Publications
Below you can find a list of our published research.
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Below you can find a list of our published research.
6205 results
Cited 29 times since 2013 (2.5 per year) source: EuropePMC
Circulation, Volume 128, Issue 25, 24 4 2013, Pages 2732-2744 Atrium-specific Kir3.x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans. Bingen BO, Neshati Z, Askar SF, Kazbanov IV, Ypey DL, Panfilov AV, Schalij MJ, de Vries AA, Pijnappels DA
Background: Atrial fibrillation is the most common cardiac arrhythmia. Ventricular proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium-specific Kir3.x channels, which generate a constitutively active current (I(K,ACh-c)) after atrial remodeling, might circumvent this problem. However, it is unknown whether and how I(K,ACh-c) contributes to atrial fibrillation induction, dynamics, and termination. Therefore, we investigated the effects of I(K,ACh-c) blockade... Abstract
Cited 65 times since 2013 (5.6 per year) source: EuropePMC
The American journal of cardiology, Volume 112, Issue 12, 21 3 2013, Pages 1867-1872 Outcome after ST elevation myocardial infarction in patients with cancer treated with primary percutaneous coronary intervention. Velders MA, Boden H, Hofma SH, Osanto S, van der Hoeven BL, Heestermans AA, Cannegieter SC, Jukema JW, Umans VA, Schalij MJ, van Boven AJ
The simultaneous occurrence of cancer and coronary heart disease is increasing in the Western world. Nevertheless, the influence of cancer on ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) has not been investigated extensively. This multicenter registry included patients with STEMI treated with primary PCI from 2006 to 2009. Patients were stratified according to history of cancer, and primary focus lay on all-cause and cardiac mortalities... Abstract
Cited 20 times since 2013 (1.7 per year) source: EuropePMC
PloS one, Volume 8, Issue 9, 19 3 2013, Pages e75573 Erythrocyte-bound apolipoprotein B in relation to atherosclerosis, serum lipids and ABO blood group. Klop B, van de Geijn GJ, Bovenberg SA, van der Meulen N, Elte JW, Birnie E, Njo TL, Janssen HW, van Miltenburg A, Jukema JW, Cabezas MC
Introduction: Erythrocytes carry apolipoprotein B on their membrane, but the determining factors of erythrocyte-bound apolipoprotein B (ery-apoB) are unknown. We aimed to explore the determinants of ery-apoB to gain more insight into potential mechanisms. Methods: Subjects with and without CVD were included (N = 398). Ery-apoB was measured on fresh whole blood samples using flow cytometry. Subjects with ery-apoB levels ≤ 0.20 a.u. were considered deficient. Carotid intima media thickness (CIMT)... Abstract
Cited 63 times since 2013 (5.4 per year) source: EuropePMC
PloS one, Volume 8, Issue 9, 16 3 2013, Pages e74083 BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. Boon MR, van den Berg SA, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC
Background/aims: Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system, which increases BAT differentiation and activity upon cold exposure. Recently, Bone Morphogenetic Protein 7 (BMP7) was identified as an inducer of BAT differentiation. We aimed to elucidate the role of sympathetic activation in the effect of BMP7 o... Abstract
Cited 12 times since 2013 (1 per year) source: EuropePMC
Journal of surgical education, Volume 71, Issue 2, 14 2 2013, Pages 222-228 Quality of life of surgical oncology residents and fellows across Europe. Mordant P, Deneuve S, Rivera C, Carrabin N, Mieog JS, Malyshev N, Van Der Vorst JR, Audisio RA, French Association of Young Surgical Oncologists (AJCO), European Society of Surgical Oncology Young Surgeons and Alumni Club (EYSAC)
Background: Data are currently lacking regarding the quality of life of surgical oncology (SO) trainees. We sought to assess the training conditions and quality of life of SO residents and fellows across Europe. Material and methods: Members of the European Society for Surgical Oncology were invited to complete a Web-based survey that included a questionnaire specifically designed for SO trainees. Demographics, timing, and incentive to choose for SO, quality of life, and symptoms of fatigue, sle... Abstract
Cited 16 times since 2013 (1.4 per year) source: Scopus
The American journal of cardiology, Volume 112, Issue 11, 13 2 2013, Pages 1800-1806 Multidetector row computed tomography parameters associated with paravalvular regurgitation after transcatheter aortic valve implantation. Katsanos S, Ewe SH, Debonnaire P, van der Kley F, de Weger A, Palmen M, Scholte AJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Multidetector row computed tomographic (MDCT) assessment of aortic annulus dimensions and frame position and deployment have been associated with paravalvular aortic regurgitation (PAVR) after transcatheter aortic valve implantation (TAVI). The present evaluation investigated the (pre- and postprocedure) MDCT associates of PAVR ≥2+. In total, 123 patients referred for TAVI underwent clinical evaluation, transthoracic echocardiography, and pre- and post-TAVI MDCT. Pre-TAVI MDCT measurements of th... Abstract
Cited 89 times since 2013 (7.6 per year) source: EuropePMC
