Research

Publications

Below you can find a list of our published research.

6128 results

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Current medical research and opinion, Volume 24, Issue 4, 28 4 2008, Pages 1065-1068 Determinants of CRP level in statin-treated patients. Liem AH, van de Woestijne AP, Zwinderman AH, Visseren FL, Jukema JW

Objective: All factors of the metabolic syndrome (MetS) are reported to be associated with elevated C-reactive protein (CRP) levels. As CRP levels have been found to decrease as a result of statin treatment, the present study was intended to explore the relationship between CRP and the MetS in statin treated patients. Methods: In this study, the relationship between the components of the MetS and CRP level were analysed and factors determining CRP were identified in patients with longstanding in... Abstract

Cited 78 times since 2008 (4.6 per year) source: EuropePMC

European heart journal, Volume 29, Issue 6, 27 4 2008, Pages 757-765 Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy. Ypenburg C, Lancellotti P, Tops LF, Boersma E, Bleeker GB, Holman ER, Thomas JD, Schalij MJ, Piérard LA, Bax JJ

Aims: The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). Methods and results: Sixty eight patients consecutive (LV ejection fraction 23 +/- 8%) with at least moderate MR (>or=grade 2+) were included. Echocardiography was performed at baseline, 1 day after CRT initiation and at 6 months follow-up. Speckle tr... Abstract

Cited 46 times since 2008 (2.7 per year) source: EuropePMC

Brain : a journal of neurology, Volume 131, Issue Pt 4, 26 4 2008, Pages 1069-1077 Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. Trompet S, de Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Jukema JW, Westendorp RG, PROSPER Group

Inflammation is thought to play an important role in the development of cognitive decline and dementia in old age. The interleukin-1 signalling pathway may play a prominent role in this process. The gene encoding for interleukin-1 beta-converting enzyme (ICE) is likely to influence IL-1 beta levels. Inhibition of ICE decreases the age-related increase in IL-1 beta levels and may therefore improve memory function. We assessed whether genetic variation in the ICE gene associates with cognitive fun... Abstract

Cited 32 times since 2008 (1.9 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 76, Issue 7, 21 3 2008, Pages 809-819 Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton. Lie-Venema H, Eralp I, Markwald RR, van den Akker NM, Wijffels MC, Kolditz DP, van der Laarse A, Schalij MJ, Poelmann RE, Bogers AJ, Gittenberger-de Groot AC

The epicardium is embryologically formed by outgrowth of proepicardial cells over the naked heart tube. Epicardium-derived cells (EPDCs) migrate into the myocardium, contributing to myocardial architecture, valve development, and the coronary vasculature. Defective EPDC formation causes valve malformations, myocardial thinning, and coronary defects. In the atrioventricular (AV) valves and the fibrous heart skeleton isolating atrial from ventricular myocardium, EPDCs colocalize with periostin, a... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

International journal of oral and maxillofacial surgery, Volume 37, Issue 5, 12 2 2008, Pages 448-452 Biomechanical evaluation of the consolidation period of alveolar distraction osteogenesis with three-dimensional finite element analysis. Veziroglu F, Yilmaz D

In this study, three-dimensional (3D) modeling and finite element analysis were used to determine the optimum consolidation period for implant loading under forces of different directions and amounts after alveolar distraction osteogenesis. A 3D model of an atrophic edentulous alveolar crest was prepared. Distraction osteogenesis with the required bone height was simulated. After a consolidation period of 4, 8, 12 and 16 weeks, horizontal, vertical and oblique forces were applied to the conical... Abstract

Cited 44 times since 2008 (2.6 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 8 2 2008, Pages 95-101 Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB, Ordovas JM, Schaefer EJ, PROSPER Study Group

Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms (SNPs), R46L and E670G, in 5783 elderly participants in Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), of whom 43% had a history of vascular disease at baseline... Abstract

Cited 44 times since 2008 (2.6 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 7 1 2008, Pages 109-114 Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Polisecki E, Muallem H, Maeda N, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Westendorp RG, de Craen AJ, Buckley BM, Ordovas JM, Schaefer EJ, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Investigators

Our purpose was to evaluate associations of single nucleotide polymorphisms (SNPs) at the low density lipoprotein (LDL) receptor (LDLR C44857T, minor allele frequency (MAF) 0.26, and A44964G, MAF 0.25, both in the untranslated region) and HMG-CoA reductase (HMGCR i18 T>G, MAF 0.019) gene loci with baseline lipid values, statin-induced LDL-cholesterol (C) lowering response, and incident coronary heart disease (CHD) and cardiovascular disease (CVD) on trial. Our population consisted of 5804 eld... Abstract

