7503 results
Annals of vascular surgery,
2 1 2025, Pages S0890-5096(25)00855-6
Considerations with respect to elective Abdominal Aortic Aneurysm repair in older people.
Biemond MJ, Paping JHM, Bulder RMA, Hultgren R, Mooijaart SP, Hamming JF, Lindeman JH
Objectives: The epidemiology of abdominal aortic aneurysm (AAA) is changing, with progressively more older patients receiving repair. Advancing age associates with an increased procedural risk, but also with a decreasing life-time rupture risk. This national study aims to provide background information for decision-making in older people. Methods: National administrative data (Statistics Netherlands) was used to estimate time-varying trends in the age and sex distribution of patients that underw...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 12, 2 1 2025, Pages e014049
International Survey on Vein of Marshall Retrograde Ethanol Infusion.
De Becker B, Derval N, Amin R, El Haddad M, Pambrun T, Bouyer B, Francois C, De Smet M, Channan EM, Blankoff N, Krahnefeld O, Agdirlioglu T, Minois D, Andorin A, Bessiere F, Gardey K, Sesselberg HW, Leyton-Mange JS, Marchand H, Mariottini C, Miled M, Sebag FA, Lellouche N, Andronache M, Marchese P, Rossi A, Nesti M, Herzet JM, Rodríguez Manero M, Pavlović N, Anselme F, Chaumont C, Wijnmaalen AP, Piers SRD, Waktare JEP, Najm A, Almorad A, Sousa PA, Lepièce C, Badot D, Auquier N, Efremidis M, Lian E, Maslova V, Tavernier R, Duytschaever M, Le Polain de Waroux JB, Valderrabano M, Knecht S
Background: Retrograde ethanolization of the vein of Marshall (VOM) has been identified as an adjunct technique in the treatment of persistent atrial fibrillation (AF) and left atrial tachycardia, as stated in the last consensus statement on ablation of AF. However, there is a lack of high-volume data on the technique. Methods: Through the collection of data from worldwide centers, we performed this international survey that aims to analyze the safety and procedural characteristics of VOM ethano...
Abstract
Giornale italiano di cardiologia (2006),
Volume 26, Issue 12 Suppl. 1, 1 1 2025, Pages e1-e108
[2025 ESC/EACTS Guidelines for the management of valvular heart disease].
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
Volume 39, Issue 12, 1 1 2025, Pages 2028-2029
Reading the palms: Palmar hyperlinearity and type 2 biomarkers as early predictors of atopic dermatitis onset in infancy?
Vroman F, de Graaf M
Abstract
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 31, Issue 24, 1 1 2025, Pages 5306-5316
Prognosis and Biological Characteristics of ER-Low Metastatic Breast Cancer: Results from a Multicenter Cohort and the TONIC Trial.
Miglietta F, De Graaf M, Vernieri C, Piacentini F, Cacciatore M, Botticelli A, Vingiani A, Fotia G, Nicolè L, Griguolo G, Giarratano T, Massa D, Pellegrini V, Schiavi F, Porra F, Fassan M, Pruneri G, Dei Tos AP, Guarneri V, Kok M, Dieci MV
Purpose: The purpose of this study was to assess prognosis of estrogen receptor (ER)-low expression and its dynamics in HER2- metastatic breast cancer and to compare sensitivity to nivolumab between ER-low and triple-negative breast cancer (TNBC). Experimental design: Two cohorts were analyzed: a multicenter cohort of 982 patients with HER2- metastatic breast cancer and one prospective cohort of 110 patients with ER
Abstract
Circulation,
Volume 152, Issue 24, 1 1 2025, Pages 1666-1678
Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes After Acute Coronary Syndrome.
Tsimikas S, Szarek M, Cobbaert CM, Romijn F, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Yuan C, Gong XM, Goodman SG, White HD, Witztum JL, Steg PG, Schwartz GG, ODYSSEY OUTCOMES Investigators
Background: Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) reflect pro-inflammatory properties of Lp(a) (lipoprotein(a)). The effect of OxPL-apoB on major adverse cardiovascular events (MACE) in patients with acute coronary syndrome in recent the era is not known. Methods: OxPL-apoB levels and Lp(a) were measured in 11 630 participants before and 5185 participants 4 months after randomization to alirocumab or placebo in the ODYSSEY OUTCOMES trial. Proportional hazards models adjusted...
Abstract
Stem cell research,
Volume 90, 1 1 2025, Pages 103877
Generation of three induced pluripotent stem cell clones from a functional single ventricle patient carrying the BRAF c.1897 T > C variant.
