Research

Publications

Below you can find a list of our published research.

7401 results

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 1, 1 1 2021, Pages 68 Correction to: Percutaneous coronary intervention for chronic total coronary occlusion: Do. Or do not. There is no try. Knaapen P, Henriques JP, Nap A, Arslan F

Abstract

Journal of atrial fibrillation, Volume 13, Issue 4, 31 5 2021, Pages 2360 Chronic Obstructive Pulmonary Disease and Risk of Atrial Arrhythmias After ST-Segment Elevation Myocardial Infarction. Goedemans L, Abou R, Montero-Cabezas JM, Ajmone Marsan N, Delgado V, J Bax J

Background: ST-segment elevation myocardial infarction (STEMI) and cardiac arrhythmias frequently occur in patients with chronic obstructive pulmonary disease (COPD). However, little is known about the association of COPD with the occurrence of atrial arrhythmias after STEMI. Methods: This retrospective analysis consisted of 320 patients with first STEMI without a history of atrial arrhythmias, with available 24-hour holter-ECG at 3- and/or 6 months follow-up. In total, 80 COPD patients were com... Abstract

Cited 5 times since 2020 (1.1 per year) source: EuropePMC

Injury, Volume 52, Issue 4, 31 5 2021, Pages 1002-1010 Measurement properties of Patient-Reported Outcome Measures in patients with a tibial shaft fracture; validation study alongside the multicenter TRAVEL study. Leliveld MS, Verhofstad MHJ, Van Lieshout EMM, TRAVEL Study Investigators

The aim of this study was to evaluate the measurement properties of the Short Musculoskeletal Function Assessment (SMFA) and Lower Extremity Functional Scale (LEFS) in patients who sustained a tibial shaft fracture, by comparing them with the scores of a general health-related quality of life instrument scale (i.e., EuroQoL-5D). Data of 136 patients participating in a multicenter randomized controlled trial comparing incisions for intramedullary nail entry in adults with a tibial shaft fracture... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 8, Issue 1, 29 5 2021, Pages 2 Malignant Arrhythmic Mitral Valve Prolapse: A Continuum of Clinical Challenges from Diagnosis to Risk Stratification and Patient Management. Yedidya I, van Wijngaarden AL, Ajmone Marsan N

Mitral valve prolapse (MVP) is a common valvular disease, which may remain a benign condition for a long period of time. However, some patients experience malignant ventricular arrhythmias and sudden cardiac death (SCD). It is still largely unknown how to risk-stratify these patients, and no specific recommendations have been proposed to help the clinical decision-making. We present the case of a young man whose first clinical presentation was an out-of-hospital cardiac arrest and was subsequent... Abstract

Cited 4 times since 2020 (0.8 per year) source: EuropePMC

Annals of vascular surgery, Volume 73, 28 4 2021, Pages 407-416 Nationwide Study to Predict Colonic Ischemia after Abdominal Aortic Aneurysm Repair in The Netherlands. Willemsen SI, Ten Berge MG, Statius van Eps RG, Veger HTC, van Overhagen H, van Dijk LC, Putter H, Wever JJ, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit and the Dutch Institute for Clinical Auditing

Background: Colonic ischemia remains a severe complication after abdominal aortic aneurysm (AAA) repair and is associated with a high mortality. With open repair being one of the main risk factors of colonic ischemia, deciding between endovascular or open aneurysm repair should be based on tailor-made medicine. This study aims to identify high-risk patients of colonic ischemia, a risk that can be taken into account while deciding on AAA treatment strategy. Methods: A nationwide population-based... Abstract

Cited 5 times since 2020 (1.1 per year) source: EuropePMC

Cell and tissue research, Volume 383, Issue 3, 28 4 2021, Pages 987-1002 Isthmin1, a secreted signaling protein, acts downstream of diverse embryonic patterning centers in development. Kesavan G, Raible F, Gupta M, Machate A, Yilmaz D, Brand M

Extracellular signals play essential roles during embryonic patterning by providing positional information in a concentration-dependent manner, and many such signals, like Wnt, fibroblast growth factor (FGF), Hedgehog (Hh), and retinoic acid, act by being secreted into the extracellular space, thereby triggering receptor-mediated responses in other cells. Isthmin1 (ism1) is a secreted protein whose gene expression pattern coincides with that of early dorsal determinants, nodal ligand genes like... Abstract

Cited 17 times since 2020 (3.6 per year) source: EuropePMC

International journal of molecular sciences, Volume 22, Issue 1, 24 4 2020, Pages E135 Circulating tRNA Fragments as a Novel Biomarker Class to Distinguish Acute Stroke Subtypes. Nguyen TTM, van der Bent ML, Wermer MJH, van den Wijngaard IR, van Zwet EW, de Groot B, Quax PHA, Kruyt ND, Nossent AY

