Research

Publications

Below you can find a list of our published research.

6177 results

Cited 6 times since 2024 (6.4 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 17, Issue 9, 15 3 2024, Pages 1062-1076 Artificial Intelligence-Enabled Quantitative Coronary Plaque and Hemodynamic Analysis for Predicting Acute Coronary Syndrome. Koo BK, Yang S, Jung JW, Zhang J, Lee K, Hwang D, Lee KS, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Bax JJ, Shaw LJ, Stone PH, Narula J

Background: A lesion-level risk prediction for acute coronary syndrome (ACS) needs better characterization. Objectives: This study sought to investigate the additive value of artificial intelligence-enabled quantitative coronary plaque and hemodynamic analysis (AI-QCPHA). Methods: Among ACS patients who underwent coronary computed tomography angiography (CTA) from 1 month to 3 years before the ACS event, culprit and nonculprit lesions on coronary CTA were adjudicated based on invasive coronary a... Abstract

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, Volume 67, Issue 7, 14 2 2024, Pages 1623-1634 Validation of a prediction model for early reconnection after cryoballoon ablation. van Waaij K, Keçe F, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Piers SRD, Mertens BJ, Zeppenfeld K, Trines SA

Background: We previously developed an early reconnection/dormant conduction (ERC) prediction model for cryoballoon ablation to avoid a 30-min waiting period with adenosine infusion. We now aimed to validate this model based on time to isolation, number of unsuccessful cryo-applications, and nadir balloon temperature. Methods: Consecutive atrial fibrillation patients who underwent their first cryoballoon ablation in 2018-2019 at the Leiden University Medical Center were included. Model performan... Abstract

Cited 4 times since 2024 (4.2 per year) source: EuropePMC

Frontiers in immunology, Volume 15, 13 2 2024, Pages 1327051 CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization. Singh A, Kraaijeveld AO, Curaj A, Wichapong K, Hammerich L, de Jager SCA, Bot I, Atamas SP, van Berkel TJC, Jukema JW, Comerford I, McColl SR, Mees B, Heemskerk JWM, Nicolaes GAF, Hackeng T, Liehn EA, Tacke F, Biessen EAL

Introduction: The CC chemokine ligand 18 (CCL18) is a chemokine highly expressed in chronic inflammation in humans. Recent observations of elevated CCL18 plasma levels in patients with acute cardiovascular syndromes prompted an investigation into the role of CCL18 in the pathogenesis of human and mouse atherosclerosis. Methods and results: CCL18 was profoundly upregulated in ruptured human atherosclerotic plaque, particularly within macrophages. Repeated administration of CCL18 in Western-type d... Abstract

The American journal of cardiology, Volume 222, 8 2 2024, Pages 78-86 Significant Mitral Regurgitation After Permanent Right Ventricular Pacemaker Implantation: Prognostic Implications. Nabeta T, Galloo X, Tops L, Stassen J, Marsan NA, van der Bijl P, Bax JJ

The underlying mechanisms leading to the development of mitral regurgitation (MR) after right ventricular (RV) pacemaker (PM) implantation and its prognostic value have yet to be fully understood. The purpose of this study was to evaluate the prevalence and clinical variables associated with the development of MR after RV pacing and its association with outcomes. A total of 451 patients (mean age 69 ± 15 years, 61% male) who underwent de novo RV PM implantation were included. The development of... Abstract

Research and practice in thrombosis and haemostasis, Volume 8, Issue 4, 6 1 2024, Pages 102437 Performance of risk scores in predicting major bleeding in left ventricular assist device recipients: a comparative external validation. van der Horst SFB, de Jong Y, van Rein N, Jukema JW, Palmen M, Janssen E, Bonneville EF, Klok FA, Huisman MV, Tops LF, den Exter PL

Background: Implantation of a left ventricular assist device (LVAD) is a crucial therapeutic option for selected end-stage heart failure patients. However, major bleeding (MB) complications postimplantation are a significant concern. Objectives: We evaluated current risk scores' predictive accuracy for MB in LVAD recipients. Methods: We conducted an observational, single-center study of LVAD recipients (HeartWare or HeartMate-3, November 2010-December 2022) in the Netherlands. The primary o... Abstract

