Research

Publications

Below you can find a list of our published research.

8892 results

Journal of the American Heart Association, Volume 13, Issue 17, 29 5 2024, Pages e034760 Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants. Young WJ, van der Most PJ, Bartz TM, Bos MM, Biino G, Duong T, Foco L, Lominchar JT, Müller-Nurasyid M, Nardone GG, Pecori A, Ramirez J, Repetto L, Schramm K, Shen X, van Duijvenboden S, van Heemst D, Weiss S, Yao J, Benjamins JW, Alonso A, Spedicati B, Biggs ML, Brody JA, Dörr M, Fuchsberger C, Gögele M, Guo X, Ikram MA, Jukema JW, Kääb S, Kanters JK, Lifelines Cohort Study, Lin HJ, Linneberg A, Nauck M, Nolte IM, Pianigiani G, Santin A, Soliman EZ, Tesolin P, Vaccargiu S, Waldenberger M, van der Harst P, Verweij N, Arking DE, Concas MP, De Grandi A, Girotto G, Grarup N, Kavousi M, Mook-Kanamori DO, Navarro P, Orini M, Padmanabhan S, Pattaro C, Peters A, Pirastu M, Pramstaller PP, Heckbert SR, Sinner M, Snieder H, Völker U, Wilson JF, Gauderman WJ, Lambiase PD, Sotoodehnia N, Tinker A, Warren HR, Noordam R, Munroe PB

Background: Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome-wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained. Previous work supports a causal effect of lower serum calcium concentrations on longer ventricular repolarization time. We hypothesized calcium interactions with QT and JT variant associations could explain a proportion of the missing heritability.... Abstract

Cited 3 times since 2024 (2.6 per year) source: EuropePMC

European journal of heart failure, Volume 26, Issue 10, 27 4 2024, Pages 2173-2182 Heart failure risk assessment in patients with hypertrophic cardiomyopathy based on the H2FPEF score. Laenens D, Zegkos T, Kamperidis V, Wong RCC, Li TY, Sia CH, Kong WKF, Efthimiadis G, Poh KK, Ziakas A, Bax JJ, Ajmone Marsan N

Aims: The aim of this study was to investigate whether the H2FPEF score, which was developed to improve the diagnosis of heart failure (HF) with preserved ejection fraction, is associated with HF outcomes in patients with hypertrophic cardiomyopathy (HCM). Methods and results: Patients with HCM and preserved left ventricular ejection fraction (LVEF ≥50%) were included from a multicentre registry and the H2FPEF score was calculated. Patients were divided into three groups: low (0-1), intermediate... Abstract

Journal of cardiovascular development and disease, Volume 11, Issue 9, 27 4 2024, Pages 264 Exploring Sex Differences in Pain Manifestation of Coronary Artery Disease through Mendelian Randomization. Methorst R, Jongbloed MRM, Noordam R, DeRuiter MC

Pain manifestation following coronary artery disease (CAD) disease differs between men and women. Here, we aimed to provide evidence favoring possible differences in pain manifestation between men and women following CAD using Mendelian randomization (MR). We used summary-level data from sex-stratified genome-wide association studies on CAD and self-reported and clinically diagnosed chest, neck and shoulder, back, and facial pain using data from the UK Biobank cohort (N > 450,000) followed by... Abstract

Cited 11 times since 2024 (9.6 per year) source: EuropePMC

Nature biomedical engineering, Volume 8, Issue 8, 26 4 2024, Pages 941-962 Standardizing designed and emergent quantitative features in microphysiological systems. Nahon DM, Moerkens R, Aydogmus H, Lendemeijer B, Martínez-Silgado A, Stein JM, Dostanić M, Frimat JP, Gontan C, de Graaf MNS, Hu M, Kasi DG, Koch LS, Le KTT, Lim S, Middelkamp HHT, Mooiweer J, Motreuil-Ragot P, Niggl E, Pleguezuelos-Manzano C, Puschhof J, Revyn N, Rivera-Arbelaez JM, Slager J, Windt LM, Zakharova M, van Meer BJ, Orlova VV, de Vrij FMS, Withoff S, Mastrangeli M, van der Meer AD, Mummery CL

Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide physiological mechanical cues to cells, include fluid flow and can be interlinked (hence, they are often referred to as microfluidic tissue chips or organs-on-chips). Here, by means of examples of MPSs of the vascular system, intestine, brain and heart, we advocate for the development of standards that allow for compa... Abstract

