Research

Publications

Below you can find a list of our published research.

8892 results

Cited 215 times since 2020 (41.8 per year) source: EuropePMC

The New England journal of medicine, Volume 383, Issue 15, 30 5 2020, Pages 1447-1457 Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation. Brouwer J, Nijenhuis VJ, Delewi R, Hermanides RS, Holvoet W, Dubois CLF, Frambach P, De Bruyne B, van Houwelingen GK, Van Der Heyden JAS, Toušek P, van der Kley F, Buysschaert I, Schotborgh CE, Ferdinande B, van der Harst P, Roosen J, Peper J, Thielen FWF, Veenstra L, Chan Pin Yin DRPP, Swaans MJ, Rensing BJWM, van 't Hof AWJ, Timmers L, Kelder JC, Stella PR, Baan J, Ten Berg JM

Background: The effect of single as compared with dual antiplatelet treatment on bleeding and thromboembolic events after transcatheter aortic-valve implantation (TAVI) in patients who do not have an indication for long-term anticoagulation has not been well studied. Methods: In a randomized, controlled trial, we assigned a subgroup of patients who were undergoing TAVI and did not have an indication for long-term anticoagulation, in a 1:1 ratio, to receive aspirin alone or aspirin plus clopidogr... Abstract

Cited 1265 times since 2020 (246 per year) source: EuropePMC

The New England journal of medicine, Volume 383, Issue 14, 29 5 2020, Pages 1305-1316 Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck KH, Mont L, Ng GA, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G, EAST-AFNET 4 Trial Investigators

Background: Despite improvements in the management of atrial fibrillation, patients with this condition remain at increased risk for cardiovascular complications. It is unclear whether early rhythm-control therapy can reduce this risk. Methods: In this international, investigator-initiated, parallel-group, open, blinded-outcome-assessment trial, we randomly assigned patients who had early atrial fibrillation (diagnosed ≤1 year before enrollment) and cardiovascular conditions to receive either ea... Abstract

Cited 18 times since 2020 (3.5 per year) source: EuropePMC

The American journal of cardiology, Volume 135, 28 4 2020, Pages 84-90 Prognostic Implications of Significant Isolated Tricuspid Regurgitation in Patients With Atrial Fibrillation Without Left-Sided Heart Disease or Pulmonary Hypertension. Dietz MF, Goedemans L, Vo NM, Prihadi EA, van der Bijl P, Gersh BJ, Ajmone Marsan N, Delgado V, Bax JJ

The prognostic impact of isolated tricuspid regurgitation (TR) in patients with atrial fibrillation (AF) has not been investigated. The purpose of this study was to investigate the prognostic implications of significant isolated TR in AF patients without left-sided heart disease, pulmonary hypertension, or primary structural abnormalities of the tricuspid valve. A total of 63 AF patients with moderate and severe TR were matched for age and gender to 116 AF patients without significant TR. Patien... Abstract

Cited 50 times since 2020 (9.7 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 13, Issue 12, 26 4 2020, Pages 2576-2587 Sex Differences in Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve: Lessons From ADVANCE. Fairbairn TA, Dobson R, Hurwitz-Koweek L, Matsuo H, Norgaard BL, Rønnow Sand NP, Nieman K, Bax JJ, Pontone G, Raff G, Chinnaiyan KM, Rabbat M, Amano T, Kawasaki T, Akasaka T, Kitabata H, Binukrishnan S, Rogers C, Berman D, Patel MR, Douglas PS, Leipsic J

Objectives: This study is to determine the management and clinical outcomes of patients investigated with coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) according to sex. Background: Women are underdiagnosed with conventional ischemia testing, have lower rates of obstructive coronary artery disease (CAD) at invasive coronary angiography (ICA), yet higher mortality compared to men. Whether FFRCT improves sex-based patient management decisions compared to C... Abstract

Cited 12 times since 2020 (2.3 per year) source: EuropePMC

Preventive veterinary medicine, Volume 183, 25 4 2020, Pages 105130 Standardizing output-based surveillance to control non-regulated cattle diseases: Aspiring for a single general regulatory framework in the European Union. Costa L, Duarte EL, Knific T, Hodnik JJ, van Roon A, Fourichon C, Koleci X, van Schaik G, Gunn G, Madouasse A, Berezowski J, Santman-Berends I

Several European countries have implemented country specific programmes to control cattle diseases with little or no regulation in the European Union (EU). These control programmes vary between member states, impairing a confident comparison of freedom from disease when cattle originate from different countries. In order to facilitate safe trade, there is a need to support the development of transparent methods that enable comparison of outputs of surveillance, control or eradication programmes.... Abstract

Cited 7 times since 2020 (1.4 per year) source: EuropePMC

BMJ open, Volume 10, Issue 8, 24 4 2020, Pages e036220 Design and rationale of DUTCH-AF: a prospective nationwide registry programme and observational study on long-term oral antithrombotic treatment in patients with atrial fibrillation. Chu G, Seelig J, Trinks-Roerdink EM, van Alem AP, Alings M, van den Bemt B, Boersma LV, Brouwer MA, Cannegieter SC, Ten Cate H, Kirchhof CJ, Crijns HJ, van Dijk EJ, Elvan A, van Gelder IC, de Groot JR, den Hartog FR, de Jong JS, de Jong S, Klok FA, Lenderink T, Luermans JG, Meeder JG, Pisters R, Polak P, Rienstra M, Smeets F, Tahapary GJ, Theunissen L, Tieleman RG, Trines SA, van der Voort P, Geersing GJ, Rutten FH, Hemels ME, Huisman MV

