Research

Publications

Below you can find a list of our published research.

6173 results

Cited 18 times since 2022 (5.5 per year) source: EuropePMC

Nature biomedical engineering, Volume 6, Issue 4, 6 1 2022, Pages 389-402 Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation. Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF

The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 2, 3 1 2022, Pages 76-83 No substantial excess all-cause mortality among cardiac implantable electronic device patients during the first COVID‑19 lockdown in the Leiden area. Feijen M, Egorova AD, van der Velde ET, Schalij MJ, Beeres SLMA

In the Netherlands, the coronavirus disease 2019 (COVID‑19) pandemic has resulted in excess mortality nationwide. Chronic heart disease patients are at risk for a complicated COVID‑19 course. The current study investigates all-cause mortality among cardiac implantable electronic device (CIED) patients during the first peak of the pandemic and compares the data to the statistics for the corresponding period in the two previous years. Data of adult CIED patients undergoing follow-up at the Leiden... Abstract

Cited 16 times since 2022 (4.8 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 2, 1 1 2022, Pages e62-e84 Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging. Marwick TH, Gimelli A, Plein S, Bax JJ, Charron P, Delgado V, Donal E, Lancellotti P, Levelt E, Maurovich-Horvat P, Neubauer S, Pontone G, Saraste A, Cosyns B, Edvardsen T, Popescu BA, Galderisi M, Derumeaux G, Reviewers: This document was reviewed by members of the 2020–2022 EACVI Scientific Documents Committee, Bäck M, Bertrand PB, Dweck M, Keenan N, Magne J, Neglia D, Stankovic I

Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem wil... Abstract

Cited 3 times since 2022 (0.9 per year) source: EuropePMC

European heart journal. Cardiovascular pharmacotherapy, Volume 8, Issue 1, 1 1 2022, Pages 77-84 Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations. Woudstra OI, Kuijpers JM, Jongbloed MRM, van Dijk APJ, Sieswerda GT, Vliegen HW, Egorova AD, Kiès P, Duijnhouwer AL, Robbers-Visser D, Konings TC, Zwinderman AH, Meijboom FJ, Mulder BJM, Bouma BJ

Aims: Heart failure is the main threat to long-term health in adults with transposition of the great arteries (TGA) corrected by an atrial switch operation (AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements. We aimed to evaluate medication use in TGA-AtrSO patients and examine the association of use of renin-angio... Abstract

Journal of chromatographic science, Volume 60, Issue 1, 1 1 2022, Pages 96-103 Application of Tandem Dispersive Liquid-Liquid Microextraction as an Efficient Method for Preconcentration of Two Antidepressant Drugs in Real Samples Combined with High Performance Liquid Chromatography. Arabkhani B, Goudarzi N, Bagherian G, Chamjangali MA

In the present work, tandem dispersive liquid-liquid microextraction (TDLLME) coupled with liquid chromatography was used for the determination of the two antidepressant drugs citalopram (CIT) and sertraline (SER) in complicated matrices. Indeed, the present approach was used to improve the suitability and appropriateness of the dispersive liquid-liquid microextraction (DLLME) method in complicated matrices. Firstly, 10 mL of the sample solution containing the two understudied drugs was extracte... Abstract

Cited 4 times since 2022 (1.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 2, 1 1 2022, Pages 266-274 Associations between dyspnoea, coronary atherosclerosis, and cardiovascular outcomes: results from the long-term follow-up CONFIRM registry. van Rosendael AR, Bax AM, van den Hoogen IJ, Smit JM, Al'Aref SJ, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Peña JM, Lin FY, Shaw LJ, Narula J, Min JK, Bax JJ

Aims: The relationship between dyspnoea, coronary artery disease (CAD), and major cardiovascular events (MACE) is poorly understood. This study evaluated (i) the association of dyspnoea with the severity of anatomical CAD by coronary computed tomography angiography (CCTA) and (ii) to which extent CAD explains MACE in patients with dyspnoea. Methods and results: From the international COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 4425 p... Abstract

