6173 results
Cited 6 times since 2021 (1.6 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 30 5 2021, Pages 687885
Radiation Induces Valvular Interstitial Cell Calcific Response in an <i>in vitro</i> Model of Calcific Aortic Valve Disease.
Meerman M, Driessen R, van Engeland NCA, Bergsma I, Steenhuijsen JLG, Kozono D, Aikawa E, Hjortnaes J, Bouten CVC
Background: Mediastinal ionizing radiotherapy is associated with an increased risk of valvular disease, which demonstrates pathological hallmarks similar to calcific aortic valve disease (CAVD). Despite advances in radiotherapy techniques, the prevalence of comorbidities such as radiation-associated valvular disease is still increasing due to improved survival of patients receiving radiotherapy. However, the mechanisms of radiation-associated valvular disease are largely unknown. CAVD is conside...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
JMIR cardio,
Volume 5, Issue 2, 30 5 2021, Pages e27867
Financial Incentives for Healthy Living for Patients With Cardiac Disease From the Perspective of Health Care Professionals: Interview Study.
de Buisonjé D, Van der Geer J, Keesman M, Van der Vaart R, Reijnders T, Wentzel J, Kemps H, Kraaijenhagen R, Janssen V, Evers A
Background: A promising new approach to support lifestyle changes in patients with cardiovascular disease (CVD) is the use of financial incentives. Although financial incentives have proven to be effective, their implementation remains controversial, and ethical objections have been raised. It is unknown whether health care professionals (HCPs) involved in CVD care find it acceptable to provide financial incentives to patients with CVD as support for lifestyle change. Objective: This study aims...
Abstract
Cited 9 times since 2021 (2.5 per year)
source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society,
Volume 110, Issue 11, 28 4 2021, Pages 1734-1742
Echocardiography-derived total atrial conduction time (PA-TDI duration): risk stratification and guidance in atrial fibrillation management.
Müller P, Weijs B, Bemelmans NMAA, Mügge A, Eckardt L, Crijns HJGM, Bax JJ, Linz D, den Uijl DW
Atrial fibrillation (AF) is a major cause of cardiovascular morbidity and mortality. To early detect and to avoid AF-related complications, several cardiac imaging modalities and approaches aim to quantify the severity of the underlying atrial cardiomyopathy (i.e., the extent of atrial remodeling). However, most established cardiac imaging modalities just incorporate single components of atrial remodeling and do not reflect the complete multifactorial process, which may contribute to their limit...
Abstract
European heart journal. Case reports,
Volume 5, Issue 8, 27 4 2021, Pages ytab288
4D flow MRI of type B dissection with later retrograde progression to type A dissection in Marfan: a case report.
van Hout MJP, Juffermans JF, Scholte AJ, Lamb HJ
Background: Due to the malfunction of connective tissue, Marfan patients are at increased risk of aortic dissection. Uncomplicated acute type B dissection is usually managed with medical therapy. Retrograde progression or new type A dissection is a relatively rare but often fatal complication that occur most frequently in the first 6 months after acute type B dissection. Case summary: We present a 31-year-old male with Marfan syndrome and a recent uncomplicated type B dissection from the left su...
Abstract
Cited 11 times since 2021 (3 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 9, 26 4 2021, Pages 102
The Coronary Arteries in Adults after the Arterial Switch Operation: A Systematic Review.
Engele LJ, Mulder BJM, Schoones JW, Kiès P, Egorova AD, Vliegen HW, Hazekamp MG, Bouma BJ, Jongbloed MRM
Coronary artery status in adults long after the arterial switch operation (ASO) is unclear. We conducted a systematic review to provide an overview of coronary complications during adulthood and to evaluate the value of routine coronary imaging in adults after ASO, in light of current guidelines. Articles were screened for the inclusion of adult ASO patients and data on coronary complications and findings of coronary imaging were collected. A total of 993 adults were followed with a median avail...
Abstract
Cited 13 times since 2021 (3.6 per year)
source: EuropePMC
Angiogenesis,
Volume 25, Issue 1, 25 4 2021, Pages 129-143
PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting.
Perrotta P, de Vries MR, Peeters B, Guns PJ, De Meyer GRY, Quax PHA, Martinet W
Vein grafting is a frequently used surgical intervention for cardiac revascularization. However, vein grafts display regions with intraplaque (IP) angiogenesis, which promotes atherogenesis and formation of unstable plaques. Graft neovessels are mainly composed of endothelial cells (ECs) that largely depend on glycolysis for migration and proliferation. In the present study, we aimed to investigate whether loss of the glycolytic flux enzyme phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PF...
Abstract
Cited 11 times since 2021 (3 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 24 4 2021, Pages 17121
Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data.
Yoon YE, Baskaran L, Lee BC, Pandey MK, Goebel B, Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Narula J, Bax JJ, Lin FY, Shaw L, Chang HJ
Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national re...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Frontiers in physiology,
Volume 12, 23 4 2021, Pages 710020
The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes.