Bos TA, Polyakova E, DeRuiter MC, Nühn E, Jongbloed MRM
Cardiofaciocutaneous syndrome is a genetic disorder characterized by congenital heart disease, developmental delays and ectodermal abnormalities. Cardiofaciocutaneous syndrome is caused by pathogenic variants in the genes of the RAS/MAPK pathway, particularly BRAF. However, the mechanism by which congenital heart defects arise in RASopathy patients is still poorly understood. Therefore, using non-integrating episomal vectors, we generated three hiPSC clones from peripheral blood mononuclear cell...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 12, 1 1 2025, Pages euaf252
Cardiac implantable electronic device upgrades and downgrades: a Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Asia Pacific Heart Rhythm Association (APHRS), Canadian Heart Rhythm Society (CHRS), Heart Rhythm Society (HRS), and the Latin American Heart Rhythm Society (LAHRS).
Keene D, Nielsen JC, Burri H, Chavez-Gutierrez CA, Deharo JC, Drossart I, Ip JE, Israel CW, Johansen JB, Kosztin A, Lau CP, Levy S, Manlucu J, Marcantoni L, Pujol-Lopez M, Rao A, Starck C, Tolosana JM, Van Erven L, Vogler J, Kaza N
Cardiac implantable electronic device upgrade and downgrade procedures are increasingly being performed. Whilst the most appropriate guideline-recommended device may have been followed during a patient's initial procedure, the requirements of patients can change over time. This could be due to worsening of cardiac function due to detrimental effects of pacing itself or the diagnosis, development, or progression of another cardiac comorbidity. Device downgrades are also performed when a pati...
Abstract
Cited 1 times since 2025 (20.2 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 64, Issue SI, 1 1 2025, Pages SI122-SI130
Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis.
Velauthapillai A, Bootsma MFR, Bruni C, Bergmann C, Matucci-Cerinic M, Launay D, Riemekasten G, Garzanova L, Airò P, Rezus E, da Silva JAP, Del Galdo F, Hunzelmann N, Chung LS, Krasowska D, Distler O, van den Ende CHM, Vonk MC, EUSTAR Collaborators
Background: Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in systemic sclerosis (SSc). Methods: A cohort was created using data from the EUSTAR database and Nijmegen Systemic Sclerosis cohort, including adult patients who started their first immunosuppressive treatment (i.e. mycophenolate mofetil, methotrexate, cyclophos...
Abstract
JACC. Cardiovascular interventions,
Volume 18, Issue 23, 1 1 2025, Pages 2833-2845
Anatomical vs Physiological Lesion Characteristics in Prediction of Acute Coronary Syndrome.
Yang S, Chung JW, Park SH, Zhang J, Lee K, Hwang D, Lee KS, Na SH, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Taylor CA, Bax JJ, Shaw LJ, Stone PH, Narula J, Koo BK
Background: Acute coronary syndrome (ACS) arises from a complex interplay among luminal narrowing, plaque morphology, and hemodynamic environment. Objectives: The authors aimed to compare the effectiveness of anatomy- and physiology-based ACS risk assessment. Methods: In this international, multicenter, internal case-control study, 351 ACS patients who underwent coronary computed tomography angiography (CCTA) 1 month to 3 years before the event were analyzed. Lesions were classified as culprit o...
Abstract
Microbial genomics,
Volume 11, Issue 12, 1 1 2025
IS<i>1216</i> drives the evolution of pRUM-like multidrug resistance plasmids in <i>Enterococcus faecium</i>.
Allen F, McInnes RS, van Schaik W, Moran RA
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium, but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of two clinical E. faecium strains isolated in Birmingham, UK, we found two pRUM-like plasmids, pHHEf1 and pHHEf2. They were ~25 kb in size and shared the same 10 kb backbone but contained starkly different accessory regions that were bounded by and interspersed with the IS26 family insertion sequence IS...
Abstract
JAMA network open,
Volume 8, Issue 12, 1 1 2025, Pages e2548538
Economic Evaluation of Comprehensive Genomic Profiling in an Advanced Solid Cancer Population.
van Schaik LF, Maes B, Volders PJ, Froyen G, Aftimos P, de Azambuja E, Blommestein HM, van Harten WH, Retèl VP
Importance: Developments in genomic profiling introduced larger gene panels with decreasing sequencing costs. Although the feasibility of comprehensive genomic profiling (CGP) has been demonstrated, its health economic impact remains uncertain. Objective: To provide insights into the costs related to clinical implementation of CGP-based advice in a large prospective cohort. Design, setting, and participants: In this economic evaluation of a prospective Belgian multicenter observational study (Be...
