Publications
Below you can find a list of our published research.
Op korte termijn komt deze Hart Long Centrum website te vervallen. Alle informatie kunt u vanaf heden vinden op https://www.lumc.nl/patientenzorg/specialistische-centra/hart-long-centrum/voor-patienten/
Below you can find a list of our published research.
7971 results
Cited 34 times since 2019 (5.3 per year) source: EuropePMC
Brain : a journal of neurology, Volume 142, Issue 1, 1 1 2019, Pages 35-49 Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly. Kim A, Savary C, Dubourg C, Carré W, Mouden C, Hamdi-Rozé H, Guyodo H, Douce JL, FREX Consortium, GoNL Consortium, Pasquier L, Flori E, Gonzales M, Bénéteau C, Boute O, Attié-Bitach T, Roume J, Goujon L, Akloul L, Odent S, Watrin E, Watrin E, Dupé V, de Tayrac M, David V
Holoprosencephaly is a pathology of forebrain development characterized by high phenotypic heterogeneity. The disease presents with various clinical manifestations at the cerebral or facial levels. Several genes have been implicated in holoprosencephaly but its genetic basis remains unclear: different transmission patterns have been described including autosomal dominant, recessive and digenic inheritance. Conventional molecular testing approaches result in a very low diagnostic yield and most c... Abstract
Cited 2 times since 2019 (0.3 per year) source: EuropePMC
Tijdschrift voor psychiatrie, Volume 61, Issue 10, 1 1 2019, Pages 683-691 [Guided web-based intervention for sleeping problems (I-Sleep) in depressed patients within outpatient specialist mental health care: a pilot study]. Dozeman E, van Straten A, van Genugten CR, van Schaik DJF
Background: Insomnia in depressed patients is usually targeted by medication, while cognitive behavioural treatment for insomnia (CBT-I) is the treatment of first choice. Effective online CBT-I is available but is not frequently offered in regular care. AIM: To determine the feasibility and indications for effectiveness of I-Sleep, an online CBT-I module, for uni- and bipolar depressed patients in specialised mental health care settings. METHOD: In a pilot study I-Sleep (5 sessions) was offered... Abstract
Tijdschrift voor psychiatrie, Volume 61, Issue 10, 1 1 2019, Pages 678-680 [Too early for pharmacogenetics in psychiatric practice? Implementation is in full swing]. van Westrhenen R, Bet PM, van Weelden M, van Schaik RHN
Cited 2 times since 2019 (0.3 per year) source: EuropePMC
Turkish neurosurgery, Volume 29, Issue 3, 1 1 2019, Pages 340-348 Analysis of Cavernous Malformations: Experience with 18 Cases. Haciyakupoglu E, Yilmaz DM, Kinali B, Akbas T, Haciyakupoglu S
Aim: To analyze the results of stereotactic radiosurgery (SRS) or surgical treatment of 18 cases with cavernous malformation and report 2 cases with unusual localization and size. Material and methods: We present 11 and 8 patients who underwent surgery and SRS between 2010 and 2018 respectively. The operated group comprised six men and five women (mean age, 33.6 years). SRS was performed in five men and three women (mean age, 33.3 years). All patients were diagnosed and followed-up with magnetic... Abstract
Cited 4 times since 2019 (0.6 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 1144, 1 1 2019, Pages 101-121 Stem Cells for the Oromaxillofacial Area: Could they be a promising source for regeneration in dentistry? Mendi A, Ulutürk H, Ataç MS, Yılmaz D
Oromaxillofacial tissues (OMT) are composed of tooth and bone, together with nerves and blood vessels. Such a composite material is a huge source for mesenchymal stem cells (MSCs) that can be obtained with ease from extracted teeth, teeth structures and socket blood, flapped gingiva tissue, and mandibular/maxillar bone marrow. They offer a biological answer for restoring damaged dental tissues such as the regeneration of alveolar bone, prevention of pulp tissue defects, and dental structures. De... Abstract
Cited 10 times since 2019 (1.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 1, 1 1 2019, Pages 18-23 Expectations and perceived barriers to widespread implementation of e‑Health in cardiology practice: Results from a national survey in the Netherlands. Treskes RW, Wildbergh TX, Schalij MJ, Scherptong RWC
