6131 results
Cited 26 times since 2012 (2 per year)
source: EuropePMC
Pharmacogenomics,
Volume 13, Issue 7, 1 1 2012, Pages 831-840
Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives.
Postmus I, Verschuren JJ, de Craen AJ, Slagboom PE, Westendorp RG, Jukema JW, Trompet S
Statins are the most commonly prescribed class of drug worldwide and therapy is highly effective in reducing low-density lipoprotein cholesterol levels and cardiovascular events. However, there is large variability in clinical response to statin treatment. Recent research provides evidence that genetic variation contributes to this variable response to statin treatment. Until recently, pharmacogenetic studies have used mainly candidate gene approaches to investigate these effects. Since candidat...
Abstract
Cited 26 times since 2012 (2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 98, Issue 9, 1 1 2012, Pages 743-754
Transcatheter aortic valve implantation: implications of multimodality imaging in patient selection, procedural guidance, and outcomes.
Delgado V, Kapadia S, Schalij MJ, Schuijf JD, Tuzcu EM, Bax JJ
Abstract
Cited 1 times since 2012 (0.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 5, 1 1 2012, Pages 240-244
Einthoven dissertation prizes 2011.
van der Wall EE, Schalij MJ, Umans V, van Gilst WH
Abstract
Journal of the American College of Cardiology,
Volume 59, Issue 21, 1 1 2012, Pages e41
Quadruple valve replacement: visualization with 256-slice computed tomography.
Symersky P, Budde RP, Koolbergen DR, de Mol BA
Abstract
Cited 10 times since 2012 (0.8 per year)
source: Scopus
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 5, 1 1 2012, Pages 202-207
Preexisting heart failure is an underestimated risk factor in cardiac surgery.
Kortekaas KA, Lindeman JH, Versteegh MI, Stijnen T, Dion RA, Klautz RJ
Background: Heart failure is characterised as a strong risk factor for systemic failure after cardiac surgery. However, the impact has never been substantiated. Methods: Patients with heart failure (n = 48) - scheduled for elective ventricular reconstruction or external constraint device-were compared with a one-to-one matched control group of patients without heart failure undergoing cardiac surgery between 2006 and 2009. Results: As expected, patients with heart failure more frequently experie...
Abstract
Cited 34 times since 2012 (2.6 per year)
source: EuropePMC
Archives of orthopaedic and trauma surgery,
Volume 132, Issue 8, 24 4 2012, Pages 1191-1197
Contralateral hip fractures and other osteoporosis-related fractures in hip fracture patients: incidence and risk factors. An observational cohort study of 1,229 patients.
Vochteloo AJ, Borger van der Burg BL, Röling MA, van Leeuwen DH, van den Berg P, Niggebrugge AH, de Vries MR, Tuinebreijer WE, Bloem RM, Nelissen RG, Pilot P
Purpose: To report risk factors, 1-year and overall risk for a contralateral hip and other osteoporosis-related fractures in a hip fracture population. Methods: An observational study on 1,229 consecutive patients of 50 years and older, who sustained a hip fracture between January 2005 and June 2009. Fractures were scored retrospectively for 2005-2008 and prospectively for 2008-2009. Rates of a contralateral hip and other osteoporosis-related fractures were compared between patients with and wit...
Abstract
Cited 14 times since 2012 (1.1 per year)
source: EuropePMC
International journal of cardiology,
Volume 167, Issue 4, 23 4 2012, Pages 1305-1310
Does left ventricular size impact on intrinsic right ventricular function in hypoplastic left heart syndrome?
Schlangen J, Fischer G, Steendijk P, Petko C, Scheewe J, Hart C, Hansen JH, Ahrend F, Rickers C, Kramer HH, Uebing A
Background: The size of the remnant left ventricle (LV) may influence right ventricular function and thus long-term outcome in palliated hypoplastic left heart syndrome (HLHS). We therefore sought to assess the impact of the size of the hypoplastic LV on intrinsic RV function in HLHS patients after Fontan surgery. Methods: Fifty-seven HLHS patients were studied 2.5 (range: 0.8-12.6) years after Fontan-type palliation with the pressure-volume conductance system. The patient cohort was divided int...
Abstract
Cited 18 times since 2012 (1.4 per year)
source: EuropePMC
Heart rhythm,
Volume 9, Issue 10, 20 3 2012, Pages 1605-1612
The mode of death in implantable cardioverter-defibrillator and cardiac resynchronization therapy with defibrillator patients: results from routine clinical practice.
