Research

Publications

Below you can find a list of our published research.

6343 results

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 11, 25 4 2025, Pages 2111-2123 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 32618 (Cardiac) complexity needs interaction. De Coster T

The heart exemplifies a complex system where electrical, mechanical, and biochemical processes interact dynamically. Understanding cardiac complexity requires exploring these interactions across multiple levels, from cellular dynamics to organ-wide behavior. This collection examines key interactions in cardiology, including excitation-contraction coupling, arrhythmia quantification, electromechanical modeling, and imaging advances. By integrating mathematical, computational, and clinical perspec... Abstract

NeuroImage. Clinical, Volume 48, 19 3 2025, Pages 103881 Brain age gap reduction following exercise mirrors clinical improvements in schizophrenia spectrum disorders. Yilmaz D, Papiol S, Keeser D, Cole JH, Malchow B, Walter H, Meyer-Lindenberg A, Hirjak D, Schmitt A, Falkai P, Maurus I, Roell L

Schizophrenia spectrum disorders (SSD) are associated with accelerated brain aging, reflected in an increased brain age gap. This gap serves as a biomarker, indicating poorer brain health, cognitive deficits, and greater severity in specific symptom domains. Exercise holds promise as an adjunct therapy to mitigate these deficits by potentially promoting brain recovery. However, the extent of overall improvements in brain health following exercise, along with their predictors and relationships to... Abstract

Applied and environmental microbiology, Volume 91, Issue 10, 19 3 2025, Pages e0082225 Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model. Leng J, Ferrandis-Vila M, Oldenkamp R, Mehat JW, Fivian-Hughes AS, Kumar Tiwari S, Van der Putten B, Trung Nguyen V, Bethe A, Clark J, Singh P, Semmler T, Schwarz S, Alvarez J, Hoa NT, Bootsma M, Menge C, Berens C, Schultsz C, Ritchie JM, La Ragione RM

The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken c... Abstract

American journal of clinical dermatology, 19 3 2025 Systemic Treatments in Moderate-to-Severe Atopic Dermatitis in Pediatric Patients up to 12 Years of Age: Real-World Treatment Outcomes from the PEDISTAD Registry. Paller AS, Marcoux D, Ramien M, Baselga E, Carvalho VO, Ardusso LRF, de Graaf M, Pasmans S, Toledo-Bahena M, Rubin C, Joyce JC, Lee LW, Gupta R, Adams B, Ardeleanu M, Zhang A

Background: Atopic dermatitis (AD), a chronic systemic disease, can cause intense skin itching and negatively impact sleep, mood, and quality of life (QoL) for patients and families. Methods: PEDISTAD is an ongoing, 10-year, observational registry describing disease characteristics, atopic comorbidities, and treatment patterns in pediatric patients (aged Abstract

Microbiology spectrum, Volume 13, Issue 10, 18 3 2025, Pages e0176225 Activity of HOCl-generating e-bandage with clinically available hydrogels against Staphylococcus aureus and Acinetobacter baumannii biofilms. Dagsuyu E, Kies P, Karau MJ, Patel R, Beyenal H

Biofilms hinder wound infection healing, making wound infections a healthcare challenge for which innovative treatments are needed. A 1.77 cm2 electrochemical bandage (e-bandage), which generates the biocide hypochlorous acid (HOCl), has shown promising anti-biofilm activity in vitro, ex vivo, and in vivo. The e-bandage is a three-electrode system operationalized by a hydrogel. In addition to providing a conductive electrolyte for the electrodes, the hydrogel provides a protective barrier for th... Abstract

Signal transduction and targeted therapy, Volume 10, Issue 1, 18 3 2025, Pages 311 Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction. Garoffolo G, Ferrari S, De Martino S, Pizzo E, Candino V, Curini L, Macrì F, Kruithof BPT, Mongelli A, Grillo M, Fanotti N, Fejzaj P, Casaburo M, Alanazi A, Marsan NA, Khaliel F, Alsulbud A, Agrifoglio M, Colombo GI, Chiesa M, Farsetti A, Gaetano C, Raucci A, Pesce M

Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatments to halt its progression are not yet available. We hypothesized that calcification of the human valve interstitial cells (VICs) is associated with cellular senescence and alterations in the epigenetic setup, like in arteries. To verify this hypothesis, we ex... Abstract

