9618 results
Cited 61 times since 2007 (3.4 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 27, Issue 9, 28 4 2007, Pages 2050-2057
Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis.
Hauer AD, van Puijvelde GH, Peterse N, de Vos P, van Weel V, van Wanrooij EJ, Biessen EA, Quax PH, Niethammer AG, Reisfeld RA, van Berkel TJ, Kuiper J
Objective: Vascular endothelial growth factor receptor 2 (VEGFR2)-overexpressing cells may form an interesting target for the treatment of atherosclerosis because of their involvement in processes that contribute to this disease, such as angiogenesis. Methods and results: We vaccinated mice against VEGFR2 by an orally administered DNA vaccine, comprising a plasmid, encoding murine VEGFR2, carried by live attenuated Salmonella typhimurium. This vaccine induces cellular immunity against cells that...
Abstract
Cited 74 times since 2007 (4.1 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 83, Issue 2, 27 4 2007, Pages 288-292
Cytochrome P450 2C9 *2 and *3 polymorphisms and the dose and effect of sulfonylurea in type II diabetes mellitus.
Becker ML, Visser LE, Trienekens PH, Hofman A, van Schaik RH, Stricker BH
Sulfonylurea hypoglycemics are mainly metabolized by the cytochrome P450 2C9 (CYP2C9) enzyme. The CYP2C9*2 and *3 polymorphisms encode proteins with less enzymatic activity and are correlated with elevated serum levels of sulfonylurea, as demonstrated in healthy volunteers. In this study, the effect of these variants is described for patients with diabetes mellitus treated with sulfonylurea. Associations between CYP2C9 polymorphisms, prescribed doses of sulfonylurea, and change in glucose levels...
Abstract
Cited 17 times since 2007 (0.9 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 82, Issue 1-2, 26 4 2007, Pages 159-165
Diagnostic validity and costs of pooled fecal samples and individual blood or fecal samples to determine the cow- and herd-status for Mycobacterium avium subsp. paratuberculosis.
van Schaik G, Pradenas F M, Mella N A, Kruze V J
Two tests are used on a regular basis to detect Mycobacterium avium subsp. paratuberculosis (Map): ELISA and fecal culture. Fecal culture is considered more sensitive and specific but is costly and requires 3-4 months for results. Pooling of fecal samples of individual animals may reduce the high costs of fecal culture. The objective of the study was to investigate the diagnostic validity and costs for pooling of fecal samples in dairy farms relative to culture or an ELISA on individual samples...
Abstract
Cited 46 times since 2007 (2.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 9, Issue 8, 22 4 2007, Pages 808-813
Importance of the echocardiographic evaluation of right ventricular function in patients with AL amyloidosis.
Ghio S, Perlini S, Palladini G, Marsan NA, Faggiano G, Vezzoli M, Klersy C, Campana C, Merlini G, Tavazzi L
Background: Patients with AL amyloidosis often present with signs of congestive heart failure. Aim: This study was prospectively designed to assess the significance of RV dysfunction in AL amyloidosis. Methods and results: Seventy-four patients with biopsy proven AL amyloidosis underwent a thorough echocardiographic evaluation. A tricuspid annular plane systolic excursion (TAPSE)
Abstract
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 34, Issue 3, 19 3 2007, Pages 378
The Oslo Balloon Angioplasty versus Conservative Treatment Study (OBACT) - The 2-years results of a single centre, prospective, randomised study in patients with intermittent claudication.
Breek JC, De Vries J, Hamming JF
Abstract
Cited 30 times since 2007 (1.7 per year)
source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 21, Issue 12, 19 3 2007, Pages 3369-3379
Fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene.
van Tuyn J, Pijnappels DA, de Vries AA, de Vries I, van der Velde-van Dijke I, Knaän-Shanzer S, van der Laarse A, Schalij MJ, Atsma DE
Myocardial scar formation impairs heart function by inducing cardiac remodeling, decreasing myocardial compliance, and compromising normal electrical conduction. Conversion of myocardial scar fibroblasts (MSFs) into (functional) cardiomyocytes may be an effective alternative treatment to limit loss of cardiac performance after myocardial injury. In this study, we investigated whether the phenotype of MSFs can be modified by gene transfer into cells with properties of cardiomyocytes. To this end,...
Abstract
Cited 198 times since 2007 (10.9 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 48, Issue 7, 15 3 2007, Pages 1104-1111
Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT?
Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, van der Wall EE, Schalij MJ, Garcia EV, Bax JJ
Unlabelled: Cardiac resynchronization therapy (CRT) is now a well-recognized therapeutic option for patients with end-stage heart failure. However, not all patients respond to CRT, and, therefore, preimplantation identification of responders is desirable. The aim of the present study was to investigate whether the degree of left ventricular (LV) dyssynchrony, as assessed with phase analysis from gated myocardial perfusion SPECT (GMPS), can predict which patients will respond to CRT. Methods: For...
Abstract
Cited 71 times since 2007 (3.9 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 48, Issue 7, 15 3 2007, Pages 1135-1146
Assessment of myocardial viability in patients with heart failure.
Schinkel AF, Poldermans D, Elhendy A, Bax JJ
The prognosis for patients with chronic ischemic left ventricular dysfunction is poor, despite advances in different therapies. Noninvasive assessment of myocardial viability may guide patient management. Multiple imaging techniques have been developed to assess viable and nonviable myocardium by evaluating perfusion, cell membrane integrity, mitochondria, glucose metabolism, scar tissue, and contractile reserve. PET, (201)Tl and (99m)Tc scintigraphy, and dobutamine stress echocardiography have...
Abstract
Cited 17 times since 2007 (0.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 100, Issue 3, 14 2 2007, Pages 476-482
Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy.
Van de Veire NR, Bleeker GB, Ypenburg C, De Sutter J, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
This study evaluated the value of triplane tissue Doppler imaging (TDI) to predict acute response after cardiac resynchronization therapy (CRT). Forty-nine patients scheduled for CRT underwent triplane echocardiography with simultaneous TDI acquisition before and 48 hours after implantation. A 3-dimensional left ventricular (LV) volume was generated and LV volumes and ejection fraction were calculated. A parametric imaging technique, tissue synchronization imaging, was applied to portray the are...
Abstract
Cited 2 times since 2007 (0.1 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 81, Issue 4, 12 2 2007, Pages 265-273
Factors associated with variation in Neospora caninum bulk-milk S/P ratios in initially bulk-milk negative testing Dutch dairy herds.
Bartels CJ, van Schaik G, van Maanen K, Wouda W, Dijkstra T
We conducted a study on 81 initially bulk-milk ELISA negative dairy herds taken from a random sample of Dutch dairy herds to evaluate variation in bulk-milk S/P ratios and to study reasons for bulk-milk conversion. These herds were repeatedly (3-month intervals) tested between April 2004 and August 2005 and serostatus of all animals had previously been established as negative (N), low-positive (LP) or high-positive (HP). Of these herds, herd- and test-related factors associated with variation in...
Abstract
Cited 87 times since 2007 (4.8 per year)
source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Volume 25, Issue 19, 11 2 2007, Pages 2719-2726
Cigarette smoking and irinotecan treatment: pharmacokinetic interaction and effects on neutropenia.
van der Bol JM, Mathijssen RH, Loos WJ, Friberg LE, van Schaik RH, de Jonge MJ, Planting AS, Verweij J, Sparreboom A, de Jong FA
Purpose: Several constituents of cigarette smoke are known to interact with drug metabolizing enzymes and potentially affect treatment outcome with substrate drugs. The purpose of this study was to determine the effects of cigarette smoking on the pharmacokinetics and adverse effects of irinotecan. Patients and methods: A total of 190 patients (49 smokers, 141 nonsmokers) treated with irinotecan (90-minute intravenous administration on a 3-week schedule) were evaluated for pharmacokinetics. Comp...
Abstract
Cited 288 times since 2007 (15.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 49, Issue 24, 4 1 2007, Pages 2303-2311
Outcome of pregnancy in women with congenital heart disease: a literature review.
Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Yap SC, Moons P, Ebels T, van Veldhuisen DJ, ZAHARA Investigators
A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more...
Abstract
Cited 21 times since 2007 (1.2 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 104, Issue 24, 4 1 2007, Pages 10000-10005
Global distribution of negative cofactor 2 subunit-alpha on human promoters.
Albert TK, Grote K, Boeing S, Stelzer G, Schepers A, Meisterernst M
Negative cofactor 2 (NC2) forms a stable complex with TATA-binding protein (TBP) on promoters in vitro. Its association with TBP prevents the binding of TFIIB and leads to inhibition of preinitiation complex formation. Here, we investigate the association of NC2 subunit-alpha with human RNA polymerase II promoter regions by using gene-specific ChIP and genome-wide promoter ChIPchip analyses. We find NC2alpha associated with a large number of human promoters, where it peaks close to the core regi...
