Research

Publications

Below you can find a list of our published research.

8569 results

Cited 42 times since 2014 (3.6 per year) source: EuropePMC

Human molecular genetics, Volume 23, Issue 20, 26 4 2014, Pages 5545-5557 Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. Rafnar T, Sulem P, Thorleifsson G, Vermeulen SH, Helgason H, Saemundsdottir J, Gudjonsson SA, Sigurdsson A, Stacey SN, Gudmundsson J, Johannsdottir H, Alexiusdottir K, Petursdottir V, Nikulasson S, Geirsson G, Jonsson T, Aben KK, Grotenhuis AJ, Verhaegh GW, Dudek AM, Witjes JA, van der Heijden AG, Vrieling A, Galesloot TE, De Juan A, Panadero A, Rivera F, Hurst C, Bishop DT, Sak SC, Choudhury A, Teo MT, Arici C, Carta A, Toninelli E, de Verdier P, Rudnai P, Gurzau E, Koppova K, van der Keur KA, Lurkin I, Goossens M, Kellen E, Guarrera S, Russo A, Critelli R, Sacerdote C, Vineis P, Krucker C, Zeegers MP, Gerullis H, Ovsiannikov D, Volkert F, Hengstler JG, Selinski S, Magnusson OT, Masson G, Kong A, Gudbjartsson D, Lindblom A, Zwarthoff E, Porru S, Golka K, Buntinx F, Matullo G, Kumar R, Mayordomo JI, Steineck DG, Kiltie AE, Jonsson E, Radvanyi F, Knowles MA, Thorsteinsdottir U, Kiemeney LA, Stefansson K

Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants at 12 loci that associate with risk of the disease. We report here the results of a GWAS of UBC including 1670 UBC cases and 90 180 controls, followed by replication analysis in additional 5266 UBC cases and 10 456 controls. We tested a dataset containing 34.2 million variants, generated by imputation based on whole-genome sequencing of 2230 Icelanders. Several correlated variants at 20p12, repres... Abstract

Cited 22 times since 2014 (1.9 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 5, 24 4 2014, Pages 913-920 I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis. Zhou Y, Zhou W, Folks RD, Manatunga DN, Jacobson AF, Bax JJ, Garcia EV, Chen J

Objectives: The purpose of this study is to assess mIBG uptake in scar border zone and its relation with ventricular arrhythmia (VA) inducibility on electrophysiology (EP) testing using I-123 mIBG SPECT and resting Tc-99m SPECT myocardial perfusion imaging (MPI). Methods: Forty-seven patients from a previous clinical trial were retrospectively analyzed. These patients underwent I-123 mIBG and resting Tc-99m tetrofosmin SPECT, and EP testing. Twenty-eight patients were positive (EP+) and 19 patie... Abstract

Cited 520 times since 2014 (44.6 per year) source: EuropePMC

Lab on a chip, Volume 14, Issue 13, 23 4 2014, Pages 2202-2211 Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Bertassoni LE, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino AL, Barabaschi G, Demarchi D, Dokmeci MR, Yang Y, Khademhosseini A

Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limite... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 4, 22 4 2014, Pages 311-319 Diagnosis and treatment of pulmonary hypertension. Haeck ML, Vliegen HW

Abstract

Cited 4 times since 2014 (0.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 15, Issue 10, 22 4 2014, Pages 1183 Helical flow pattern in the right pulmonary artery after Fontan palliation. Houtzager JH, Westenberg JJ, de Koning PJ, Hazekamp MG, Roest AA

Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 17, 16 3 2014, Pages 1360-1365 Persistent neo-aortic growth during adulthood in patients after an arterial switch operation. van der Bom T, van der Palen RL, Bouma BJ, van Veldhuisen SL, Vliegen HW, Konings TC, Zwinderman AH, Blom NA, Koolbergen DR, Hazekamp MG, Mulder BJ

Objective: After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childhood. Methods: All 116 ASO patients operated in a tertiary referral centre and born before 1995 were... Abstract

American heart journal, Volume 168, Issue 1, 14 2 2014, Pages e5 Response to the letter to the editor by Ariza-Solé et al. Velders MA, James SK, Libungan B, Sarno G, Fröbert O, Carlsson J, Schalij MJ, Albertsson P, Lagerqvist B

