6177 results
Cited 6 times since 2008 (0.4 per year)
source: EuropePMC
Experimental gerontology,
Volume 43, Issue 8, 22 4 2008, Pages 801-805
Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study.
Trompet S, de Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Jukema JW, PROSPER Group
Inflammation plays a prominent role in the development of atherosclerosis, which is the most important risk factor for vascular events. Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine and is found to be expressed in atherosclerotic lesions. We investigated the association between the C804A polymorphism within the LTA gene and coronary and cerebrovascular events in 5804 participants of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). The primary endpoint was the combi...
Abstract
Cited 47 times since 2008 (2.8 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 15, Issue 4, 21 3 2008, Pages 503-509
Different manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus.
Scholte AJ, Schuijf JD, Kharagjitsingh AV, Dibbets-Schneider P, Stokkel MP, Jukema JW, van der Wall EE, Bax JJ, Wackers FJ
Background: We sought to assess prospectively the evidence for silent coronary artery disease (CAD) in asymptomatic patients with type 2 diabetes mellitus by stress single-photon emission computed tomography (SPECT) myocardial perfusion imaging, coronary artery calcium (CAC) scoring, and multislice computed tomographic (MSCT) coronary angiography. Methods: One hundred asymptomatic patients (aged 30 to 72 years) with type 2 diabetes mellitus and one or more risk factors for CAD were prospectively...
Abstract
Cited 20 times since 2008 (1.2 per year)
source: EuropePMC
Acta physiologica (Oxford, England),
Volume 194, Issue 2, 17 3 2008, Pages 111-122
Left ventricular function in the post-infarct failing mouse heart by magnetic resonance imaging and conductance catheter: a comparative analysis.
Winter EM, Grauss RW, Atsma DE, Hogers B, Poelmann RE, van der Geest RJ, Tschöpe C, Schalij MJ, Gittenberger-de Groot AC, Steendijk P
Aim: Murine myocardial infarction (MI) models are increasingly used in heart failure studies. Magnetic resonance imaging (MRI) and pressure-volume loops by conductance catheter (CC) enable physiological phenotyping. We performed a comparative analysis of MRI vs. CC to assess left ventricular (LV) function in the failing mouse heart. Methods: MI was created by LAD ligation. MRI (day 14) and CC (day 15) were used to determine LV end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fr...
Abstract
Cited 28 times since 2008 (1.6 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 15, Issue 3, 16 3 2008, Pages 442-455
Cardiac neuronal imaging: application in the evaluation of cardiac disease.
Henneman MM, Bengel FM, van der Wall EE, Knuuti J, Bax JJ
Abstract
Cited 297 times since 2008 (17.4 per year)
source: EuropePMC
Circulation,
Volume 117, Issue 16, 14 2 2008, Pages 2051-2060
Role of left ventricular stiffness in heart failure with normal ejection fraction.
Westermann D, Kasner M, Steendijk P, Spillmann F, Riad A, Weitmann K, Hoffmann W, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C
Background: Increased left ventricular stiffness is a distinct finding in patients who have heart failure with normal ejection fraction (HFNEF). To elucidate how diastolic dysfunction contributes to heart failure symptomatology during exercise, we conducted a study using an invasive pressure-volume loop approach and measured cardiac function at rest and during atrial pacing and handgrip exercise. Methods and results: Patients with HFNEF (n=70) and patients without heart failure symptoms (n=20) w...
Abstract
Cited 45 times since 2008 (2.6 per year)
source: EuropePMC
The Journal of allergy and clinical immunology,
Volume 121, Issue 5, 11 2 2008, Pages 1196-1202
Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma.
Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ
Background: Smooth muscle content is increased within the airway wall in patients with asthma and is likely to play a role in airway hyperresponsiveness. However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly. Objective: We examined the expression of contractile and structural proteins of smooth muscle cells, as well as extracellular matrix proteins, in bronchial biopsies of patients with asthma, and r...
Abstract
Cited 43 times since 2008 (2.5 per year)
source: EuropePMC
Circulation research,
Volume 102, Issue 9, 3 1 2008, Pages 1046-1056
Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice.
Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q
We have recently demonstrated that stem cell antigen 1-positive (Sca-1(+)) progenitors exist in the vascular adventitia of apolipoprotein E-deficient (apoE(-/-)) mice and contribute to smooth muscle cell (SMC) accumulation in vein graft atherosclerosis. Using a combined proteomic and metabolomic approach, we now characterize these local progenitors, which participate in the formation of native atherosclerotic lesions in chow-fed apoE(-/-) mice. Unlike Sca-1(+) progenitors from embryonic stem cel...