Cited 38 times since 2008 (2.2 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 8, 7 1 2008, Pages 1196-1200 Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery. Dunkelgrun M, Hoeks SE, Welten GM, Vidakovic R, Winkel TA, Schouten O, van Domburg RT, Bax JJ, Kuijper R, Chonchol M, Verhagen HJ, Poldermans D

Anemia is common in patients scheduled for vascular surgery and is a risk factor for adverse cardiac outcome. However, it is unclear whether this is an independent risk factor or an expression of underlying co-morbidities. In total, 1,211 patients (77% men, 68 +/- 11 years of age) were enrolled. Anemia was defined as serum hemoglobin levels Abstract

Cited 53 times since 2008 (3.1 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 7, 6 1 2008, Pages 1023-1029 Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomography and noninvasive assessment of left ventricular dyssynchrony by 3-dimensional tissue synchronization imaging in patients with heart failure scheduled for cardiac resynchronization therapy. Van de Veire NR, Marsan NA, Schuijf JD, Bleeker GB, Wijffels MC, van Erven L, Holman ER, De Sutter J, van der Wall EE, Schalij MJ, Bax JJ

Objectives of this study were to perform a prospective head-to-head comparison between multi-slice computed tomography (MSCT) venography and invasive venography in cardiac resynchronization therapy (CRT) candidates as well as to evaluate the relation between left ventricular (LV) lead position and effect on LV dyssynchrony and immediate response to CRT. Twenty-one consecutive heart failure patients scheduled for CRT implantation were prospectively enrolled to undergo 64-slice MSCT to visualize t... Abstract

Cited 90 times since 2008 (5.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 51, Issue 6, 1 1 2008, Pages 618-626 Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study. van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ

Objectives: Our purpose was to evaluate the efficacy and safety of drug-eluting stents in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). Background: There is inconsistent and limited evidence about the efficacy and safety of drug-eluting stents in STEMI patients. Methods: A single-blind, single-center, randomized study was performed to compare bare-metal stents (BMS) with sirolimus-eluting stents (SES) in 310 STEMI patients. The... Abstract

Cited 51 times since 2008 (3 per year) source: EuropePMC

The Journal of cardiovascular surgery, Volume 49, Issue 1, 1 1 2008, Pages 51-58 Intramuscular or combined intramuscular/intra-arterial administration of bone marrow mononuclear cells: a clinical trial in patients with advanced limb ischemia. Van Tongeren RB, Hamming JF, Fibbe WE, Van Weel V, Frerichs SJ, Stiggelbout AM, Van Bockel JH, Lindeman JH

Aim: Recent evidence indicates that bone marrow mononuclear cells (BMC) promote collateral vessel formation in patients with severe peripheral arterial disease (PAD). However, aspects concerning optimal administration mode, durability and long-term safety require consideration. Combined intra-arterial (IA) plus intramuscular (IM) BMC delivery may be more effective than exclusive intramuscular injections. The aim of this study was to evaluate feasibility, safety and effect of exclusive IM versus... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

Clinical nuclear medicine, Volume 33, Issue 2, 1 1 2008, Pages 89-93 Myocardial perfusion scintigraphy with adenosine: does it impair the left ventricular ejection fraction obtained with gated SPECT? Brinkman N, Dibbets-Schneider P, Scholte AJ, Stokkel MP

Background: The aim of this study was to assess whether adenosine impairs left ventricular ejection fraction (LVEF) obtained with gated SPECT in patients with a normal myocardial perfusion scintigram. Materials and methods: This prospective study included 160 consecutive patients with a normal myocardial perfusion scintigraphy (MPS), who were stressed with either exercise (n = 64) or with adenosine (n = 96). Student t-test or chi test was used to compare patient's characteristics and functi... Abstract

Cited 47 times since 2008 (2.8 per year) source: EuropePMC

International journal of cardiology, Volume 132, Issue 2, 1 1 2008, Pages 257-262 Coronary collaterals improve prognosis in patients with ischemic heart disease. Regieli JJ, Jukema JW, Nathoe HM, Zwinderman AH, Ng S, Grobbee DE, van der Graaf Y, Doevendans PA

Background: The recruitment of coronary collateral vessels results from an endogenous adaptation to ischemic heart disease (IHD). Presence of collaterals may exert protection at the time of acute or chronic obstructive coronary disease. The protective role of collaterals in patients with extensive coronary artery disease however, has been disputed. We examined the effects of coronary collateral circulation on cardiovascular outcomes, with an emphasis on clinical prognostic value and on a putativ... Abstract

Cited 18 times since 2008 (1.1 per year) source: EuropePMC

Journal of anatomy, Volume 212, Issue 3, 1 1 2008, Pages 286-294 Chronic right ventricular pressure overload results in a hyperplastic rather than a hypertrophic myocardial response. Leeuwenburgh BP, Helbing WA, Wenink AC, Steendijk P, de Jong R, Dreef EJ, Gittenberger-de Groot AC, Baan J, van der Laarse A