Circulation, Volume 128, Issue 21, 13 2 2013, Pages 2289-2295 Initial human feasibility of infusion needle catheter ablation for refractory ventricular tachycardia. Sapp JL, Beeckler C, Pike R, Parkash R, Gray CJ, Zeppenfeld K, Kuriachan V, Stevenson WG
Background: Ablation of ventricular tachycardia (VT) is sometimes unsuccessful when ablation lesions are of insufficient depth to reach arrhythmogenic substrate. We report the initial experience with the use of a catheter with an extendable/retractable irrigated needle at the tip capable of intramyocardial mapping and ablation. Methods and results: Sequential consenting patients with recurrent VT underwent ablation with the use of a needle-tipped catheter. At target sites, the needle was advance... Abstract
Cited 101 times since 2013 (8.6 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 5, 13 2 2013, Pages 875-883 Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy: implications for the ablation strategy. Piers SR, Tao Q, van Huls van Taxis CF, Schalij MJ, van der Geest RJ, Zeppenfeld K
Background: There are limited data on typical arrhythmogenic substrates and associated ventricular tachycardias (VT) in patients with nonischemic cardiomyopathy. The substrate location may have implications for the ablation strategy. Methods and results: Nineteen consecutive patients with nonischemic cardiomyopathy (age 58±14 years, 79% men, left ventricular ejection fraction 41±11%) who underwent contrast-enhanced MRI and VT ablation were included. On the basis of 3-dimensional contrast-enhance... Abstract
Cited 28 times since 2013 (2.4 per year) source: EuropePMC
Journal of the American Society of Nephrology : JASN, Volume 24, Issue 12, 12 2 2013, Pages 2105-2117 Common variants in Mendelian kidney disease genes and their association with renal function. Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A, Rao M, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra BA, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Döring A, Wichmann HE, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG,
Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidne... Abstract
Cited 23 times since 2013 (2 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 147, Issue 5, 12 2 2013, Pages 1561-1567 Left and right ventricular performance after arterial switch operation. Klitsie LM, Roest AA, Kuipers IM, Hazekamp MG, Blom NA, Ten Harkel AD
Objective: Recent descriptions of decreased exercise capacity 10 to 15 years after arterial switch operation (ASO) suggest subclinical hemodynamic restrictions. Persistent impairment of ventricular performance following ASO may add to this. We aimed to characterize the time course of changes in biventricular performance within the first year following ASO. Methods: We prospectively included 26 patients with transposition of the great arteries undergoing ASO and 20 age-matched controls. Left and... Abstract
Cited 42 times since 2013 (3.6 per year) source: EuropePMC
The American journal of pathology, Volume 183, Issue 4, 10 2 2013, Pages 1137-1143 Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans. van Riel D, Leijten LME, de Graaf M, Siegers JY, Short KR, Spronken MIJ, Schrauwen EJA, Fouchier RAM, Osterhaus ADME, Kuiken T
Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential... Abstract
Cited 6 times since 2013 (0.5 per year) source: EuropePMC
International journal of cardiology, Volume 169, Issue 3, 10 2 2013, Pages 190-195 The wealth of nations and the dissemination of cardiovascular research. Winnik S, Speer T, Raptis DA, Walker JH, Hasun M, Clavien PA, Komajda M, Bax JJ, Tendera M, Fox K, Van de Werf F, Mundow C, Lüscher TF, Ruschitzka F, Nallamothu BK, Matter CM
Background: This study aimed at understanding whether investigators from less wealthy countries were at a disadvantage in disseminating their research, after accounting for potential differences in research quality and infrastructure. Methods and results: In this bibliometric analysis a representative random selection of 10% (n=1002 studies) of all abstracts submitted to the European Society of Cardiology (ESC) congress 2006 was followed for publication and citation from September 2006 to Decemb... Abstract
Cited 18 times since 2013 (1.5 per year) source: EuropePMC
International journal of cardiology, Volume 169, Issue 2, 8 2 2013, Pages 139-144 Postoperative arrhythmias in adults with congenital heart disease: incidence and risk factors. Koyak Z, Achterbergh RC, de Groot JR, Berger F, Koolbergen DR, Bouma BJ, Lagrand WK, Hazekamp MG, Blom NA, Mulder BJ
Background: Little is known about the clinical impact of arrhythmias after surgery for congenital heart disease (CHD) in adults. Therefore, we investigated the prevalence of in-hospital arrhythmias after CHD surgery and their impact on clinical outcome. Methods: This was a multicenter retrospective study and included adults who underwent congenital cardiac surgery between January 2009 and December 2011. Clinical events were defined as all cause mortality, heart failure (HF) requiring medical tre... Abstract
Cited 42 times since 2013 (3.6 per year) source: EuropePMC
International journal of cardiology, Volume 169, Issue 3, 7 1 2013, Pages 183-189 A cornerstone of heart failure treatment is not effective in experimental right ventricular failure. Borgdorff MA, Bartelds B, Dickinson MG, Steendijk P, Berger RM