Ördög B, Teplenin A, De Coster T, Bart CI, Dekker SO, Zhang J, Ypey DL, de Vries AAF, Pijnappels DA
Aim: Channelrhodopsins (ChRs) are a large family of light-gated ion channels with distinct properties, which is of great importance in the selection of a ChR variant for a given application. However, data to guide such selection for cardiac optogenetic applications are lacking. Therefore, we investigated the functioning of different ChR variants in normal and pathological hypertrophic cardiomyocytes subjected to various illumination protocols. Methods and Results: Isolated neonatal rat ventricul...
Abstract
Cited 17 times since 2021 (4.6 per year)
source: EuropePMC
European journal of heart failure,
Volume 23, Issue 10, 22 4 2021, Pages 1597-1609
Guidance on the management of left ventricular assist device (LVAD) supported patients for the non-LVAD specialist healthcare provider: executive summary.
Ben Gal T, Ben Avraham B, Milicic D, Crespo-Leiro MG, Coats AJS, Rosano G, Seferovic P, Ruschitzka F, Metra M, Anker S, Filippatos G, Altenberger J, Adamopoulos S, Barac YD, Chioncel O, de Jonge N, Elliston J, Frigerio M, Goncalvesova E, Gotsman I, Grupper A, Hamdan R, Hammer Y, Hasin T, Hill L, Itzhaki Ben Zadok O, Abuhazira M, Lavee J, Mullens W, Nalbantgil S, Piepoli MF, Ponikowski P, Potena L, Ristic A, Ruhparwar A, Shaul A, Tops LF, Tsui S, Winnik S, Jaarsma T, Gustafsson F
The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of patients on the device and the scarcity of donor hearts has significantly increased the population of LVAD supported patients. Device-related, and patient-device interaction complications impose a significant burden on the medical system exceeding the capacity of LVAD implanting centres. The probability of an L...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
JTCVS open,
Volume 8, 21 3 2021, Pages 668-676
Incidence and risk factors of unplanned emergency department visits following thoracic surgery.
Hazewinkel MHJ, Berendsen RR, van Klink RCJ, Dik H, Wink J, Braun J, de Lind van Wijngaarden RAF
Background: Unplanned visits for care following a surgical procedure can represent a lapse in quality of care. The purpose of this study was to define the proportion of patients undergoing thoracic surgery who return to the emergency department (ED) within 6 months after discharge and the reasons for the returns. In addition, the risk factors for ED visits after thoracic surgery were identified. Methods: All adult patients undergoing thoracic surgery at the Leiden University Medical Center betwe...
Abstract
Cited 7 times since 2021 (1.9 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 36, 20 3 2021, Pages 100858
Referral and participation in cardiac rehabilitation of patients following acute coronary syndrome; lessons learned.
Rodrigo SF, Van Exel HJ, Van Keulen N, Van Winden L, Beeres SLMA, Schalij MJ
Purpose: Cardiac rehabilitation (CR) after hospitalization for acute coronary syndrome (ACS) has shown to reduce mortality, readmissions, and improve quality of life. CR is recommended by international guidelines but previous studies have shown low participation rates. Systematic CR referral might improve CR participation. Methods: The present study evaluates CR referral and CR participation of patients hospitalized for ACS in 2017 and treated according to local protocol, which includes systemat...
Abstract
Cited 21 times since 2021 (5.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 12, 18 3 2021, Pages 2429-2440
Association of Tube Voltage With Plaque Composition on Coronary CT Angiography: Results From PARADIGM Registry.
Takagi H, Leipsic JA, Indraratna P, Gulsin G, Khasanova E, Tzimas G, Lin FY, Shaw LJ, Lee SE, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Maffei E, Pontone G, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Bax JJ, Chang HJ
Objectives: This study sought to investigate the impact of low tube voltage scanning heterogeneity of coronary luminal attenuation on plaque quantification and characterization with coronary computed tomography angiography (CCTA). Background: The impact of low tube voltage and coronary luminal attenuation on quantitative coronary plaque remains uncertain. Methods: A total of 1,236 consecutive patients (age: 60 ± 9 years; 41% female) who underwent serial CCTA at an interval of ≥2 years were inclu...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
Frontiers in immunology,
Volume 12, 18 3 2021, Pages 676662
Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies.
Loeven MA, Maciej-Hulme ML, Yanginlar C, Hubers MC, Kellenbach E, de Graaf M, van Kuppevelt TH, Wetzels J, Rabelink TJ, Smith RJH, van der Vlag J
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G). Complement regulatory protein Factor H (FH) inhibits complement activity, whereas FH-related proteins (FHRs) lack a complement regulatory domain. FH and FHRs compete for binding to host cell glycans, in particular heparan sulfates (HS). HS is a glycosaminoglycan with an immense structural variability, where distinct sulfation patterns mediate...