The Science of the total environment, Volume 951, 25 4 2024, Pages 175620 Corrigendum to "Accumulation of airborne microplastics on leaves of different tree species in the urban environment" [Sci. Total Environ. Volume 948, 20 October 2024, page 174907]. Leitão IA, Van Schaik L, Iwasaki S, Ferreira AJD, Geissen V

Abstract

Cited 2 times since 2024 (1.7 per year) source: EuropePMC

British journal of cancer, Volume 131, Issue 7, 24 4 2024, Pages 1224-1236 IMPRESS: Improved methylation profiling using restriction enzymes and smMIP sequencing, combined with a new biomarker panel, creating a multi-cancer detection assay. Vandenhoeck J, Neefs I, Vanpoucke T, Ibrahim J, Suls A, Peeters D, Schepers A, Hoischen A, Fransen E, Peeters M, Van Camp G, Op de Beeck K

Background: Despite the worldwide progress in cancer diagnostics, more sensitive diagnostic biomarkers are needed. The methylome has been extensively investigated in the last decades, but a low-cost, bisulfite-free detection method for multiplex analysis is still lacking. Methods: We developed a methylation detection technique called IMPRESS, which combines methylation-sensitive restriction enzymes and single-molecule Molecular Inversion Probes. We used this technique for the development of a mu... Abstract

Cited 1 times since 2024 (0.9 per year) source: EuropePMC

International journal of cardiology. Heart & vasculature, Volume 54, 22 4 2024, Pages 101494 The use of pledget-reinforced sutures during surgical aortic valve replacement: A systematic review and meta-analysis. Taco Boltje JW, Carvalho Mota MT, Vriesendorp MD, Vonk ABA, Groenwold RHH, Klautz RJM, Velders BJJ

Objective: Literature presents conflicting results on the pros and cons of pledget-reinforced sutures during surgical aortic valve replacement (SAVR). We aimed to investigate the effect of pledget-reinforced sutures versus sutures without pledgets during SAVR on different outcomes in a systematic review and meta-analysis. Methods: A literature search was performed in five different medical literature databases. Studies must include patients undergoing SAVR and must compare any pledget-reinforced... Abstract

Cited 2 times since 2024 (1.7 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 10, Issue 11, 21 3 2024, Pages 2303-2311 Excellent Outcomes After First-Line Ablation in Post-MI Patients With Tolerated VT and LVEF >35. Rademaker R, de Riva M, Piers SRD, Wijnmaalen AP, Zeppenfeld K

Background: Post-myocardial infarction (MI) patients with ventricular tachycardia (VT) are considered at risk for VT recurrence and sudden cardiac death (SCD). Recent guidelines indicate that in selected patients catheter ablation should be considered instead of an implantable cardioverter-defibrillator (ICD). Objectives: This study aimed to analyze outcomes of patients referred for VT ablation according to left ventricular ejection fraction (LVEF), tolerance of VT, and acute ablation outcome. M... Abstract

Mikrochimica acta, Volume 191, Issue 9, 20 3 2024, Pages 548 Monitoring lipopolysaccharide-induced macrophage polarization by surface-enhanced Raman scattering. Yılmaz D, Culha M

Macrophages are among the most important components of the innate immune system where the interaction of pathogens and their phagocytosis occur as the first barrier of immunity. When nanomaterials interact with the human body, they have to face macrophages as well. Thus, understanding of nanomaterials-macrophage interactions and underlying mechanisms is crucial. For this purpose, various methods are used. In this study, surface-enhanced Raman scattering (SERS) is proposed by studying lipopolysac... Abstract

Microbiology spectrum, Volume 12, Issue 10, 20 3 2024, Pages e0094624 Impact of carbon dioxide concentrations on laboratory sensitivity of Mycoplasma species isolated from dairy cows. Biesheuvel MM, Kalbfleisch K, De Buck J, van Engelen E, van Schaik G, Moroni P, Gioia G, Nobrega D, Samera GJ, Adams PJ, Walcott JR, Barkema HW

Conventional Mycoplasma spp. diagnostics involve culture, often considered the gold standard in diagnostic test evaluation. However, culture protocols lack empirical derivation and primarily adhere to National Mastitis Council recommendations, tracing back to initial cultivation of Mycoplasma bovis. Despite a wide range of carbon dioxide (CO2) supplementation reported in literature, specific impacts of CO2 on Mycoplasma spp. growth remain unexplored. Our objective was to assess the effect of CO2... Abstract