Thijssen J, van Rees JB, Venlet J, Borleffs CJ, Höke U, Putter H, van der Velde ET, van Erven L, Schalij MJ
Background: Although data on the mode of death of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy with defibrillator (CRT-D) patients have been examined in randomized clinical trials, in routine clinical practice data are scarce. To provide reasonable expectations and prognosis for patients and physicians, this study assessed the mode of death in routine clinical practice. Objective: To assess the mode of death in ICD/CRT-D recipients in routine clinical practi...
Abstract
Interactive cardiovascular and thoracic surgery,
Volume 15, Issue 1, 19 3 2012, Pages 10-13
Surgical left ventricular radius enlargement by patch insertion on the beating heart: a new experimental aneurysm model.
Gründeman PF, van der Spoel TI, Steendijk P, van Slochteren F, Cramer MJ, Doevendans PA, Pasterkamp G
We presented a novel experimental aneurysm model for studies in left ventricular (LV) reconstruction techniques and assessed LV function. In eight pigs, the LV radius and geometry were enlarged surgically on the beating heart by inserting an aortic allograft construct. Haemodynamics and LV dimensions were assessed by echocardiography at baseline and under dobutamine stress. Surgery was successfully performed without lethal blood loss or arrhythmias. LV end-diastolic and end-systolic short-axis a...
Abstract
Cited 1 times since 2012 (0.1 per year)
source: EuropePMC
Congestive heart failure (Greenwich, Conn.),
Volume 18, Issue 4, 18 3 2012, Pages 198-204
Prognostic implications of left ventricular dilation in patients with nonischemic heart failure: interactions with restrictive filling pattern and mitral regurgitation.
Ghio S, Temporelli PL, Marsan NA, Poppe K, Giannuzzi P, Dini FL, Rossi A, Doughty RN, Whalley G, MeRGE HF collaborators
The aim of this study was to evaluate whether small left ventricular (LV) volumes increase the negative prognostic impact of a restrictive filling pattern (RFP) and that of mitral regurgitation (MR) in patients with nonischemic heart failure (HF). The Meta-analysis Research Group in Echocardiography (MeRGE) is a meta-analysis that collated individual patient data from several prospective echocardiography outcome studies. This analysis was restricted to 10 studies and 601 patients with nonischemi...
Abstract
Cited 14 times since 2012 (1.1 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 25, Issue 6, 17 3 2012, Pages 674-681
Right ventricular longitudinal peak systolic strain measurements from the subcostal view in patients with suspected pulmonary hypertension: a feasibility study.
Haeck ML, Scherptong RW, Antoni ML, Marsan NA, Vliegen HW, Holman ER, Schalij MJ, Bax JJ, Delgado V
Background: The assessment of right ventricular (RV) function with two-dimensional echocardiography can be challenging in patients with pulmonary hypertension, especially in those with chronic pulmonary disease. The aim of the present study was to evaluate the feasibility of measuring RV longitudinal peak systolic strain (LPSS) in the echocardiographic subcostal view in patients with suspected pulmonary hypertension. Methods: A total of 179 patients evaluated for pulmonary hypertension were incl...
Abstract
Cited 798 times since 2012 (61.9 per year)
source: EuropePMC
Nature genetics,
Volume 44, Issue 5, 15 3 2012, Pages 491-501
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, M
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identifi...
Abstract
Cited 6 times since 2012 (0.5 per year)
source: EuropePMC
Antonie van Leeuwenhoek,
Volume 102, Issue 2, 10 2 2012, Pages 401-406
In vivo analysis of Saccharomyces cerevisiae plasma membrane ATPase Pma1p isoforms with increased in vitro H+/ATP stoichiometry.
de Kok S, Yilmaz D, Daran JM, Pronk JT, van Maris AJ
Plasma membrane H(+)-ATPase isoforms with increased H(+)/ATP ratios represent a desirable asset in yeast metabolic engineering. In vivo proton coupling of two previously reported Pma1p isoforms (Ser800Ala, Glu803Gln) with increased in vitro H(+)/ATP stoichiometries was analysed by measuring biomass yields of anaerobic maltose-limited chemostat cultures expressing only the different PMA1 alleles. In vivo H(+)/ATP stoichiometries of wildtype Pma1p and the two isoforms did not differ significantly.
Abstract
Cited 18 times since 2012 (1.4 per year)
source: EuropePMC
Injury,
Volume 43, Issue 7, 6 1 2012, Pages 1107-1111
Below-elbow cast for metaphyseal both-bone fractures of the distal forearm in children: a randomised multicentre study.