Abstract
European journal of human genetics : EJHG,
29 5 2025
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines.
Coenen MJH, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, Swen JJ, Touw DJ, van Westrhenen R, Deneer VHM, van Schaik RHN
The Dutch Pharmacogenetics Working Group (DPWG) describes gene-drug interactions to facilitate pharmacogenetic implementation in clinical practice. The current guideline describes the gene-drug interactions for TPMT, NUDT15 and thiopurines (azathioprine, 6-mercaptopurine and thioguanine). Evidence based recommendations were obtained via a literature review of published studies. This literature review showed that gene variants leading to a decreased activity of TPMT and/or NUDT15 result in higher...
Abstract
Nature communications,
Volume 16, Issue 1, 28 4 2025, Pages 10707
Unveiling the global urban virome through wastewater metagenomics.
Worp N, Nieuwenhuijse DF, Izquierdo-Lara RW, Schapendonk CME, Brinch C, Jensen EEB, Munk P, Hendriksen RS, Global Sewage Surveillance Consortium, Aarestrup F, Oude Munnink BB, Koopmans MPG, de Graaf M
Understanding global viral dynamics is critical for public health. Traditional surveillance focuses on individual pathogens and symptomatic cases, which may miss asymptomatic infections or newly emerging viruses, delaying detection and response. Wastewater-based epidemiology has been used to track pathogens through targeted molecular assays, but its reliance on predefined targets limits detection of the full viral spectrum. Here, we analyse longitudinal wastewater samples from 62 cities across s...
Abstract
The American journal of cardiology,
27 4 2025, Pages S0002-9149(25)00691-5
Intravascular Lithotripsy in Diabetic Patients Undergoing Percutaneous Coronary Intervention: Long-Term Outcomes from the BENELUX Registry.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, Sagris M, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Diabetes mellitus (DM) is associated with increased coronary calcification and adverse outcomes after percutaneous coronary intervention (PCI), yet the performance of intravascular lithotripsy (IVL) in this high-risk population remains insufficiently defined. This study, conducted within the all-comers BENELUX-IVL registry, evaluated the safety and efficacy of IVL-assisted PCI in patients with and without DM. The primary endpoint was major adverse cardiovascular events (MACE) at 1 and 2 years, d...
Abstract
Communications biology,
Volume 8, Issue 1, 26 4 2025, Pages 1684
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling.
Muntjewerff EM, Epremidze D, Nezhyva M, Kal S, Rohm TV, Tang K, Singh K, Espes D, Jati S, Bootsma M, Mannaa AM, Ikebuchi H, Nilsson AM, Rajasekaran M, Andrén PE, Jansson ET, Mahata SK, Christoffersson G
Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the roles of these peptides in pancreatic endocrine function, morphology, neurotransmitter dynamics, and systemic glucose homeostasis. CST-KO mice displayed impaired insulin secretion in vivo (but not ex vivo), disru...
Abstract
JAMA cardiology,
26 4 2025
Interventions for Tricuspid Regurgitation.
Praz F, Angellotti D, Ajmone Marsan N, Butler J
Abstract
BMC primary care,
25 4 2025
Navigating chest pain online: who uses health information and what actions follow?
van Dijkman ED, de Boer YK, de Hollander EL, Numans ME, Siebelink HJ, Bonten TN
Abstract
Polymers,
Volume 17, Issue 23, 24 4 2025, Pages 3115
Snail Shell-Reinforced Waste-Based Polymer Composites for Radiation Shielding and Anti-Reflective Applications.
Pekdemir ME, Pekdemir SS, Yılmaz D, Onay H, Nazem Qader I
The increasing demand for sustainable and multifunctional materials in radiation shielding and optical applications has driven research toward utilizing natural and waste-derived reinforcements in polymer matrices. However, achieving effective attenuation performance across different radiation types using eco-friendly fillers remains a significant challenge. In this study, polyvinyl chloride (PVC)/Polystyrene (PSt) blend composites (1:1 weight ratio) were reinforced with powdered snail shell (SS...
Abstract
Nature human behaviour,
24 4 2025
Culture is critical in driving orangutan diet development past individual potentials.
Howard-Spink E, Tennie C, Mitra Setia T, Perawati D, van Schaik C, Barrett B, Whiten A, Schuppli C
Humans accumulate extensive repertoires of culturally transmitted information, reaching breadths exceeding any individual's innovation capacity (culturally dependent repertoires). It is unclear whether other animals require social learning to acquire adult-like breadths of information in the wild, including by key developmental milestones, or whether animals are capable of constructing their knowledge repertoires primarily through independent exploration. We investigated whether social lear...
Abstract