Cited 1 times since 2024 (0.9 per year) source: EuropePMC

Microbiology spectrum, Volume 12, Issue 10, 20 3 2024, Pages e0420823 An interlaboratory proficiency test using metagenomic sequencing as a diagnostic tool for the detection of RNA viruses in swine fecal material. Liu L, Hakhverdyan M, Wallgren P, Vanneste K, Fu Q, Lucas P, Blanchard Y, de Graaf M, Oude Munnink BB, van Boheemen S, Bossers A, Hulst M, Van Borm S

Metagenomic shotgun sequencing (mNGS) can serve as a generic molecular diagnostic tool. An mNGS proficiency test (PT) was performed in six European veterinary and public health laboratories to detect porcine astroviruses in fecal material and the extracted RNA. While different mNGS workflows for the generation of mNGS data were used in the different laboratories, the bioinformatic analysis was standardized using a metagenomic read classifier as well as read mapping to selected astroviral referen... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 32, Issue 10, 19 3 2024, Pages 356-362 Trends in adoption of extravascular cardiac implantable electronic devices: the Dutch cohort. Breeman KTN, Knops RE, van der Stoel MD, Boersma LVA, Yap SC, van Erven L, van Dijk VF, Maass AH, Wilde AAM, Tjong FVY, Device Registration Committee of the Netherlands Heart Registration

Introduction: Conventional implantable cardioverter-defibrillators (ICDs) and pacemakers carry a risk of pocket- and lead-related complications in particular. To avoid these complications, extravascular devices (EVDs) have been developed, such as the subcutaneous ICD (S-ICD) and leadless pacemaker (LP). However, data on patient or centre characteristics related to the actual adoption of EVDs are lacking. Objective: To assess real-world nationwide trends in EVD adoption in the Netherlands. Method... Abstract

Cited 6 times since 2024 (5.1 per year) source: EuropePMC

EBioMedicine, Volume 107, 17 3 2024, Pages 105279 NMR metabolomics-guided DNA methylation mortality predictors. Bizzarri D, Reinders MJT, Kuiper L, Beekman M, Deelen J, van Meurs JBJ, van Dongen J, Pool R, Boomsma DI, Ghanbari M, Franke L, BBMRI Consortium, Slagboom PE, van den Akker EB

Background: 1H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics data in four Dutch population studies (N = 5238, ∼40% of which male) we investigated whether the mortality signal captured by 1H-NMR metabolomics could guide the construction of DNA methylation-based mortality predictors. Findings: We trained DNA methylation... Abstract

Cited 1 times since 2024 (0.9 per year) source: EuropePMC

BMC public health, Volume 24, Issue 1, 16 3 2024, Pages 2235 Assessing the knowledge, attitude, and practice of frontline physicians in Egyptian university hospitals regarding pharyngitis and acute rheumatic fever: a cross-sectional study that calls for action. Abdelsayed K, Ali HT, Helal MB, Assar A, Madany M, Gabra MD, Abdelrahman A, Goudy Y, Dandrawy A, Soliman ZA, Qubaisy HM, Shahin GMM, ARF –RHD Prevention Group, Azimullah PC

Background: Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) remain major public health issues. Although the primary and secondary prevention of RHD through appropriate management of bacterial pharyngitis and ARF are well-described in the literature, few studies address the knowledge, attitude, and practice (KAP) of developing countries. We aimed to evaluate the KAP of the frontline physicians in Egyptian university hospitals regarding pharyngitis and ARF. Methods: We employed a cro... Abstract

Cited 4 times since 2024 (3.4 per year) source: EuropePMC

Genome medicine, Volume 16, Issue 1, 15 3 2024, Pages 101 Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD. Knikman JE, Zhai Q, Lunenburg CATC, Henricks LM, Böhringer S, van der Lee M, de Man FM, Offer SM, Shrestha S, Creemers GJ, Baars A, Dezentjé VO, Imholz ALT, Jeurissen FJF, Portielje JEA, Jansen RLH, Hamberg P, Droogendijk HJ, Koopman M, Nieboer P, van de Poel MHW, Mandigers CMPW, van Schaik RHN, Gelderblom H, Mathijssen RHJ, Schellens JHM, Cats A, Guchelaar HJ, Swen JJ

