8892 results
BJU international,
Volume 135, Issue 5, 4 1 2024, Pages 766-774
The impact of positive surgical margins after cystectomy on oncological outcomes: a nationwide study.
Bosveld J, Nguyen TQ, Boormans JL, Witjes JA, van der Heijden AG, Mehra N, Kiemeney LA, Aben KKH, ProBCI Study Group, Meijer RP, Richters A
Objective: To evaluate whether surgical margin status, alongside existing postoperative risk indicators, improves the identification of bladder cancer patients who may benefit from adjuvant therapy following radical cystectomy (RC). Methods: In this nationwide cohort study, patients aged ≥18 years diagnosed with muscle-invasive bladder cancer (MIBC) without nodal or distant metastasis (cT2-4aN0/xM0) between November 2017 and December 2020 who underwent RC were selected from the Netherlands Cance...
Abstract
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society,
2 1 2024, Pages S1090-3798(24)00172-7
Corrigendum to "Re-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes" [Europ. J. Paediatr. Neurol. 41 (2022) 8-18 doi.org/10.1016/j.ejpn.2022.08.006].
Yılmaz Ü, Gücüyener K, Yavuz M, Ibrahim Oncel, Canpolat M, Saltık S, Ünver O, Çıtak Kurt AN, Tosun A, Yılmaz S, Özgör B, İlknur Erol, Öztoprak Ü, Elitez DA, Çobanoğulları Direk M, Bodur M, Teber S, Anlar B, Turkish Pediatric Multiple Sclerosis Study Group
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 1, 1 1 2024, Pages 173-174
Mural thickening of the coronary arteries in a COVID-19 patient.
Groen RA, de Graaf MA, Stöger JL, van der Woude D, Antoni ML
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 26, Issue 12, 1 1 2024, Pages euae283
Ventricular septal defect characteristics influence presence of septal anatomical isthmuses in patients with repaired tetralogy of Fallot.
Wallet J, Kimura Y, Blom NA, Hazekamp MG, Bartelings MM, Jongbloed MRM, Zeppenfeld K
Aims: In repaired tetralogy of Fallot (rTOF), the septal anatomical isthmuses (AI), AI 3, between the ventricular septal defect (VSD) and pulmonary annulus, and AI 4, between the VSD and tricuspid annulus, are important ventricular tachycardia (VT) substrates when slow conducting. Our aim was to assess the influence of VSD characteristics, specifically the presence of muscular or fibrous tissue at its border, on the presence or absence of septal AIs, potentially related to VT. Methods and result...
Abstract
Cited 3 times since 2024 (3.4 per year)
source: EuropePMC
Current protocols,
Volume 4, Issue 12, 1 1 2024, Pages e70068
Cryopreservation of Human Adult Ventricular Tissue for the Preparation of Viable Myocardial Slices.
Lodrini AM, Groeneveld EJ, Palmen M, Hjortnaes J, Smits AM, Goumans MJ
Living myocardial slices (LMS) are ultrathin sections of adult myocardium that can be maintained in culture. These slices provide a unique platform for studying interactions between cardiomyocytes (CMs), other cardiac cell types, and the extracellular matrix while maintaining the cytoarchitecture and electrical phenotype of CMs over extended periods. Despite their advantages over other cardiac models, LMS have limitations, particularly their reliance on slice quality. The primary factor influenc...
Abstract
Cited 2 times since 2024 (2.3 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 41, Issue 12, 1 1 2024, Pages e70047
Core Laboratory Versus Center-Reported Echocardiographic Assessment of the Native and Bioprosthetic Aortic Valve.
Velders BJJ, Vriesendorp MD, Weissman NJ, Sabik JF, Reardon MJ, Dagenais F, Moront MG, Rao V, Fukuhara S, Günzinger R, van Leeuwen WJ, Brown WM, Groenwold RHH, Klautz RJM, Asch FM
Background: Insights into quantitative differences between core laboratory and center-reported echocardiographic assessment of the native and bioprosthetic aortic valve are lacking. We aimed to explore clinically relevant differences between these evaluations. Methods: Data were used from the PERIcardial SurGical AOrtic Valve ReplacemeNt (PERIGON) Pivotal Trial for the Avalus valve. In this trial, patients with an indication for surgical aortic valve replacement (SAVR) due to aortic stenosis or...
