6177 results
Cited 8 times since 2009 (0.5 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 23, Issue 5, 1 1 2009, Pages 583-597
Morbidity and mortality caused by cardiac adverse events after revascularization for critical limb ischemia.
Flu HC, Lardenoye JH, Veen EJ, Aquarius AE, Van Berge Henegouwen DP, Hamming JF
Background: We assessed cardiac adverse events (AEs) after primary lower extremity arterial revascularization (LEAR) for critical lower limb ischemia (CLI) in order to evaluate the impact of cardiac AEs on the clinical outcome. We created an optimized care protocol concerning CLI patients' preoperative work-up as well as intra- and postoperative surveillance according to recent important literature and guidelines. Methods: We conducted a prospective analysis of clinical outcome after LEAR u...
Abstract
Cited 177 times since 2009 (11.3 per year)
source: EuropePMC
The New England journal of medicine,
Volume 361, Issue 10, 1 1 2009, Pages 980-989
Fluvastatin and perioperative events in patients undergoing vascular surgery.
Schouten O, Boersma E, Hoeks SE, Benner R, van Urk H, van Sambeek MR, Verhagen HJ, Khan NA, Dunkelgrun M, Bax JJ, Poldermans D, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group
Background: Adverse cardiac events are common after vascular surgery. We hypothesized that perioperative statin therapy would improve postoperative outcomes. Methods: In this double-blind, placebo-controlled trial, we randomly assigned patients who had not previously been treated with a statin to receive, in addition to a beta-blocker, either 80 mg of extended-release fluvastatin or placebo once daily before undergoing vascular surgery. Lipid, interleukin-6, and C-reactive protein levels were me...
Abstract
Cited 127 times since 2009 (8.1 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 20, 30 5 2009, Pages 2470-2477
Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis.
van Bommel RJ, Bax JJ, Abraham WT, Chung ES, Pires LA, Tavazzi L, Zimetbaum PJ, Gerritse B, Kristiansen N, Ghio S
Aims: Predictors of Response to Cardiac Resynchronization Therapy (CRT) (PROSPECT) was the first large-scale, multicentre clinical trial that evaluated the ability of several echocardiographic measures of mechanical dyssynchrony to predict response to CRT. Since response to CRT may be defined as a spectrum and likely influenced by many factors, this sub-analysis aimed to investigate the relationship between baseline characteristics and measures of response to CRT. Methods and results: A total of...
Abstract
Cited 19 times since 2009 (1.2 per year)
source: EuropePMC
International journal of cardiology,
Volume 147, Issue 1, 28 4 2009, Pages 52-57
Can we use the end systolic volume index to monitor intrinsic right ventricular function after repair of tetralogy of Fallot?
Uebing A, Fischer G, Schlangen J, Apitz C, Steendijk P, Kramer HH
Background: After tetralogy of Fallot (ToF) repair the right ventricle (RV) is commonly exposed to abnormal volume load resulting from pulmonary regurgitation (PR) leading to progressive RV dilatation. The objective of this study was to assess the relationship between RV volumes, especially the end systolic volume index (ESVi), and RV contractility in patients after ToF repair and significant PR and to determine whether RV dilatation reflects intrinsic RV dysfunction in these patients. Methods:...
Abstract
Cited 37 times since 2009 (2.4 per year)
source: EuropePMC
PloS one,
Volume 4, Issue 8, 27 4 2009, Pages e6809
Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study.
Birjmohun RS, Vergeer M, Stroes ES, Sandhu MS, Ricketts SL, Tanck MW, Wareham NJ, Jukema JW, Kastelein JJ, Khaw KT, Boekholdt SM
Background: Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospe...
Abstract
Cited 12 times since 2009 (0.8 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 19, 27 4 2009, Pages 2304-2307
Three-dimensional speckle tracking echocardiography: a novel approach in the assessment of left ventricular volume and function?
Flu WJ, van Kuijk JP, Bax JJ, Gorcsan J, Poldermans D
Abstract
Cited 363 times since 2009 (23.2 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 22, 27 4 2009, Pages 2769-2812
Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery.
Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery, European Society of Cardiology (ESC), Poldermans D, Bax JJ, Boersma E, De Hert S, Eeckhout E, Fowkes G, Gorenek B, Hennerici MG, Iung B, Kelm M, Kjeldsen KP, Kristensen SD, Lopez-Sendon J, Pelosi P, Philippe F, Pierard L, Ponikowski P, Schmid JP, Sellevold OF, Sicari R, Van den Berghe G, Vermassen F
Abstract
Cited 20 times since 2009 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 95, Issue 23, 25 4 2009, Pages 1931-1936
Aortic elasticity and size are associated with aortic regurgitation and left ventricular dysfunction in tetralogy of Fallot after pulmonary valve replacement.