Introduction: Expectations of physicians concerning e‑Health and perceived barriers to implementation in clinical practice are scarcely reported in the literature. The purpose of this study was to assess these aspects of cardiovascular e‑Health. Methods: A survey was sent to members of the Netherlands Society of Cardiology. In total, the questionnaire contained 30 questions about five topics: personal use of smartphones, digital communication between respondents and patients, current e‑Health im... Abstract
Cited 98 times since 2019 (15.3 per year) source: EuropePMC
Circulation, Volume 139, Issue 5, 1 1 2019, Pages 620-635 Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels. Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, Delgado GE, Guo X, Bartz TM, Martinez-Perez A, Germain M, de Haan HG, Ozel AB, Polasek O, Smith AV, Eicher JD, Reiner AP, Tang W, Davies NM, Stott DJ, Rotter JI, Tofler GH, Boerwinkle E, de Maat MPM, Kleber ME, Welsh P, Brody JA, Chen MH, Vaidya D, Soria JM, Suchon P, van Hylckama Vlieg A, Desch KC, Kolcic I, Joshi PK, Launer LJ, Harris TB, Campbell H, Rudan I, Becker DM, Li JZ, Rivadeneira F, Uitterlinden AG, Hofman A, Franco OH, Cushman M, Psaty BM, Morange PE, McKnight B, Chong MR, Fernandez-Cadenas I, Rosand J, Lindgren A, INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium (ISGC), Gudnason V, Wilson JF, Hayward C, Ginsburg D, Fornage M, Rosendaal FR, Souto JC, Becker LC, Jenny NS, März W, Jukema JW, Dehghan A, Trégouët DA, Morrison AC, Johnson AD, O'Donnell CJ, Strachan DP, Lowenstein CJ, Smith NL
Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. Methods: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. All studies performed linear regression analysis using an additive genetic model an... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
International journal of integrated care, Volume 18, Issue 4, 31 5 2019, Pages 15 The Integrated Dyspnea Clinic: An Evaluation of Efficiency. Rietbroek MV, Slats AM, Kiès P, de Grooth GJ, Chavannes NH, Taube C, Bonten TN
Introduction: Dyspnea is a common complaint and in 70 to 90% the origin is pulmonary or cardiovascular. However, referral to the "wrong" specialism could result in diagnostic- and treatment delay. Integrated care by a cardiologist and a pulmonologist could improve this. The aim of the present study was to evaluate whether integrated care for patients with dyspnea is more efficient and effective than regular care. Methods: Consecutive patients (n = 235) seen at our dyspnea clinic after... Abstract
Cited 8 times since 2018 (1.2 per year) source: EuropePMC
Journal of the neurological sciences, Volume 397, 31 5 2019, Pages 141-145 Intravenous immunoglobulins in patients with clinically suspected chronic immune-mediated neuropathy. Lucke IM, Adrichem ME, Wieske L, van der Kooi AJ, Verhamme C, van Schaik IN, Eftimov F
Intravenous immunoglobulins (IVIg) are an efficacious treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). IVIg is considered in patients who have a high suspicion of an inflammatory neuropathy, but do not meet diagnostic criteria. The objective of this retrospective study was to assess which diagnostic results led to the decision to administer IVIg and to determine the rate of improvement. We included consecutive patients suspecte... Abstract
Cited 39 times since 2018 (6.1 per year) source: EuropePMC
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, Volume 38, Issue 8, 28 4 2018, Pages 2133-2140 Point-of-Care Ultrasonography (POCUS) in a Community Emergency Department: An Analysis of Decision Making and Cost Savings Associated With POCUS. Van Schaik GWW, Van Schaik KD, Murphy MC
Objectives: Point-of-care ultrasonography (POCUS) is an increasingly integral part of emergency medicine. This study investigated community emergency department physicians' choices regarding ultrasonography as a branch point in clinical decision making. Methods: During shifts covering all days of the week and all time-spans over a 3-month period, emergency department physicians were interviewed whenever POCUS was used. Questions focused on the role of POCUS in clinical management and on tes... Abstract