Annals of vascular surgery, Volume 122, 17 3 2025, Pages 774-779 Diagnostic Accuracy of Elastic Deformation for Detecting High Aneurysm Sac Pressure After Endovascular Aneurysm Repair. van Rijn K, van Genderen OS, Putter H, Eiberg JP, van Wissen RC, Hamming JF, van Schaik J, van der Vorst JR

Objectives: Elastic deformation (ED) is a novel noninvasive follow-up modality after endovascular aortic repair (EVAR). ED is defined as the percentage of diameter change of the aneurysm sac after application of a controlled ultrasound transducer pressure. It is hypothesized that low aneurysm sac deformation indicates high sac pressure. The current study aims to determine the ideal cutoff value of ED and analyze the corresponding diagnostic accuracy. Methods: A prospective cohort study was perfo... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 33, Issue 11, 17 3 2025, Pages 335-342 Radiofrequency ablation of supraventricular tachyarrhythmias in newborns and infants: why, when, and how? Palma A, Bertels RA, de Riva M, Zeppenfeld K, Blom NA

Supraventricular tachyarrhythmias (SVTs) in newborns and infants ( Abstract

Transfusion, 17 3 2025 Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients. van Hout FMA, Caram-Deelder C, Pors A, Middelburg RA, Klautz RJM, Rosseel PMJ, Helmerhorst HJF, van de Watering LMG, Kerkhoffs JL, Palmen M, van der Bom JG

Background: The changes in platelet structure and function arising from its collection and storage are collectively called "platelet storage lesion." In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis-generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017. Study design and methods: We explored whether longer storage duration of platelets is associate... Abstract

Innovations (Philadelphia, Pa.), 16 3 2025, Pages 15569845251367418 Application of Augmented Reality in Robot-Assisted Mitral Valve Repair Surgery: A Feasibility Study. Peek JJ, Hildebrandt K, Zhang X, Kharbanda RK, Oudeman MAP, Klautz RJM, Palmen M, Mahtab EAF

Objective: In mitral valve surgery, it is important to be aware of adjacent intraoperatively invisible anatomy, to avoid complications and enhance safety. In this feasibility study, we aimed to develop semi-automated intraoperative 3-dimensional (3D) augmented reality (3D-AR) overlays for robotic mitral valve repair. Methods: In 5 patients undergoing robot-assisted mitral valve repair, a 3D point cloud was generated, using intraoperatively recorded images from both eyes of the stereoscopic da Vi... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 21, Issue 18, 15 3 2025, Pages e1081-e1089 VARC-HBR criteria validation in TAVI patients on oral anticoagulation. Overduin DC, van Ginkel DJ, Bor WL, Kobari Y, Aarts HM, Dubois C, De Backer O, Rooijakkers MJP, Rosseel L, Veenstra L, van der Kley F, van Bergeijk KH, van Mieghem NM, Agostoni P, Voskuil M, Schotborgh CE, Ijsselmuiden AJJ, Van Heyden JAS, Hermanides RS, Barbato E, Mylotte D, Fabris E, Frambach P, Dujardin K, Ferdinande B, Peper J, Rensing BJWM, Timmers L, Swaans MJ, Brouwer J, Nijenhuis VJ, Adriaenssens T, Vriesendorp PA, Montero-Cabezas JM, Jattari HE, Halim J, Van den Branden BJL, Leonora R, Vanderheyden M, Lauterbach M, Wykrzykowska JJ, van 't Hof AWJ, van Royen N, Tijssen JGP, Delewi R, Ten Berg JM

Background: Bleeding remains a frequent complication after transcatheter aortic valve implantation (TAVI). Recently, the Valve Academic Research Consortium High Bleeding Risk (VARC-HBR) criteria were introduced to identify patients at (very) high risk of bleeding. Aims: This study aimed to evaluate the validity of the VARC-HBR criteria for predicting bleeding risk in TAVI patients and to compare its performance with other existing criteria. Methods: Data were obtained from the POPular PAUSE TAVI... Abstract

Interventional cardiology (London, England), Volume 20, 9 2 2025, Pages e23 Introduction to Pulmonary Embolism Treatment: An Evolving Paradigm. Montero-Cabezas JM

