Research

Publications

Below you can find a list of our published research.

7434 results

Cited 23 times since 2018 (3.2 per year) source: EuropePMC

BMC genomics, Volume 19, Issue 1, 25 4 2018, Pages 90 A SNP panel for identification of DNA and RNA specimens. Yousefi S, Abbassi-Daloii T, Kraaijenbrink T, Vermaat M, Mei H, van 't Hof P, van Iterson M, Zhernakova DV, Claringbould A, Franke L, 't Hart LM, Slieker RC, van der Heijden A, de Knijff P, BIOS consortium, 't Hoen PAC

Background: SNP panels that uniquely identify an individual are useful for genetic and forensic research. Previously recommended SNP panels are based on DNA profiles and mostly contain intragenic SNPs. With the increasing interest in RNA expression profiles, we aimed for establishing a SNP panel for both DNA and RNA-based genotyping. Results: To determine a small set of SNPs with maximally discriminative power, genotype calls were obtained from DNA and blood-derived RNA sequencing data belonging... Abstract

Cited 55 times since 2018 (7.7 per year) source: EuropePMC

Frontiers in cardiovascular medicine, Volume 5, 24 4 2018, Pages 3 Inflammation in Vein Graft Disease. de Vries MR, Quax PHA

Bypass surgery is one of the most frequently used strategies to revascularize tissues downstream occlusive atherosclerotic lesions. For venous bypass surgery the great saphenous vein is the most commonly used vessel. Unfortunately, graft efficacy is low due to the development of vascular inflammation, intimal hyperplasia and accelerated atherosclerosis. Moreover, failure of grafts leads to significant adverse outcomes and even mortality. The last couple of decades not much has changed in the tre... Abstract

Cited 13 times since 2018 (1.8 per year) source: EuropePMC

Journal of thrombosis and haemostasis : JTH, Volume 16, Issue 3, 19 3 2018, Pages 519-528 Determinants of impaired renal and vascular function are associated with elevated levels of procoagulant factors in the general population. Dekkers IA, de Mutsert R, de Vries APJ, Rosendaal FR, Cannegieter SC, Jukema JW, le Cessie S, Rabelink TJ, Lamb HJ, Lijfering WM

Essentials Why venous thrombosis is more prevalent in chronic kidney disease is unclear. We investigated whether renal and vascular function are associated with hypercoagulability. Coagulation factors showed a procoagulant shift with impaired renal and vascular function. This suggests that renal and vascular function play a role in the etiology of thrombosis. Summary: Background Impaired renal and vascular function have been associated with venous thrombosis, but the mechanism is unclear. Object... Abstract

Cited 17 times since 2018 (2.4 per year) source: EuropePMC

Nutrition & diabetes, Volume 8, Issue 1, 17 3 2018, Pages 6 Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes. van Eyk HJ, van Schinkel LD, Kantae V, Dronkers CEA, Westenberg JJM, de Roos A, Lamb HJ, Jukema JW, Harms AC, Hankemeier T, van der Stelt M, Jazet IM, Rensen PCN, Smit JWA

Background/objectives: Endocannabinoids (ECs) are associated with obesity and ectopic fat accumulation, both of which play a role in the development of cardiovascular disease (CVD) in type 2 diabetes (T2D). The effect of prolonged caloric restriction on ECs in relation to fat distribution and cardiac function is still unknown. Therefore, our aim was to investigate this relationship in obese T2D patients with coronary artery disease (CAD). Subjects/methods: In a prospective intervention study, ob... Abstract

Cited 221 times since 2018 (30.9 per year) source: EuropePMC

Nature communications, Volume 9, Issue 1, 17 3 2018, Pages 260 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Jiang X, O'Reilly PF, Aschard H, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakar

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC... Abstract

Cited 16 times since 2018 (2.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 3, 17 3 2018, Pages 476-493 Targeted Imaging for Cell Death in Cardiovascular Disorders. Shekhar A, Heeger P, Reutelingsperger C, Arbustini E, Narula N, Hofstra L, Bax JJ, Narula J

Cell death is desirable in cancer cells and undesirable in organs with limited regenerative potential, like the heart. Cell death comes in many forms, but only apoptosis and to a lesser degree necrosis is currently relevant to the clinical imager. Noninvasive imaging of cell death is an attractive option to understand pathophysiology, track disease activity, and evaluate response to intervention. Apoptosis seems to be the most promising target for imaging cell death, because it could be reversib... Abstract

Cited 7 times since 2018 (1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 9, 17 3 2018, Pages 1362-1364 Regional Left Ventricular Myocardial Mechanics in Degenerative Myxomatous Mitral Valve Disease: A Comparison Between Fibroelastic Deficiency and Barlow's Disease. van Wijngaarden SE, Abou R, Hiemstra YL, Ajmone Marsan N, Bax JJ, Delgado V

Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Pediatric cardiology, Volume 39, Issue 4, 16 3 2018, Pages 690-694 Pulmonary Valve Morphology in Patients with Bicuspid Aortic Valves. Koenraadt WMC, Bartelings MM, Gittenberger-de Groot AC, Bökenkamp R, DeRuiter MC, Schalij MJ, Jongbloed MRM

The aortic and pulmonary valve share a common developmental origin from the embryonic arterial trunk. Bicuspid aortic valve is the most common congenital anomaly and can occur isolated as well as in association with other congenital heart disease (CHD). Data on pulmonary valve morphology in these cases are scarce. In this study, we aimed to determine pulmonary valve morphology in hearts with BAV associated with CHD. In 83 post-mortem heart specimens with BAV and associated CHD, pulmonary valve m... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Patient preference and adherence, Volume 12, 15 3 2018, Pages 119-128 Patients' perceptions of conservative treatment for a small abdominal aortic aneurysm. Tomee SM, Gebhardt WA, de Vries JP, Hamelinck VC, Hamming JF, Lindeman JH

Background: An abdominal aortic aneurysm (AAA) is a progressive, generally symptomless disease that could ultimately result in a fatal rupture. Current guidelines advise conservative follow-up, and preventive surgical repair once the risk of rupture outweighs the cost of repair (55 mm in men). In developed countries, the majority of patients are diagnosed with AAAs less than 55 mm, and so enter a period of conservative surveillance. An important question is how patients perceive and cope with ri... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

Journal of clinical lipidology, Volume 12, Issue 2, 11 2 2018, Pages 266-276.e3 Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco) genetics. Smit RAJ, Jukema JW, Postmus I, Ford I, Slagboom PE, Heijmans BT, Le Cessie S, Trompet S

In recent years, visit-to-visit variability of serum lipids has been linked to both clinical outcomes and surrogate markers for vascular disease. In this article, we present an overview of the current evidence connecting this intraindividual variability to these outcome measures, discuss its interplay with lipid-lowering treatment, and describe the literature regarding genetic factors of possible interest. In addition, we undertook an explorative genome-wide association analysis on visit-to-visi... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 5, 8 2 2018, Pages 668-676 Fast nonclinical ventricular tachycardia inducible after ablation in patients with structural heart disease: Definition and clinical implications. Watanabe M, de Riva M, Piers SRD, Dekkers OM, Ebert M, Venlet J, Trines SA, Schalij MJ, Pijnappels DA, Zeppenfeld K

Background: Noninducibility of ventricular tachycardia (VT) with an equal or longer cycle length (CL) than that of the clinical VT is considered the minimum ablation endpoint in patients with structural heart disease. Because their clinical relevance remains unclear, fast nonclinical VTs are often not targeted. However, an accepted definition for fast VT is lacking. The shortest possible CL of a monomorphic reentrant VT is determined by the ventricular refractory period (VRP). Objective: The pur... Abstract

Cited 8 times since 2018 (1.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 104, Issue 14, 5 1 2018, Pages 1200-1207 Impact of surgery on presence and dimensions of anatomical isthmuses in tetralogy of Fallot. Kapel GFL, Laranjo S, Blom NA, Hazekamp MG, Schalij MJ, Bartelings MM, Jongbloed MRM, Zeppenfeld K

Objective: In tetralogy of Fallot (TOF), the dominant ventricular tachycardia substrates are slow-conducting anatomical isthmuses. Surgical correction has evolved, which might have influenced isthmus presence and dimensions. Methods: One hundred and forty-two postmortem TOF specimens (84/58 corrected/uncorrected) were studied for isthmus presence. Isthmus 1 is located between the tricuspid annulus and right ventricular (RV) outflow tract (RVOT) patch/RV incision, isthmus 2 between RVOT patch/RV... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

BMJ case reports, Volume 2018, 3 1 2018, Pages bcr-2017-222693 Non-surgical intervention for retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: treatment with ulipristal acetate. Kortekaas KE, Pelikan HMP

This case report describes a very rare coexistence of retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: benign metastasising leiomyoma (BML). Despite surgical treatment growth of multiple nodules in the lungs, omentum, mesenterium and retroperitoneum was observed by CT scan. We started off-label ulipristal acetate treatment with impressive results. The lesions on the CT scan disappeared, and the patient was asymptomatic after treatment. Abstract

Cited 17 times since 2018 (2.4 per year) source: EuropePMC

BMJ quality & safety, Volume 27, Issue 9, 3 1 2018, Pages 758-762 The problem with using patient complaints for improvement. de Vos MS, Hamming JF, Marang-van de Mheen PJ

'The Problem with…' series covers controversial topics related to efforts to improve healthcare quality, including widely recommended, but deceptively difficult strategies for improvement and pervasive problems that seem to resist solution. Abstract

The Annals of thoracic surgery, Volume 105, Issue 6, 3 1 2018, Pages 1860-1861 Reply. Kamperidis V, Delgado V, Bax JJ