Myocardial hyperplasia is generally considered to occur only during fetal development. However, recent evidence suggests that this type of response may also be triggered by cardiac overload after birth. In congenital heart disease, loading conditions are frequently abnormal, thereby affecting ventricular function. We hypothesized that chronic right ventricular pressure overload imposed on neonatal hearts initiates a hyperplastic response in the right ventricular myocardium. To test this, young l... Abstract

Cited 14 times since 2008 (0.8 per year) source: EuropePMC

Current medical research and opinion, Volume 24, Issue 2, 1 1 2008, Pages 359-364 ApoB/A1 and LDL-C/HDL-C and the prediction of cardiovascular risk in statin-treated patients. Liem AH, van de Woestijne AP, Roeters van Lennep HW, Zwinderman AH, van der Steeg WA, Jukema JW

Background: It is generally accepted that low density lipoprotein cholesterol (LDL-C) or calculated ratios such as LDL-C to high density lipoprotein cholesterol (HDL-C) (LDL-C/HDL-C) are useful predictors of risk of cardiovascular disease in the primary as well as in the secondary prevention setting. However, there is accumulating evidence that the ratio of the corresponding apolipoproteins (apoB/A1) might be superior in some populations. Little is known with regard to the prognostic significanc... Abstract

Cited 151 times since 2008 (8.8 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 85, Issue 2, 1 1 2008, Pages 430-6; discussion 436-7 Restrictive mitral annuloplasty cures ischemic mitral regurgitation and heart failure. Braun J, van de Veire NR, Klautz RJ, Versteegh MI, Holman ER, Westenberg JJ, Boersma E, van der Wall EE, Bax JJ, Dion RA

Background: Restrictive mitral annuloplasty with revascularization is considered the best approach to ischemic mitral regurgitation with heart failure, but late results are controversial. We report late outcome in relation to preoperative left ventricular end-diastolic diameter (LVEDD) cutoff values, previously identified to predict intermediate-term left ventricular reverse remodeling. Methods: One hundred consecutive ischemic mitral regurgitation patients underwent restrictive mitral annulopla... Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

European heart journal, Volume 29, Issue 3, 1 1 2008, Pages 283-284 Preoperative cardiac risk assessment in vascular surgery patients: seeing beyond the perioperative period. Schouten O, Bax JJ, Poldermans D

Abstract

Cited 72 times since 2008 (4.2 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 105, Issue 5, 30 5 2008, Pages 1692-1697 Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins. Thomae AW, Pich D, Brocher J, Spindler MP, Berens C, Hock R, Hammerschmidt W, Schepers A

In all eukaryotic cells, origins of DNA replication are characterized by the binding of the origin recognition complex (ORC). How ORC is positioned to sites where replication initiates is unknown, because metazoan ORC binds DNA without apparent sequence specificity. Thus, additional factors might be involved in ORC positioning. Our experiments indicate that a family member of the high-mobility group proteins, HMGA1a, can specifically target ORC to DNA. Coimmunoprecipitations and imaging studies... Abstract

Cited 40 times since 2008 (2.3 per year) source: EuropePMC

Journal of affective disorders, Volume 110, Issue 1-2, 30 5 2008, Pages 27-35 Depressive symptoms in peripheral arterial disease: a follow-up study on prevalence, stability, and risk factors. Smolderen KG, Aquarius AE, de Vries J, Smith OR, Hamming JF, Denollet J

Background: Depressive symptoms are associated with poor prognosis in coronary artery disease, but there is a paucity of research on these symptoms in peripheral arterial disease (PAD). We examined the clinical correlates and 18-month course of depressive symptoms in PAD patients. Methods: 166 patients with symptomatic lower-extremity PAD (39% women; M age=64.9 +/- 10 years) completed the 10-item Center for Epidemiological Studies Depression scale. A score > or =4 indicates clinically relevan... Abstract

Cited 45 times since 2008 (2.6 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 21, Issue 7, 28 4 2008, Pages 801-807 Real-time three-dimensional echocardiography as a novel approach to quantify left ventricular dyssynchrony: a comparison study with phase analysis of gated myocardial perfusion single photon emission computed tomography. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ

Background: Different imaging modalities have been explored for assessment of left ventricular (LV) dyssynchrony. Gated myocardial perfusion single photon emission computed tomography (GMPS) with phase analysis is a reliable technique to quantify LV dyssynchrony and predict response to cardiac resynchronization therapy. Objective: Real-time 3-dimensional echocardiography (RT3DE) is a novel imaging technique that provides a LV systolic dyssynchrony index, based on regional volumetric changes as a... Abstract