Abstract
Journal of travel medicine,
Volume 31, Issue 8, 1 1 2024, Pages taae131
Antimicrobial resistance genes acquisition among Dutch intercontinental travellers: a prospective multicentre study.
Chan J, van Best N, Arcilla M, van Hattem J, Melles DC, de Jong MD, Schultsz C, van Genderen PJJ, Bootsma MCJ, Goorhuis A, Grobusch MP, Oude Lashof AM, Verbrugh HA, Penders J, COMBAT-Study Consortium
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 1, 1 1 2024, Pages ezae414
Seven-year outcomes after surgical aortic valve replacement with a stented bovine pericardial bioprosthesis in over 1100 patients: a prospective multicentre analysis.
Sabik JF, Rao V, Dagenais F, Moront MG, Reardon MJ, Patel HJ, Oh JK, Fukuhara S, Labrousse L, Günzinger R, Baig K, Ito S, Wu T, Klautz RJM, PERIGON Investigators
Objectives: Safety, efficacy and durability are important considerations when selecting a bioprosthesis for aortic valve replacement (AVR). This study assessed 7-year clinical outcomes and haemodynamic performance of the Avalus bioprosthesis. Methods: Patients indicated for surgical AVR were enrolled in this prospective, nonrandomized trial, conducted across 39 sites globally. The primary end-point of this analysis was freedom from surgical explant or percutaneous valve-in-valve reintervention d...
Abstract
JACC. Cardiovascular interventions,
Volume 17, Issue 23, 1 1 2024, Pages 2713-2731
Tricuspid Valve S-Curves and Chamber Views: Implications for Transcatheter Tricuspid and Pulmonary Valve Interventions, Part 2 of the S-Curves and Chamber Views Series.
Zgheib A, De Backer O, Afilalo J, Quagliana A, Campens L, Al Asmar M, Al Ismaili A, Angiolillo D, Ajmone-Marsan N, Von Bardeleben RS, Buithieu J, Cavalcante J, Chetrit M, Choi C, Coisne A, Delgado V, Donal E, Duncan A, Dreyfus J, Fam N, Grapsa J, Granada J, Gackowski A, Hahn R, Ho E, Latib A, Medina de Chazal HA, Martucci G, Maisano F, Messika-Zeitoun D, Modine T, Muraru D, Mousavi N, Praz F, Redwood S, Patterson T, Sarano M, Spaziano M, Swaans M, Sitges M, Zamorano JL, van Mieghem N, Tchetche D, Tournoux F, Wunderlich N, Prendergast B, Piazza N, PCR Tricuspud Valve Focus Group
Despite the challenges associated with periprocedural imaging, transcatheter tricuspid valve interventions have shown important impact on outcomes. A comprehensive understanding of the anatomy of the right heart and surrounding structures is crucial. One way to optimize these interventions is by identifying the optimal fluoroscopic viewing angles along the S-curve of the tricuspid valve. Integration of chamber views using multimodality imaging (multislice computed tomography, fluoroscopy, and ec...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 1, 1 1 2024, Pages euae300
Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user.
De Coster T, Nobacht A, Oostendorp T, de Vries AAF, Coronel R, Pijnappels DA
In 2024, we celebrate the 100th anniversary of Willem Einthoven receiving the Nobel Prize for his discovery of the mechanism of the electrocardiogram (ECG). Building on Einthoven's legacy, electrocardiography allows the monitoring of cardiac bioelectricity through solutions to the so-called forward and inverse problems. These solutions link local cardiac electrical signals with the morphology of the ECG, offering a reversible connection between the heart's electrical activity and its r...
Abstract
Cited 2 times since 2024 (2.3 per year)
source: EuropePMC
Interdisciplinary cardiovascular and thoracic surgery,
Volume 40, Issue 1, 1 1 2024, Pages ivae227
Examining the learning curves in robotic cardiac surgery wet lab simulation training.