Abstract

Cited 14 times since 2014 (1.2 per year) source: EuropePMC

Experimental cell research, Volume 327, Issue 2, 13 2 2014, Pages 297-306 Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones. Dambrot C, Buermans HP, Varga E, Kosmidis G, Langenberg K, Casini S, Elliott DA, Dinnyes A, Atsma DE, Mummery CL, Braam SR, Davis RP

Recent methodological advances have improved the ease and efficiency of generating human induced pluripotent stem cells (hiPSCs), but this now typically results in a greater number of hiPSC clones being derived than can be wholly characterized. It is therefore imperative that methods are developed which facilitate rapid selection of hiPSC clones most suited for the downstream research aims. Here we describe a combination of procedures enabling the simultaneous screening of multiple clones to det... Abstract

Cited 15 times since 2014 (1.3 per year) source: EuropePMC

Circulation. Cardiovascular quality and outcomes, Volume 7, Issue 3, 13 2 2014, Pages 437-444 Left ventricular reverse remodeling, device-related adverse events, and long-term outcome after cardiac resynchronization therapy in the elderly. Höke U, Putter H, Van Der Velde ET, Schalij MJ, Delgado V, Bax JJ, Marsan NA

Background: Limited data are available on efficacy, safety, and long-term prognosis after cardiac resynchronization therapy (CRT) in elderly patients. We aimed at evaluating the effect of CRT, device-related adverse events, and long-term outcome after CRT among elderly patients. Methods and results: A total of 798 CRT recipients (208 elderly: age, ≥75 years; 590 nonelderly: age, Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 6, 10 2 2014, Pages 1151-1159 Associations of atherosclerosis in the descending thoracic aorta on CTA with arterial stiffness and chronic kidney disease in asymptomatic patients with diabetes mellitus. Roos CJ, Delgado V, de Koning EJ, Rabelink TJ, Jukema JW, Bax JJ, Scholte AJ

The relation between atherosclerosis in the descending thoracic aortic (DTA), arterial stiffness and chronic kidney disease (CKD) in patients with diabetes mellitus (DM) remains unclear. The current aim was to evaluate associations of DTA atherosclerosis with arterial stiffness and parameters of CKD in asymptomatic patients with DM. A total of 213 asymptomatic patients with diabetes (mean age 52 years, 56% men) underwent cardiovascular risk assessment including multi-slice computed tomography (f... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 3, 9 2 2014, Pages 230-239 Cardiac resynchronisation therapy in populations underrepresented in randomised controlled trials. Höke U, Delgado V, Marsan NA, Bax JJ

Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

Atherosclerosis, Volume 235, Issue 1, 8 2 2014, Pages 176-181 ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment. Akao H, Polisecki E, Schaefer EJ, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Packard C, Buckley BM, Kajinami K, PROspective Study of Pravastatin in the Elderly at Risk Investigator

Aims: Our goals were to examine the relationships of a specific ATP-binding cassette transporter A1 (ABCA1) variant, rs2230806 (R219K), on baseline lipids, low-density lipoprotein cholesterol (LDL-C) lowering due to pravastatin, baseline heart disease, and cardiac endpoints on trial. Methods and results: The ABCA1 R219K variant was assessed in 5414 participants in PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) (mean age 75.3 years), who had been randomized to pravastatin 40 mg... Abstract

Cited 5 times since 2014 (0.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 5, 1 1 2014, Pages 240-245 Unroofed coronary sinus newly diagnosed in adult patients after corrected congenital heart disease. Pérez Matos AJ, Planken RN, Bouma BJ, Groenink M, Backx AP, de Winter RJ, Koolbergen DR, Mulder BJ, Boekholdt SM

Patients with congenital heart disease corrected in early childhood may later in life present with cardiac symptoms caused by other associated congenital anomalies that were initially not diagnosed. Nowadays, several noninvasive imaging modalities are available for the visualisation of cardiac anatomy in great detail. We describe two patients with an unroofed coronary sinus, a rare congenital anomaly which could be diagnosed using a combination of modalities including echocardiography, cardiac C... Abstract

Cited 50 times since 2014 (4.3 per year) source: EuropePMC

Future virology, Volume 9, Issue 5, 1 1 2014, Pages 513-524 Avian influenza A viruses: from zoonosis to pandemic. Richard M, de Graaf M, Herfst S

