Research

Publications

Below you can find a list of our published research.

9618 results

Cited 8 times since 1998 (0.3 per year) source: EuropePMC

Cardiovascular drugs and therapy, Volume 12 Suppl 1, 1 1 1998, Pages 111-118 Proposed synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis. Jukema JW, van Boven AJ, Zwinderman AH, Van der Laarse A, Bruschke AV

Lipid-lowering therapy now has undoubtedly proven to be an effective therapeutic modality to retard the progression of coronary atherosclerosis. An additional approach for prevention of the progression of atherosclerosis is calcium channel blocker (CCB) treatment. Evidence indicating that CCBs inhibit atherosclerosis is less unequivocal than the clear evidence for lipid-lowering therapy. Many investigations support the view that a number of key processes in atherosclerosis may be influenced by C... Abstract

Cited 40 times since 1998 (1.5 per year) source: EuropePMC

American heart journal, Volume 135, Issue 4, 1 1 1998, Pages 571-576 Depressed heart rate variability is associated with events in patients with stable coronary artery disease and preserved left ventricular function. REGRESS Study Group. van Boven AJ, Jukema JW, Haaksma J, Zwinderman AH, Crijns HJ, Lie KI

Background: Little is known about the value of heart rate variability in patients with symptomatic coronary artery disease with a preserved left ventricular function. We hypothesized that in these patients heart rate variability might be a helpful adjunct to conventional parameters to predict clinical events. Methods: In a prospective 2-year follow-up study ambulatory electrocardiographic recordings were performed in 263 consecutive male patients (mean age 56+/-8 years) with stable angina pector... Abstract

Cited 3 times since 1998 (0.1 per year) source: EuropePMC

Lancet (London, England), Volume 351, Issue 9111, 1 1 1998, Pages 1288 Intravenous immunoglobulins and transforming growth factor beta. van Schaik IN, Vermeulen M, Brand A

Abstract

Cited 1 times since 1998 (0 per year) source: EuropePMC

The Turkish journal of pediatrics, Volume 40, Issue 2, 1 1 1998, Pages 279-281 Subcutaneous granuloma annulare and IgA-IgG2 deficiency. Kütükçüler N, Tütüncüoğlu S, Yilmaz D, Akalin T, Kandiloğlu G

Subcutaneous granuloma annulare (SGA) is a benign granulomatous disease occurring in childhood, with lesions most commonly located about the elbow, knee and scalp. the etiology of SGA remains obscure. We present a typical case with SGA also showing laboratory findings of IgA and IgG2 deficiency. Histologic findings of the lesions on the scalp were characterized by multiple large foci of complete collagen degeneration with a peripheral pallsade of histiocytes; the foci of degeneration was edemato... Abstract

Cited 6 times since 1998 (0.2 per year) source: EuropePMC

International journal of cardiac imaging, Volume 14, Issue 2, 1 1 1998, Pages 123-126 Embolization as a treatment of life-threatening haemoptysis in an adult with Tetralogy of Fallot with pulmonary atresia. van der Weijden P, Baur LH, Kool LJ, Vliegen HW, van der Wall EE

Aim: Description of embolization as a treatment for bleeding bronchopulmonary collaterals in congenital heart disease. Methods: After palliative corrective surgery of Tetralogy of Fallot with pulmonary atresia, haemoptysis due to ruptured bronchopulmonary collaterals is a well known complication. We describe a 31 year old patient with haemoptysis after incomplete correction because of Tetralogy of Fallot with pulmonary atresia. Because supportive treatment failed, the bleeding site was localized... Abstract

Cited 11 times since 1998 (0.4 per year) source: EuropePMC

The Veterinary record, Volume 142, Issue 10, 1 1 1998, Pages 240-242 Exploratory study on the economic value of a closed farming system on Dutch dairy farms. van Schaik C, Dijkhuizen AA, Benedictus G, Barkema HW, Koole JL

A closed farming system may prevent the introduction of infectious diseases on to dairy farms and could be a good starting point for the eradication of these diseases. In order to introduce a closed farming system, farmers need to be made aware of how these diseases are introduced into the herd. Farmers will be more likely to implement a closed farming system when the economic value is quantified and attractive. An exploratory study was carried out to investigate the technical and economic resul... Abstract

Tijdschrift voor diergeneeskunde, Volume 123, Issue 6, 1 1 1998, Pages 180-183 [Introduction of BHV1 on dairy farms. Risk assessment by cattle farmers and veterinarians]. van Schaik G, Dijkhuizen AA, Huirne RB, Benedictus G

A study is being carried out at Wageningen Agricultural University together with, among others, the Animal Health Service to determine the possibilities and economic consequences of a more closed farming system for (Dutch) dairy farms. Three identical workshops, held in the evening, were organized as part of the study. The opinion of farmers and their veterinarians on the importance of risk factors for the introduction of diseases on a farm was determined, using Bovine Herpes Virus type 1 (BHV1)... Abstract

