Research

Publications

Below you can find a list of our published research.

7503 results

Cited 15 times since 2022 (4 per year) source: EuropePMC

Nature communications, Volume 13, Issue 1, 9 2 2022, Pages 1222 Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus. Stacey D, Chen L, Stanczyk PJ, Howson JMM, Mason AM, Burgess S, MacDonald S, Langdown J, McKinney H, Downes K, Farahi N, Peters JE, Basu S, Pankow JS, Tang W, Pankratz N, Sabater-Lleal M, de Vries PS, Smith NL, CHARGE Hemostasis Working Group, Gelinas AD, Schneider DJ, Janjic N, Samani NJ, Ye S, Summers C, Chilvers ER, Danesh J, Paul DS

Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human r... Abstract

Cited 16 times since 2022 (4.2 per year) source: EuropePMC

Diagnostics (Basel, Switzerland), Volume 12, Issue 3, 9 2 2022, Pages 669 Sclerodermic Cardiomyopathy-A State-of-the-Art Review. Giucă A, Gegenava T, Mihai CM, Jurcuţ C, Săftoiu A, Gȋrniţă DM, Popescu BA, Ajmone Marsan N, Jurcuț R

Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imagi... Abstract

Cited 14 times since 2022 (3.7 per year) source: EuropePMC

Frontiers in endocrinology, Volume 13, 9 2 2022, Pages 845937 Dextroamphetamine Treatment in Children With Hypothalamic Obesity. van Schaik J, Welling MS, de Groot CJ, van Eck JP, Juriaans A, Burghard M, Oude Ophuis SBJ, Bakker B, Tissing WJE, Schouten-van Meeteren AYN, van den Akker ELT, van Santen HM

Introduction: Hypothalamic obesity (HO) in children has severe health consequences. Lifestyle interventions are mostly insufficient and currently no drug treatment is approved for children with HO. Amphetamines are known for their stimulant side-effect on resting energy expenditure (REE) and suppressing of appetite. Earlier case series have shown positive effects of amphetamines on weight in children with acquired HO. We present our experiences with dextroamphetamine treatment in the, up to now,... Abstract

Cited 16 times since 2022 (4.2 per year) source: EuropePMC

ESC heart failure, Volume 9, Issue 3, 9 2 2022, Pages 1597-1607 Right ventricular-pulmonary artery coupling in cardiac resynchronization therapy: evolution and prognosis. Stassen J, Galloo X, Hirasawa K, Chimed S, Marsan NA, Delgado V, van der Bijl P, Bax JJ

Aims: Chronic pressure overload and right ventricular (RV) dysfunction can lead to RV-pulmonary artery (PA) uncoupling in patients with heart failure. The evolution and prognostic values of RV-PA coupling assessed by echocardiography in patients undergoing cardiac resynchronization therapy (CRT) have not been thoroughly investigated. The aim of this study was to evaluate the evolution and prognostic value of tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (P... Abstract

Cited 9 times since 2022 (2.4 per year) source: EuropePMC

Emergent materials, Volume 5, Issue 1, 9 2 2022, Pages 105-132 Nanotechnology in food and water security: on-site detection of agricultural pollutants through surface-enhanced Raman spectroscopy. Yılmaz D, Günaydın BN, Yüce M

Agricultural pollutants are harmful components threatening human health, wildlife, the environment, and the ecosystem. To avoid their exposure, developing prevention and detection systems with high sensitivity and selectivity is required. Most conventional methods, including molecular and chromatographic techniques, cannot be adopted for outdoor on-site detection even though they can provide sensitive and selective detection. Thus, detection platforms that can provide on-site detection via minia... Abstract

Cited 4 times since 2022 (1.1 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 9, 7 1 2022, Pages 870390 Corrigendum: Robotic Cardiac Surgery in Europe: Status 2020. Cerny S, Oosterlinck W, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, Pettinari M, Van Praet F, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Gianoli M, Agnino A, Philipsen T, Jansens JL, Folliguet T, Palmen M, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van den Eynde J, Bonatti J

[This corrects the article DOI: 10.3389/fcvm.2021.827515.]. Abstract

Cited 49 times since 2022 (12.9 per year) source: EuropePMC

BMC geriatrics, Volume 22, Issue 1, 5 1 2022, Pages 184 Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study. Henkens MTHM, Raafs AG, Verdonschot JAJ, Linschoten M, van Smeden M, Wang P, van der Hooft BHM, Tieleman R, Janssen MLF, Ter Bekke RMA, Hazebroek MR, van der Horst ICC, Asselbergs FW, Magdelijns FJH, Heymans SRB, CAPACITY-COVID collaborative consortium

Background: Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which comorbidities mediate the impact of age remains unknown. Methods: In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven COVID-19 patients hospitalized in Dutch hospitals (between February and July 2020) from the CAPACITY-COVID registry were included (age 69[58-77]years, 64% men). The primary outcome was defined as a combination of in-hospital mor... Abstract

