6190 results
Cited 52 times since 2016 (5.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 17, Issue 9, 18 3 2016, Pages 951-960
Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population.
Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Chiappino D, Marraccini P, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Stehli J, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Puzzuoli S, Mangione M, Marcheschi P, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Underwood SR, Knuuti J, Kaufmann PA, Neglia D, Gaemperli O, EVINCI Study Investigators
Aims: Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. Methods and results: Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with...
Abstract
Cited 55 times since 2016 (6 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 94, 17 3 2016, Pages 13-20
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Khademhosseini A, Aikawa E
Purpose: Calcific aortic valve disease (CAVD) is the most prevalent valve disease in the Western world. Recent difficulty in translating experimental results on statins to beneficial clinical effects warrants the need for understanding the role of valvular interstitial cells (VICs) in CAVD. In two-dimensional culture conditions, VICs undergo spontaneous activation similar to pathological differentiation, which intrinsically limits the use of in vitro models to study CAVD. Here, we hypothesized t...
Abstract
Cited 22 times since 2016 (2.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 50, Issue 3, 16 3 2016, Pages 456-463
Follow-up after tricuspid valve surgery in adult patients with systemic right ventricles.
Koolbergen DR, Ahmed Y, Bouma BJ, Scherptong RW, Bruggemans EF, Vliegen HW, Holman ER, Mulder BJ, Hazekamp MG
Objectives: In patients with congenitally corrected transposition of the great arteries (ccTGA) or after atrial (Mustard or Senning) correction for transposition of the great arteries (acTGA), the right ventricle (RV) supports the systemic circulation. The tricuspid valve (TV) (systemic atrioventricular valve) is prone to regurgitation in these patients and this is associated with impending RV failure and decreased survival. This study evaluates mid-term functional improvements, echocardiographi...
Abstract
Cited 34 times since 2016 (3.7 per year)
source: EuropePMC
RMD open,
Volume 2, Issue 1, 15 3 2016, Pages e000159
Therapeutic and diagnostic outcomes of a standardised, comprehensive care pathway for patients with systemic sclerosis.
Meijs J, Schouffoer AA, Ajmone Marsan N, Kroft LJ, Stijnen T, Ninaber MK, Huizinga TW, Vliet Vlieland TP, de Vries-Bouwstra JK
Objectives: To determine the outcomes, including number of medical interventions and initiation of immunosuppressive treatment of a standardised, comprehensive, diagnostic care pathway for patients with systemic sclerosis (SSc). Patient characteristics associated with need for medical interventions and with need for immunosuppressive treatment were determined. Methods: Data were routinely gathered in connection with a 2-day care pathway combining multidisciplinary care and complete diagnostic wo...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Journal of applied clinical medical physics,
Volume 17, Issue 2, 8 2 2016, Pages 291-303
Diamond detector in absorbed dose measurements in high-energy linear accelerator photon and electron beams.
Ravichandran R, Binukumar JP, Al Amri I, Davis CA
Diamond detectors (DD) are preferred in small field dosimetry of radiation beams because of small dose profile penumbras, better spatial resolution, and tissue-equivalent properties. We investigated a commercially available 'microdiamond' detector in realizing absorbed dose from first principles. A microdiamond detector, type TM 60019 with tandem electrometer is used to measure absorbed doses in water, nylon, and PMMA phantoms. With sensitive volume 0.004 mm3, radius 1.1mm, thickness 1...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Clinical and experimental rheumatology,
Volume 34, Issue 3 Suppl 97, 7 1 2016, Pages S146
Azathioprine-induced eosinophilic myocarditis in a patient with ANCA-associated vasculitis.
Berden AE, Beeres SL, Crobach S, Schalij MJ, Rabelink TJ, Teng YK
Abstract
Cited 54 times since 2016 (5.9 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 3, 7 1 2016, Pages e0144997
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.
Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Völker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dörr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS, Franceschini N, Carty CL, Virtamo J, Demissie S, Amouyel P, Arveiler D, Heckbert SR, Ferrières J, Ducimetière P, Smith NL, Wang YA, Siscovick DS, Rice KM, Wiklund PG, Taylor KD, Evans A, Kee F, Rotter JI, Karvanen J, Kuulasmaa K, Heiss G, Kraft P, Launer LJ, Hofman A, Markus MR, Rose LM, Silander K, Wagner P, Benjamin EJ, Lohman K, Stott DJ, Rivadeneira F, Harris TB, Levy D, Liu Y, Rimm EB, Jukema JW, Völzke H, Ridker PM, Blankenberg S, Franco OH, Gudnason V, Psaty BM, Boerwinkle E, O'Donnell CJ
Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods: We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10-6 in Stage I were taken to Stage II for...
Abstract
Cited 41 times since 2016 (4.5 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 18, Issue 11, 3 1 2016, Pages 1740-1747
Combined leadless pacemaker and subcutaneous implantable defibrillator therapy: feasibility, safety, and performance.
Tjong FV, Brouwer TF, Smeding L, Kooiman KM, de Groot JR, Ligon D, Sanghera R, Schalij MJ, Wilde AA, Knops RE
Aims: The subcutaneous implantable cardioverter-defibrillator (S-ICD) and leadless pacemaker (LP) are evolving technologies that do not require intracardiac leads. However, interactions between these two devices are unexplored. We investigated the feasibility, safety, and performance of combined LP and S-ICD therapy, considering (i) simultaneous device-programmer communication, (ii) S-ICD rhythm discrimination during LP communication and pacing, and (iii) post-shock LP performance. Methods and r...