: Early blood biomarkers to diagnose acute stroke could drastically reduce treatment delays. We investigated whether circulating small non-coding RNAs can serve as biomarkers to distinguish between acute ischemic stroke (IS), intracerebral hemorrhage (ICH) and stroke mimics (SM). In an ongoing observational cohort study, we performed small RNA-sequencing in plasma obtained from a discovery cohort of 26 patients (9 IS, 8 ICH and 9 SM) presented to the emergency department within 6 h of symptom on... Abstract

Cited 3 times since 2020 (0.6 per year) source: EuropePMC

EClinicalMedicine, Volume 31, 23 4 2020, Pages 100661 Continuous postoperative pericardial flushing reduces postoperative bleeding after coronary artery bypass grafting: A randomized trial. Diephuis EC, de Borgie CA, Zwinderman A, Winkelman JA, van Boven WP, Henriques JPS, Eberl S, Juffermans NP, Schultz MJ, Klautz RJM, Koolbergen DR

Background: Prolonged or excessive bleeding after cardiac surgery can lead to a broad spectrum of secondary complications. One of the underlying causes is incomplete wound drainage, with subsequent accumulation of blood and clots in the pericardium. We developed the continuous postoperative pericardial flushing (CPPF) therapy to improve wound drainage and reduce postoperative blood loss and bleeding-related complications after cardiac surgery. This study compared CPPF to standard care in patient... Abstract

European heart journal supplements : journal of the European Society of Cardiology, Volume 22, Issue Suppl Pt t, 23 4 2020, Pages P1-P3 Cardiovascular disease in the COVID-19 pandemic: risk and risk reduction. Bax JJ, Prendergast B, Leclercq C

Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 1, 15 3 2020, Pages 1-3 Percutaneous coronary intervention for chronic total coronary occlusion: Do. Or do not. There is no try. Knaapen P, Henriques JP, Nap A, Arslan F

Abstract

Cited 7 times since 2020 (1.5 per year) source: EuropePMC

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume 103, 14 2 2020, Pages 300-304 A high-throughput drug screening strategy against coronaviruses. Liu J, Li K, Cheng L, Shao J, Yang S, Zhang W, Zhou G, de Vries AAF, Yu Z

The emergence and re-emergence of coronaviruses (CoV) continually cause circulating epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. The resultant disease, coronavirus disease 2019 (COVID-19), has rapidly developed into a worldwide pandemic, leading to severe health and economic burdens. Although the recently announced vaccines against COVID-19 has rekindled hope, there is still a major challenge to urgently meet the global need for rapid trea... Abstract

Cited 6 times since 2020 (1.3 per year) source: Scopus

International journal of medical informatics, Volume 147, 13 2 2020, Pages 104364 A multi-stakeholder approach to eHealth development: Promoting sustained healthy living among cardiovascular patients. Breeman LD, Keesman M, Atsma DE, Chavannes NH, Janssen V, van Gemert-Pijnen L, Kemps H, Kraaij W, Rauwers F, Reijnders T, Scholte Op Reimer W, Wentzel J, Kraaijenhagen RA, Evers AWM, BENEFIT consortium

Background: Healthy living is key in the prevention and rehabilitation of cardiovascular disease (CVD). Yet, supporting and maintaining a healthy lifestyle is exceptionally difficult and people differ in their needs regarding optimal support for healthy lifestyle interventions. Objective: The goals of this study were threefold: to uncover stakeholders' needs and preferences, to translate these to core values, and develop eHealth technology based on these core values. Our primary research qu... Abstract

Trauma case reports, Volume 31, 11 2 2020, Pages 100379 A 'Final Destination injury': Penetrating trauma of the neck and a pneumomediastinum by a metal part shot from a lawnmower. Quax MLJ, Eefting D, Jansen JC, Blok JJ

Introduction: Outside of war regions, penetrating neck injury is rare. Penetrating neck injury due to a lawnmower has never been described, despite the annual 74.000 injuries caused by lawnmowers in the United States. In this report, the case of a 65-year old women, admitted after a penetrating neck injury due to a metal piece shot from a lawnmower, is described. Report: A 65-year old women, with no relevant medical history, presented at the Emergency Department after she was hit in the neck by... Abstract

Cited 76 times since 2020 (15.9 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 14, Issue 1, 9 2 2020, Pages e008509 Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration. Cadrin-Tourigny J, Bosman LP, Wang W, Tadros R, Bhonsale A, Bourfiss M, Lie ØH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE, Judge DP, Yap SC, Van der Heijden JF, Tandri H, Jongbloed JDH, van Tintelen JP, Platonov PG, Duru F, Haugaa KH, Khairy P, Hauer RNW, Calkins H, Te Riele ASJM, James CA

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients with ARVC. However, since this outcome may overestimate the risk for SCD, we aimed to specifically predict life-threatening VA (LTVA) as a closer surrogate for SCD. Methods: We assembled a retrospective cohort of definite ARVC cases from 15 centers in North America and Europe.... Abstract