Cited 12 times since 2018 (1.9 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 5, Issue 3, 26 4 2018, Pages 318-326 Incidence and Clinical Significance of Cerebral Embolism During Atrial Fibrillation Ablation With Duty-Cycled Phased-Radiofrequency Versus Cooled-Radiofrequency: A Randomized Controlled Trial. Keçe F, Bruggemans EF, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Meulman TJ, Brugman JA, Rooijmans AM, van Buchem MA, Middelkoop HA, Eikenboom J, Schalij MJ, Zeppenfeld K, Trines SA
Objectives: The purpose of this study was to randomly compare the incidence of asymptomatic cerebral embolism (ACE) between the second-generation pulmonary vein ablation catheter (PVAC Gold) and the irrigated Thermocool catheter. Background: Pulmonary vein isolation (PVI) with the PVAC is associated with ACE. The PVAC Gold was designed to avoid this complication. Methods: Patients with paroxysmal atrial fibrillation were randomized 1:1 to PVI with the PVAC Gold or Thermocool catheter. Cerebral m... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
Clinica chimica acta; international journal of clinical chemistry, Volume 490, 21 3 2018, Pages 77-80 Confirmation practice in pharmacogenetic testing; how good is good enough? Lunenburg CATC, Guchelaar HJ, van Schaik RHN, Neumaier M, Swen JJ
Pharmacogenetic testing is increasingly implemented in routine diagnostics. However, quality control measures, in particular confirmation practices e.g. the use of two independent genotyping techniques, are subject of debate and there are no clear guidelines. The aim of the current paper is to discuss the current practice in confirmation testing in the field of pharmacogenetics and draw attention to this situation. DPYD genotyping is used as a case example to highlight the importance of assignin... Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 26, Issue 1, 21 3 2018, Pages 62-71 Secondary Fill Minimizes Gutter Size in Chimney EVAS Configurations In Vitro. van Schaik TG, Meekel JP, Jongkind V, Lely RJ, Truijers M, Hoksbergen AWJ, Wisselink W, Blankensteijn JD, Yeung KK
Purpose: To investigate in an in vitro model if secondary endobag filling can reduce gutter size during chimney endovascular aneurysm sealing (chEVAS). Materials and methods: Nellix EVAS systems were deployed in 2 silicone juxtarenal aneurysm models with suprarenal aortic diameters of 19 and 24 mm. Four configurations were tested: EVAS with 6-mm balloon-expandable (BE) or self-expanding (SE) chimney grafts (CGs) in the renal branches of both models. Balloons were inflated simultaneously in the C... Abstract
Cited 19 times since 2018 (2.9 per year) source: EuropePMC
PLoS computational biology, Volume 14, Issue 12, 20 3 2018, Pages e1006637 Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern. Vandersickel N, Watanabe M, Tao Q, Fostier J, Zeppenfeld K, Panfilov AV
Rotors are functional reentry sources identified in clinically relevant cardiac arrhythmias, such as ventricular and atrial fibrillation. Ablation targeting rotor sites has resulted in arrhythmia termination. Recent clinical, experimental and modelling studies demonstrate that rotors are often anchored around fibrotic scars or regions with increased fibrosis. However, the mechanisms leading to abundance of rotors at these locations are not clear. The current study explores the hypothesis whether... Abstract
Molecular biology reports, Volume 46, Issue 1, 19 3 2018, Pages 1013-1021 Feasibility of a quantitative polymerase chain reaction assay for diagnosing pneumococcal pneumonia using oropharyngeal swabs. van Schaik ML, Duijkers R, Paternotte N, Jansen R, Rozemeijer W, van der Reijden WA, Boersma WG
