9618 results
Cited 7 times since 2011 (0.5 per year)
source: EuropePMC
Disease markers,
Volume 30, Issue 5, 1 1 2011, Pages 245-252
Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction.
Bergheanu SC, van der Laarse A, van der Bom JG, van der Hoeven BL, le Cessie S, de Jong MG, Liem SS, Schalij MJ, Jukema JW
High Asymmetric Dimethylarginine (ADMA) levels are associated with increased platelet activity, elevated blood pressure, vasoconstriction and impaired vascular relaxation. We hypothesized that the myocardial infarction morning peak of occurrence is closely related to a morning peak of ADMA levels. We performed a cross-sectional study among patients with documented myocardial infarction who had been enrolled in the prospective MISSION! Intervention Study. In total, serum ADMA levels were measured...
Abstract
Cited 56 times since 2011 (3.8 per year)
source: EuropePMC
Current pharmaceutical design,
Volume 17, Issue 19, 1 1 2011, Pages 1890-1910
Clinical applications of the urokinase receptor (uPAR) for cancer patients.
Boonstra MC, Verspaget HW, Ganesh S, Kubben FJ, Vahrmeijer AL, van de Velde CJ, Kuppen PJ, Quax PH, Sier CF
Since decades the urokinase plasminogen activator (uPA) system has been associated with the invasion of malignant cells. The receptor of urokinase (uPAR) is one of the key players in this proteolytic cascade, because it focuses uPA's proteolytic activity to the cell surface and in addition functions as a signaling receptor. uPAR is highly expressed in virtually all human cancers, suggesting possible clinical applications as diagnostic marker, predictive tool of survival or clinical response...
Abstract
Cited 97 times since 2011 (6.6 per year)
source: EuropePMC
Cytometry. Part B, Clinical cytometry,
Volume 80, Issue 1, 1 1 2011, Pages 43-50
Central memory CD4+ T cells dominate the normal cerebrospinal fluid.
de Graaf MT, Smitt PA, Luitwieler RL, van Velzen C, van den Broek PD, Kraan J, Gratama JW
Background: To use cerebrospinal fluid (CSF) immune phenotyping as a diagnostic and research tool, we have set out to establish reference values of white blood cell (WBC) subsets in CSF. Methods: We assessed the absolute numbers and percentages of WBC subsets by 6-color flow cytometry in paired CSF and blood samples of 84 individuals without neurological disease who underwent spinal anaesthesia for surgery. Leukocyte (i.e., lymphocytes, granulocytes, and monocytes), lymphocyte (i.e., T [CD4(+) a...
Abstract
Cited 56 times since 2011 (3.8 per year)
source: EuropePMC
Pharmacogenomics,
Volume 12, Issue 1, 1 1 2011, Pages 113-124
Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics.
Becquemont L, Alfirevic A, Amstutz U, Brauch H, Jacqz-Aigrain E, Laurent-Puig P, Molina MA, Niemi M, Schwab M, Somogyi AA, Thervet E, Maitland-van der Zee AH, van Kuilenburg AB, van Schaik RH, Verstuyft C, Wadelius M, Daly AK
The present article summarizes the discussions of the 3rd European Science Foundation-University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results...
Abstract
Cited 12 times since 2010 (0.8 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 41, Issue 3, 30 5 2011, Pages 418-428
T-cell-pre-stimulated monocytes promote neovascularisation in a murine hind limb ischaemia model.
Hellingman AA, Zwaginga JJ, van Beem RT, TeRM/Smart Mix Consortium, Hamming JF, Fibbe WE, Quax PH, Geutskens SB
Aim: Monocytes play a significant role in neovascularisation. The stimuli that differentiate monocytes along a pro-angio-/arteriogenic-supporting pathway are currently unclear. We investigated whether pre-stimulation of human monocytes with soluble T-cell-derived factors improves revascularisation in murine hind limb ischaemia as a new option for therapeutic angio- and arteriogenesis. Design: Human monocytes were cultured with or without soluble T-cell-derived factors. Unstimulated and pre-stimu...
Abstract
Cited 13 times since 2010 (0.9 per year)
source: EuropePMC
Foot (Edinburgh, Scotland),
Volume 21, Issue 3, 23 4 2010, Pages 124-128
Foot and ankle fractures at the supination line.
Schepers T, van Schie-van der Weert EM, de Vries MR, van der Elst M
Background: The supination line is a fictive line along the foot and ankle, on which over twenty fracture types and approximately ten different ligamentous sprain-injuries have been identified. Objective: The current study was conducted to evaluate the incidence of different types of supination line injuries visible at the initial radiographs at the Emergency Department and to determine the type and percentage of misdiagnosed injuries. Method: Retrospective study of consecutive patients who visi...
Abstract
Cited 16 times since 2010 (1.1 per year)
source: EuropePMC
American journal of obstetrics and gynecology,
Volume 204, Issue 3, 22 4 2010, Pages 236.e1-8
General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect.