Cited 133 times since 2020 (27.8 per year) source: EuropePMC

Nature communications, Volume 11, Issue 1, 8 2 2020, Pages 6285 Cerebral small vessel disease genomics and its implications across the lifespan. Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, Kumar RB, van den Akker EB, McWhirter RE, Trompet S, Mishra A, Saba Y, Satizabal CL, Beaudet G, Petit L, Tsuchida A, Zago L, Schilling S, Sigurdsson S, Gottesman RF, Lewis CE, Aggarwal NT, Lopez OL, Smith JA, Valdés Hernández MC, van der Grond J, Wright MJ, Knol MJ, Dörr M, Thomson RJ, Bordes C, Le Grand Q, Duperron MG, Smith AV, Knopman DS, Schreiner PJ, Evans DA, Rotter JI, Beiser AS, Maniega SM, Beekman M, Trollor J, Stott DJ, Vernooij MW, Wittfeld K, Niessen WJ, Soumaré A, Boerwinkle E, Sidney S, Turner ST, Davies G, Thalamuthu A, Völker U, van Buchem MA, Bryan RN, Dupuis J, Bastin ME, Ames D, Teumer A, Amouyel P, Kwok JB, Bülow R, Deary IJ, Schofield PR, Brodaty H, Jiang J, Tabara Y, Setoh K, Miyamoto S, Yoshida K, Nagata M, Kamatani Y, Matsuda F, Psaty BM, Bennett DA, De Jager PL, Mosley TH, Sachdev PS, Schmidt R, Warren HR, Evangelou E

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime imp... Abstract

Cited 17 times since 2020 (3.6 per year) source: EuropePMC

Cancer treatment and research communications, Volume 25, 8 2 2020, Pages 100266 Utilization of systemic treatment for metastatic bladder cancer in everyday practice: Results of a nation-wide population-based cohort study. Richters A, Mehra N, Meijer RP, Boormans JL, van der Heijden AG, Smilde TJ, van der Heijden MS, Kiemeney LA, Aben KK

Background: With the introduction of new therapeutic options, the landscape of metastatic bladder cancer (mBC) management is shifting. We describe current clinical practice and outcomes of mBC patients as a benchmark for translation of developments into clinical practice in the near future. Patients and methods: Nation-wide population-based cohort study including all patients diagnosed with synchronous metastatic bladder cancer in the Netherlands in 2016-2017, identified through the Netherlands... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

European heart journal. Case reports, Volume 4, Issue 6, 7 1 2020, Pages 1-5 To treat or not to treat: left ventricular thrombus in a patient with cerebral amyloid angiopathy: a case report. Hilt AD, Rasing I, Schalij MJ, Wermer MJH

Background: Cerebral amyloid angiopathy (CAA) is an important cause of cognitive impairment and spontaneous lobar intracerebral haemorrhage in older individuals. When necessary, anticoagulant treatment in these patients comes with two dilemmas; significant intracerebral bleeding risk with treatment vs. high risk of embolic stroke with no treatment. Case summary: A 66-year-old female patient presented to the emergency clinic with a ST-elevation myocardial infarction. Her past medical history reve... Abstract

Cited 13 times since 2020 (2.7 per year) source: EuropePMC

Cancer treatment and research communications, Volume 25, 4 1 2020, Pages 100264 Survival after radical cystectomy: Progressive versus De novo muscle invasive bladder cancer. Vlaming M, Kiemeney LALM, van der Heijden AG

Background: Despite treatment with radical cystectomy, patients with muscle invasive bladder cancer (MIBC) have a poor survival. It has been reported that survival is worse in NMIBC patients who progressed to MIBC in comparison to patients with de novo MIBC. The objective of this study was to compare survival of progressive versus de novo MIBC. Secondary objective was to explain this difference in survival by clinicopathological factors. Methods: 431 patients with MIBC who underwent radical cyst... Abstract

American journal of physiology. Heart and circulatory physiology, Volume 320, Issue 1, 4 1 2020, Pages H245-H247 A shock-free approach for ambulatory cardioversion in atrial fibrillation. De Coster T

Atrial fibrillation (AF), the most common persistent arrhythmia, is terminated most effectively by electrical cardioversion. This therapy requires in-hospital sedation to relieve the pain caused by electric shocks. Recently, our research group showed how the heart itself could be enabled to detect and terminate arrhythmias, including AF, thereby revealing the discovery of fully biological, shock-free cardioversion. Because of its biological nature, neither electric shocks nor hardware/software i... Abstract

Cited 5 times since 2020 (1 per year) source: EuropePMC

International journal of molecular sciences, Volume 21, Issue 23, 3 1 2020, Pages E9244 Assessment of Microvessel Permeability in Murine Atherosclerotic Vein Grafts Using Two-Photon Intravital Microscopy. Baganha F, Ritsma L, Quax PHA, de Vries MR

Plaque angiogenesis and plaque hemorrhage are major players in the destabilization and rupture of atherosclerotic lesions. As these are dynamic processes, imaging of plaque angiogenesis, especially the integrity or leakiness of angiogenic vessels, can be an extremely useful tool in the studies on atherosclerosis pathophysiology. Visualizing plaque microvessels in 3D would enable us to study the architecture and permeability of adventitial and intimal plaque microvessels in advanced atherosclerot... Abstract