Research

Publications

Below you can find a list of our published research.

6125 results

Cited 6 times since 1999 (0.2 per year) source: EuropePMC

Early human development, Volume 55, Issue 3, 1 1 1999, Pages 237-245 Electrocortical brain activity during hypoxia and hypotension in anesthetized newborn lambs. van de Bor M, Meinesz J, Benders MJ, Steendijk P, Lopes Cardozo RH, van Bel F

Blood gas and blood pressure disturbances do influence cerebral blood flow in newborns. To what extent cerebral blood flow changes affect electrocortical brain activity remains uncertain. We studied the effect of severe hypoxia and hemorrhagic hypotension on carotid artery blood flow and electrocortical brain activity in newborn anesthetized lambs. During hypoxia carotid artery blood flow increased significantly, whereas electrocortical brain activity remained unchanged. The hemorrhagic hypotens... Abstract

Cited 12 times since 1999 (0.5 per year) source: EuropePMC

Cardiovascular research, Volume 43, Issue 1, 1 1 1999, Pages 86-95 Right ventricular systolic function and ventricular interaction during acute embolisation of the left anterior descending coronary artery in sheep. Jerzewski A, Steendijk P, Pattynama PM, Leeuwenburgh BP, de Roos A, Baan J

Objective: Regional LV ischemia involving the septum affects LV systolic function and geometry. We investigated the effects of these changes on RV function and geometry. Methods: In six closed-chest sheep end-systolic pressure-volume relationships (ESPVRs) were constructed from ventricular volumes, measured with magnetic resonance imaging (MRI) and matching intraventricular pressures, before and after selective embolisation of the left anterior descending coronary artery (LAD). The extent of myo... Abstract

Cited 10 times since 1999 (0.4 per year) source: EuropePMC

European journal of clinical investigation, Volume 29, Issue 6, 1 1 1999, Pages 553-560 Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases. De Vries MR, Borel Rinkes IH, Swaak AJ, Hack CE, Van De Velde CJ, Wiggers T, Tollenaar RA, Kuppen PJ, Eggermont AM

Background: In this study, we have evaluated hepatotoxicity, secondary cytokine production and hepatic acute-phase response (APR) in patients who underwent isolated hepatic perfusion (IHP) with tumour necrosis factor (TNF) alpha and melphalan for irresectable colorectal liver metastases. Design: An extracorporeal veno-venous bypass was used to shunt blood from the lower body and intestines to the heart. Inflow catheters were placed in the hepatic artery and portal vein, and an outflow catheter i... Abstract

Cited 17 times since 1999 (0.7 per year) source: EuropePMC

Journal of chromatography. A, Volume 844, Issue 1-2, 1 1 1999, Pages 295-305 Trace-level determination of polar flavour compounds in butter by solid-phase extraction and gas chromatography-mass spectrometry. Adahchour M, Vreuls RJ, van der Heijden A, Brinkman UA

Volatile compounds are responsible for the aromas of butter. A simple technique for the determination of these components is described which is based on solid-phase extraction (SPE) after melting of the butter and separation of the aqueous phase from the fat. Volatile flavours present in the water fraction are collected by off-line SPE on cartidges packed with a copolymer sorbent. After desorption with 500 microliters of methyl acetate, 1-microliter aliquots are quantified and/or identified by g... Abstract

Cited 12 times since 1999 (0.5 per year) source: EuropePMC

Acta cardiologica, Volume 54, Issue 3, 1 1 1999, Pages 163-168 Treatment and prevention of coronary heart disease by lowering serum cholesterol levels; from the pioneer work of C.D. de Langen to the third "Dutch Consensus on Cholesterol". Jukema JW, Simoons ML

In the beginning of this century a possible relation was observed between cholesterol-rich foods, blood cholesterol levels and atherosclerosis by "pioneers" in this field as Anitschkow and De Langen. In the second half of this century a definite link was established between serum cholesterol levels and development of coronary heart disease (CHD). In angiographic studies it has recently been shown that a decrease in total cholesterol as well as in low-density lipoprotein cholesterol lev... Abstract