Cited 10 times since 2021 (3 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 5, 23 4 2021, Pages 486-494.e2 Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis. Stassen J, Butcher SC, Namazi F, Ajmone Marsan N, Bax JJ, Delgado V

Background: Atrial fibrillation (AF) is a frequent complication of rheumatic mitral stenosis (MS) and is associated with worse outcomes. Prediction of new-onset AF by assessing left atrial (LA) mechanics with speckle-tracking echocardiography might be useful for risk stratification and guiding therapeutic strategies. Therefore, the aim of this study was to assess the association of LA reservoir strain (LASr) and strain rate (LASRr) with AF at follow-up in patients with rheumatic MS. Methods: Lef... Abstract

Cited 82 times since 2021 (24.6 per year) source: EuropePMC

Nature immunology, Volume 23, Issue 1, 22 4 2021, Pages 23-32 Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8<sup>+</sup> T cell responses following COVID-19. Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP, in collaboration with BEAT-COVID group, in collaboration with COVID-19 LUMC group

Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates1-6. Here, we characterized nasal and systemic immune cells in individuals with COVID-19 who were hospitalized or convalescent and compared the immune cells to those seen in healthy donors. We observed increased nasal granulocytes, monocytes, CD11c+ natura... Abstract

Cited 3 times since 2021 (0.9 per year) source: EuropePMC

Journal of orthopaedic surgery and research, Volume 16, Issue 1, 20 3 2021, Pages 722 Does circumferential casting prevent fracture redisplacement in reduced distal radius fractures? A retrospective multicentre study. Berger AC, Barvelink B, Reijman M, Gosens T, Kraan GA, De Vries MR, Verhofstad MHJ, Lansink KWW, Hannemann PFW, Colaris JW

Background: This study evaluates whether a circumferential cast compared to a plaster splint leads to less fracture redisplacement in reduced extra-articular distal radius fractures (DRFs). Methods: This retrospective multicentre study was performed in four hospitals (two teaching hospitals and two academic hospitals). Adult patients with a displaced extra-articular DRF, treated with closed reduction, were included. Patients were included from a 5-year period (January 2012-January 2017). Accordi... Abstract

Cited 7 times since 2021 (2.1 per year) source: EuropePMC

Insights into imaging, Volume 12, Issue 1, 18 3 2021, Pages 186 The impact and challenges of implementing CTCA according to the 2019 ESC guidelines on chronic coronary syndromes: a survey and projection of CTCA services in the Netherlands. van den Boogert TPW, Claessen BEPM, Boekholdt SM, Leiner T, Vliegenthart R, Schuiling SF, Timmer JR, Bekkers SCAM, Voskuil M, Siebelink HJ, van Es W, Lamb HJ, Prokop M, Damman P, Stoker J, Willems HC, Henriques JP, Planken RN

Background: The 2019 ESC-guidelines on chronic coronary syndromes (ESC-CCS) recommend computed tomographic coronary angiography (CTCA) or non-invasive functional imaging instead of exercise ECG as initial test to diagnose obstructive coronary artery disease. Since impact and challenges of these guidelines are unknown, we studied the current utilisation of CTCA-services, status of CTCA-protocols and modeled the expected impact of these guidelines in the Netherlands. Methods and results: A survey... Abstract

International journal of cardiology, Volume 351, 17 3 2021, Pages 61-64 Actual management costs of patients with non-valvular atrial fibrillation treated with percutaneous left atrial appendage closure or oral anticoagulation. D'Ancona G, Arslan F, Safak E, Weber D, Al Ammareen R, Ince H

Aims: Comparing actual management costs in patients with non-valvular atrial fibrillation (AF) treated with percutaneous left atrial appendage closure (LAAC) or OAC only. Methods and results: Patients undergoing percutaneous LAAC and AF patients treated with OAC only were matched for gender, age, and diagnosis related groups (DRG) clinical complexity level (CCL). Costs for cardiovascular outpatient clinic visits and hospitalizations were derived from the actual reimbursement records. Between 1/2... Abstract

