment of coronary artery calcification. This study aimed to evaluate contemporary utilisation patterns, safety and efficacy of IVL in an unselected real-world patient cohort. Methods: We included 454 patients undergoing IVL from May 2019 to February 2024 across seven centres in two European countries. Key endpoints included device success, technical success, procedural success, IVL-related complications and major adverse ca...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 168, 23 4 2024, Pages D8394
[Quick decisionmaking for acute pulmonary embolism patients].
Op de Hoek LJ, Montero Cabezas JM, den Exter PL, Al Amri I, Elzo Kraemer CV, Klok FA
Treatment options for patients with severe pulmonary embolism (PE) have increased substantially over the past decade. Although systemic thrombolysis is still the reperfusion therapy of choice for hemodynamically unstable PE patients, several new catheter guided reperfusion therapies have emerged as possibly safer alternatives. These therapies are increasingly implemented in clinical practice even though their efficacy and safety are yet to be proven by clinical outcome studies. Along with the ri...
Abstract
International journal of cardiology. Congenital heart disease,
Volume 19, 20 3 2024, Pages 100560
Using machine learning analysis to describe patterns in tissue Doppler and speckle tracking echocardiography in patients with transposition of the great arteries after arterial switch operation.
Terol Espinosa de Los Monteros C, van der Palen RLF, Van den Eynde J, Rammeloo L, Hazekamp MG, Blom NA, Kuipers IM, Ten Harkel ADJ
Background: Advanced echocardiographic techniques such as Tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) can detect more subtle changes in ventricular performance. We aimed to study the ventricular performance in patients with transposition of the great arteries (TGA) at mid-term follow-up after the arterial switch operation (ASO) with advanced echocardiographic techniques. In addition, we sought to discover new clinical phenotypes using unsupervised machine learning. M...
Abstract
BMJ open,
Volume 14, Issue 12, 20 3 2024, Pages e086629
DIAMACC: protocol of a prospective diagnostic accuracy study of the maximal systolic acceleration to detect peripheral arterial disease in patients with diabetes-related foot ulceration in the Netherlands.
Willems S, Schepers A, Hamming J, Brouwers JJWM
Introduction: Foot ulcers are one of the most serious complications of diabetes, leading to significant risks on amputation and mortality. Peripheral arterial disease (PAD) is an important factor for the development and the outcome of diabetic foot ulcers (DFU). Although prompt and accurate detection of PAD is critical to reduce complications, its diagnosis can be challenging with currently used bedside tests (such as ankle-brachial index and toe pressure) due to medial arterial calcification. A...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 1, 18 3 2024, Pages e036206
Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation.
Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y, Antoine C, Rusinaru D, Grigioni F, Ajmone Marsan N, van Wijngaarden A, Hochstadt A, Roussel JC, Diouf M, Thapa P, Michelena HI, Enriquez-Sarano M, Tribouilloy C
Background: The prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently associated with mortality in patients with DMR. Methods and results: We used data from the MIDA-Q (Mitral Regurgitation International DAtabase-Quantitative) registry, which included patients with isolated DMR due to mitral valve prolapse from January 2003 to...
Abstract
The Lancet. Microbe,
Volume 6, Issue 2, 18 3 2024, Pages 100942
Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study.
Mbow M, Hoving D, Cisse M, Diallo I, Honkpehedji YJ, Huisman W, Pothast CR, Jongsma MLM, König MH, de Kroon AC, Linh LTK, Azimi S, Tak T, Kruize YCM, Kurniawan F, Dia YA, Zhang JLH, Prins C, Roukens AHE, de Vries JJC, Wammes LJ, Smits HH, Adegnika AA, Zlei M, Kuijpers TW, Wieske L, Dieye A, Mboup S, Kremsner PG, Eftimov F, Velavan TP, Berlin I, Heemskerk MHM, Yazdanbakhsh M, Jochems SP, BEAT-COVID consortium, COVID-19 Leiden University Medical Center study team
Background: SARS-CoV-2 has been associated with a higher proportion of asymptomatic infections and lower mortality in sub-Saharan Africa than high-income countries. However, there is currently a lack of data on cellular immune responses to SARS-CoV-2 in people living in Africa compared with people in high-income regions of the world. We aimed to assess geographical variation in peripheral and mucosal immune responses. Methods: In this retrospective, population-based, cross-sectional study, we an...
Abstract
BMC infectious diseases,
Volume 24, Issue 1, 18 3 2024, Pages 1444
The frequency of serious bacterial infection in febrile infants less than 90 days infected with SARS-CoV-2 and other respiratory viral pathogens.
Yigit H, Ulusoy E, Guneysu ST, Colak O, Gultekingil A, Guleryuz OD, Yilmaz D, Duman M, Teksam O
Background: The primary aim of this study was to compare the groups, SARS-CoV-2-positive and -negative patients, in terms of the frequency of SBI. The SARS-CoV-2-positive group was compared with the other-RVPs-positive group as a secondary evaluation in terms of serious bacterial infection (SBI). Methods: This retrospective multicenter cohort study was conducted at four university hospitals from March 2020 to December 2021. Patients under 90 days old, with a measured fever of ≥ 38 °C, who were t...
Abstract
Multiple sclerosis and related disorders,
Volume 93, 15 3 2024, Pages 106205
Children with MOG-IgG positive bilateral optic neuritis misdiagnosed as fulminant idiopathic intracranial hypertension.
Wendel EM, Tibussek D, Barisic N, Bertolini A, Panzer A, Chang P, Geis T, Knierim E, Nikolaus M, Nosadini M, Sartori S, Schoene-Bake JC, Yilmaz D, Reindl M, Pakeerathan T, Ayzenberg I, Rostásy K
Background: Fulminant idiopathic intracranial hypertension (IIH) is characterized by headache, rapid decrease of vision and elevated CSF-opening pressure. Objective: To delineate a subgroup of MOGAD mimicking fulminant IIH. Methods: In this case series children with MOGAD with vision loss, optic disc swelling and elevated CSF opening pressure, initially diagnosed with fulminant IIH, were included. Results: 8 MOGAD patients (median age 12.5y, f:m = 7:1) with an initial diagnosis of fulminant IIH...
Abstract