Background: Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure treatment) is effective in RV failure. We investigated the effects of combination treatment of aldosterone-blocker eplerenone+angiotensin II receptor blocker losartan (Ep/Lo) on RV... Abstract
Cited 14 times since 2013 (1.2 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 64, 5 1 2013, Pages 51-58 C57BL/6 NK cell gene complex is crucially involved in vascular remodeling. de Vries MR, Seghers L, van Bergen J, Peters HA, de Jong RC, Hamming JF, Toes RE, van Hinsbergh VW, Quax PH
Objective: NK cells are known to be involved in cardiovascular disease processes. One of these processes, vascular remodeling, may strongly differ between individuals and mouse strains such as the C57BL/6 and BALB/c. Moreover, C57BL/6 and BALB/c mice vary in immune responses and in the composition of their Natural Killer gene Complex (NKC). Here we study the role of NK cells, and in particular the C57BL/6 NKC in vascular remodeling and intimal hyperplasia formation. Methods and results: C57BL/6,... Abstract
Cited 16 times since 2013 (1.4 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 46, Issue 6, 4 1 2013, Pages 624-629 Results from craniocaudal carotid body tumor resection: should it be the standard surgical approach? Paridaans MP, van der Bogt KE, Jansen JC, Nyns EC, Wolterbeek R, van Baalen JM, Hamming JF
Objectives: To evaluate results after carotid body tumor (CBT) surgery using a novel dissection technique. Methods: A retrospective analysis of all operated CBT in the last 6 years was carried out and results were compared with the current literature and our previous series, which reported another 111 cases operated on until 2005. Results: Forty-five CBTs were removed in 41 (56% hereditary cases) patients (seven Shamblin I, 22 II, and 16 III). There were no cases of permanent cranial nerve injur... Abstract
Cited 35 times since 2013 (3 per year) source: EuropePMC
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Volume 66, Issue 12, 4 1 2013, Pages 1732-1740 Treatment of infantile haemangiomas with atenolol: comparison with a historical propranolol group. de Graaf M, Raphael MF, Breugem CC, Knol MJ, Bruijnzeel-Koomen CA, Kon M, Breur JM, Pasmans SG
Propranolol, a lipophilic non-selective beta-blocker, has proven to be effective in the treatment of infantile haemangioma (IH). However, several side effects have been reported. Atenolol, a hydrophilic selective beta-1 blocker, could be an alternative and associated with fewer side effects. Thirty consecutive patients with IH were treated with atenolol between June 2010 and May 2011. The therapeutic effect was judged by clinical assessment and quantified by using a visual analogue scale (VAS) a... Abstract
Cited 192 times since 2013 (16.4 per year) source: EuropePMC
European heart journal, Volume 34, Issue 45, 2 1 2013, Pages 3491-3500 Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Groenink M, den Hartog AW, Franken R, Radonic T, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Spijkerboer AM, Marquering HA, Zwinderman AH, Mulder BJ
Aim: Patients with Marfan syndrome have an increased risk of life-threatening aortic complications, mostly preceded by aortic dilatation. Treatment with losartan, an angiotensin-II receptor-1 blocker, may reduce aortic dilatation rate in Marfan patients. Methods and results: In this multicentre, open-label, randomized controlled trial with blinded assessments, we compared losartan treatment with no additional treatment in operated and unoperated adults with Marfan syndrome. The primary endpoint... Abstract
Cited 11 times since 2013 (0.9 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 37, Issue 1, 2 1 2013, Pages 25-34 Cost-effectiveness of primary prevention implantable cardioverter defibrillator treatment: data from a large clinical registry. Thijssen J, van den Akker van Marle ME, Borleffs CJ, van Rees JB, de Bie MK, van der Velde ET, van Erven L, Schalij MJ
Background: Although randomized trials have shown the beneficial effect on survival of an implantable cardioverter defibrillator (ICD) as primary prevention therapy in selected patients, data concerning the cost-effectiveness in routine clinical practice remain scarce. Accordingly, the purpose of this study was to assess the cost-effectiveness of primary prevention ICD implantation in the real world. Methods: Patients receiving primary prevention single-chamber or dual-chamber ICD implantation a... Abstract
Cited 31 times since 2013 (2.6 per year) source: EuropePMC
PloS one, Volume 8, Issue 9, 2 1 2013, Pages e72642 Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Lloyd SM, Stott DJ, de Craen AJ, Kearney PM, Sattar N, Perry I, Packard CJ, Briggs A, Marchbank L, Comber H, Jukema JW, Westendorp RG, Trompet S, Buckley BM, Ford I
Background: The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), a placebo-controlled trial of pravastatin, demonstrated a 19% reduction in coronary outcomes (p=0.006) after a mean of 3.2 years, with no impact on stroke outcomes or all-cause mortality. However, there was a suggestion of increased cancer risk. Our aim is to determine the long-term benefits and safety of pravastatin treatment in older people using post-trial follow-up of the PROSPER participants. Methods: 5,804 (... Abstract