Abstract
Cited 4 times since 2007 (0.2 per year)
source: EuropePMC
International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation,
Volume 30, Issue 2, 1 1 2007, Pages 163-165
Factors important in the design of information material for scoliosis.
van Schaik P, Flynn D, van Wersch A, Ryan KA, Ferguson V
The aim of this study was to identify the most salient characteristics for designing written information for persons with idiopathic scoliosis and their families. A sample of 106 persons with idiopathic scoliosis (n=83) and family members of persons with idiopathic scoliosis (n=23) completed a postal questionnaire to assess perceived level of scoliosis-related knowledge, importance attached to generic design characteristics of information material and preferences for presentation of risk informa...
Abstract
Cited 19 times since 2007 (1 per year)
source: EuropePMC
Journal of the American Geriatrics Society,
Volume 55, Issue 6, 1 1 2007, Pages 872-877
The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study.
de Ruijter W, Westendorp RG, Macfarlane PW, Jukema JW, Assendelft WJ, Gussekloo J
Objectives: To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status. Design: Observational, prospective cohort study with complete 6-year follow-up. Setting: General population. Participants: A population-based sample of 566 85-year-old participants (377 women, 189 men), without exclusion criteria. Measurements: Annual ECG recording an...
Abstract
Cited 8 times since 2007 (0.4 per year)
source: EuropePMC
American journal of Alzheimer's disease and other dementias,
Volume 22, Issue 3, 1 1 2007, Pages 167-175
The Closing Group: Therapeutic recreation for nursing home residents with dementia and accompanying agitation and/or anxiety.
Putman L, Wang JT
Long-term care residents who have a dementia diagnosis could account for as much 50% of a nursing home's population. Often residents with dementia experience a distressing behavioral symptom that affects the resident experiencing the symptom(s), other nursing home residents, visitors, and staff. The Closing Group intervention was developed as a nonpharmacological alternative that aims to reduce agitation and anxiety, increase socialization, decrease restraint use, and decrease antipsychotic...
Abstract
Cited 20 times since 2007 (1.1 per year)
source: EuropePMC
Environmental science & technology,
Volume 41, Issue 12, 1 1 2007, Pages 4286-4291
Copper(II) binding to dissolved organic matter fractions in municipal solid waste incinerator bottom ash leachate.
Olsson S, Van Schaik JW, Gustafsson JP, Kleja DB, Van Hees PA
Information on Cu speciation in municipal solid waste incineration (MSWI) bottom ash leachate is needed for Cu leaching predictions and toxicity estimates. The complexation of Cu with dissolved organic matter (DOM) in leachates from a stored MSWI bottom ash was studied potentiometrically using a Cu-ion selective electrode. More than 95% of the copper was bound to DOM in the hydrophilic fraction of the leachate, indicating that the hydrophilic acids contribute to Cu complex formation. The hydroph...
Abstract
Cited 26 times since 2007 (1.4 per year)
source: EuropePMC
American journal of primatology,
Volume 69, Issue 6, 1 1 2007, Pages 641-651
Demography and life history of Thomas langurs (Presbytis thomasi).
Wich SA, Steenbeek R, Sterck EH, Korstjens AH, Willems EP, Van Schaik CP
Life history data from wild primate populations are necessary to explain variation in primate social systems and explain differences between primates and other mammals. Here we report life history data from a 12.5-year study on wild Thomas langurs. Mean age at first reproduction was 5.4 years and the sex ratio at birth was even. The mean interbirth interval (IBI) after a surviving infant was 26.8 mo, after nonsurviving infants 17.7 mo, and combined 22.0 mo. Mean annual birth rate of adult female...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 151, Issue 24, 1 1 2007, Pages 1375; author reply 1375
[The metabolic syndrome].
van der Heijden AJ
Abstract
Cited 120 times since 2007 (6.6 per year)
source: EuropePMC
Journal of immunology (Baltimore, Md. : 1950),
Volume 178, Issue 12, 1 1 2007, Pages 7678-7685
Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity.
Heijink IH, Kies PM, Kauffman HF, Postma DS, van Oosterhout AJ, Vellenga E
Airway epithelial cells are well-known producers of thymus- and activation-regulated chemokine (TARC), a Th2 cell-attracting chemokine that may play an important role in the development of allergic airway inflammation. However, the mechanism responsible for up-regulation of TARC in allergy is still unknown. In the asthmatic airways, loss of expression of the cell-cell contact molecule E-cadherin and reduced epithelial barrier function has been observed, which may be the result of an inadequate r...
Abstract