Grotenhuis HB, Ottenkamp J, de Bruijn L, Westenberg JJ, Vliegen HW, Kroft LJ, de Roos A
Background: Aortic wall pathology and concomitant aortic dilatation have been described in tetralogy of Fallot (TOF) patients, which may negatively affect aortic valve and left ventricular systolic function. Objective: To assess aortic dimensions, aortic elasticity, aortic valve competence and biventricular function in repaired TOF patients after pulmonary valve replacement (PVR) using magnetic resonance imaging (MRI). Methods: MRI was performed in 16 patients with TOF after PVR (10 male; mean a...
Abstract
Cited 47 times since 2009 (3 per year)
source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology,
Volume 116, Issue 12, 13 2 2009, Pages 1593-1601
Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect.
Yap SC, Drenthen W, Meijboom FJ, Moons P, Mulder BJ, Vliegen HW, van Dijk AP, Jaddoe VW, Steegers EA, Roos-Hesselink JW, Pieper PG, ZAHARA investigators
Objective: To compare the risks of complications during pregnancy in women with repaired and unrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. Design: A retrospective multicentre study. Setting: Tertiary centres in the Netherlands and Belgium. Population: Women with ASD without associated complex cardiac lesions. Methods: Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 m...
Abstract
Cited 19 times since 2009 (1.2 per year)
source: EuropePMC
Circulation,
Volume 120, Issue 8, 10 2 2009, Pages 669-676
p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
van Tiel CM, Bonta PI, Rittersma SZ, Beijk MA, Bradley EJ, Klous AM, Koch KT, Baas F, Jukema JW, Pons D, Sampietro ML, Pannekoek H, de Winter RJ, de Vries CJ
Background: The cyclin-dependent kinase inhibitor p27(kip1) is a key regulator of smooth muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We therefore hypothesized that common genetic variations or single nucleotide polymorphisms in p27(kip1) may serve as a useful tool in risk stratification for in-stent restenosis. Methods and results: Three single nucleotide polymorphisms concerning the p27(kip1) gene (-838C>A, rs36228499; -79C>T, rs34330; +326G...
Abstract
Cited 65 times since 2009 (4.1 per year)
source: EuropePMC
Circulation. Heart failure,
Volume 2, Issue 6, 6 1 2009, Pages 643-653
A new direction for cardiac regeneration therapy: application of synergistically acting epicardium-derived cells and cardiomyocyte progenitor cells.
Winter EM, van Oorschot AA, Hogers B, van der Graaf LM, Doevendans PA, Poelmann RE, Atsma DE, Gittenberger-de Groot AC, Goumans MJ
Background: Adult human epicardium-derived cells (EPDCs), transplanted into the infarcted heart, are known to improve cardiac function, mainly through paracrine protection of the surrounding tissue. We hypothesized that this effect might be further improved if these supportive EPDCs were combined with cells that could possibly supply the ischemic heart with new cardiomyocytes. Therefore, we transplanted EPDCs together with cardiomyocyte progenitor cells that can generate mature cardiomyocytes in...
Abstract
Cited 89 times since 2009 (5.7 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 2, Issue 5, 5 1 2009, Pages 548-554
Predicting ventricular arrhythmias in patients with ischemic heart disease: clinical application of the ECG-derived QRS-T angle.
Borleffs CJ, Scherptong RW, Man SC, van Welsenes GH, Bax JJ, van Erven L, Swenne CA, Schalij MJ
Background: In patients with primary prevention implantable cardioverter-defibrillators (ICDs), the incidence of life-threatening ventricular arrhythmias resulting in ICD therapy is relatively low, prompting for better risk stratification. The aim of this study was to assess the value of the QRS-T angle for prediction of ICD therapy and mortality in primary prevention patients with ischemic heart disease. Methods and results: ICD patients (n=412, 361 men; age, 63+/-11 years) with ischemic heart...
Abstract
Cited 138 times since 2009 (8.8 per year)
source: EuropePMC
Journal of neurology,
Volume 257, Issue 1, 4 1 2009, Pages 85-90
Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
Trompet S, van Vliet P, de Craen AJ, Jolles J, Buckley BM, Murphy MB, Ford I, Macfarlane PW, Sattar N, Packard CJ, Stott DJ, Shepherd J, Bollen EL, Blauw GJ, Jukema JW, Westendorp RG
Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in t...