Cited 4 times since 2022 (1.1 per year) source: EuropePMC

Drug discovery today, Volume 27, Issue 6, 4 1 2022, Pages 1716-1723 Advanced molecular imaging for the characterisation of complex medicines. Yilmaz D, Sharp PS, Main MJ, Simpson PB

A growing number and diversity of complex medicines is in development and reaching the market, with many of these medicines utilising innovative delivery technology to achieve appropriate biodistribution and exposure. Accurate assessment of biodistribution, cell penetration, internalised form, cargo release and efficacy are essential for the development of these medicines. Advanced imaging technologies, deploying different labelling techniques that allow the assessment of both carrier and cargo,... Abstract

Cited 16 times since 2022 (4.2 per year) source: EuropePMC

ESMO open, Volume 7, Issue 2, 3 1 2022, Pages 100416 Circulating tumour cells to drive the use of neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer. Beije N, de Kruijff IE, de Jong JJ, Klaver SO, de Vries P, Jacobs RAL, Somford DM, Te Slaa E, van der Heijden AG, Alfred Witjes J, Fossion LMCL, Boevé ER, van der Hoeven J, van Melick HHE, Wijburg CJ, Bickerstaffe H, Martens JWM, de Wit R, Kraan J, Sleijfer S, Boormans JL

Background: Guidelines recommend neoadjuvant chemotherapy (NAC) for the treatment of nonmetastatic muscle-invasive bladder cancer (MIBC). NAC is, however, underutilized in practice because of its associated limited overall survival (OS) benefit and significant treatment-related toxicity. We hypothesized that the absence of circulating tumour cells (CTCs) identifies MIBC patients with such a favourable prognosis that NAC may be withheld. Patients and methods: The CirGuidance study was an open-lab... Abstract

Cited 12 times since 2022 (3.2 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 30, Issue 3, 3 1 2022, Pages 364-371 Normalization of Time-Intensity Curves for Quantification of Foot Perfusion Using Near-Infrared Fluorescence Imaging With Indocyanine Green. Van Den Hoven P, Tange F, Van Der Valk J, Nerup N, Putter H, Van Rijswijk C, Van Schaik J, Schepers A, Vahrmeijer A, Hamming J, Van Der Vorst J

Purpose: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) is gaining popularity for the quantification of tissue perfusion, including foot perfusion in patients with lower extremity arterial disease (LEAD). However, the absolute fluorescence intensity is influenced by patient-and system-related factors limiting reliable and valid quantification. To enhance the quality of quantitative perfusion assessment using ICG NIR fluorescence imaging, normalization of the measured time... Abstract

Cited 9 times since 2022 (2.4 per year) source: EuropePMC

Seminars in nuclear medicine, Volume 52, Issue 5, 2 1 2022, Pages 597-610 Nuclear medicine imaging methods of radiation-induced cardiotoxicity. Polomski ES, Antoni ML, Jukema JW, Kroep JR, Dibbets-Schneider P, Sattler MGA, de Geus-Oei LF

Breast cancer survival is significantly improved over the past decades due to major improvements in anti-tumor therapies and the implementation of regular screening, which leads to early detection of breast cancer. Therefore, it is of utmost importance to prevent patients from long-term side effects, including radiotherapy-induced cardiotoxicity. Radiotherapy may contribute to damage of myocardial structures on the cellular level, which eventually could result in various types of cardiovascular... Abstract

Cited 12 times since 2022 (3.1 per year) source: EuropePMC

Vascular and endovascular surgery, Volume 56, Issue 5, 2 1 2022, Pages 472-479 Doppler Ultrasonography Derived Maximal Systolic Acceleration: Value Determination With Artificially Induced Stenosis. Brouwers JJWM, van Doorn LP, Pronk L, van Wissen RC, Putter H, Schepers A, Hamming JF

BackgroundIn diagnosing peripheral arterial disease (PAD), medial arterial calcification (MAC) hampers arterial compression and could lead to unreliable ankle brachial index (ABI), toe brachial index (TBI) and toe pressure (TP). Doppler ultrasonography (DUS) derived maximal systolic acceleration (ACCmax) might be more accurate to diagnose PAD. In an in vitro study, a strong correlation between ACCmax and the severity of stenotic disease was determined. The aim of this study was to investigate th... Abstract

Cited 58 times since 2022 (15.2 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 15, Issue 5, 1 1 2022, Pages 523-532 The PARTNER 3 Bicuspid Registry for Transcatheter Aortic Valve Replacement in Low-Surgical-Risk Patients. Williams MR, Jilaihawi H, Makkar R, O'Neill WW, Guyton R, Malaisrie SC, Brown DL, Blanke P, Leipsic JA, Pibarot P, Hahn RT, Leon MB, Cohen DJ, Bax JJ, Kodali SK, Mack MJ, Lu M, Webb JG