Introduction: Anticoagulation therapy is pivotal in the management of stroke prevention in atrial fibrillation (AF). Prospective registries, containing longitudinal data are lacking with detailed information on anticoagulant therapy, treatment adherence and AF-related adverse events in practice-based patient cohorts, in particular for non-vitamin K oral anticoagulants (NOAC). With the creation of DUTCH-AF, a nationwide longitudinal AF registry, we aim to provide clinical data and answer question... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 164, 20 3 2020, Pages D5241 [Investigation into medical disciplinary law critically examined]. Hamming JF

There is a suggestion that the medical disciplinary committees (MDC) in the Netherlands are making more severe rulings on medical professionals. In a 10-year analysis of MDC rulings, it appears that complaints made by patients are more frequently being judged to be well-founded, and that the measures being taken are more severe. The authors conclude that there is a numerical basis for the increasing severity of the rulings. However, a numerical trend as such does not constitute proof of this, as... Abstract

Cited 27 times since 2020 (5.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 13, Issue 11, 19 3 2020, Pages 2386-2396 Sex Differences in Compositional Plaque Volume Progression in Patients With Coronary Artery Disease. Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ

Objectives: This study sought to explore sex-based differences in total and compositional plaque volume (PV) progression. Background: It is unclear whether sex has an impact on PV progression in patients with coronary artery disease (CAD). Methods: The study analyzed a prospective multinational registry of consecutive patients with suspected CAD who underwent 2 or more clinically indicated coronary computed tomography angiography (CTA) at ≥2-year intervals. Total and compositional PV at baseline... Abstract

Cited 17 times since 2020 (3.3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 14, Issue 4, 19 3 2020, Pages 730-739 Regurgitant Volume/Left Ventricular End-Diastolic Volume Ratio: Prognostic Value in Patients With Secondary Mitral Regurgitation. Namazi F, van der Bijl P, Fortuni F, Mertens BJA, Kamperidis V, van Wijngaarden SE, Stone GW, Narula J, Ajmone Marsan N, Vahanian A, Delgado V, Bax JJ

Objectives: The purpose of this study was to investigate the prognostic implications of the ratio of mitral regurgitant volume (RVol) to left ventricular (LV) end-diastolic volume (EDV) in patients with significant secondary mitral regurgitation (MR). Background: Quantification of secondary MR remains challenging, and its severity can be over- or underestimated when using the proximal isovelocity surface area method, which does not take LV volume into account. This limitation can be addressed by... Abstract

Cited 12 times since 2020 (2.3 per year) source: EuropePMC

BMC genomics, Volume 21, Issue 1, 18 3 2020, Pages 568 Conditionally essential genes for survival during starvation in Enterococcus faecium E745. de Maat V, Arredondo-Alonso S, Willems RJL, van Schaik W

Background: The nosocomial pathogen Enterococcus faecium can survive for prolonged periods of time on surfaces in the absence of nutrients. This trait is thought to contribute to the ability of E. faecium to spread among patients in hospitals. There is currently a lack of data on the mechanisms that are responsible for the ability of E. faecium to survive in the absence of nutrients. Results: We performed a high-throughput transposon mutant library screening (Tn-seq) to identify genes that have... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 97, Issue 3, 18 3 2020, Pages 488-492 Reverse remodeling after percutaneous transluminal septal myocardial ablation in severe but asymptomatic LVOT obstruction (RASTA) study: Rationale and design of transcatheter septal reduction in asymptomatic patients with severe hypertrophic obstructive cardiomyopathy. Arslan F, Akdim F, Ten Berg JM

Objectives: The aim of this study is to evaluate the impact of percutaneous transluminal septal myocardial ablation (PTSMA) on remodeling in asymptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM) and severe left ventricular outflow tract (LVOT) obstruction. Background: Symptoms justify invasive treatment in HOCM patients with LVOT obstruction. Adverse structural and functional changes (remodeling) in the heart occur preceding heart failure and sudden cardiac death. Early invas... Abstract

The American journal of emergency medicine, Volume 38, Issue 12, 15 3 2020, Pages 2762 Corrigendum to "Clinical Use of Copeptin in Migraine Patients Admitted to the Emergency Department" [American Journal of Emergency Medicine, Volume 38, Issue 9, September 2020, P1910-1914]. Yilmaz DY, Armağan HH, Karaman K, Şirin FB, Bozkurt M, Karaibrahimoğlu A, Yalçin İG, Beceren NG, Tomruk Ö