Abstract
Cited 29 times since 2009 (1.8 per year)
source: EuropePMC
Nucleic acids research,
Volume 37, Issue 17, 3 1 2009, Pages 5725-5736
Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease.
van Nierop GP, de Vries AA, Holkers M, Vrijsen KR, Gonçalves MA
Homologous recombination (HR) is a highly accurate mechanism of DNA repair that can be exploited for homology-directed gene targeting. Since in most cell types HR occurs very infrequently (approximately 10(-6) to 10(-8)), its practical application has been largely restricted to specific experimental systems that allow selection of the few cells that become genetically modified. HR-mediated gene targeting has nonetheless revolutionized genetics by greatly facilitating the analysis of mammalian ge...
Abstract
Cited 18 times since 2009 (1.1 per year)
source: EuropePMC
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Volume 24, Issue 3-4, 3 1 2009, Pages 201-210
Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.
Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A
Background: We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins. Methods: Rats were treated with MCT in low dose (30 mg/kg, MCT30, n=10) to induce compensated RV hypertrophy, in high dose (80 mg/kg, MCT80, n=11) to...
Abstract
Cited 12 times since 2009 (0.8 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 2, 1 1 2009, Pages 202-208
Intima media thickness of the common carotid artery in vascular surgery patients: a predictor of postoperative cardiovascular events.
Flu WJ, van Kuijk JP, Hoeks SE, Kuiper R, Schouten O, Goei D, Winkel T, van Gestel YR, Verhagen HJ, Bax JJ, Poldermans D
Background: Cardiovascular (CV) complications are the leading cause of morbidity and mortality in vascular surgery patients. The Revised Cardiac Risk (RCR) index, identifying cardiac risk factors, is commonly used for preoperative risk stratification. However, a more direct marker of the underlying atherosclerotic disease, such as the common carotid artery intimamedia thickness (CCA-IMT) may be of predictive value as well. The current study evaluated the prognostic value of the CCA-IMT for posto...
Abstract
Cited 178 times since 2009 (11.3 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 13, Issue 8A, 1 1 2009, Pages 1577-1585
Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis.
van Solingen C, Seghers L, Bijkerk R, Duijs JM, Roeten MK, van Oeveren-Rietdijk AM, Baelde HJ, Monge M, Vos JB, de Boer HC, Quax PH, Rabelink TJ, van Zonneveld AJ
MicroRNAs are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function and have been proposed to be involved in neovascularization. Previously, using an extensive cloning and sequencing approach, we identified miR-126 to be specifically and highly expressed in human endothelial cells (EC). Here, we demonstrate EC-specific expression of miR-126 in capillaries and the larger vessels in vivo. We therefore explored the potentia...
Abstract
Cited 222 times since 2009 (14.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 9, 1 1 2009, Pages 764-776
The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy.
Tops LF, Schalij MJ, Bax JJ
Cardiac pacing is the only effective treatment for patients with sick sinus syndrome and atrioventricular conduction disorders. In cardiac pacing, the endocardial pacing lead is typically positioned at the right ventricular (RV) apex. At the same time, there is increasing indirect evidence, derived from large pacing mode selection trials and observational studies, that conventional RV apical pacing may have detrimental effects on cardiac structure and left ventricular function, which are associa...
Abstract
Cited 3 times since 2009 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 57, Issue 4, 1 1 2009, Pages 415-441
Advanced applications of 3-dimensional echocardiography.
Ng AC, Delgado V, Bertini M, Nucifora G, Shanks M, Ajmone Marsan N, Holman E, Van De Veire NR, Leung DY, Bax JJ
Over the last few decades, advancements in ultrasound, electronic and computing technologies have permitted current second generation 3-dimensional (3D) echocardiography to display on-line 3D rendered images of the heart. Since various studies demonstrated its superiority over 2-dimensional echocardiography, there is growing enthusiasm to embrace this new 3D echocardiographic technology. With its increasing widespread clinical availability, 3D echocardiography is getting closer to routine clinic...
Abstract
Cited 42 times since 2009 (2.7 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 32, Issue 8, 1 1 2009, Pages 1040-1049
Relevance of echocardiographic evaluation of right ventricular function in patients undergoing cardiac resynchronization therapy.
Scuteri L, Rordorf R, Marsan NA, Landolina M, Magrini G, Klersy C, Frattini F, Petracci B, Vicentini A, Campana C, Tavazzi L, Ghio S
Aims: Right ventricular (RV) dysfunction is a marker of poor prognosis in heart failure (HF) patients. It is still unclear whether RV function might influence response to cardiac resynchronization therapy (CRT). Methods: Forty-four consecutive patients with HF, large QRS, and either intraventricular or interventricular dyssynchrony underwent echocardiographic evaluation before, 1 month after, and 6 months after CRT. Response to CRT was considered in case of significant LV reverse remodeling, def...
Abstract