Obermann-Borst SA, Isaacs A, Younes Z, van Schaik RH, van der Heiden IP, van Duyn CM, Steegers EA, Steegers-Theunissen RP
Objective: We sought to investigate maternal and child functional MDR1 C3435T polymorphism, periconception medication, folic acid use, and the risk of a congenital heart defect (CHD) in the offspring. Study design: MDR1 3435C>T genotyping was performed in 283 case triads (mother, father, child) and 308 control triads. Information on periconception medication and folic acid use was obtained through questionnaires. Results: Mothers with MDR1 3435CT/TT genotype and using medication showed a sign...
Abstract
Cited 20 times since 2010 (1.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 19, Issue 1, 22 4 2010, Pages 24-30
Improvements in 25 Years of Implantable Cardioverter Defibrillator Therapy.
van Welsenes GH, Borleffs CJ, van Rees JB, Atary JZ, Thijssen J, van der Wall EE, Schalij MJ
In 1980, Dr. Michel Mirowski and his team inserted the first implantable cardioverter defibrillator (ICD) in a patient. Initially, ICD therapy was not widely accepted, and many physicians actually considered this therapy unethical. Large secondary and primary prevention trials, demonstrating a beneficial effect of ICD therapy in selected patients not only on arrhythmic death but also on all-cause mortality, stimulated a rapid growth in the number of implants and increased patient's and phys...
Abstract
Cited 18 times since 2010 (1.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 107, Issue 4, 22 4 2010, Pages 609-614
Usefulness of repeated N-terminal pro-B-type natriuretic peptide measurements as incremental predictor for long-term cardiovascular outcome after vascular surgery.
Goei D, van Kuijk JP, Flu WJ, Hoeks SE, Chonchol M, Verhagen HJ, Bax JJ, Poldermans D
Plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels improve preoperative cardiac risk stratification in vascular surgery patients. However, single preoperative measurements of NT-pro-BNP cannot take into account the hemodynamic stress caused by anesthesia and surgery. Therefore, the aim of the present study was to assess the incremental predictive value of changes in NT-pro-BNP during the perioperative period for long-term cardiac mortality. Detailed cardiac histories, rest left...
Abstract
Cited 7 times since 2010 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 107, Issue 5, 22 4 2010, Pages 736-740
Value of the surface electrocardiogram in detecting right ventricular dilatation in the presence of left bundle branch block.
Van Bommel RJ, Marsan NA, Delgado V, van Rijnsoever EP, Schalij MJ, Bax JJ, Wellens HJ
Approximately 20% of patients with heart failure have left bundle branch block (LBBB) on surface electrocardiogram (ECG). In this group of patients, detection of right ventricular (RV) dilatation on standard ECG can be of clinical relevance because RV enlargement is an important prognostic marker. Consequently, the aim of this study was to evaluate diagnostic accuracy for several electrocardiographic criteria in determining significant RV dilatation in these patients. Standard 12-lead ECGs were...
Abstract
Cited 116 times since 2010 (7.9 per year)
source: EuropePMC
The Plant cell,
Volume 22, Issue 12, 21 3 2010, Pages 4195-4215
Nucleocytoplasmic distribution is required for activation of resistance by the potato NB-LRR receptor Rx1 and is balanced by its functional domains.
Slootweg E, Roosien J, Spiridon LN, Petrescu AJ, Tameling W, Joosten M, Pomp R, van Schaik C, Dees R, Borst JW, Smant G, Schots A, Bakker J, Goverse A
The Rx1 protein, as many resistance proteins of the nucleotide binding-leucine-rich repeat (NB-LRR) class, is predicted to be cytoplasmic because it lacks discernable nuclear targeting signals. Here, we demonstrate that Rx1, which confers extreme resistance to Potato virus X, is located both in the nucleus and cytoplasm. Manipulating the nucleocytoplasmic distribution of Rx1 or its elicitor revealed that Rx1 is activated in the cytoplasm and cannot be activated in the nucleus. The coiled coil (C...
Abstract
Cited 182 times since 2010 (12.4 per year)
source: EuropePMC
Circulation,
Volume 123, Issue 1, 20 3 2010, Pages 70-78
Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy.
Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ
Background: The relative merits of left ventricular (LV) dyssynchrony, LV lead position, and myocardial scar to predict long-term outcome after cardiac resynchronization therapy remain unknown and were evaluated in the present study. Methods and results: In 397 ischemic heart failure patients, 2-dimensional speckle tracking imaging was performed, with comprehensive assessment of LV radial dyssynchrony, identification of the segment with latest mechanical activation, and detection of myocardial s...
Abstract
The international journal of cardiovascular imaging,
Volume 27, Issue 7, 18 3 2010, Pages 1089-1093
Functional analysis by 64-slice CT scanning: prediction of left ventricular dysfunction together with reduction in radiation exposure?
van der Wall EE, de Graaf FR, van Velzen JE, Jukema JW, Schuijf JD, Bax JJ
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
Case reports in oncology,
Volume 4, Issue 2, 17 3 2010, Pages 323-326
Imatinib treatment alone in Philadelphia-positive acute lymphoblastic leukemia: is it enough?