Abstract
Cited 36 times since 2016 (3.9 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 2, Issue 4, 2 1 2016, Pages 229-243
P2Y12 receptor inhibitors in patients with non-ST-elevation acute coronary syndrome in the real world: use, patient selection, and outcomes from contemporary European registries.
Zeymer U, Widimsky P, Danchin N, Lettino M, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Sendón JL, Tousek P, Weidinger F, Weston CF, Zaman A, Andell P, Li J, Jukema JW, PIRAEUS group
Aims: Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results: A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic ma...
Abstract
Cited 311 times since 2016 (33.9 per year)
source: EuropePMC
The New England journal of medicine,
Volume 374, Issue 12, 2 1 2016, Pages 1134-1144
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffman P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Lemieux Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferra
Background: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. Methods: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. Results: We confirme...
Abstract
Cited 88 times since 2016 (9.6 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 37, 2 1 2016, Pages 2823-2829
Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.
Ghadri JR, Sarcon A, Diekmann J, Bataiosu DR, Cammann VL, Jurisic S, Napp LC, Jaguszewski M, Scherff F, Brugger P, Jäncke L, Seifert B, Bax JJ, Ruschitzka F, Lüscher TF, Templin C, InterTAK Co-investigators:
Aims: Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS. Methods and results: Takotsubo syndrome patient...
Abstract
Cited 19 times since 2016 (2.1 per year)
source: EuropePMC
Critical care medicine,
Volume 44, Issue 3, 1 1 2016, Pages e158-67
Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine.
Alogna A, Manninger M, Schwarzl M, Zirngast B, Steendijk P, Verderber J, Zweiker D, Maechler H, Pieske BM, Post H
Objectives: The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (40.5°C), normothermia (38.0°C), and mild hypothermia (33.0°C) on left ventricular contractile function in healthy pigs and compared them with dobutamine infusion. Design: Animal st...
Abstract
Annals of surgery,
Volume 263, Issue 3, 1 1 2016, Pages e41
Comment on "Trainee Participation Is Associated With Adverse Outcomes in Emergency General Surgery: An Analysis of the National Surgical Quality Improvement Program Database".
Graat LJ, Roukema JA, Hamming JF
Abstract
Cited 13 times since 2016 (1.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 9, 1 1 2016, Pages 1123-1124
Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot.
Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJM, Bouma BJ
Abstract
Cited 335 times since 2016 (36.5 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 351, Issue 6278, 1 1 2016, Pages 1166-1171
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ, CHD Exome+ Consortium, CARDIoGRAM Exome Consortium, Global Lipids Genetics Consortium
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains unclear. Through targeted sequencing of coding regions of lipid-modifying gene...
Abstract
Cited 4 times since 2016 (0.4 per year)
source: EuropePMC
Journal of atrial fibrillation,
Volume 8, Issue 5, 29 5 2016, Pages 1362
Cardiac Resynchronization Therapy in Non-Ischemic Cardiomyopathy.
Shanks M, Delgado V, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic card...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 69, Issue 4, 23 4 2016, Pages 460-461
Could Descending Septal Artery Be Another Variant of the Dual Left Anterior Descending Artery? Response.
Montero-Cabezas JM, Delgado V, Karalis I, Schalij MJ
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
Journal of internal medicine,
Volume 279, Issue 6, 23 4 2016, Pages 592-605
Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages.
Frodermann V, van Duijn J, van Puijvelde GH, van Santbrink PJ, Lagraauw HM, de Vries MR, Quax PH, Bot I, Foks AC, de Jager SC, Kuiper J
Background: Staphylococcus aureus cell wall components can induce IL-10 responses by immune cells, which may be atheroprotective. Therefore, in this study, we investigated whether heat-killed S. aureus (HK-SA) could inhibit the development of atherosclerosis. Methods: Atherosclerosis-susceptible LDL receptor-deficient mice were administered intraperitoneal HK-SA twice weekly and fed a Western-type diet for 6 weeks. Results: HK-SA administration resulted in a 1.6-fold increase in IL-10 production...
Abstract
Cited 98 times since 2016 (10.7 per year)
source: EuropePMC
Cardiovascular research,
Volume 110, Issue 1, 23 4 2016, Pages 6-22
The multifactorial nature of microRNAs in vascular remodelling.
Welten SM, Goossens EA, Quax PH, Nossent AY
Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive changes of the vessel wall through, among others, cell proliferation and migration, but also apoptosis and necrosis of the various cell types in the vessel wall. Vascular remodelling can be beneficial, e.g. during neovascularization after ischaemia, as well as pathological, e.g. during atherosclerosis and aneurysm formation. In recent years, it has become clear that microRNAs are able to target many gene...
Abstract
Cited 25 times since 2016 (2.7 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 47, 22 4 2016, Pages 3536-3543
The 200th anniversary of the stethoscope: Can this low-tech device survive in the high-tech 21st century?
Bank I, Vliegen HW, Bruschke AV
In 1816, Laennec discovered that auscultation of the heart and lungs could effectively be performed by placing a hollow cylinder (initially made of a roll of paper) between the chest of the patient and the ear of the examiner. This was the first step in the development of the stethoscope, which was a breakthrough in the diagnosis and management of cardiac and pulmonary patients. Technical improvements of the stethoscope followed and in cardiac patients auscultation soon became a major diagnostic...
Abstract