Abstract
Cited 15 times since 2008 (0.9 per year)
source: EuropePMC
Journal of virology,
Volume 82, Issue 12, 2 1 2008, Pages 5693-5702
The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency.
Lindner SE, Zeller K, Schepers A, Sugden B
Epstein-Barr virus (EBV) replicates its genome as a licensed plasmid in latently infected cells. Although replication of this plasmid is essential for EBV latent infection, its synthesis still fails for 16% of the templates in S phase. In order to understand these failures, we sought to determine whether the affinity of the initiator protein (EBNA1) for its binding sites in the origin affects the efficiency of plasmid replication. We have answered this question by using several engineered origin...
Abstract
Cited 7 times since 2008 (0.4 per year)
source: EuropePMC
Circulation research,
Volume 102, Issue 7, 1 1 2008, Pages 749-751
Pitx2: a challenging teenager.
Poelmann RE, Jongbloed MR, Gittenberger-de Groot AC
Abstract
Cited 53 times since 2008 (3.1 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 1, Issue 2, 1 1 2008, Pages 192-201
Stent malapposition after sirolimus-eluting and bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: acute and 9-month intravascular ultrasound results of the MISSION! intervention study.
van der Hoeven BL, Liem SS, Dijkstra J, Bergheanu SC, Putter H, Antoni ML, Atsma DE, Bootsma M, Zeppenfeld K, Jukema JW, Schalij MJ
Objectives: Acute and late stent malapposition (SM) after bare-metal stents (BMS) and sirolimus-eluting stents (SES) in ST-segment elevation myocardial infarction patients were studied. Background: Stent thrombosis may be caused by SM after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction patients. Methods: Post-procedure and follow-up intravascular ultrasound data were available in 184 out of 310 patients (60%; 104 SES, 80 BMS) included in the MISSION! In...
Abstract
Cited 92 times since 2008 (5.4 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 1, Issue 2, 1 1 2008, Pages 176-182
Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis.
Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Reiber JH, Schalij MJ, Wijns W, Bax JJ
Objectives: The purpose of this study was to perform a head-to-head comparison of plaque observations with multislice computed tomography (MSCT) to virtual histology intravascular ultrasound (VH IVUS). Background: The VH IVUS allows in vivo coronary plaque characterization with high spatial resolution. Noninvasively, plaques may be evaluated with MSCT, but limited data are available. Methods: A total of 50 patients underwent 64-slice MSCT followed by VH IVUS. The Agatston score was evaluated on...
Abstract
Cited 32 times since 2008 (1.9 per year)
source: EuropePMC
European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology,
Volume 15, Issue 2, 1 1 2008, Pages 140-144
Exercise training increases oxygen uptake efficiency slope in chronic heart failure.
Gademan MG, Swenne CA, Verwey HF, van de Vooren H, Haest JC, van Exel HJ, Lucas CM, Cleuren GV, Schalij MJ, van der Wall EE
Background and aim: The oxygen uptake efficiency slope (OUES) is a novel measure of cardiopulmonary reserve. OUES is measured during an exercise test, but it is independent of the maximally achieved exercise intensity. It has a higher prognostic value in chronic heart failure (CHF) than other exercise test-derived variables such as(Equation is included in full-text article.)or(Equation is included in full-text article.)slope. Exercise training improves(Equation is included in full-text article.)...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 56, Issue 2, 1 1 2008, Pages 227-235
Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.
Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE
Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (New York Heart Association [NYHA] class III or IV, depressed left ventricular [LV] ejection fraction, and prolonged QRS duration) result in at least 30% of the selected patients with no response to CRT. Recent studies with echocardiography have shown that the presence of LV dyssynchrony is an important predictor for response to CRT. However, the r...
Abstract
Cited 12 times since 2008 (0.7 per year)
source: EuropePMC
The Journal of general virology,
Volume 89, Issue Pt 4, 1 1 2008, Pages 975-983
Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses.
de Graaf M, Herfst S, Schrauwen EJA, Choi Y, van den Hoogen BG, Osterhaus ADME, Fouchier RAM
Human metapneumovirus (HMPV) and avian metapneumovirus (AMPV) have a similar genome organization and protein composition, but a different host range. AMPV subgroup C (AMPV-C) is more closely related to HMPV than other AMPVs. To investigate the specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses, a minireplicon system was generated for AMPV-C and used in combination with minireplicon systems for HMPV lineages A1 and B1. Viral RNA-like mol...