Cited 3 times since 2021 (0.9 per year) source: EuropePMC

Journal of patient safety, Volume 18, Issue 4, 17 3 2021, Pages e760-e768 Measuring What Matters at Morbidity and Mortality Conferences: A Scoping Review of Effectiveness Measures. Verhagen MJ, de Vos MS, Smaggus A, Hamming JF

Objective: Efforts to study morbidity and mortality conferences (M&MC) are hampered by the lack of rigorous instruments to assess the effectiveness of the conferences for the purpose of quality improvement and medical education. This might limit further advancement of the practice. The aim of this scoping review was to determine commonly used effectiveness measures of M&MC in the literature. Method: A scoping review was performed of quantitative, qualitative, and mixed methods studies of... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 165, 16 3 2021, Pages D6492 [Appreciative calamity investigation]. Hamming JF, den Dijker L, Steneker I

Calamity investigations often lead to recommendations that are difficult to implement and that are of little relevance, because the analysis is carried out according to a cause and effect system. The complexity of care provision requires a different method that respects the complexity of day-to-day care and is able to assess it correctly. Research according to the Safety-II philosophy clearly shows the variable interactions and dependencies present in daily work. These investigations require mor... Abstract

Cited 3 times since 2021 (0.9 per year) source: EuropePMC

JMIR cardio, Volume 5, Issue 2, 16 3 2021, Pages e26072 Real-World Experience of mHealth Implementation in Clinical Practice (the Box): Design and Usability Study. Biersteker T, Hilt A, van der Velde E, Schalij MJ, Treskes RW

Background: Mobile health (mHealth) is an emerging field of scientific interest worldwide. Potential benefits include increased patient engagement, improved clinical outcomes, and reduced health care costs. However, mHealth is often studied in projects or trials, and structural implantation in clinical practice is less common. Objective: The purpose of this paper is to outline the design of the Box and its implementation and use in an outpatient clinic setting. The impact on logistical outcomes... Abstract

Cited 9 times since 2021 (2.7 per year) source: EuropePMC

Nanoscale, Volume 13, Issue 48, 16 3 2021, Pages 20451-20461 Controlled delivery of gold nanoparticle-coupled miRNA therapeutics <i>via</i> an injectable self-healing hydrogel. van der Ven CFT, Tibbitt MW, Conde J, van Mil A, Hjortnaes J, Doevendans PA, Sluijter JPG, Aikawa E, Langer RS

Differential expression of microRNAs (miRNAs) plays a role in many diseases, including cancer and cardiovascular diseases. Potentially, miRNAs could be targeted with miRNA-therapeutics. Sustained delivery of these therapeutics remains challenging. This study couples miR-mimics to PEG-peptide gold nanoparticles (AuNP) and loads these AuNP-miRNAs in an injectable, shear thinning, self-assembling polymer nanoparticle (PNP) hydrogel drug delivery platform to improve delivery. Spherical AuNPs coated... Abstract

Cited 4 times since 2021 (1.2 per year) source: EuropePMC

Journal of the American Heart Association, Volume 10, Issue 24, 16 3 2021, Pages e023300 Cardiovascular Effects of Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Therapy With Early Tacrolimus Withdrawal in Renal Transplant Recipients: An Analysis of the Randomized TRITON Study. Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Ajmone Marsan N, Bax JJ, De Fijter JW, Delgado V

Background After renal transplantation, there is a need of immunosuppressive regimens that effectively prevent allograft rejection while minimizing cardiovascular complications. This substudy of the TRITON trial evaluated the cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in renal transplant recipients. Methods and Results Renal transplant recipients were randomized to MSC therapy, infused at weeks 6 and 7 after transplantation, with withdrawal at week... Abstract