Streptococcus pneumoniae is the most important pathogen causing community-acquired pneumonia (CAP). The current diagnostic microbial standard detects S. pneumoniae in less than 30% of CAP cases. A quantitative polymerase chain reaction (PCR) targeting autolysin (lytA) is able to increase the rate of detection. The aim of this study is validation of this quantitative PCR in vitro using different available strains and in vivo using clinical samples (oropharyngeal swabs). The PCR autolysin (lytA) w... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
PloS one, Volume 13, Issue 12, 19 3 2018, Pages e0208570 A supported self-help for recurrent depression in primary care; An economic evaluation alongside a multi-center randomised controlled trial. Biesheuvel-Leliefeld KEM, Bosmans JE, Dijkstra-Kersten SMA, Smit F, Bockting CLH, van Schaik DJF, van Marwijk HWJ, van der Horst HE
Background: Major depression is a prevalent mental disorder with a high risk of relapse or recurrence. Only few studies have focused on the cost-effectiveness of interventions aimed at the prevention of relapse or recurrence of depression in primary care. Aim: To evaluate the cost-effectiveness of a supported Self-help Preventive Cognitive Therapy (S-PCT) added to treatment-as-usual (TAU) compared with TAU alone for patients with a history of depression, currently in remission. Methods: An econo... Abstract
Cited 4 times since 2018 (0.6 per year) source: EuropePMC
Injury, Volume 50, Issue 2, 19 3 2018, Pages 286-291 Migration of Aortic Occlusion Balloons in an in vitro model of the human circulation. Borger van der Burg BLS, Van Schaik J, Brouwers JJWM, Wong CY, Rasmussen TE, Hamming JF, Hoencamp R
Background: Aortic Occlusion Balloons (AOB) are used for hemorrhage control in hemodynamically unstable patients. Stability of an AOB is essential for reliable aortic occlusion. The primary aim of this study is to determine whether different types of AOB migrate after total, intermittent or partial occlusion in a porcine aorta positioned in an in vitro model. Materials and methods: A porcine thoracic aortic section was positioned in a model of the human circulation. Primary and secondary migrati... Abstract
Cited 25 times since 2018 (3.9 per year) source: EuropePMC
International journal of molecular sciences, Volume 19, Issue 12, 19 3 2018, Pages E4124 Medicinal Leech CNS as a Model for Exosome Studies in the Crosstalk between Microglia and Neurons. Raffo-Romero A, Arab T, Al-Amri IS, Le Marrec-Croq F, Van Camp C, Lemaire Q, Salzet M, Vizioli J, Sautiere PE, Lefebvre C
In healthy or pathological brains, the neuroinflammatory state is supported by a strong communication involving microglia and neurons. Recent studies indicate that extracellular vesicles (EVs), including exosomes and microvesicles, play a key role in the physiological interactions between cells allowing central nervous system (CNS) development and/or integrity. The present report used medicinal leech CNS to investigate microglia/neuron crosstalk from ex vivo approaches as well as primary culture... Abstract
Cited 33 times since 2018 (5.1 per year) source: EuropePMC
The Journal of pediatrics, Volume 207, 18 3 2018, Pages 109-116.e2 Low Cerebral Oxygenation in Preterm Infants Is Associated with Adverse Neurodevelopmental Outcome. Alderliesten T, van Bel F, van der Aa NE, Steendijk P, van Haastert IC, de Vries LS, Groenendaal F, Lemmers P
Objective: To assess whether high and low levels of cerebral oxygenation (regional cerebral oxygenation [rScO2]) in infants born at Abstract
Cited 6 times since 2018 (0.9 per year) source: EuropePMC
Brain and behavior, Volume 9, Issue 1, 18 3 2018, Pages e01184 Vibrotactile sensitivity of patients with HIV-related sensory neuropathy: An exploratory study. Karpul D, McIntyre S, van Schaik A, Breen PP, Heckmann JM
Background: HIV-associated distal polyneuropathy (HIV-PN) affects large and small sensory nerve fibers and can cause tactile insensitivity. This exploratory study forms part of an effort to apply subsensory electrical nerve stimulation (SENS) to improve tactile sensitivity of patients with HIV-PN. This work presented an opportunity to use a robust protocol to quantitatively describe the vibrotactile sensitivity of individuals with HIV-PN on effective antiretroviral therapy (ART) and correlate th... Abstract