6173 results
Cited 8 times since 2022 (3.3 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 28, Issue 24, 1 1 2022, Pages 5396-5404
Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer.
Feng E, Rydzewski NR, Zhang M, Lundberg A, Bootsma M, Helzer KT, Lang JM, Aggarwal R, Small EJ, Quigley DA, Sjöström M, Zhao SG
Purpose: Although numerous biology-driven subtypes have been described previously in metastatic castration-resistant prostate cancer (mCRPC), unsupervised molecular subtyping based on gene expression has been less studied, especially using large cohorts. Thus, we sought to identify the intrinsic molecular subtypes of mCRPC and assess molecular and clinical correlates in the largest combined cohort of mCRPC samples with gene expression data available to date. Experimental design: We combined and...
Abstract
Cited 5 times since 2022 (2.1 per year)
source: EuropePMC
JAMA dermatology,
Volume 158, Issue 12, 1 1 2022, Pages 1409-1413
Association of Serum Dupilumab Levels at 16 Weeks With Treatment Response and Adverse Effects in Patients With Atopic Dermatitis: A Prospective Clinical Cohort Study From the BioDay Registry.
Spekhorst LS, de Graaf M, Loeff F, Zuithoff NPA, Bakker D, Boesjes CM, Thijs J, Achten R, van Wijk F, Rispens T, de Bruin-Weller MS
Importance: The registered dose of dupilumab for adult patients with atopic dermatitis (AD) is 300 mg every other week. At present, it is unknown whether serum dupilumab levels are associated with treatment response or adverse effects. Objectives: To evaluate serum dupilumab levels at 16 weeks of treatment and to explore the association of serum dupilumab levels with treatment response and adverse effects in patients with AD. Design, setting, and participants: This clinical, prospective, observa...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Langenbeck's archives of surgery,
Volume 407, Issue 8, 1 1 2022, Pages 3909
Correction to: Outcomes of parathyroidectomy versus calcimimetics for secondary hyperparathyroidism and kidney transplantation: a propensity-matched analysis.
Koh EY, van der Plas WY, Dulfer RR, Pol RA, Kruijff S, Rotmans JI, Appelman-Dijkstra N, Schepers A, de Borst MH, Hoorn EJ, van Ginhoven TM, Nieveen van Dijkum EJM, Vogt L, Engelsman AF, Dutch Hyperparathyroidism Study Group
Abstract
Cited 9 times since 2022 (3.8 per year)
source: EuropePMC
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 33, Issue 12, 1 1 2022, Pages e13887
Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28-week clinical and biomarker results from the BioDay registry.
Kamphuis E, Boesjes CM, Loman L, Bakker DS, Poelhekken M, Zuithoff NPA, Kamsteeg M, Romeijn GLE, van Wijk F, de Bruin-Weller MS, de Graaf M, Schuttelaar MLA
Background: Dupilumab has proven to be an effective and safe treatment for atopic dermatitis (AD) in pediatric patients in clinical trials. However, few daily practice studies are available. The aim of this study is to evaluate the effect of 28 weeks dupilumab treatment on effectiveness, safety, and serum biomarkers in pediatric patients with moderate-to-severe AD in daily practice. Methods: Patients visited the outpatient clinic at baseline, 4, 16, and 28 weeks of treatment. Disease severity wa...
Abstract
Cited 97 times since 2022 (40.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 24, Issue 12, 1 1 2022, Pages 1981-2003
EHRA expert consensus statement on arrhythmic mitral valve prolapse and mitral annular disjunction complex in collaboration with the ESC Council on valvular heart disease and the European Association of Cardiovascular Imaging endorsed cby the Heart Rhythm Society, by the Asia Pacific Heart Rhythm Society, and by the Latin American Heart Rhythm Society.
Sabbag A, Essayagh B, Barrera JDR, Basso C, Berni A, Cosyns B, Deharo JC, Deneke T, Di Biase L, Enriquez-Sarano M, Donal E, Imai K, Lim HS, Marsan NA, Turagam MK, Peichl P, Po SS, Haugaa KH, Shah D, de Riva Silva M, Bertrand P, Saba M, Dweck M, Townsend SN, Ngarmukos T, Fenelon G, Santangeli P, Sade LE, Corrado D, Lambiase P, Sanders P, Delacrétaz E, Jahangir A, Kaufman ES, Saggu DK, Pierard L, Delgado V, Lancellotti P
Abstract
Cited 14 times since 2022 (5.9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 24, Issue 1, 1 1 2022, Pages 142-151
Prognostic value of left atrial reservoir function in patients with severe primary mitral regurgitation undergoing mitral valve repair.
