Research

Publications

Below you can find a list of our published research.

7368 results

Cited 9 times since 2011 (0.6 per year) source: EuropePMC

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, Volume 50, Issue 3, 25 4 2011, Pages 307-310 Demographics and functional outcome of toe fractures. Van Vliet-Koppert ST, Cakir H, Van Lieshout EM, De Vries MR, Van Der Elst M, Schepers T

Toe fractures are common; however, there are few data on demographics and functional outcome. We studied outcomes in 339 consecutive patients with toe fractures treated between January 2006 and September 2008. Two hundred and sixty-four patients, aged 16 to 75, were mailed an outcome questionnaire, and overall subjective satisfaction with the outcome of treatment was measured using a visual analog scale (VAS). Most frequently affected were the first (38%) and fifth (30%) toes, and most (75.6%) o... Abstract

Cited 27 times since 2011 (1.9 per year) source: EuropePMC

Heart rhythm, Volume 8, Issue 8, 21 3 2011, Pages 1254-1263 Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart. Vicente-Steijn R, Passier R, Wisse LJ, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC, Jongbloed MR

Background: Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) in the mouse is expressed in the developing cardiac conduction system (CCS). In the sinoatrial node (SAN), HCN4 is the predominant isoform responsible for the funny current. To date, no data are available on HCN4 expression during chicken CCS development. Objective: The purpose of this study was to provide the full-length sequence of Hcn4 and describe its expression pattern during development in relation to the CCS... Abstract

Cited 70 times since 2011 (5 per year) source: Scopus

The Annals of thoracic surgery, Volume 92, Issue 4, 21 3 2011, Pages 1244-1251 Outcomes after transcatheter aortic valve implantation: transfemoral versus transapical approach. Ewe SH, Delgado V, Ng AC, Antoni ML, van der Kley F, Marsan NA, de Weger A, Tavilla G, Holman ER, Schalij MJ, Bax JJ

Background: Transcatheter aortic valve implantation is commonly implanted through a transfemoral (TFA) or transapical approach (TAA) for patients with severe aortic stenosis. This study aimed to describe the clinical and echocardiographic outcomes of TFA versus TAA. Methods: Clinical and echocardiographic evaluations were performed at baseline, post-TAVI (transcatheter aortic valve implantation), at 6 and 12 months follow-up in 107 consecutive patients who underwent TAVI with balloon-expandable... Abstract

Cited 26 times since 2011 (1.9 per year) source: EuropePMC

Thyroid : official journal of the American Thyroid Association, Volume 21, Issue 5, 21 3 2011, Pages 471-476 Both exogenous subclinical hyperthyroidism and short-term overt hypothyroidism affect myocardial strain in patients with differentiated thyroid carcinoma. Abdulrahman RM, Delgado V, Hoftijzer HC, Ng AC, Ewe SH, Marsan NA, Holman ER, Hovens GC, Corssmit EP, Romijn JA, Bax JJ, Smit JW

Background: The cardiovascular effects of transitions from exogenous subclinical hyperthyroidism to short-term overt hypothyroidism in patients treated for differentiated thyroid carcinoma remain unclear. The present study aims at evaluating the changes in multidirectional myocardial strain using two-dimensional (2D) speckle tracking during this controlled transition from exogenous subclinical hyperthyroidism to overt hypothyroidism. Methods: The study included 14 patients with differentiated th... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 28, Issue 2, 19 3 2011, Pages 425-428 Reduction of radiation dose using 80 kV tube voltage: a feasible strategy? van der Wall EE, van Velzen JE, de Graaf FR, Jukema JW

Abstract

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 3 2011 WITHDRAWN: Predictors of long-term survival in pulmonary hypertension treated with bosentan. Bresser P, Vis JC, Berger RM, Vliegen HW, Vonk MC, Snijder RJ, van den Toorn LM, van Dijk AP, Boomars KA, van Daal GJ, Mulder BJ

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy. Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 142, Issue 3, 12 2 2011, Pages e93-100 Cardiac support device, restrictive mitral valve annuloplasty, and optimized medical treatment: a multimodality approach to nonischemic cardiomyopathy. Braun J, Ciarka A, Versteegh MI, Delgado V, Boersma E, Verwey HF, Schalij MJ, Bax JJ, Dion RA, van de Veire NR, Klautz RJ

Objective: Nonischemic dilated cardiomyopathy with functional mitral regurgitation carries a poor prognosis. Mitral valve surgery with implantation of a cardiac support device can treat mitral regurgitation and promote left ventricular reverse remodeling. This observational study evaluates clinical and echocardiographic outcomes of an individualized medico-surgical approach, focusing on mitral regurgitation recurrence and left ventricular reverse remodeling. Methods: Sixty-nine consecutive patie... Abstract