Atroshchenko GV, Navarra E, Valdis M, Sandoval E, Hashemi N, Cerny S, Pereda D, Palmen M, Bjerrum F, Bruun NH, Tolsgaard MG
Background: Simulation-based training has gained distinction in cardiothoracic surgery as robotic-assisted cardiac procedures evolve. Despite the increasing use of wet lab simulators, the effectiveness of these training methods and skill acquisition rates remain poorly understood. Objectives: This study aimed to compare learning curves and assess the robotic cardiac surgical skill acquisition rate for cardiac and noncardiac surgeons who had no robotic experience in a wet lab simulation setting....
Abstract
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 20, Issue 4, 29 5 2024, Pages 475-486
Sex and Common Germline Variants Affect the Toxicity Profile and Pharmacokinetics of Alectinib: A Nationwide Cohort Study in Patients With ALK-Positive NSCLC.
Heersche N, Lanser DAC, Muntinghe-Wagenaar MB, Mohmaed Ali MI, Ulas EB, Trooster TMA, de Jonge E, Oomen-de Hoop E, Paats MS, Bahce I, Croes S, Hendriks LEL, van der Wekken AJ, Dingemans AC, Huitema ADR, van Schaik RHN, Mathijssen RHJ, Veerman GDM
Introduction: Alectinib, a small-molecule kinase inhibitor, is used as first-line treatment for ALK-positive (ALK+) NSCLC. Albeit generally well-tolerated, a considerable subset of patients requires dose adjustments due to drug-related toxicity. Single-nucleotide polymorphisms in genes related to the metabolism of alectinib may upfront identify patients at risk for toxicity. Methods: In this multicenter observational cohort study in patients with advanced ALK+ NSCLC receiving alectinib treatment...
Abstract
Cited 3 times since 2024 (3.4 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 66, Issue 1, 29 5 2024, Pages 3-16
Hemodynamic considerations in arteriovenous vascular access modalities for hemodialysis.
White NA, Xiao Z, De Winter EP, Li M, De Vries MR, Van Der Bogt KE, Rotmans JI
Arteriovenous fistulas and arteriovenous grafts are the most commonly used vascular access for hemodialysis in patients with end-stage chronic kidney disease. However, both methods face significant challenges due to the hemodynamic disturbances induced by the arteriovenous anastomosis. This causes changes in vascular structure and blood flow velocity near the anastomosis site after the fistula/graft surgery, and introduces abnormal wall shear stress and cyclic stretch. This leads to endothelial...
Abstract
Cited 3 times since 2024 (3.4 per year)
source: EuropePMC
Talanta,
Volume 285, 29 5 2024, Pages 127293
Flexible 3D nanofiber-based SERS biosensor for detection of miRNA-223-3p in early Laryngeal Cancer diagnosis.
Martino S, Yilmaz D, Tammaro C, Misso G, Esposito A, Falco M, Cossu AM, Lombardi A, Amler E, Divin R, Giannetti A, Scrima M, Dardano P, De Stefano L, Rea I, De Luca AC, Caraglia M
MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nucleotides) that regulate gene expression and are associated with various diseases, including Laryngeal Cancer (LCa), which has a high mortality rate due to late diagnosis. Traditional methods for miRNA detection present several drawbacks (time-consuming steps, high cost and high false positive rate). Early-stage diagnosis and selective detection of miRNAs remain challenging. This study proposes a 3D flexible biosensor that combines nanofibers...
Abstract
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Volume 44, Issue 2, 29 5 2024, Pages 333-342
Overview of Pediatric Respiratory Syncytial Virus (RSV) infections: has risk perception for RSV changed in children with comorbid conditions?