Trials, Volume 25, Issue 1, 6 1 2024, Pages 303 Refraining from closed reduction of displaced distal radius fractures in the emergency department-in short: the RECORDED trial. Derksen BM, Jawahier PA, Wijers O, Knops SP, de Vries MR, van Hooff CCD, Verhofstad MHJ, Schep NWL

Background: With roughly 45,000 adult patients each year, distal radius fractures are one of the most common fractures in the emergency department. Approximately 60% of all these fractures are displaced and require surgery. The current guidelines advise to perform closed reduction of these fractures awaiting surgery, as it may lead to post-reduction pain relief and release tension of the surrounding neurovascular structures. Recent studies have shown that successful reduction does not warrant co... Abstract

International journal of cardiology. Heart & vasculature, Volume 52, 2 1 2024, Pages 101418 Coronary calcifications as assessed on routine non-gated chest CT; a gatekeeper to tailor downstream additional imaging in patients with stable chest pain. Groen RA, van Dijkman PRM, Jukema JW, Bax JJ, Lamb HJ, de Graaf MA

Background and aims: Currently applied methods for risk-assessment in coronary artery disease (CAD) often overestimate patients' risk for obstructive CAD. To enhance risk estimation, assessment of coronary artery calcium (CAC) can be applied. In 10 % of patients presenting with stable chest pain a previous non-gated computed tomography (CT) has been performed, suitable for CAC-assessment. This study is the first to investigate the clinical utility of CAC-assessment on non-gated CT for risk-... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 17, Issue 10, 1 1 2024, Pages 1229-1245 Mitral Annular Disjunction in the Context of Mitral Valve Prolapse: Identifying the At-Risk Patient. Van der Bijl P, Stassen J, Haugaa KH, Essayagh B, Basso C, Thiene G, Faletra FF, Edvardsen T, Enriquez-Sarano M, Nihoyannopoulos P, Ajmone Marsan N, Chandrashekhar YS, Bax JJ

Mitral annular disjunction (MAD), a separation between the left atrium/mitral valve annulus and the left ventricular myocardium, is frequently seen in patients with arrhythmic mitral valve prolapse. Although an association exists between MAD and ventricular arrhythmias, little is known regarding the identification of individuals at high risk. Multimodality imaging including echocardiography, computed tomography, cardiac magnetic resonance, and positron emission tomography can play an important r... Abstract

Medicine, Volume 103, Issue 22, 1 1 2024, Pages e38359 All-cause mortality and related factors in patients with varying degrees of peripheral blood eosinophilia. Yilmaz D, Sahin E

The aim of this study was to investigate all-cause mortality rates and related factors in patients with different levels of eosinophilia. This retrospective cohort study was conducted between January 2020 and December 2022 in the Internal Medicine Department of Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkiye. A total of 161 patients with eosinophilia (at least 3 times) were included and divided into groups with absolute eosinophil counts of 500-999/µL (mild), 1000-1500/µL (modera... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 65, Issue 5, 1 1 2024, Pages ezae157 Glenn shunt as a rescue strategy for acute right ventricular failure after right ventricular myocardial infarction. den Haan MC, Palmen M, Egorova AD, Hazekamp MG

We present the case of a 52-year-old woman with cardiogenic shock and refractory right ventricular failure due to spontaneous dissection of the right coronary artery. She remained dependent on mechanical support for several weeks. Both a right ventricular assist device implant and a bidirectional cavopulmonary anastomosis were explored as long-term support options. A history of malignancy and possible right ventricular functional recovery resulted in a decision in favour of the bidirectional cav... Abstract

Cited 14 times since 2024 (14.3 per year) source: EuropePMC

European heart journal, Volume 45, Issue 20, 1 1 2024, Pages 1783-1800 Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography. Nurmohamed NS, van Rosendael AR, Danad I, Ngo-Metzger Q, Taub PR, Ray KK, Figtree G, Bonaca MP, Hsia J, Rodriguez F, Sandhu AT, Nieman K, Earls JP, Hoffmann U, Bax JJ, Min JK, Maron DJ, Bhatt DL

Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual's complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and charac... Abstract

European heart journal, Volume 45, Issue 20, 1 1 2024, Pages 1840-1842 Arrhythmic risk in young women with mitral valve prolapse: keep your eyes open but don't jump at every shadow. Zeppenfeld K, de Riva M

Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

Blood, Volume 143, Issue 18, 1 1 2024, Pages 1845-1855 A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels. de Vries PS, Reventun P, Brown MR, Heath AS, Huffman JE, Le NQ, Bebo A, Brody JA, Temprano-Sagrera G, Raffield LM, Ozel AB, Thibord F, Jain D, Lewis JP, Rodriguez BAT, Pankratz N, Taylor KD, Taylor KD, Polasek O, Chen MH, Yanek LR, Carrasquilla GD, Marioni RE, Kleber ME, Trégouët DA, Yao J, Li-Gao R, Joshi PK, Trompet S, Martinez-Perez A, Ghanbari M, Howard TE, Reiner AP, Arvanitis M, Ryan KA, Bartz TM, Rudan I, Faraday N, Linneberg A, Ekunwe L, Davies G, Delgado GE, Suchon P, Guo X, Rosendaal FR, Klaric L, Noordam R, van Rooij F, Curran JE, Wheeler MM, Osburn WO, O'Connell JR, Boerwinkle E, Beswick A, Psaty BM, Kolcic I, Souto JC, Becker LC, Hansen T, Doyle MF, Harris SE, Moissl AP, Deleuze JF, Rich SS, van Hylckama Vlieg A, Campbell H, Stott DJ, Soria JM, de Maat MPM, Almasy L, Brody LC, Auer PL, Mitchell BD, Ben-Shlomo Y, Fornage M, Hayward C, Mathias RA, Kilpeläinen TO, Lange LA, Cox SR, März W, Morange PE, Rotter JI, Mook-Kanamori DO, Wilson JF, van der Harst P, Jukema JW, Ikram MA, Blangero J, Kooperber

Abstract: Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine (TOPMed) program along with TOPMed-based imputation of genotypes in additional samples to identify genetic associations with circulating FVIII and VWF levels in a single-variant meta-analysis, including up to 45 289 participants. Gene-based aggregate tests were implem... Abstract

Cited 9 times since 2024 (9.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 26, Issue 5, 1 1 2024, Pages euae108 Pre- and post-procedural cardiac imaging (computed tomography and magnetic resonance imaging) in electrophysiology: a clinical consensus statement of the European Heart Rhythm Association and European Association of Cardiovascular Imaging of the European Society of Cardiology. Deneke T, Kutyifa V, Hindricks G, Sommer P, Zeppenfeld K, Zeppenfeld K, Carbucicchio C, Pürerfellner H, Heinzel FR, Traykov VB, De Riva M, Pontone G, Lehmkuhl L, Haugaa K, Sarkozy A, Gimelli A, Tondo C, Ernst S, Antz M, Westwood M

Imaging using cardiac computed tomography (CT) or magnetic resonance (MR) imaging has become an important option for anatomic and substrate delineation in complex atrial fibrillation (AF) and ventricular tachycardia (VT) ablation procedures. Computed tomography more common than MR has been used to detect procedure-associated complications such as oesophageal, cerebral, and vascular injury. This clinical consensus statement summarizes the current knowledge of CT and MR to facilitate electrophysio... Abstract

Cited 2 times since 2024 (2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 25, Issue 6, 1 1 2024, Pages 764-770 Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause? Verheul LM, Guglielmo M, Groeneveld SA, Kirkels FP, Scrocco C, Cramer MJ, Bootsma M, Kapel GFL, Alings M, Evertz R, Mulder BA, Prakken NHJ, Balt JC, Volders PGA, Hirsch A, Yap SC, Postema PG, Nijveldt R, Velthuis BK, Behr ER, Wilde AAM, Hassink RJ

Aims: Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort. Methods and results: This retrospective multi-centre study included 185 IVF patients [median age 39 (27, 52) years, 40% female]. Cardiac magnetic resonance ima... Abstract

Cited 3 times since 2024 (3.1 per year) source: EuropePMC

European heart journal, Volume 45, Issue 20, 1 1 2024, Pages 1831-1839 Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum. Sabbag A, Aabel EW, Castrini AI, Siontis KC, Laredo M, Nizard J, Duthoit G, Asirvatham S, Sehrawat O, Kirkels FP, van Rosendael PJ, Beinart R, Acha MR, Peichl P, Lim HS, Sohns C, Martins R, Font J, Truong NNK, Estensen M, Haugaa KH