Cited 129 times since 2011 (9.2 per year) source: EuropePMC

Circulation research, Volume 108, Issue 9, 10 2 2011, Pages 1093-1101 Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition. Egorova AD, Khedoe PP, Goumans MJ, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP

Rationale: Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such as nitric oxide production and initiation of gene expression. Cilia are present on ECs in areas of low or disturbed flow and absent in areas of high flow. In the embryonic heart, high-flow regime applies to the endocardial cushion area, and the absence of cilia here coincides with the p... Abstract

Cited 13 times since 2011 (0.9 per year) source: Scopus

Logopedics, phoniatrics, vocology, Volume 36, Issue 4, 8 2 2011, Pages 139-144 Informing and supporting partners and children of persons with aphasia: a comparison of supply and demand. Manders E, Mariën A, Janssen V

In this study we investigated how important significant others find it to be informed, supported, and trained by speech-language pathologists (SLPs) and to what extent they perceive their expectations and needs as to these aspects to be fulfilled. Furthermore SLPs were asked about the importance of informing and supporting family members and as to how far they believe they provide adequate care in that field. A questionnaire was completed by 77 relatives of persons with aphasia, a parallel versi... Abstract

Cited 1217 times since 2011 (87 per year) source: EuropePMC

Nature genetics, Volume 43, Issue 4, 6 1 2011, Pages 333-338 Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and we... Abstract

Cited 253 times since 2011 (18.1 per year) source: EuropePMC

European heart journal, Volume 32, Issue 11, 2 1 2011, Pages 1316-1330 A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension. Genders TS, Steyerberg EW, Alkadhi H, Leschka S, Desbiolles L, Nieman K, Galema TW, Meijboom WB, Mollet NR, de Feyter PJ, Cademartiri F, Maffei E, Dewey M, Zimmermann E, Laule M, Pugliese F, Barbagallo R, Sinitsyn V, Bogaert J, Goetschalckx K, Schoepf UJ, Rowe GW, Schuijf JD, Bax JJ, de Graaf FR, Knuuti J, Kajander S, van Mieghem CA, Meijs MF, Cramer MJ, Gopalan D, Feuchtner G, Friedrich G, Krestin GP, Hunink MG, CAD Consortium

Aims: The aim was to validate, update, and extend the Diamond-Forrester model for estimating the probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Methods and results: Prospectively collected data from 14 hospitals on patients with chest pain without a history of CAD and referred for conventional coronary angiography (CCA) were used. Primary outcome was obstructive CAD, defined as ≥ 50% stenosis in one or more vessels on CCA. The validity of the Diamond-Forrester... Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

International journal of cardiology, Volume 149, Issue 2, 1 1 2011, Pages 246-247 Wanted! 8000 heart patients: identification of adult patients with a congenital heart defect lost to follow-up. Vis JC, van der Velde ET, Schuuring MJ, Engelfriet-Rijk LCJM, Harms IM, Mantels S, Bouma BJ, Mulder BJM

Abstract

Cited 32 times since 2011 (2.3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 91, Issue 3, 1 1 2011, Pages 716-723 Automated assessment of the aortic root dimensions with multidetector row computed tomography. Delgado V, Ng AC, Schuijf JD, van der Kley F, Shanks M, Tops LF, van de Veire NR, de Roos A, Kroft LJ, Schalij MJ, Bax JJ

Background: Accurate aortic root measurements and evaluation of spatial relationships with coronary ostia are crucial in preoperative transcatheter aortic valve implantation assessments. Standardization of measurements may increase intraobserver and interobserver reproducibility to promote procedural success rate and reduce the frequency of procedurally related complications. This study evaluated the accuracy and reproducibility of a novel automated multidetector row computed tomography (MDCT) i... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Future cardiology, Volume 7, Issue 2, 1 1 2011, Pages 227-240 Treatment of congenital heart disease: risk-reducing measures in young adults. van der Bom T, Luijendijk P, Bouma BJ, Koolbergen DR, de Groot JR, Mulder BJ

Adults with congenital heart disease form a new and relatively young population, since surgical treatment of heart defects became available three to four decades ago. Owing to improved survival this population is steadily growing in number and age. Little is known regarding long-term survival; however, late complications occur frequently. During adulthood, almost half of the patients have one or more complication, such as endocarditis, stroke, systemic or pulmonary hypertension, aortic aneurysm... Abstract