Colaris JW, Biter LU, Allema JH, Bloem RM, van de Ven CP, de Vries MR, Kerver AJ, Reijman M, Verhaar JA
Introduction: Minimally displaced metaphyseal both-bone fractures of the distal forearm in children are often treated with an above-elbow cast (AEC). Treatment with a below-elbow cast (BEC) could give more comfort, but might lead to fracture displacement reducing pronation and supination. Because this has not been systematically investigated, we set up a randomised multicentre study. The purpose of this study was to find out whether BEC causes equal limitation of pronation and supination but wit...
Abstract
Cited 6 times since 2012 (0.5 per year)
source: EuropePMC
The Netherlands journal of medicine,
Volume 70, Issue 3, 1 1 2012, Pages 155
Valproic acid-induced DRESS syndrome with acute liver failure.
van Zoelen MA, de Graaf M, van Dijk MR, Bogte A, van Erpecum KJ, Rockmann H, Maarschalk-Ellerbroek LJ
Abstract
Cited 13 times since 2012 (1 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 7, Issue 12, 1 1 2012, Pages 1396-1405
Pre-infarction angina predicts thrombus burden in patients admitted for ST-segment elevation myocardial infarction.
Ahmed TA, Sorgdrager BJ, Cannegieter SC, van der Laarse A, Schalij MJ, Jukema W
Aims: In patients with ST-elevation myocardial infarction (STEMI), high thrombotic burden, subsequent distal embolisation and myocardial no-reflow remain a large obstacle that may negate the benefits of urgent coronary revascularisation. We aimed at assessing the predictors of: 1) thrombus grade in patients undergoing primary percutaneous coronary intervention (PPCI) and 2) infarct size, in order to optimise therapy to reduce thrombus burden. Methods and results: One-hundred and fifty-three cons...
Abstract
Cited 21 times since 2012 (1.6 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 20, Issue 4, 1 1 2012, Pages 167-175
Treatment options in end-stage heart failure: where to go from here?
Haeck ML, Hoogslag GE, Rodrigo SF, Atsma DE, Klautz RJ, van der Wall EE, Schalij MJ, Verwey HF
Chronic heart failure is a major healthcare problem associated with high morbidity and mortality. Despite significant progress in treatment strategies, the prognosis of heart failure patients remains poor. The golden standard treatment for heart failure is heart transplantation after failure of medical therapy, surgery and/or cardiac resynchronisation therapy. In order to improve patients' outcome and quality of life, new emerging treatment modalities are currently being investigated, inclu...
Abstract
Cited 16 times since 2012 (1.2 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 5, Issue 2, 1 1 2012, Pages e38-40
Bipolar ablation of ventricular tachycardia in a patient after atrial switch operation for dextro-transposition of the great arteries.
Piers SR, Dyrda K, Tao Q, Zeppenfeld K
Abstract
Cited 85 times since 2012 (6.6 per year)
source: EuropePMC
Cold Spring Harbor perspectives in biology,
Volume 4, Issue 4, 1 1 2012, Pages a007989
Wnt signaling, stem cells, and cancer of the gastrointestinal tract.
Schepers A, Clevers H
The Wnt signaling pathway was originally uncovered as one of the prototype developmental signaling cascades in invertebrates as well as in vertebrates. The first indication that Wnt signaling also plays a role in the adult animal came from the study of the intestine of Tcf-4 (Tcf7L2) knockout mice. The gastrointestinal epithelium continuously self-renews over the lifetime of an organism and is, in fact, the most rapidly self-renewing tissue of the mammalian body. Recent studies indicate that Wnt...
Abstract
Cited 37 times since 2012 (2.9 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 3, 30 5 2012, Pages e32963
Inflammation aggravates disease severity in Marfan syndrome patients.
Radonic T, de Witte P, Groenink M, de Waard V, Lutter R, van Eijk M, Jansen M, Timmermans J, Kempers M, Scholte AJ, Hilhorst-Hofstee Y, van den Berg MP, van Tintelen JP, Pals G, Baars MJ, Mulder BJ, Zwinderman AH
Background: Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocular and skeletal systems, associated with large clinical variability. Numerous studies reveal an involvement of TGF-β signaling. However, the contribution of tissue inflammation is not addressed so far. Methodology/principal findings: Here we showed that both TGF-β and inflammation are up-regulated in patients with MFS. We analyzed transcriptome-wide gene expression in 55 MFS patients us...
Abstract
