6136 results
Cited 30 times since 2012 (2.4 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 16, Issue 10, 1 1 2012, Pages 2440-2450
Shear induced collateral artery growth modulated by endoglin but not by ALK1.
Seghers L, de Vries MR, Pardali E, Hoefer IE, Hierck BP, ten Dijke P, Goumans MJ, Quax PH
Transforming growth factor-beta (TGF-β) stimulates both ischaemia induced angiogenesis and shear stress induced arteriogenesis by signalling through different receptors. How these receptors are involved in both these processes of blood flow recovery is not entirely clear. In this study the role of TGF-β receptors 1 and endoglin is assessed in neovascularization in mice. Unilateral femoral artery ligation was performed in mice heterozygous for either endoglin or ALK1 and in littermate controls. C...
Abstract
Cited 5 times since 2012 (0.4 per year)
source: EuropePMC
Lancet (London, England),
Volume 380, Issue 9852, 1 1 2012, Pages 1471-1472
Hypertension in developing countries.
Koopman JJ, van Bodegom D, Beenakker KG, Jukema JW, Westendorp RG
Abstract
Cited 16 times since 2012 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 98, Issue 20, 1 1 2012, Pages 1529-1536
Late acquired stent malapposition: why, when and how to handle?
Karalis I, Ahmed TA, Jukema JW
Abstract
Cited 15 times since 2012 (1.2 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 29, Issue 3, 28 4 2012, Pages 609-616
Relationship between left ventricular diastolic function and arterial stiffness in asymptomatic patients with diabetes mellitus.
Roos CJ, Auger D, Djaberi R, de Koning EJ, Rabelink TJ, Pereira AM, Bax JJ, Delgado V, Jukema JW, Scholte AJ
Left ventricular (LV) diastolic dysfunction and increased arterial stiffness are common in patients with diabetes mellitus (DM). However, the relation between these two pathophysiological factors remains unclear. The aim of this study was to investigate the relationship between LV diastolic function and arterial stiffness as assessed with applanation tonometry. In 142 asymptomatic patients with DM (mean age 48 years, 75 (53 %) men, 72 (51 %) patients with type 2 DM) LV diastolic function was ass...
Abstract
Cited 148 times since 2012 (11.9 per year)
source: Scopus
European journal of preventive cardiology,
Volume 20, Issue 4, 28 4 2012, Pages 620-640
Lifestyle modification programmes for patients with coronary heart disease: a systematic review and meta-analysis of randomized controlled trials.
Janssen V, De Gucht V, Dusseldorp E, Maes S
Background: Lifestyle modification programmes for coronary heart disease patients have been shown to effectively improve risk factors and related health behaviours, quality of life, reincidence, and mortality. However, improvements in routine cardiac care over the recent years may offset the incremental benefit associated with older programmes. Purpose: To determine the efficacy of lifestyle modification programmes for coronary heart disease patients developed over the last decade (1999-2009) by...
Abstract
Cited 29 times since 2012 (2.3 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 15, Issue 2, 28 4 2012, Pages 290-296
Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients.
de Bie MK, Koopman MG, Gaasbeek A, Dekker FW, Maan AC, Swenne CA, Scherptong RW, van Dessel PF, Wilde AA, Schalij MJ, Rabelink TJ, Jukema JW
Aims: In order to improve the abysmal outcome of dialysis patients, it is critical to identify patients with a high mortality risk. The spatial QRS-T angle, which can be easily calculated from the 12 lead electrocardiogram (ECG), might be useful in the prognostication in dialysis patients. The objective of this study was to establish the prognostic value of the spatial QRS-T angle. Methods and results: All patients who initiated dialysis therapy between 2002 and 2009 in the hospitals of Leiden (...
Abstract
Cited 2 times since 2012 (0.2 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 29, Issue 2, 22 4 2012, Pages 453-461
Effect of dose reduction on image quality and diagnostic performance in coronary computed tomography angiography.
van der Bijl N, Joemai RM, Mertens BJ, de Roos A, Veldkamp WJ, Bax JJ, Schuijf JD, Geleijns J, Kroft LJ
To evaluate the effect of radiation dose reduction on image quality and diagnostic accuracy of coronary computed tomography (CT) angiography. Coronary CT angiography studies of 40 patients with (n = 20) and without (n = 20) significant (≥50 %) stenosis were included (26 male, 14 female, 57 ± 11 years). In addition to the original clinical reconstruction (100 % dose), simulated images were created that correspond to 50, 25 and 12.5 % of the original dose. Image quality and diagnostic performance...