Zoonotic influenza A viruses originating from the animal reservoir pose a threat for humans, as they have the ability to trigger pandemics upon adaptation to and invasion of an immunologically naive population. Of particular concern are the H5N1 viruses that continue to circulate in poultry in numerous countries in Europe, Asia and Africa, and the recently emerged H7N9 viruses in China, due to their relatively high number of human fatalities and pandemic potential. To start a pandemic, zoonotic... Abstract

Cited 27 times since 2014 (2.3 per year) source: EuropePMC

BMC public health, Volume 14, 28 4 2014, Pages 410 The Carriage Of Multiresistant Bacteria After Travel (COMBAT) prospective cohort study: methodology and design. Arcilla MS, van Hattem JM, Bootsma MC, van Genderen PJ, Goorhuis A, Schultsz C, Stobberingh EE, Verbrugh HA, de Jong MD, Melles DC, Penders J

Background: Antimicrobial resistance (AMR) is one of the major threats to public health around the world. Besides the intense use and misuse of antimicrobial agents as the major force behind the increase in antimicrobial resistance, the exponential increase of international travel may also substantially contribute to the emergence and spread of AMR. However, knowledge on the extent to which international travel contributes to this is still limited. The Carriage Of Multiresistant Bacteria After T... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

Atherosclerosis, Volume 235, Issue 1, 26 4 2014, Pages 58-64 In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study. Postmus I, Johnson PC, Trompet S, de Craen AJ, Slagboom PE, Devlin JJ, Shiffman D, Sacks FM, Kearney PM, Stott DJ, Buckley BM, Sattar N, Ford I, Westendorp RG, Jukema JW

Background: Statin therapy is widely used in the prevention and treatment of cardiovascular events and is associated with significant risk reductions. However, there is considerable variation in response to statin therapy both in terms of LDL cholesterol reduction and clinical outcomes. It has been hypothesized that genetic variation contributes importantly to this individual drug response. Methods and results: We investigated the interaction between genetic variants and pravastatin or placebo t... Abstract

Cited 32 times since 2014 (2.7 per year) source: EuropePMC

Diabetologia, Volume 57, Issue 7, 26 4 2014, Pages 1332-1338 Validation of a model to estimate personalised screening frequency to monitor diabetic retinopathy. van der Heijden AA, Walraven I, van 't Riet E, Aspelund T, Lund SH, Elders P, Polak BC, Moll AC, Keunen JE, Dekker JM, Nijpels G

Aims/hypothesis: Our study aimed to validate a model to determine a personalised screening frequency for diabetic retinopathy. Methods: A model calculating a personalised screening interval for monitoring retinopathy based on patients' risk profile was validated using the data of 3,319 type 2 diabetic patients in the Diabetes Care System West-Friesland, the Netherlands. Two-field fundus photographs were graded according to the EURODIAB coding system. Sight-threatening retinopathy (STR) was... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

BMJ case reports, Volume 2014, 25 4 2014, Pages bcr2013203342 Graves' disease as an uncommon cause of acute pericarditis. Kortekaas KA, van der Lienden B, Jong S, Riezebos R

Acute pericarditis is either dry, fibrinous or effusive, independent of its aetiology. A case is presented involving a 44-year-old man with acute pericarditis. The cause was established to be an aggravation of Graves' disease due to non-compliance with treatment. Pericarditis is an uncommon cardiac complication of Graves' disease and is associated with more recurrent episodes when not detected. Pharmacological treatment should include anti-inflammatory drugs in combination with treatme... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 101, Issue 1, 23 4 2014, Pages 72-81 Advanced techniques in dobutamine stress echocardiography: focus on myocardial deformation analysis. Joyce E, Delgado V, Bax JJ, Marsan NA

Abstract

Cited 101 times since 2014 (8.6 per year) source: EuropePMC

BioMed research international, Volume 2014, 23 4 2014, Pages 893106 The multifaceted functions of CXCL10 in cardiovascular disease. van den Borne P, Quax PH, Hoefer IE, Pasterkamp G

C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. After binding to its receptor CXCR3, CXCL10 evokes a range of inflammatory responses: key features in cardiovascular disease (CVD).... Abstract