Cited 139 times since 2011 (9.9 per year) source: EuropePMC

Annals of surgical oncology, Volume 18, Issue 9, 1 1 2011, Pages 2483-2491 Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer. Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers. Materials and methods: A small, portable version of the FLARE imaging system, termed Mini-FLARE, was developed for capturing color video and two semi-independent channels of NIR fluorescence (700 and 800 nm) in real time. Initial optimization of lymphatic tracer dose was performed using 35-kg Yorkshire pigs and a 6-patient pilot clinical trial.... Abstract

Cited 92 times since 2011 (6.6 per year) source: EuropePMC

Breast cancer research and treatment, Volume 127, Issue 1, 1 1 2011, Pages 163-170 Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients. Hutteman M, Mieog JS, van der Vorst JR, Liefers GJ, Putter H, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Near-infrared (NIR) fluorescence imaging has the potential to improve sentinel lymph node (SLN) mapping in breast cancer. Indocyanine green (ICG) is currently the only clinically available fluorophore that can be used for SLN mapping. Preclinically, ICG adsorbed to human serum albumin (ICG:HSA) improves its performance as a lymphatic tracer in some anatomical sites. The benefit of ICG:HSA for SLN mapping of breast cancer has not yet been assessed in a clinical trial. We performed a double-blind,... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

Acta chirurgica Belgica, Volume 111, Issue 2, 1 1 2011, Pages 78-82 Outcome of patients with ruptured abdominal aortic aneurysm after cardiopulmonary resuscitation. Greeven AP, Bouwman LH, Smeets HJ, van Baalen JM, Hamming JF

Purpose: Ruptured aneurysm of the abdominal aorta (RAAA) is a condition associated with high mortality rate. If Cardiopulmonary Resuscitation (CPR) is required, outcome is considered even worse. The aim of this study was to assess the effect of CPR on 30-day mortality of RAAA patients. Furthermore the Hardman index was evaluated. Methods: 109 patients with RAAA during a 5 year period (2001-2005) were analysed retrospectively. 30-day mortality, the presence of CPR and Hardman risk factors were re... Abstract

Cited 33 times since 2011 (2.4 per year) source: EuropePMC

Pediatric dermatology, Volume 28, Issue 2, 1 1 2011, Pages 169-171 Hypoglycemia as a result of propranolol during treatment of infantile hemangioma: a case report. Breur JM, de Graaf M, Breugem CC, Pasmans SG

Propranolol is a new and promising treatment for hemangiomas of infancy. We report of a patient in whom steroid maintenance therapy is successfully tapered after introduction of propranolol. This patient, however, developed symptomatic hypoglycemic events presumably because of a concurrent deficiency of epinephrine and cortisol as a direct result of both beta-blockage by propranolol and adrenal insufficiency as a result of prednisone use. Extreme care should be taken in patients treated with bot... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Volume 17, Issue 3, 1 1 2011, Pages 261-269 Clinical value of myocardial perfusion scintigraphy as a screening tool in liver transplant candidates. Oprea-Lager DE, Sorgdrager BJ, Jukema JW, Scherptong RW, Ringers J, Coenraad MJ, van Hoek B, Stokkel MP

A cardiac evaluation before orthotopic liver transplantation (OLT) is imperative. Previous investigations have demonstrated that mild to moderate reversible perfusion defects on myocardial perfusion scintigraphy (MPS) in general are associated with a low risk for perioperative cardiac events. The objective of this study was to assess any perfusion defects in consecutive patients with chronic liver disease who were undergoing OLT. OLT candidates underwent extensive cardiovascular screening that i... Abstract

Cited 21 times since 2011 (1.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 4, Issue 3, 1 1 2011, Pages 246-256 Feasibility of diastolic function assessment with cardiac CT: feasibility study in comparison with tissue Doppler imaging. Boogers MJ, van Werkhoven JM, Schuijf JD, Delgado V, El-Naggar HM, Boersma E, Nucifora G, van der Geest RJ, Paelinck BP, Kroft LJ, Reiber JH, de Roos A, Bax JJ, Lamb HJ

Objectives: This study aimed to demonstrate the feasibility of multidetector row computed tomography (CT) for assessment of diastolic function in comparison with 2-dimensional (2D) echocardiography using tissue Doppler imaging (TDI). Background: Diastolic left ventricular (LV) function plays an important role in patients with cardiovascular disease. 2D echocardiography using TDI has been used most commonly to evaluate diastolic LV function. Although the role of cardiac CT imaging for evaluation... Abstract