Cited 1 times since 2021 (0.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 6, 15 3 2021, Pages 328-334 Sex differences in treatment strategy for coronary artery aneurysms: Insights from the international Coronary Artery Aneurysm Registry. Arslan F, Núñez-Gil IJ, Rodríguez-Olivares R, Cerrato E, Bollati M, Nombela-Franco L, Terol B, Alfonso-Rodríguez E, Camacho Freire SJ, Villablanca PA, Amat Santos IJ, De la Torre Hernández JM, Pascual I, Liebetrau C, Alkhouli M, Fernández-Ortiz A, Coronary Artery Aneurysm Registry (CAAR) investigators

Introduction: Sex disparities exist in coronary artery disease (CAD) in terms of risk profile, clinical management and outcome. It is unclear if differences are also present in coronary aneurysms, a rare variant of CAD. Methods: Patients were selected from the international Coronary Artery Aneurysm Registry (CAAR; ClinicalTrials.gov: NCT02563626), and differences between groups were analysed according to sex. The CAAR database is a prospective multicentre registry of 1565 patients with coronary... Abstract

Cited 10 times since 2021 (3 per year) source: EuropePMC

Annals of surgery, 14 2 2021 Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study. Alberga AJ, von Meijenfeldt GCI, Rastogi V, de Bruin JL, Wever JJ, van Herwaarden JA, Hamming JF, Hazenberg CEVB, van Schaik J, Mees BME, van der Laan MJ, Zeebregts CJ, Schurink GWH, Verhagen HJM, Dutch Society of Vascular Surgery*, the Steering Committee of the Dutch Surgical Aneurysm Audit, the Dutch Institute for Clinical Auditing

Objective: We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR. Summary of background data: Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic aneurysms (complex AAs). It is unclear if a volume-outcome association exists in endovascular treatment of complex AAs (complex EVAR). Methods: All patients prospectively registered in the Dutch Surgical Aneury... Abstract

Cited 5 times since 2021 (1.5 per year) source: EuropePMC

International journal of cardiology. Heart & vasculature, Volume 38, 13 2 2021, Pages 100926 Ascending aorta curvature and flow displacement are associated with accelerated aortic growth at long-term follow-up: A MRI study in Marfan and thoracic aortic aneurysm patients. van Hout MJP, Juffermans JF, Lamb HJ, Kröner ESJ, van den Boogaard PJ, Schalij MJ, Dekkers IA, Scholte AJ, Westenberg JJ

Background: Aortic aneurysm formation is associated with increased risk of aortic dissection. Current diagnostic strategies are focused on diameter growth, the predictive value of aortic morphology and function remains underinvestigated. We aimed to assess the long-term prognostic value of ascending aorta (AA) curvature radius, regional pulse wave velocity (PWV) and flow displacement (FD) on aortic dilatation/elongation and evaluated adverse outcomes (proximal aortic surgery, dissection/rupture,... Abstract

Cited 4 times since 2021 (1.2 per year) source: EuropePMC

Trials, Volume 22, Issue 1, 11 2 2021, Pages 902 The effectiveness of antibacterial therapeutic clothing based on silver or chitosan as compared with non-antibacterial therapeutic clothing in patients with moderate to severe atopic dermatitis (ABC trial): study protocol for a pragmatic randomized controlled trial. Ragamin A, Fieten KB, Tupker RA, de Wit J, van Mierlo MMF, Jansen MS, Bronner MB, Schappin R, Schuren FHJ, Romeijn MLE, Arents BWM, Polinder S, de Graaf M, Rustemeyer T, Schuttelaar MLA, Pasmans SGMA

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10 to 20% of children and between 2 and 15% of the adults in Western Europe. Since 2000, therapeutic clothing or functional textiles based on silver or chitosan as antibacterial agents were introduced for AD. These agents aim to reduce skin colonization with Staphylococcus (S.) aureus. Increased colonization with S. aureus is correlated with increased AD severity. The antimicrobial effects of silver and chitos... Abstract