Abstract
Cited 14 times since 2012 (1.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 29, Issue 3, 22 4 2012, Pages 633-641
Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis.
van Schinkel LD, Auger D, van Elderen SG, Ajmone Marsan N, Delgado V, Lamb HJ, Ng AC, Smit JW, Bax JJ, Westenberg JJ, de Roos A
Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle t...
Abstract
Cited 17 times since 2012 (1.4 per year)
source: EuropePMC
Pediatric cardiology,
Volume 34, Issue 3, 22 4 2012, Pages 630-638
Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery.
Klitsie LM, Hazekamp MG, Roest AA, Van der Hulst AE, Gesink-van der Veer BJ, Kuipers IM, Blom NA, Ten Harkel AD
Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response, which can lead to myocardial damage. However, knowledge concerning the time course of ventricular performance deterioration and restoration after correction of a congenital heart defect (CHD) in pediatric patients is sparse. Therefore, the authors perioperatively quantified left ventricular (LV) and right ventricular (RV) performance using echocardiography. Their study included 141...
Abstract
Cited 26 times since 2012 (2.1 per year)
source: EuropePMC
International journal of cardiology,
Volume 167, Issue 6, 20 3 2012, Pages 2977-2982
MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome.
Kröner ES, Scholte AJ, de Koning PJ, van den Boogaard PJ, Kroft LJ, van der Geest RJ, Hilhorst-Hofstee Y, Lamb HJ, Siebelink HM, Mulder BJ, Groenink M, Radonic T, van der Wall EE, de Roos A, Reiber JH, Westenberg JJ
Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional...
Abstract
Cited 19 times since 2012 (1.5 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 94, Issue 6, 13 2 2012, Pages 2077-2082
Mild residual pulmonary stenosis in tetralogy of fallot reduces risk of pulmonary valve replacement.
van der Hulst AE, Hylkema MG, Vliegen HW, Delgado V, Hazekamp MG, Rijlaarsdam ME, Holman ER, Blom NA, Roest AA
Background: Current surgical strategies that aim at preventing pulmonary regurgitation in patients with corrected tetralogy of Fallot (cToF) may result in a certain grade of residual pulmonary stenosis (PS). The clinical implications of a postoperative residual PS in cToF patients remain unclear. Pulmonary valve replacement (PVR) is frequently needed during follow-up of cToF patients. The aim of the current study was to determine the role of residual PS in the need for PVR during follow-up in cT...
Abstract
Cited 12 times since 2012 (1 per year)
source: EuropePMC
Cardiovascular research,
Volume 97, Issue 1, 12 2 2012, Pages 171-181
Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms.
Askar SF, Bingen BO, Schalij MJ, Swildens J, Atsma DE, Schutte CI, de Vries AA, Zeppenfeld K, Ypey DL, Pijnappels DA
Aims: Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models. Methods and results: Fibrosis was mi...
Abstract
Cited 17 times since 2012 (1.4 per year)
source: EuropePMC
Cardiovascular research,
Volume 97, Issue 1, 12 2 2012, Pages 161-170
Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization.
Bingen BO, Askar SF, Schalij MJ, Kazbanov IV, Ypey DL, Panfilov AV, Pijnappels DA
Aims: Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysiological parameters, allowing a search for novel factors and underlying mechanisms affecting stability...
Abstract
Cited 53 times since 2012 (4.2 per year)
source: EuropePMC
Human molecular genetics,
Volume 21, Issue 24, 8 2 2012, Pages 5329-5343
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, WTCCC2, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that ar...
Abstract
Cited 54 times since 2012 (4.3 per year)
source: EuropePMC
PLoS pathogens,
Volume 8, Issue 9, 6 1 2012, Pages e1002908
Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection.