Abstract

Cited 18 times since 2018 (2.5 per year) source: EuropePMC

Expert review of medical devices, Volume 15, Issue 2, 2 1 2018, Pages 119-126 Implementation of smart technology to improve medication adherence in patients with cardiovascular disease: is it effective? Treskes RW, Van der Velde ET, Schoones JW, Schalij MJ

Introduction: Medication adherence is of key importance in the treatment of cardiovascular disease. Studies consistently show that a substantial proportion of patients is non-adherent. Areas covered: For this review, telemedicine solutions that can potentially improve medication adherence in patients with cardiovascular disease were reviewed. A total of 475 PubMed papers were reviewed, of which 74 were assessed. Expert commentary: Papers showed that evidence regarding telemedicine solutions is m... Abstract

Cited 3 times since 2018 (0.4 per year) source: EuropePMC

The journal of vascular access, Volume 19, Issue 1, 1 1 2018, Pages 84-88 Supervised preoperative forearm exercise to increase blood vessel diameter in patients requiring an arteriovenous access for hemodialysis: rationale and design of the PINCH trial. Wilschut ED, Rotmans JI, Bos EJ, van Zoest D, Eefting D, Hamming JF, van der Bogt KEA

Background: Failure of maturation occurs in 30%-60% of arteriovenous fistula (AVF) creation for hemodialysis, with highest rates in distal radiocephalic fistulas. This is partly due to initial small blood vessel size with limited blood flow capacity. Forearm exercise has shown potential as stimulus for increasing blood vessel size in patients with end-stage renal disease (ESRD) and may promote maturation of AVFs in the upper limb when applied postoperatively. However, it is unknown if forearm ex... Abstract

Cited 20 times since 2018 (2.8 per year) source: EuropePMC

Circulation. Genomic and precision medicine, Volume 11, Issue 1, 1 1 2018, Pages e001758 ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Bihlmeyer NA, Brody JA, Smith AV, Warren HR, Lin H, Isaacs A, Liu CT, Marten J, Radmanesh F, Hall LM, Grarup N, Mei H, Müller-Nurasyid M, Huffman JE, Verweij N, Guo X, Yao J, Li-Gao R, van den Berg M, Weiss S, Prins BP, van Setten J, Haessler J, Lyytikäinen LP, Li M, Alonso A, Soliman EZ, Bis JC, Austin T, Chen YI, Psaty BM, Harrris TB, Launer LJ, Padmanabhan S, Dominiczak A, Huang PL, Xie Z, Ellinor PT, Kors JA, Campbell A, Murray AD, Nelson CP, Tobin MD, Bork-Jensen J, Hansen T, Pedersen O, Linneberg A, Sinner MF, Peters A, Waldenberger M, Meitinger T, Perz S, Kolcic I, Rudan I, de Boer RA, van der Meer P, Lin HJ, Taylor KD, de Mutsert R, Trompet S, Jukema JW, Maan AC, Stricker BHC, Rivadeneira F, Uitterlinden A, Völker U, Homuth G, Völzke H, Felix SB, Mangino M, Spector TD, Bots ML, Perez M, Raitakari OT, Kähönen M, Mononen N, Gudnason V, Munroe PB, Lubitz SA, van Duijn CM, Newton-Cheh CH, Hayward C, Rosand J, Samani NJ, Kanters JK, Wilson JG, Kääb S, Polasek O, van der Harst P, Heckbert SR, Rotter JI, Moo

Background: QT interval, measured through a standard ECG, captures the time it takes for the cardiac ventricles to depolarize and repolarize. JT interval is the component of the QT interval that reflects ventricular repolarization alone. Prolonged QT interval has been linked to higher risk of sudden cardiac arrest. Methods and results: We performed an ExomeChip-wide analysis for both QT and JT intervals, including 209 449 variants, both common and rare, in 17 341 genes from the Illumina Infinium... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 162, 1 1 2018, Pages D2109 [The (un)predictability of coronary atherosclerosis]. Elffers TW, Jukema JW

Coronary atherosclerosis is a common disease. The plaques developing inside coronary vessels may have serious consequences such as myocardial infarction. However, the course of this multifactorial and heterogeneous disease is difficult to predict and is different for each patient. Atherosclerosis is often described as a gradually progressive disease, but in addition to slow progression, a certain periodicity is often seen. There may be periods with more stability and periods of regression. Sever... Abstract

Cited 21 times since 2018 (2.9 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 26, Issue 1, 1 1 2018, Pages 13-20 Nationwide claims data validated for quality assessments in acute myocardial infarction in the Netherlands. Eindhoven DC, van Staveren LN, van Erkelens JA, Ikkersheim DE, Cannegieter SC, Umans VAWM, Mosterd A, van Wijngaarden J, Schalij MJ, Borleffs CJW

Introduction: Since health insurance is compulsory in the Netherlands, the centrally registered medical claims data might pose a unique opportunity to evaluate quality of (cardiac) care on a national level without additional collection of data. However, validation of these claims data has not yet been assessed. Design: Retrospective cohort study. Methods: National claims data ('national registry') were compared with data collected by patient records reviews in four representative hospi... Abstract