Background and aims: Arrhythmic mitral valve prolapse (AMVP) is linked to life-threatening ventricular arrhythmias (VAs), and young women are considered at high risk. Cases of AMVP in women with malignant VA during pregnancy have emerged, but the arrhythmic risk during pregnancy is unknown. The authors aimed to describe features of women with high-risk AMVP who developed malignant VA during the perinatal period and to assess if pregnancy and the postpartum period were associated with a higher ri... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 25, Issue 6, 1 1 2024, Pages 727-734 EACVI survey on radiation exposure in interventional echocardiography. Galli E, Soliman-Aboumarie H, Gargani L, Szymański P, Gimelli A, Petersen SE, Sade LE, Stankovic I, Donal E, Cosyns B, Agricola E, Dweck MR, Ajmone Marsan N, Delgado V, Muraru D

Aims: The European Association of Cardiovascular Imaging (EACVI) Scientific Initiatives Committee performed a global survey on radiation exposure in interventional echocardiography. The survey aimed to collect data on local practices for radioprotection in interventional echocardiography and to assess the awareness of echocardiography operators about radiation-related risks. Methods and results: A total of 258 interventional echocardiographers from 52 different countries (48% European) responded... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, Volume 26, Issue 6, 30 5 2024, Pages 1239-1249 Dissecting the surgeon's personality: cross-cultural comparisons in Western Europe. Sier VQ, Bisset CN, Tesselaar DAJ, Schmitz RF, Schepers A, Moug SJ, van der Vorst JR, SUPER and Plato Project Collaborators

Aim: The surgeon's personality contributes to variation in surgical decision-making. Previous work on surgeon personality has largely been reserved to Anglo-Saxon studies, with limited international comparisons. In this work we built upon recent work on gastrointestinal surgeon personality and aimed to detect international variations. Method: Gastrointestinal surgeons from the UK and the Netherlands were invited to participate in validated personality assessments (44-item, 60-item Big Five... Abstract

Cited 33 times since 2024 (33.6 per year) source: EuropePMC

Nature genetics, Volume 56, Issue 5, 30 5 2024, Pages 778-791 Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E, Hellwege JN, Yengo L, Young WJ, Traylor M, Giri A, Zheng Z, Zeng J, Chasman DI, Morris AP, Caulfield MJ, Hwang SJ, Kooner JS, Conen D, Attia JR, Morrison AC, Loos RJF, Kristiansson K, Schmidt R, Hicks AA, Pramstaller PP, Nelson CP, Samani NJ, Risch L, Gyllensten U, Melander O, Riese H, Wilson JF, Campbell H, Rich SS, Psaty BM, Lu Y, Rotter JI, Guo X, Rice KM, Vollenweider P, Sundström J, Langenberg C, Tobin MD, Giedraitis V, Luan J, Tuomilehto J, Kutalik Z, Ripatti S, Salomaa V, Girotto G, Trompet S, Jukema JW, van der Harst P, Ridker PM, Giulianini F, Vitart V, Goel A, Watkins H, Harris SE, Deary IJ, van der Most PJ, Oldehinkel AJ, Keavney BD, Hayward C, Campbell A, Boehnke M, Scott LJ, Boutin T, Mamasoula C, Järvelin MR, Peters A, Gieger C, Lakatta EG, Cucca F, Hui J, Knekt P, Enroth S, De Borst MH, Polašek O, Concas MP, Catamo E, Cocca M, Li-Gao R, Hofer E, Schmidt H, Spedicati B, Waldenberger M, Strachan DP, Laan M, Teumer A, D

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P Abstract

Cited 3 times since 2024 (3 per year) source: EuropePMC

Journal of cardiovascular medicine (Hagerstown, Md.), Volume 25, Issue 6, 26 4 2024, Pages 438-449 Coronary calcified nodules versus nonnodular coronary calcifications: a systematic review and meta-analysis. Oliveri F, Van Oort MJH, Al Amri I, Bingen BO, Van der Kley F, Jukema JW, Jurado-Roman A, Montero Cabezas J

Background: Percutaneous coronary intervention (PCI) on severely calcified coronary lesions is challenging. Coronary calcified nodule (CN) refers to an eccentric and protruding coronary calcification associated with plaque vulnerability and adverse clinical events. This study aims to conduct an extensive review of CNs, focusing on its prognostic impact in comparison with nonnodular coronary calcification (N-CN). Method: A systematic literature review on PubMed, MEDLINE, and EMBASE databases was... Abstract