Ay Y, Yilmaz D, Balkan C, Karapinar B, Karadas N, Kavakli K
BCR-ABL fusion gene t(9;22)(q34;q11) occurs in only 3% of pediatric acute lymphoblastic leukemia (ALL) cases. Previously, less than 40% of Philadelphia-positive ALL patients were cured with intensive chemotherapy. The use of imatinib (340 mg/m(2)/day) added to an intensive chemotherapy regimen has improved the outcome in this population at 3 years to an event-free survival of 80%. Imatinib treatment alone was administered after remission induction chemotherapy to a patient with Philadelphia-posi...
Abstract
Cited 18 times since 2010 (1.2 per year)
source: EuropePMC
Journal of the American Society of Nephrology : JASN,
Volume 22, Issue 3, 16 3 2010, Pages 508-517
γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.
Dimke H, San-Cristobal P, de Graaf M, Lenders JW, Deinum J, Hoenderop JG, Bindels RJ
The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal convoluted tubule. (22)Na(+) uptake experiments in the Xenopus laevis oocyte showed that γ-adducin stimulat...
Abstract
Cited 54 times since 2010 (3.7 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 19, Issue 4, 15 3 2010, Pages 438-444
SGCE isoform characterization and expression in human brain: implications for myoclonus-dystonia pathogenesis?
Ritz K, van Schaik BD, Jakobs ME, van Kampen AH, Aronica E, Tijssen MA, Baas F
Myoclonus-dystonia (M-D) is a neurological movement disorder with involuntary jerky and dystonic movements as major symptoms. About 50% of M-D patients have a mutation in ɛ-sarcoglycan (SGCE), a maternally imprinted gene that is widely expressed. As little is known about SGCE function, one can only speculate about the pathomechanisms of the exclusively neurological phenotype in M-D. We characterized different SGCE isoforms in the human brain using ultra-deep sequencing. We show that a major brai...
Abstract
Clinical autonomic research : official journal of the Clinical Autonomic Research Society,
Volume 21, Issue 3, 15 3 2010, Pages 177-179
Poikilothermia in a 38-year-old Fabry patient.
Biegstraaten M, van Schaik IN, Hollak CE, Wieling W, Linthorst GE
A Fabry patient with poikilothermia is described. Laboratory investigations, neuro-imaging and autonomic function tests did not disclose a cause. Assessment of intra-epidermal nerve fibre density and quantitative sensory testing revealed small fibre neuropathy with a highly impaired cold sensation. We speculate that the poikilothermia is either caused by a vascular lesion in the hypothalamus not visible on MRI or by small fibre neuropathy leading to disturbed body temperature perception and ther...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
BMC bioinformatics,
Volume 11, 14 2 2010, Pages 598
Initial steps towards a production platform for DNA sequence analysis on the grid.
Luyf AC, van Schaik BD, de Vries M, Baas F, van Kampen AH, Olabarriaga SD
Background: Bioinformatics is confronted with a new data explosion due to the availability of high throughput DNA sequencers. Data storage and analysis becomes a problem on local servers, and therefore it is needed to switch to other IT infrastructures. Grid and workflow technology can help to handle the data more efficiently, as well as facilitate collaborations. However, interfaces to grids are often unfriendly to novice users. Results: In this study we reused a platform that was developed in...
Abstract
Cited 17 times since 2010 (1.2 per year)
source: EuropePMC
Journal of bacteriology,
Volume 193, Issue 4, 10 2 2010, Pages 1003-1006
The recombinase IntA is required for excision of esp-containing ICEEfm1 in Enterococcus faecium.
Top J, Sinnige JC, Majoor EA, Bonten MJ, Willems RJ, van Schaik W
Comparative genome analysis of Enterococcus faecium recently revealed that a genomic island containing the esp gene, referred to as the esp-containing pathogenicity island (esp PAI), can be transferred by conjugation and contains a partial Tn916-like element and an integrase gene, intA. Here, we characterize the role of intA in the excision of the esp PAI. An intA insertion-deletion mutant in E. faecium E1162 (E1162ΔintA) was constructed and in trans complemented with wild-type intA (E1162ΔintA:...
Abstract
Cited 2 times since 2010 (0.1 per year)
source: EuropePMC
International journal of clinical oncology,
Volume 16, Issue 5, 8 2 2010, Pages 574-576
Blue toe syndrome and sunitinib.
Postema PG, Regeer MV, van der Valk PR, Stroes ES, Richel DJ
We present a patient with metastatic renal cell carcinoma treated with sunitinib, a multitargeted tyrosine kinase inhibitor. The patient experienced bilateral blue toe syndrome which we related to sunitinib use. Discontinuation of sunitinib to lower the patient's prothrombotic state and increase the ability to form collaterals, together with the addition of low-molecular-weight heparin to treat the occluding thrombi, resulted in waning of the blue toe syndrome. This case adds to the accumul...
Abstract