Abstract
Cited 128 times since 2008 (7.5 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 51, Issue 16, 1 1 2008, Pages 1588-1596
Long-term prognosis of patients with peripheral arterial disease: a comparison in patients with coronary artery disease.
Welten GM, Schouten O, Hoeks SE, Chonchol M, Vidakovic R, van Domburg RT, Bax JJ, van Sambeek MR, Poldermans D
Objectives: This study was designed to compare the long-term outcomes of patients with peripheral arterial disease (PAD) with a risk factor matched population of coronary artery disease (CAD) patients, but without PAD. Background: The PAD is considered to be a risk factor for adverse late outcome. Methods: A total of 2,730 PAD patients undergoing vascular surgery were categorized into groups: 1) carotid endarterectomy (n = 560); 2) elective abdominal aortic surgery (AAA) (n = 923); 3) acute AAA...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 56, Issue 2, 1 1 2008, Pages 215-226
Multi-slice computed tomography coronary angiography: anatomic vs functional assessment in clinical practice.
Van Werkhoven JM, Schuijf JD, Jukema JW, Van Der Wall EE, Bax JJ
Non-invasive imaging plays an increasingly important role in the diagnosis and risk stratification of coronary artery disease (CAD). Several techniques such as stress echocardiography and myocardial perfusion imaging have become available to assess cardiac function and myocardial perfusion. With the arrival of multi-slice computed tomography coronary angiography (CTA), non-invasive imaging of coronary anatomy has also become possible. Studies concerning the diagnostic accuracy have demonstrated...
Abstract
Cited 4 times since 2008 (0.2 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 7, Issue 3, 28 4 2008, Pages 517-518
Early atrial septal defect surgery due to a bronchogenic cyst causing congestive heart failure by left atrium compression.
Mosquera VX, Rijlaarsdam M, Filippini L, Hazekamp MG
We report on an uncommon case of a 10-month-old patient who required early surgical closure of an ostium secumdum atrial septal defect due to the concomitant presence of a big subcarinal bronchogenic cyst compressing the left atrium and, therefore, increasing the left-to-right shunt. It led to refractory congestive heart failure symptoms, establishing thereby an earlier indication of surgical treatment.
Abstract
Cited 21 times since 2008 (1.2 per year)
source: EuropePMC
Journal of neuroimmunology,
Volume 195, Issue 1-2, 20 3 2008, Pages 164-170
B and T cell imbalances in CSF of patients with Hu-antibody associated PNS.
de Graaf M, de Beukelaar J, Bergsma J, Kraan J, van den Bent M, Klimek M, van Norden Y, Kusuma A, Smitt PS, Gratama JW
In paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (approximately 20x) and relative (approximately 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolut...
Abstract
Cited 51 times since 2008 (3 per year)
source: EuropePMC
Circulation,
Volume 117, Issue 12, 10 2 2008, Pages 1508-1517
Epicardium-derived cells in development of annulus fibrosis and persistence of accessory pathways.
Kolditz DP, Wijffels MC, Blom NA, van der Laarse A, Hahurij ND, Lie-Venema H, Markwald RR, Poelmann RE, Schalij MJ, Gittenberger-de Groot AC
Background: The developmental mechanisms underlying the persistence of myocardial accessory atrioventricular pathways (APs) that bypass the annulus fibrosis are mainly unknown. In the present study, we investigated the role of epicardium-derived cells (EPDCs) in annulus fibrosis formation and the occurrence of APs. Methods and results: EPDC migration was mechanically inhibited by in ovo microsurgery in quail embryos. In ovo ECGs were recorded in wild-type (n=12) and EPDC-inhibited (n=12) hearts...
Abstract
Cited 11 times since 2008 (0.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 101, Issue 8, 4 1 2008, Pages 1179-1184
Effects of percutaneous transluminal septal myocardial ablation for obstructive hypertrophic cardiomyopathy on systolic and diastolic left ventricular function assessed by pressure-volume loops.
Meliga E, Steendijk P, Valgimigli M, Ten Cate FJ, Serruys PW
The aim of the present study was to determine the long-term effects of percutaneous transluminal septal myocardial ablation (PTSMA) on systolic and diastolic left ventricular (LV) functions in patients with obstructive hypertrophic cardiomyopathy (HC). Ten consecutive patients with symptomatic HC despite optimal medical treatment were referred for PTSMA at our center. LV systolic and diastolic functions were assessed by online LV pressure-volume loops obtained by conductance catheter at baseline...
Abstract