International journal of cardiac imaging, Volume 15, Issue 3, 1 1 1999, Pages 209-214 Dynamic obstruction, an unusual complication after aortic valve replacement with a stentless porcine valve. van Roosmalen RP, Baur LH, Braun J, Atsma DE, Hazekamp MG, van der Wall EE, Huysmans HA

In the early nineties, the stentless porcine aortic bioprosthesis has been reintroduced successfully. Because of the limited experience, knowledge of clinical complications is limited. Therefore, we describe an unusual complication of dynamic obstruction after aortic valve replacement with a stentless porcine valve in a 70 year old man 18 months after implantation. We discuss the complications of stentless aortic prostheses known so far, describe operative techniques used and their characteristi... Abstract

Cited 17 times since 1999 (0.7 per year) source: EuropePMC

International journal of cardiac imaging, Volume 15, Issue 3, 1 1 1999, Pages 253-8; discussion 259 Diagnosis and management of anomalous origin of the right coronary artery from the left coronary sinus. Bekedam MA, Vliegen HW, Doornbos J, Jukema JW, de Roos A, van der Wall EE

The anomalous origin of the right coronary artery (RCA) from the left sinus of Valsalva coursing between the aorta and the pulmonary artery or right ventricular outflow tract, is considered a potentially fatal abnormality which may require surgery. However, diagnosing the correct course with coronary arteriography may be difficult. Fast gradient echo magnetic resonance (MR) imaging can be helpful to identify and confirm the course of aberrant coronary arteries and their relationship to the surro... Abstract

Cited 44 times since 1999 (1.7 per year) source: EuropePMC

Journal of hepatology, Volume 30, Issue 5, 1 1 1999, Pages 876-881 Hepatic arterial pulsatility index in cirrhosis: correlation with portal pressure. Schneider AW, Kalk JF, Klein CP

Background/aims: Determination of the pulsatility index by means of duplex sonography provides the opportunity to evaluate the vascular resistance of the hepatic artery noninvasively. The aim of this study was to investigate the relationship between the hepatic arterial pulsatility index and the hepatic venous pressure gradient in cirrhosis. Methods: In 50 patients with cirrhosis, hepatic venous pressure gradient was determined in the fasting state. Immediately thereafter, hepatic arterial pulsa... Abstract

Cited 59 times since 1999 (2.3 per year) source: EuropePMC

Journal of lipid research, Volume 40, Issue 4, 1 1 1999, Pages 735-743 Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. Henderson HE, Kastelein JJ, Zwinderman AH, Gagné E, Jukema JW, Reymer PW, Groenemeyer BE, Lie KI, Bruschke AV, Hayden MR, Jansen H

Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparin LPL (PH-LPL) activity and lipids and lipoproteins in a large, well-defined cohort of Dutch males with coronary artery disease (CAD). These subjects were drawn from the REGRESS study, totaled 730 in nu... Abstract

Cited 66 times since 1999 (2.5 per year) source: EuropePMC

The American journal of cardiology, Volume 83, Issue 6, 1 1 1999, Pages 852-856 Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. de Maat MP, Jukema JW, Ye S, Zwinderman AH, Moghaddam PH, Beekman M, Kastelein JJ, van Boven AJ, Bruschke AV, Humphries SE, Kluft C, Henney AM

It has proved difficult to identify high-risk patients for atherosclerosis and to determine how they might respond to medication. Recently, a common promoter variant of the human stromelysin-1 gene has been reported, which has been shown to affect the transcription. We investigated whether this polymorphism had any impact on the risk of events, especially restenosis and progression of coronary artery disease and whether the effect was modulated by treatment with pravastatin. The stromelysin-1 ge... Abstract