Yilmaz D, Tasar S, Tuz AE, Eroz NA, Oncel EK, Aksay AK, Yilmaz N
Objective: Respiratory syncytial virus (RSV) is the primary etiology of lower respiratory tract infection in children. The fluctuating incidence of RSV, particularly in light of the COVID-19 pandemic, has shifted the spotlight onto preventive strategies. Our study aims to investigate both the risk factors and clinical symptoms of RSV. Materials and methods: From February 2015 to February 2023, samples were analyzed during all seasons to identify viral respiratory infections. RSV was identified i...
Abstract
Cited 2 times since 2024 (2.3 per year)
source: EuropePMC
Scientific reports,
Volume 14, Issue 1, 26 4 2024, Pages 29256
Severe and post-COVID-19 are associated with high expression of vimentin and reduced expression of N-cadherin.
Yilmaz E, Yilmaz D, Cacan E
SARS-CoV-2 penetrates human cells via its spike protein, which mainly interacts with ACE2 receptors, triggering viral replication and an exacerbated immune response characterized by a cytokine storm. Vimentin III, an intermediate filament protein predominantly found in mesenchymal cells, has garnered considerable attention in recent research due to its multifaceted biological roles and significance in the endothelial-mesenchymal transition (EndMT) during various fibrotic processes. However, the...
Abstract
Cited 7 times since 2024 (7.9 per year)
source: EuropePMC
Genome medicine,
Volume 16, Issue 1, 25 4 2024, Pages 137
Genomic surveillance of multidrug-resistant organisms based on long-read sequencing.
Landman F, Jamin C, de Haan A, Witteveen S, Bos J, van der Heide HGJ, Schouls LM, Hendrickx APA, Dutch CPE/MRSA surveillance study group
Background: Multidrug-resistant organisms (MDRO) pose a significant threat to public health worldwide. The ability to identify antimicrobial resistance determinants, to assess changes in molecular types, and to detect transmission are essential for surveillance and infection prevention of MDRO. Molecular characterization based on long-read sequencing has emerged as a promising alternative to short-read sequencing. The aim of this study was to characterize MDRO for surveillance and transmission s...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 105, Issue 2, 24 4 2024, Pages 385-393
Intravascular Lithotripsy in Acute Coronary Syndromes: Procedural and One-Year Clinical Outcomes From the BENELUX-IVL Registry.
Oliveri F, van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, van der Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Despite the excellent success and safety of intravascular lithotripsy (IVL) in heavily calcified lesions, evidence in acute coronary syndromes (ACS) remains limited. Aims: This study aimed to evaluate the procedural and clinical outcomes of IVL in heavily calcified ACS. Methods: Patients who underwent IVL between 2019 and 2024 from the ongoing prospective BENELUX registry were eligible for inclusion. Patients were therefore classified in ACS and chronic coronary syndrome (CCS) groups...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 111, 23 4 2024, Pages 203-211
A Diagnostic Comparison Study between Maximal Systolic Acceleration and Acceleration Time to Detect Peripheral Arterial Disease.
Willems SA, van Bennekom OO, Schepers A, van Schaik J, van der Vorst JR, Hamming JF, Brouwers JJWM
Background: Detecting peripheral arterial disease (PAD) can be particularly challenging in patients with diabetes mellitus (DM) or chronic kidney disease (CKD) due to medial arterial calcification (MAC). Current bedside tests, such as the ankle-brachial index, are less accurate in these patient groups. The primary aim of this study is to evaluate the diagnostic accuracy of point-of-care duplex ultrasound parameters maximal systolic acceleration (ACCmax) and acceleration time (AT) to detect PAD,...
Abstract
BMC cancer,
Volume 24, Issue 1, 22 4 2024, Pages 1441
Relevant factors for policy concerning comprehensive genomic profiling in oncology: stakeholder perspectives.
van Schaik LF, Engelhardt EG, van Harten WH, Retèl VP
Background: Comprehensive genomic profiling (CGP) can identify targets beyond standard of care, potentially revolutionizing personalized cancer management. However, conducting well designed studies in this rapidly evolving field is complex and demands time and investments. Consequently, the total added value of CGP remains uncertain. Clinical benefit and costs often are driving factors in coverage decisions. Recently, five additional factors were identified in the literature that can influence t...
Abstract