Stassen J, van Wijngaarden AL, Butcher SC, Palmen M, Herbots L, Bax JJ, Delgado V, Ajmone Marsan N
Aims: Mitral regurgitation (MR) has a significant haemodynamic impact on the left atrium. Assessment of left atrial reservoir strain (LARS) may have important prognostic implications, incremental to left atrial (LA) volume, and conventional parameters of left ventricular (LV) structure and function. This study investigated whether preoperative assessment of LARS by speckle tracking echocardiography is associated with long-term outcomes in patients undergoing mitral valve repair for severe primar...
Abstract
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
Vascular biology (Bristol, England),
Volume 4, Issue 1, 30 5 2022, Pages 40-49
No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice.
Hibender S, Li S, Postma AV, Hoogeland ME, Klaver D, Pouw RB, Niessen HW, Driessen AH, Koolbergen DR, de Vries CJ, Baars MJ, Houweling AC, Krijnen PA, de Waard V
Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture. Upon whole genome sequencing of a Marfan family, we identified a complement gene C1R variant (p.Ser152Leu), which is associated with severe aortic patients. Therefore, we assessed the role of complement activation in MFS aortic tissue. Expression of various complement genes and pr...
Abstract
Cited 8 times since 2022 (3.3 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 9, Issue 3, 30 5 2022, Pages 345-355
Importance of Systematic Diagnostic Testing in Idiopathic Ventricular Fibrillation: Results From the Dutch iVF Registry.
Groeneveld SA, Verheul LM, van der Ree MH, Mulder BA, Scholten MF, Alings M, van der Voort P, Bootsma M, Evertz R, Balt JC, Yap SC, Doevendans PAFM, Postema PG, Wilde AAM, Volders PGA, Hassink RJ
Background: Idiopathic ventricular fibrillation (iVF) is a diagnosis of exclusion. Systematic diagnostic testing is important to exclude alternative causes for VF. The early use of "high yield" testing, including cardiac magnetic resonance (CMR), exercise testing, and sodium channel blocker provocation, has been increasingly recognized. Objectives: The purpose of this study was to investigate the importance and consistency of systematic diagnostic testing in iVF. Methods: This study in...
Abstract
Cited 3 times since 2022 (1.3 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 65, Issue 3, 29 5 2022, Pages 348-357
Excess Mortality for Abdominal Aortic Aneurysms and the Potential of Strict Implementation of Cardiovascular Risk Management: A Multifaceted Study Integrating Meta-Analysis, National Registry, and PHAST and TEDY Trial Data.
Tomee SM, Bulder RMA, Meijer CA, van Berkum I, Hinnen JW, Schoones JW, Golledge J, Bastiaannet E, Matsumura JS, Hamming JF, Hultgren R, Lindeman JH
Objective: Previous studies imply a profound residual mortality risk following successful abdominal aorta aneurysm (AAA) repair. This excess mortality is generally attributed to increased cardiovascular risk. The aim of this study was (1) to quantify the excess residual mortality for patients with AAA, (2) to evaluate the cross sectional level of cardiovascular risk management, and (3) to estimate the potential of optimised cardiovascular risk management to reduce the excess mortality in these p...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Herz,
Volume 48, Issue 1, 28 4 2022, Pages 3-14
[The new ESC guidelines on the management of ventricular tachyarrhythmias : Implications for daily practice].
Könemann H, Frommeyer G, Zeppenfeld K, Eckardt L
The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluat...
Abstract
Cited 3 times since 2022 (1.3 per year)
source: EuropePMC
Biomedicines,
Volume 10, Issue 12, 28 4 2022, Pages 3056
NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction.
Silvis MJM, Demkes EJ, Timmers L, Arslan F, de Jager SCA, Sluijter JPG, Mosterd A, de Kleijn DPV, Bosch L, van Hout GPJ
NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on cardiac damage in a pig model of myocardial infarction. Prior to in vivo testing, in vitro, porcine peripheral blood mononuclear cells and whole blood were treated with increasing dosages of IZD334, a novel NLRP3-inflammasome inhibitor, and were stimu...
Abstract
Cited 8 times since 2022 (3.3 per year)
source: EuropePMC
Acta dermato-venereologica,
Volume 102, 24 4 2022, Pages adv00820
Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry.
Boesjes CM, Kamphuis E, Zuithoff NPA, Bakker DS, Loman L, Spekhorst LS, Haeck I, Kamsteeg M, Van Lynden-van Nes AMT, Garritsen FM, Politiek K, Oldhoff M, De Graaf M, Schuttelaar MLA, De Bruin-Weller MS
Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks' treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included...