Objectives: The study compared 1-year outcomes between transcatheter aortic valve replacement (TAVR) patients with bicuspid aortic valve (BAV) morphology and clinically similar patients having tricuspid aortic valve (TAV) morphology. Background: There are limited prospective data on TAVR using the SAPIEN 3 device in low-surgical-risk patients with severe, symptomatic aortic stenosis and bicuspid anatomy. Methods: Low-risk, severe aortic stenosis patients with BAV were candidates for the PARTNER... Abstract

Cited 13 times since 2022 (3.4 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 578-585 Prognostic implications of cardiac damage classification based on computed tomography in severe aortic stenosis. Hirasawa K, vanRosendael PJ, Fortuni F, Singh GK, Kuneman JH, Vollema EM, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V

Aims: An echocardiographic staging system of severe aortic stenosis (AS) based on additional extra-valvular cardiac damage has been associated with prognosis after transcatheter aortic valve implantation (TAVI). Multidetector row computed tomography (MDCT) is key in the evaluation of AS patients undergoing TAVI and can potentially detect extra-valvular cardiac damage. This study aimed at evaluating the prognostic implications of an MDCT staging system of severe AS in patients undergoing TAVI. Me... Abstract

Cited 2 times since 2022 (0.5 per year) source: EuropePMC

European journal of cardiovascular nursing, Volume 21, Issue 2, 1 1 2022, Pages 169-173 Implantable cardioverter-defibrillators and the older patient: the Dutch clinical practice. Yilmaz D, Egorova AD, Schalij MJ, van Erven L

Background and objective: Balance between benefit and burden of implantable cardioverter-defibrillator (ICD) therapy is more debatable in older patients, compared to younger patients. Of around 6000 yearly implanted ICDs in the Netherlands, 1:4 is received by patients ≥75 years. We aimed to evaluate the current clinical practice in the Netherlands for ICD implants and generator replacements, with a special focus on the older ICD patients. Research design and methods: Cardiologists from all Dutch... Abstract

Cited 5 times since 2022 (1.3 per year) source: EuropePMC

The British journal of surgery, Volume 109, Issue 4, 1 1 2022, Pages 340-345 Mortality following elective abdominal aortic aneurysm repair in women. Tedjawirja VN, Alberga AJ, Hof MHP, Vahl AC, Koelemay MJW, Balm R, Dutch Society of Vascular Surgery

Background: Previous studies have focused on patient-related risk factors to explain the higher mortality risk in women undergoing elective abdominal aortic aneurysm (AAA) repair. The aim of this study was to evaluate whether hospital-related factors influence outcomes following AAA repair in women. Methods: Patients undergoing elective AAA repair in 61 hospitals in the Netherlands were identified from the Dutch Surgical Aneurysm Audit registry (2013-2018). A mixed-effects logistic regression an... Abstract

Cited 8 times since 2022 (2.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 447-449 How to do lung ultrasound. Stassen J, Bax JJ

Abstract

Cited 17 times since 2022 (4.5 per year) source: EuropePMC

Human molecular genetics, Volume 31, Issue 7, 1 1 2022, Pages 1051-1066 C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation. van Ingen E, van den Homberg DAL, van der Bent ML, Mei H, Papac-Milicevic N, Kremer V, Boon RA, Quax PHA, Wojta J, Nossent AY

We have previously shown that C/D box small nucleolar RNAs (snoRNAs) transcribed from the DLK1-DIO3 locus on human chromosome 14 (14q32) are associated with cardiovascular disease. DLK1-DIO3 snoRNAs are 'orphan snoRNAs' that have no known targets. We aimed to identify RNA targets and elucidate the mechanism-of-action of human SNORD113-6 (AF357425 in mice). As AF357425-knockout cells were non-viable, we induced overexpression or inhibition of AF357425 in primary murine fibroblasts and p... Abstract

Cited 9 times since 2022 (2.4 per year) source: EuropePMC

European journal of anaesthesiology, Volume 39, Issue 3, 1 1 2022, Pages 210-218 Association between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE). Kowark A, Berger M, Rossaint R, Schmid M, Coburn M, POSE-Study group

Background: Recent guidelines suggest that benzodiazepine premedication should be avoided in elderly patients, though with limited supporting evidence. Objective: We conducted a secondary analysis of the POSE data to explore the association of premedication in patients aged 80 years or older with 30-day mortality. Design: We used propensity score methods to perform a confounder-adjusted time-to-event analysis of the association between benzodiazepine premedication and 30-day mortality of the POS... Abstract

Cited 14 times since 2022 (3.7 per year) source: EuropePMC

British journal of nursing (Mark Allen Publishing), Volume 31, Issue 6, 1 1 2022, Pages 322-330 Evidence-informed practice: simplifying and applying the concept for nursing students and academics. Kumah EA, McSherry R, Bettany-Saltikov J, van Schaik P

Background: Nurses' ability to apply evidence effectively in practice is a critical factor in delivering high-quality patient care. Evidence-based practice (EBP) is recognised as the gold standard for the delivery of safe and effective person-centred care. However, decades following its inception, nurses continue to encounter difficulties in implementing EBP and, although models for its implementation offer stepwise approaches, factors, such as the context of care and its mechanistic nature... Abstract