Tijdschrift voor diergeneeskunde, Volume 123, Issue 5, 1 1 1998, Pages 142-143 [Acute blindness due to trauma in a Welsh pony-colt]. van Schaik AM, van der Pol BA, van der Linde-Sipman JS

A healthy, 10-day-old Welsh A pony colt was totally blind 1 day after arrival at a studfarm. Both eyes appeared normal on external inspection. The young animal had been very distressed during the 40-km journey to the studfarm. Intravenous corticosteroids were administered for 2 days, but did not result in any observable improvement. The animal was euthanized at the owner's request. Both eyes with the optic nerves were removed for histological examination. Both optic nerves showed Wallerian... Abstract

Lancet (London, England), Volume 351, Issue 9105, 1 1 1998, Pages 808 Debate grows on safety of gene-therapy vectors. Putman L

Abstract

Cited 5 times since 1998 (0.2 per year) source: EuropePMC

Pediatric research, Volume 43, Issue 3, 1 1 1998, Pages 331-337 Contribution of synchronized atrial systole to left ventricular contraction in the newborn pig heart. Klautz RJ, Baan J, Teitel DF

Synchronized atrial contraction may be much more important in the newborn, who has a faster heart rate and a less compliant ventricle, than in the adult. We therefore investigated the extent by which synchronized atrioventricular contraction contributes to cardiac output and cardiac work in a neonatal circulation, and whether this effect can be fully explained by the Starling mechanism. In neonatal piglets, left ventricular pressure and volume (conductance catheter) were measured during atrial a... Abstract

Cited 13 times since 1998 (0.5 per year) source: EuropePMC

Vision research, Volume 38, Issue 5, 1 1 1998, Pages 659-668 Stereoscopic segregation of transparent surfaces and the effect of motion contrast. Lankheet MJ, Palmen M

Stereoscopic segregation in depth was studied using two superimposed frontoparallel surfaces displayed in dynamic random dot stereograms. The two patterns were positioned symmetrically in front of and behind a binocular fixation point. They were either stationary, or they could move relative to each other. Sensitivity for segregation was established by adding gaussian distributed disparity noise to the disparities specifying the two planes, and finding the noise amplitude that gave threshold seg... Abstract

Cited 11 times since 1998 (0.4 per year) source: EuropePMC

Electroencephalography and clinical neurophysiology, Volume 108, Issue 2, 1 1 1998, Pages 110-122 Localization of spatial attention processes with the aid of a probe technique. Bruin KJ, Kenemans JL, Verbaten MN, Van der Heijden AH

A sudden visual onset is thought to 'attract attention to its location' within less than 100 ms. We attempted to measure the effect of this attentional process on the event-related potential (ERP) to a probe presented about 140 ms after the onset, and to delineate the spatiotemporal characteristics of such an effect, if any. ERPs were recorded from 30 channels from 6 subjects while they performed a target detection task. Both targets and probes could be located in each of the 4 quadran... Abstract

Cited 57 times since 1998 (2.1 per year) source: EuropePMC

The Journal of infectious diseases, Volume 177, Issue 2, 1 1 1998, Pages 269-276 Respiratory syncytial virus affects pulmonary function in BALB/c mice. van Schaik SM, Enhorning G, Vargas I, Welliver RC

BALB/c mice inoculated intranasally with respiratory syncytial virus (RSV) were studied in a whole-body plethysmograph to determine if signs of respiratory illness similar to those observed in human infants could be detected. Also, responsiveness to methacholine was assessed. RSV-infected mice showed significantly higher respiratory rates than did controls (409.2 vs. 305.2 breaths/min, P < .0001). Significantly increased airway responsiveness to methacholine was noted, infected mice respondin... Abstract

Cited 37 times since 1998 (1.3 per year) source: EuropePMC

Preventive veterinary medicine, Volume 34, Issue 2-3, 1 1 1998, Pages 125-136 Risk factors for existence of Bovine Herpes Virus 1 antibodies on nonvaccinating Dutch dairy farms. van Schaik G, Dijkhuizen AA, Huirne RB, Schukken YH, Nielen M, Hage HJ

A more closed farming system may prevent introduction of infectious diseases on dairy farms and can be a good starting point for control of these diseases. Data were available on the presence of Bovine Herpes Virus 1 (BHV1) antibodies in bulk milk and/or blood samples of Dutch dairy farms. Furthermore, information about the possible risk factors for introduction of infectious diseases was collected on 214 of these dairy farms. Data of 107 farms which had been never vaccinated against BHV1 remain... Abstract