Cited 40 times since 1999 (1.5 per year) source: EuropePMC

The American journal of cardiology, Volume 83, Issue 4, 1 1 1999, Pages 558-562 Postsurgical course of patients with congenitally corrected transposition of the great arteries. Voskuil M, Hazekamp MG, Kroft LJ, Lubbers WJ, Ottenkamp J, van der Wall EE, Zwinderman KH, Mulder BJ

Because congenitally corrected transposition is a rare congenital anomaly, little is known about the prognosis of patients with this syndrome. The present study evaluated the functional status and clinical course of 73 patients (42 male and 31 female) aged 10 days to 73 years. Follow-up was 1 week to 37 years (mean 12.7 years). Particular attention was paid to the systemic right ventricle, considering the current controversies about long-term right ventricular function. Survival of patients with... Abstract

Cited 6 times since 1999 (0.2 per year) source: EuropePMC

Basic research in cardiology, Volume 94, Issue 1, 1 1 1999, Pages 23-30 Pretreatment with allopurinol in cardiac hypoxic-ischemic reperfusion injury in newborn lambs exerts its beneficial effect through afterload reduction. Shadid M, Van Bel F, Steendijk P, Dorrepaal CA, Moison R, Van der Velde ET, Baan J

The aim of this study was to determine whether allopurinol (ALLO) reduces reperfusion injury inflicted upon the heart resulting from excess production of free oxygen radicals after hypoxia and ischemia (HI) in newborn animals. We, therefore, produced severe HI in 13 newborn lambs by low O2-ventilation and blood volume reduction. One hour before HI seven lambs received ALLO (20 mg/kg i.v.), six received a placebo (CONT). Cardiac function and hemodynamic parameters were assessed by sequential meas... Abstract

Cited 109 times since 1999 (4.2 per year) source: EuropePMC

Hepatology (Baltimore, Md.), Volume 29, Issue 2, 1 1 1999, Pages 334-339 Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis. Schneider AW, Kalk JF, Klein CP

Administration of angiotensin II causes an increase in portal pressure, and plasma concentration of angiotensin II is elevated in patients with cirrhosis, suggesting that angiotensin II may be involved in the pathogenesis of portal hypertension in cirrhosis. We evaluated the effect of the orally active angiotensin II receptor antagonist, losartan, on portal pressure in patients with cirrhosis and portal hypertension. Thirty patients with severe (hepatic venous pressure gradient [HVPG] >/= 20... Abstract

Folia medica, Volume 41, Issue 1, 1 1 1999, Pages 101-103 Statistical report from Uludag Poison Information Center--34-month experience. Ozyurt G, Tokyay N, Kucer N, Mutlu L, Onder I, Yilmaz D, Senay O

Management of poisoned patient requires accurate knowledge of intoxication. Uludaŏ Poison Information Center (UPIC), founded in January 1996, provides acquired information 24 hours a day 7 days a week for physicians and consultants. We received 2270 phone calls since January 1996 till October 1998 and evaluated the cases statistically regarding "distribution of age and gender", "calling time after poison exposure", "source of poisoning", "reason for intoxicatio... Abstract

Cited 1 times since 1999 (0 per year) source: EuropePMC

Biology of the neonate, Volume 75, Issue 2, 1 1 1999, Pages 130-136 Effect of exchange transfusion on brain perfusion and electrocortical brain activity in newborn lambs. Benders MJ, Meinesz JH, Dorrepaal CA, Steendijk P, van Bel F, van de Bor M

Changes in brain perfusion (using ultrasonic-determined changes in carotid artery blood flow: Qcar) and electrocortical brain activity (ECBA, obtained by a Lectromed cerebral function monitor) were studied during exchange transfusion using the push-pull method in the newborn lamb. Changes in mean arterial blood pressure (MABP), Qcar, heart rate (HR), and ECBA were observed during all exchange transfusions: MABP, Qcar, and ECBA decreased during the withdrawal period and increased during the infus... Abstract