Abstract

JACC. Cardiovascular imaging, 8 2 2025, Pages S1936-878X(25)00483-8 Clinical Integration of AI-Enabled Plaque Quantification to Improve Cardiovascular Risk Stratification. Shaw LJ, Blankstein R, Leipsic JA, Sengupta PP, Nieman K, Bax JJ, Zoghbi WA, Chandrashekhar Y

Abstract

Neurology, Volume 105, Issue 7, 5 1 2025, Pages e214071 Sensitivity of Different Clinical Outcome Measures in Assessing Adults With Becker Muscular Dystrophy: A 3-Year Natural History Study. Schrama EJ, Koeks Z, Van De Velde NM, Alleman I, van Benthem JJ, van Weperen PW, Hooijmans MT, Kan HE, Spitali P, Ajmone Marsan N, Atsma DE, van Duyvenvoorde HA, Verschuuren JJGM, Niks EH

Background and objectives: Slow and highly variable disease progression in Becker muscular dystrophy (BMD) stresses the need to develop sensitive outcome measures for clinical trials. We evaluated responsiveness of different outcome measures in adult patients with BMD over 3 years and explored if the sensitivity of outcome measures can be increased by selecting on phenotype or genotype. Methods: Genetically confirmed patients with BMD were recruited via the Dutch Dystrophinopathy Database. Funct... Abstract

Clinical cancer research : an official journal of the American Association for Cancer Research, 4 1 2025 Prognosis and biological characteristics of ER-low metastatic breast cancer: results from a multicenter cohort and the TONIC trial. Miglietta F, De Graaf M, Vernieri C, Piacentini F, Cacciatore M, Botticelli A, Vingiani A, Fotia G, Nicolè L, Griguolo G, Giarratano T, Massa D, Pellegrini V, Schiavi F, Porra F, Fassan M, Pruneri G, Dei Tos AP, Guarneri V, Kok M, Dieci MV

Purpose: To assess prognosis of ER-low expression and its dynamics in HER2- metastatic breast cancer (BC) and to compare sensitivity to nivolumab between ER-low and triple-negative (TN) BC. Experimental design: Two cohorts were analyzed: a multicenter cohort of 982 patients with HER2- metastatic BC, and one prospective cohort of 110 patients with ER Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 33, Issue 10, 3 1 2025, Pages 299-306 ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration. Peijster AJL, Heinen FJ, Douiyeb S, van der Stoel MD, Selder JL, Watson-de Lepper AGW, Houthuizen P, Meijs MFL, Kampschreur LM, Schalla S, Sinha BNM, Bakker ALM, Kouijzer IJE, Nijland F, Boel CHE, Riezebos RK, Duffels MGJ, Hjortnaes J, Klautz RJM, Verkaik NJ, Post MC, Chamuleau SAJ, Kamp O, Tanis W

Background: Despite advancements in diagnostics and treatment strategies, infective endocarditis continues to carry a substantial morbidity and mortality risk. In addition, the field of infective endocarditis contains many gaps in evidence, as international guidelines are predominantly based on low-level evidence. To improve infective endocarditis care and survival rates in the Netherlands, adequate evaluation of diagnostics, treatment strategies and outcomes is essential. Methods: To address th... Abstract

Atherosclerosis, Volume 409, 2 1 2025, Pages 120509 Immunopeptidomics analysis of human atherosclerosis plaques identifies antigenic drivers of atherosclerosis. Lozano Vigario F, Molenaar J, Simó Vesperinas I, van der Zon M, Crone NSA, de Jong MJM, Hemme E, Depuydt MAC, Delfos L, de Mol J, Bernabé Kleijn MN, Peeters JAHM, Wezel A, Smeets HJ, Tjokrodirijo RTN, de Ru AH, Kros A, Quax PHA, de Vries MR, Kuiper J, Bot I, van Veelen P, Slütter B

Background and aim: Atherosclerosis has an auto-immune component driven by self-reactive T and B cells. Identifying their antigenic drivers may lead to new diagnosis and treatment approaches. Here, we aim to identify immunogenic T cell epitopes derived from atherosclerosis-relevant proteins such as ApoB100 by studying the repertoire of peptides presented by HLA in human plaques. Methods: We used immunopeptidomics to identify peptides presented by HLA-DR molecules from plaques of patients that un... Abstract