Cited 39 times since 1998 (1.4 per year) source: EuropePMC

Journal of molecular biology, Volume 276, Issue 2, 1 1 1998, Pages 367-377 High-affinity DNA binding by the C-terminal domain of the transcriptional coactivator PC4 requires simultaneous interaction with two opposing unpaired strands and results in helix destabilization. Werten S, Langen FW, van Schaik R, Timmers HT, Meisterernst M, van der Vliet PC

The general transcriptional cofactor PC4 enhances transcription from various promoters and functions with a wide range of transcriptional activators. Earlier studies have suggested that this enhancement originates mostly from stabilization of the TATA-box/TFIID/TFIIA complex by simultaneous interaction of PC4 with transactivation domains of upstream-binding factors and the basal factor TFIIA. However, the C-terminal half of the protein also has been shown to exhibit substantial ssDNA binding pro... Abstract

Cited 72 times since 1998 (2.6 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 18, Issue 2, 1 1 1998, Pages 265-271 -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group. de Maat MP, Kastelein JJ, Jukema JW, Zwinderman AH, Jansen H, Groenemeier B, Bruschke AV, Kluft C

Increased plasma fibrinogen levels have been identified as a risk indicator for myocardial infarction, stroke, and thrombosis. Both environmental and genetic factors make an important contribution to plasma fibrinogen levels in humans. In the present study we evaluated, in patients with serum cholesterol levels between 4 and 8 mmol/L, the relation of plasma levels and polymorphisms of fibrinogen with coronary artery disease (CAD), cross-sectionally at baseline and after a 2-year follow-up period... Abstract

Cited 12 times since 1998 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 81, Issue 3, 1 1 1998, Pages 302-305 Subcutaneous single-incision implantation of cardioverter-defibrillators under local anesthesia by electrophysiologists in the electrophysiology laboratory. van Rugge FP, Savalle LH, Schalij MJ

Implantable cardioverter-defibrillators (ICDs) have traditionally been implanted at the operating room under general anesthesia. Endocardial lead systems and downsized devices allowed implantation by electrophysiologists in the pectoral region. The present study evaluates the safety and efficacy of subcutaneous ICD implantation performed entirely by electrophysiologists using a single-incision approach for lead insertion and device placement under local anesthesia. Between June 1996 and May 1997... Abstract

Cited 104 times since 1998 (3.8 per year) source: EuropePMC

Circulation, Volume 97, Issue 7, 1 1 1998, Pages 666-672 Functional and metabolic evaluation of the athlete's heart by magnetic resonance imaging and dobutamine stress magnetic resonance spectroscopy. Pluim BM, Lamb HJ, Kayser HW, Leujes F, Beyerbacht HP, Zwinderman AH, van der Laarse A, Vliegen HW, de Roos A, van der Wall EE

Background: The question of whether training-induced left ventricular hypertrophy in athletes is a physiological rather than a pathophysiological phenomenon remains unresolved. The purpose of the present study was to detect any abnormalities in cardiac function in hypertrophic hearts of elite cyclists and to examine the response of myocardial high-energy phosphate metabolism to high workloads induced by atropine-dobutamine stress. Methods and results: We studied 21 elite cyclists and 12 healthy... Abstract

Cited 28 times since 1998 (1 per year) source: EuropePMC

Journal of dairy science, Volume 81, Issue 2, 1 1 1998, Pages 579-584 Evaluation of the utilization of dietary nitrogen by dairy cows based on urea concentration in milk. Schepers AJ, Meijer RG

The objective of this study was to determine whether milk urea concentration is a valuable tool to monitor the utilization of dietary N by dairy cows. Data from 11 feed trials (n = 2828 observations of 356 cows) were used in this study. Dietary protein utilization was evaluated according to the Dutch DVE-OEB system. A close correlation (0.8) was found between rumen-degraded protein balance in the ration and urea concentration in milk. The effects of the balance of true protein digested in the sm... Abstract

Cited 35 times since 1998 (1.3 per year) source: EuropePMC

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, Volume 147, 1 1 1998, Pages 107-119 Isolated hepatic perfusion with tumor necrosis factor alpha and melphalan: experimental studies in pigs and phase I data from humans. de Vries MR, Borel Rinkes IH, van de Velde CJ, Wiggers T, Tollenaar RA, Kuppen PJ, Vahrmeijer AL, Eggermont AM

We report our experience with isolated hepatic perfusion (IHP) with tumor necrosis factor (TNF) and melphalan in an experimental pig study and of a phase I study in humans. IHP was performed with inflow catheters in the hepatic artery and portal vein and an outflow catheter in eh caval vein. An extracorporeal venovenous bypass was used. IHP consisted of a 60-min perfusion with hyperthermia (> 41 degrees C). For the pig protocol rhTNF alpha 50 micrograms/kg alone (n = 5) or rhTNF alpha 50 micr... Abstract