Background: The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > G/rs56038477) can mitigate the risk of severe fluoropyrimidine toxicity. However, this could not prevent all toxicities. The goal of this study was to identify additional genetic variants, both inside and outside DPYD, that may contribute to fluoropyrimidine toxicity.... Abstract

Cited 3 times since 2024 (2.5 per year) source: EuropePMC

Preventive veterinary medicine, Volume 232, 13 2 2024, Pages 106313 Risk factors for the introduction of Salmonella spp. serogroups B and D into Dutch dairy herds. Fabri ND, Santman-Berends IMGA, Weber MF, van Schaik G

Salmonella spp. infections in animals are a concern due to their zoonotic nature, welfare effects and economic impact on the livestock industry. To enable targeted surveillance, it is important to identify risk factors for the introduction of Salmonella spp. in a herd. Since 2009, Dutch dairy processors require herds delivering milk to their plants to participate in a Salmonella programme. In this programme, bulk milk is tested three times a year (i.e. test rounds) by ELISA on presence of antibo... Abstract

Cited 24 times since 2024 (20.4 per year) source: EuropePMC

The lancet. Gastroenterology & hepatology, Volume 9, Issue 10, 13 2 2024, Pages 924-934 Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial. Faber RA, Meijer RPJ, Droogh DHM, Jongbloed JJ, Bijlstra OD, Boersma F, Braak JPBM, Meershoek-Klein Kranenbarg E, Putter H, Holman FA, Mieog JSD, Neijenhuis PA, van Staveren E, Bloemen JG, Burger JWA, Aukema TS, Brouwers MAM, Marinelli AWKS, Westerterp M, Doornebosch PG, van der Weijde A, Bosscha K, Handgraaf HJM, Consten ECJ, Sikkenk DJ, Burggraaf J, Keereweer S, van der Vorst JR, Hutteman M, Peeters KCMJ, Vahrmeijer AL, Hilling DE

Background: Anastomotic leakage is a severe postoperative complication in colorectal surgery and compromised bowel perfusion is considered a major contributing factor. Conventional methods to assess bowel perfusion have a low predictive value for anastomotic leakage. We therefore aimed to evaluate the efficacy of real-time assessment with near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) in the prevention of anastomotic leakage. Methods: This multicentre, randomised, controll... Abstract

Cited 5 times since 2024 (4.2 per year) source: EuropePMC

Antimicrobial agents and chemotherapy, Volume 68, Issue 9, 13 2 2024, Pages e0065024 Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model. Molendijk MM, Boekema BKHL, Lattwein KR, Vlig M, Bode LGM, Koopmans MPG, Verbon A, de Graaf M, van Wamel WJB

Burn wounds are a major burden, with high mortality rates due to infections. Staphylococcus aureus is a major causative agent of burn wound infections, which can be difficult to treat because of antibiotic resistance and biofilm formation. An alternative to antibiotics is the use of bacteriophages, viruses that infect and kill bacteria. We investigated the efficacy of bacteriophage therapy for burn wound infections, in both a porcine and a newly developed human ex vivo skin model. In both models... Abstract

Journal of thoracic disease, Volume 16, Issue 8, 13 2 2024, Pages 4914-4923 Deep learning to predict long-term mortality from plain chest X-ray in patients referred for suspected coronary artery disease. D'Ancona G, Savardi M, Massussi M, Van Der Valk V, Scherptong RWC, Signoroni A, Farina D, Murero M, Ince H, Benussi S, Curello S, Arslan F

Background: The hypothesis that a deep learning (DL) model can produce long-term prognostic information from chest X-ray (CXR) has already been confirmed within cancer screening programs. We summarize our experience with DL prediction of long-term mortality, from plain CXR, in patients referred for angina and coronary angiography. Methods: Data of patients referred to an Italian academic hospital were analyzed retrospectively. We designed a deep convolutional neural network (DCNN) that, from CXR... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Holistic nursing practice, Volume 38, Issue 6, 9 2 2024, Pages 371-384 Effect of Acupressure on Menopausal Symptoms and Quality of Life in Postmenopausal Women: A Randomized Controlled Trial. Can AA, Yilmaz DV

This study was conducted as a randomized controlled experimental trial with the aim of determining the effect of acupressure on menopausal symptoms and quality of life in postmenopausal women, as well as the correlation between the two. This randomized controlled experimental study was conducted between May and November 2021 with women coming to a Menopause School in Turkey. A Descriptive Characteristics Form, the Menopause Rating Scale, and the World Health Organization Quality of Life Scale Sh... Abstract