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
International journal of cardiology,
Volume 373, 23 4 2022, Pages 101-106
Incremental value of left ventricular global longitudinal strain in moderate aortic stenosis and reduced left ventricular ejection fraction.
Stassen J, Singh GK, Pio SM, Chimed S, Butcher SC, Hirasawa K, Marsan NA, Bax JJ
Background: Moderate aortic stenosis (AS) often coexists with left ventricular (LV) systolic dysfunction and may affect survival through afterload mismatch. Because outcomes are ultimately driven by the condition of the LV, accurate assessment of LV performance is crucial to improve risk stratification. This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. Methods: Patients with moderate AS (aortic va...
Abstract
Cited 10 times since 2022 (4.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 25, Issue 2, 23 4 2022, Pages 213-222
Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey.
Fauvel C, Bonnet G, Mullens W, Giraldo CIS, Mežnar AZ, Barasa A, Tokmakova M, Shchendrygina A, Costa FM, Mapelli M, Zemrak F, Tops LF, Jakus N, Sultan A, Bahouth F, Hadjseyd CE, Salvat M, Anselmino M, Messroghli D, Weberndörfer V, Giverts I, Bochaton T, Courand PY, Berthelot E, Legallois D, Beauvais F, Bauer F, Lamblin N, Damy T, Girerd N, Sebbag L, Pezel T, Cohen-Solal A, Rosano G, Roubille F, Mewton N
Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists. Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a...
Abstract
Cited 27 times since 2022 (11.2 per year)
source: EuropePMC
Nature cancer,
Volume 3, Issue 11, 22 4 2022, Pages 1284-1299
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.
Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells. Senescent cells are primed for apoptotic death by NF-κB-mediated upregulation of death receptor 5 (DR5...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 49, Issue 2, 22 4 2022, Pages 825-835
The effect of age on resilience of health-related quality of life among polytrauma patients: a cross-sectional multicenter study.
de Vries R, Reininga I, de Graaf M, Banierink H, Bosma E, Munzebrock A, Heineman E, Moumni ME, Wendt K
Purpose: The aim of this study was to determine the impact of age on patient-reported health-related quality of life (HRQoL) and the capacity to show resilience-i.e., the ability to adapt to stressful adverse events-after sustaining a polytrauma. Methods: A cross-sectional multicenter cohort was conducted between 2013 and 2016 that included surviving polytrauma patients (ISS ≥ 16). HRQoL was obtained by the Short Musculoskeletal Function assessment and EuroQol (SMFA and EQ-5D-5L). The effect of...
Abstract
Cited 7 times since 2022 (2.9 per year)
source: EuropePMC
Communications medicine,
Volume 2, Issue 1, 19 3 2022, Pages 146
The importance of sustained compliance with physical distancing during COVID-19 vaccination rollout.
Teslya A, Rozhnova G, Pham TM, van Wees DA, Nunner H, Godijk NG, Bootsma M, Kretzschmar ME
Background: Increasing vaccination coverage against SARS-CoV-2 enabled relaxation of lockdowns in many countries in Europe. As the vaccination rollouts progressed, the public health authorities were seeking recommendations on the continuation of physical distancing measures during ongoing vaccination rollouts. Compliance with these measures was declining while more transmissible virus variants have emerged. Methods: We used a SARS-CoV-2 transmission model to investigate the feedback between comp...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 63, 18 3 2022, Pages 107498
Can transforming growth factor beta and downstream signalers distinguish bicuspid aortic valve patients susceptible for future aortic complications?
Grewal N, Klautz R, Poelmann RE
Patients with a bicuspid aortic valve have an extreme high risk to develop a thoracic aortic aneurysm and dissection (TAAD). TAADs form a leading cause of death worldwide, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Risk stratification for TAADs in bicuspidy is so far solely based on the aortic diameter. Exclusive use of aortic wall dimension, as in the current guidelines, is however not sufficient in selecting patients vulnerable for...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Clinical nutrition (Edinburgh, Scotland),
Volume 42, Issue 1, 17 3 2022, Pages 18-21
An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities.
de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE
Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 101, Issue 1, 16 3 2022, Pages 97-101
Bail out lithotripsy to treat delayed valve-in-valve TAVR-related coronary obstruction.
Bingen BO, Al Amri I, Montero-Cabezas JM, van der Kley F
Coronary access difficulty and stent compression by the juxtaposed aortic valve leaflet hamper percutaneous management of delayed coronary artery obstruction (CAO) after valve-in-valve (Edwards Sapien 3 in St. Jude Trifecta) transcatheter aortic valve replacement (TAVR). Here, we present a case of delayed post-TAVR CAO treated with intravascular lithotripsy and multistenting to overcome stent compression by the adjacent calcified leaflet.
Abstract