Abstract
European heart journal. Case reports,
Volume 5, Issue 9, 17 3 2021, Pages ytab335
Fusion cardiac resynchronization therapy in an left ventricular assist device patient from two devices and crossing leads: a case report.
Egorova AD, van Erven L, Beeres SLMA, Tops LF
Background: Cardiac implanted electronic devices (CIED) have significantly improved the survival and quality of life in heart failure patients. Although implantable cardioverter-defibrillators (ICD) and cardiac resynchronization therapy (CRT) have a major role in patients with moderate to severe heart failure symptoms, the role of these devices in patients with a left ventricular assist device (LVAD) is not yet well defined. The burden of CIED-related procedures in patients with an LVAD is high....
Abstract
Cited 14 times since 2021 (3.8 per year)
source: EuropePMC
Thrombosis research,
Volume 206, 17 3 2021, Pages 66-75
Efficacy and safety of a 12-week outpatient pulmonary rehabilitation program in Post-PE Syndrome.
Boon GJAM, Janssen SMJ, Barco S, Bogaard HJ, Ghanima W, Kroft LJM, Meijboom LJ, Ninaber MK, Nossent EJ, Spruit MA, Symersky P, Vliegen HW, Vonk Noordegraaf A, Huisman MV, Siegerink B, Abbink JJ, Klok FA
Background: The Post-Pulmonary Embolism Syndrome (PPES) comprises heterogeneous entities, including chronic thromboembolic disease with/without pulmonary hypertension (CTEPH/CTEPD), and deconditioning. Objectives: To assess underlying physiological determinants of PPES, and efficacy and safety of rehabilitation training in these patients. Methods: 56 consecutive PE patients with persistent dyspnea and/or functional limitations despite ≥3 months of anticoagulation underwent standardized diagnosti...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 14, Issue 8, 16 3 2021, Pages e009808
Lesion Size and Lesion Maturation After Radiofrequency Catheter Ablation for Ventricular Tachycardia in Humans With Nonischemic Cardiomyopathy.
Glashan CA, Stevenson W, Zeppenfeld K
Abstract
Cited 7 times since 2021 (1.9 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 14, Issue 8, 12 2 2021, Pages e012612
Hemodynamic Consequences of an Undersized Extracardiac Conduit in an Adult Fontan Patient Revealed by 4-Dimensional Flow Magnetic Resonance Imaging.
Rijnberg FM, van Assen HC, Hazekamp MG, Roest AAW, Westenberg JJM
Abstract
Cited 16 times since 2021 (4.3 per year)
source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology,
Volume 321, Issue 4, 11 2 2021, Pages L775-L786
Disease modeling following organoid-based expansion of airway epithelial cells.
Eenjes E, van Riet S, Kroon AA, Slats AM, Khedoe PPSJ, Boerema-de Munck A, Buscop-van Kempen M, Ninaber DK, Reiss IKM, Clevers H, Rottier RJ, Hiemstra PS
Air-liquid interface (ALI) cultures are frequently used in lung research but require substantial cell numbers that cannot readily be obtained from patients. We explored whether organoid expansion [three-dimensional (3D)] can be used to establish ALI cultures from clinical samples with low epithelial cell numbers. Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells wer...
Abstract
Cited 11 times since 2021 (3 per year)
source: EuropePMC
European heart journal open,
Volume 1, Issue 2, 9 2 2021, Pages oeab018
Segmental assessment of blood flow efficiency in the total cavopulmonary connection using four-dimensional flow magnetic resonance imaging: vortical flow is associated with increased viscous energy loss rate.
Rijnberg FM, Juffermans JF, Hazekamp MG, Helbing WA, Lamb HJ, Roest AAW, Westenberg JJM, van Assen HC
Aims: To study flow-related energetics in multiple anatomical segments of the total cavopulmonary connection (TCPC) in Fontan patients from four-dimensional (4D) flow magnetic resonance imaging (MRI), and to study the relationship between adverse flow patterns and segment-specific energetics. Methods and results: Twenty-six extracardiac Fontan patients underwent 4D flow MRI of the TCPC. A segmentation of the TCPC was automatically divided into five anatomical segments [conduit, superior vena cav...
Abstract
Cited 9 times since 2021 (2.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 341, 8 2 2021, Pages 31-38
Determinants of exercise limitation in contemporary paediatric Fontan patients with an extra cardiac conduit.
Harteveld LM, Blom NA, Terol Espinosa de Los Monteros C, van Dijk JG, Kuipers IM, Rammeloo LAJ, de Geus EJC, Hazekamp MG, Ten Harkel ADJ
Background: Although various determinants of exercise limitation in Fontan patients have been studied, most research has been performed in patients who underwent different surgical procedures with differing haemodynamic characteristics. The aim of the current study was to evaluate non-invasively measured cardiovascular parameters and their influence on exercise performance in paediatric Fontan patients with an extracardiac conduit and moderate-good systolic ventricular function. Methods: Fontan...
Abstract