Marcinowski L, Lidschreiber M, Windhager L, Rieder M, Bosse JB, Rädle B, Bonfert T, Györy I, de Graaf M, Prazeres da Costa O, Rosenstiel P, Friedel CC, Zimmer R, Ruzsics Z, Dölken L
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real-time kinetics of cellular and viral transcriptional activity during lytic murine cytomegalovirus (MCMV) infection. Microarray profiling on newly transcribed RNA obtained at different times during the first six hours of MCMV infection revealed discr...
Abstract
Cited 1385 times since 2012 (110.7 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 60, Issue 16, 5 1 2012, Pages 1581-1598
Third universal definition of myocardial infarction.
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Joint ESC/ACCF/AHA/WHF Task Force for Universal Definition of Myocardial Infarction, Authors/Task Force Members Chairpersons, Thygesen K, Alpert JS, White HD, Biomarker Subcommittee, Jaffe AS, Katus HA, Apple FS, Lindahl B, Morrow DA, ECG Subcommittee, Chaitman BR, Clemmensen PM, Johanson P, Hod H, Imaging Subcommittee, Underwood R, Bax JJ, Bonow JJ, Pinto F, Gibbons RJ, Classification Subcommittee, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Intervention Subcommittee, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasche P, Ravkilde J, Trials & Registries Subcommittee, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Trials & Registries Subcommittee, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Trials & Registries Subcommittee, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Trials & Registries Subcommittee, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Me
Abstract
Cited 23 times since 2012 (1.8 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 21, Issue 4, 5 1 2012, Pages 469-470
High prevalence of occult paragangliomas in asymptomatic carriers of SDHD and SDHB gene mutations.
Heesterman BL, Bayley JP, Tops CM, Hes FJ, van Brussel BT, Corssmit EP, Hamming JF, van der Mey AG, Jansen JC
Hereditary paraganglioma is a benign tumor syndrome with an age-dependent penetrance. Carriers of germline mutations in the SDHB or SDHD genes may develop parasympathetic paragangliomas in the head and neck region or sympathetic catecholamine-secreting abdominal and thoracic paragangliomas (pheochromocytomas). In this study, we aimed to establish paraganglioma risk in 101 asymptomatic germline mutation carriers and evaluate the results of our surveillance regimen. Asymptomatic carriers of an SDH...
Abstract
Cited 23 times since 2012 (1.8 per year)
source: EuropePMC
Rhinology,
Volume 50, Issue 3, 1 1 2012, Pages 255-261
Quality of life in extended endonasal approaches for skull base tumours.
Georgalas C, Badloe R, van Furth W, Reinartz S, Fokkens WJ
Objective: To assess the quality of life (QOL) impact of extended endonasal approaches and nasoseptal flap reconstruction for benign skull base tumours Methods: A random sample of 110 patients undergoing either limited endonasal transphenoidal hypophysectomy or extended endonasal approaches (trans-cribriform, trans-sellar, trans-tuberculum, trans-pterygoid) for the removal of benign skull base tumours were asked to complete Rhinosinusitis Outcome Measure (RSOM-31) questionnaire. Results: A total...
Abstract
Cited 2 times since 2012 (0.2 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 8 Suppl Q, 1 1 2012, Pages Q21-30
Imaging and quantification of aortic regurgitation after TAVI.
Ewe SH, Delgado V, Bax JJ
During the last decade, transcatheter aortic valve implantation (TAVI) techniques have evolved rapidly providing several systems that conform to a broad spectrum of aortic valve annulus sizes, developing new delivery systems that provide an alternative to patients with difficult vascular access and permitting more controlled and accurate prosthesis deployment that result in improved procedural outcomes. However, residual aortic regurgitation (AR) (paravalvular or transvalvular) remains a recurre...
Abstract
Cited 12 times since 2012 (1 per year)
source: EuropePMC
Current opinion in cardiology,
Volume 27, Issue 5, 1 1 2012, Pages 455-464
Contemporary imaging of normal mitral valve anatomy and function.
Debonnaire P, Palmen M, Marsan NA, Delgado V
Purpose of review: Mitral valve disease is highly prevalent. Accurate characterization of normal anatomy and function of the mitral valve is crucial to understand the pathophysiology of mitral valve disease. This review summarizes recent advances in noninvasive cardiac imaging to assess normal mitral valve anatomy and function and provides an overview of the clinical applications of these novel imaging techniques in the evaluation of patients with mitral valve disease. Recent findings: Echocardi...
Abstract