Cited 5 times since 1999 (0.2 per year) source: EuropePMC

Biology of the neonate, Volume 75, Issue 4, 1 1 1999, Pages 239-249 Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart. Shadid M, Van Bel F, Steendijk P, Dorrepaal CA, Moison R, Van Der Velde ET, Baan J

Unlabelled: Post-hypoxic-ischemic (HI) reperfusion induces excess production of non-protein-bound iron (NPBI), leading to formation of the highly reactive hydroxyl radical. We investigated whether the iron-chelator deferoxamine (DFO) could reduce reperfusion injury and improve left ventricular (LV) function. We produced severe HI in 14 newborn lambs and measured pre-HI, upon reperfusion, 60 and 120 min after HI the following parameters: mean aortic blood pressure, total peripheral resistance, st... Abstract

Cited 18 times since 1998 (0.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 66, Issue 6 Suppl, 1 1 1998, Pages S225-32 Tissue chimerism in human cryopreserved homograft valve explants demonstrated by in situ hybridization. Koolbergen DR, Hazekamp MG, Kurvers M, de Heer E, Cornelisse CJ, Huysmans HA, Bruijn JA

Background: The presence of viable cells may contribute to increased homograft valve durability. These cells may be of infiltrating recipient or persisting donor origin. In this study, in situ hybridization was used to assess the origin of cells in cryopreserved homograft valve explants. Methods: A total of 10 homografts with a donor-recipient gender mismatch were acquired from patients whose graft had been explanted at reoperation or at autopsy. The period of implantation varied from 14 days to... Abstract

Cited 15 times since 1998 (0.6 per year) source: EuropePMC

Development, growth & differentiation, Volume 40, Issue 6, 1 1 1998, Pages 577-582 Hormone-inducible expression of secreted factors in zebrafish embryos. de Graaf M, Zivkovic D, Joore J

The study of gene function at later stages of embryonic development by overexpression experiments is often complicated by genes exerting different functions at multiple stages of development, which renders analysis of stage-specific effects difficult. To address this problem an inducible expression system that supports timed expression of essentially any protein, including secreted proteins was designed. The system is based on a two step mechanism. A glucocorticoid inducible, Gal4-site binding c... Abstract

Cited 39 times since 1998 (1.5 per year) source: EuropePMC

The Journal of biological chemistry, Volume 273, Issue 50, 1 1 1998, Pages 33267-33272 Mitogenic effects of urokinase on melanoma cells are independent of high affinity binding to the urokinase receptor. Koopman JL, Slomp J, de Bart AC, Quax PH, Verheijen JH

The structural and functional properties of the urokinase-type plasminogen activator (u-PA) that are involved in the mitogenic effect of this proteolytic enzyme on human melanoma cells M14 and IF6 and the role of the u-PA receptor (u-PAR) in transducing this signal were analyzed. Native u-PA purified from urine induced a mitogenic response in quiescent IF6 and M14 cells that ranged from 25 to 40% of the mitogenic response obtained by fetal calf serum. The half-maximum response in M14 and IF6 cel... Abstract

Cited 30 times since 1998 (1.1 per year) source: EuropePMC

Circulation, Volume 98, Issue 20, 1 1 1998, Pages 2168-2179 Endocardial activation mapping of ventricular tachycardia in patients : first application of a 32-site bipolar mapping electrode catheter. Schalij MJ, van Rugge FP, Siezenga M, van der Velde ET

Background: Localization of early activated endocardial areas during ventricular tachycardia (VT) is mandatory for performance of surgical or radiofrequency catheter interventions. The use of a multielectrode catheter may shorten the procedure time and increase the accuracy of the procedure compared with single-electrode mapping techniques. This study was performed to evaluate the safety and efficacy of a 32-bipolar-electrode mapping catheter in patients. Methods and results: The basket-shaped m... Abstract