Abstract

Cited 13 times since 2020 (2.5 per year) source: EuropePMC

The American journal of cardiology, Volume 134, 15 3 2020, Pages 116-122 Comparison of the Usefulness of Strain Imaging by Echocardiography Versus Computed Tomography to Detect Right Ventricular Systolic Dysfunction in Patients With Significant Secondary Tricuspid Regurgitation. Hirasawa K, van Rosendael PJ, Dietz MF, Ajmone Marsan N, Delgado V, Bax JJ

Assessment of right ventricular (RV) systolic function in patients with significant secondary tricuspid regurgitation (STR) remains challenging. In patients with severe aortic stenosis treated with transcatheter aortic valve implantation (TAVI), STR and RV enlargement have been associated with poor outcomes. In these patients, speckle tracking echocardiography (STE) may detect RV systolic dysfunction better than 3-dimensional (3D) RV ejection fraction (EF). The purpose of this study was to inves... Abstract

Cited 78 times since 2020 (15 per year) source: EuropePMC

Circulation. Genomic and precision medicine, Volume 13, Issue 5, 14 2 2020, Pages 541-547 Metabolic Age Based on the BBMRI-NL <sup>1</sup>H-NMR Metabolomics Repository as Biomarker of Age-related Disease. van den Akker EB, Trompet S, Barkey Wolf JJH, Beekman M, Suchiman HED, Deelen J, Asselbergs FW, Boersma E, Cats D, Elders PM, Geleijnse JM, Ikram MA, Kloppenburg M, Mei H, Meulenbelt I, Mooijaart SP, Nelissen RGHH, Netea MG, Penninx BWJH, Slofstra M, Stehouwer CDA, Swertz MA, Teunissen CE, Terwindt GM, 't Hart LM, van den Maagdenberg AMJM, van der Harst P, van der Horst ICC, van der Kallen CJH, van Greevenbroek MMJ, van Spil WE, Wijmenga C, Zhernakova A, Zwinderman AH, Sattar N, Jukema JW, van Duijn CM, Boomsma DI, Reinders MJT, Slagboom PE

Background: The blood metabolome incorporates cues from the environment and the host's genetic background, potentially offering a holistic view of an individual's health status. Methods: We have compiled a vast resource of proton nuclear magnetic resonance metabolomics and phenotypic data encompassing over 25 000 samples derived from 26 community and hospital-based cohorts. Results: Using this resource, we constructed a metabolomics-based age predictor (metaboAge) to calculate an indiv... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 60, Issue 5, 13 2 2020, Pages 655-662 Editor's Choice - A Systemic Evaluation of the Costs of Elective EVAR and Open Abdominal Aortic Aneurysm Repair Implies Cost Equivalence. Bulder RMA, Eefting D, Vriens PWHE, van Tongeren RB, Matsumura JS, van den Hout WB, Hamming JF, Lindeman JHN

Objective: The suggested high costs of endovascular aneurysm repair (EVAR) hamper the choice of insurance companies and financial regulators for EVAR as the primary option for elective abdominal aortic aneurysm (AAA) repair. However, arguments used in this debate are impeded by time related aspects such as effect modification and the introduction of confounding by indication, and by asymmetric evaluation of outcomes. Therefore, a re-evaluation minimising the impact of these interferences was con... Abstract

Cited 10 times since 2020 (1.9 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 98, Issue 4, 13 2 2020, Pages 691-700 Clinical relevance of adding intravascular ultrasound to coronary angiography for the diagnosis of extrinsic left main coronary artery compression by a pulmonary artery aneurysm in pulmonary hypertension. Velázquez Martín M, Montero Cabezas JM, Huertas S, Nuche J, Albarrán A, Delgado JF, Alonso S, Sarnago F, Arribas F, Escribano Subias P

Objectives: We sought to assess the clinical value of adding intravascular ultrasound (IVUS) evaluation to coronary angiography (CA) to guide extrinsic left main coronary artery (LMCA) compression diagnosis and treatment in pulmonary hypertension (PH). Background: LMCA compression due to a pulmonary artery aneurysm (PAA) is a severe complication of PH. Although guidelines encourage the use of IVUS for LMCA disease evaluation, it has hardly been used in this scenario. Methods: We analyzed morbimo... Abstract

Cited 11 times since 2020 (2.1 per year) source: EuropePMC

Obesity facts, Volume 13, Issue 4, 11 2 2020, Pages 361-370 Experiences with Glucagon-Like Peptide-1 Receptor Agonist in Children with Acquired Hypothalamic Obesity. van Schaik J, Begijn DGA, van Iersel L, Vergeer Y, Hoving EW, Peeters B, van Santen HM

Objective: Hypothalamic obesity (HO) in children after treatment for a tumor in the suprasellar region has severe implications. Previous studies have shown various effects of glucagon-like peptide-1 (GLP-1) receptor agonist in acquired HO, but in adults only. We present our experience of GLP-1 receptor agonist (exenatide) treatment during a 1-year period on body mass index (BMI) in children with acquired HO. Patients and methods: Children with severe weight gain after treatment for suprasellar t... Abstract

Cited 5 times since 2020 (1 per year) source: EuropePMC

Langenbeck's archives of surgery, Volume 405, Issue 6, 11 2 2020, Pages 851-859 Outcomes of parathyroidectomy versus calcimimetics for secondary hyperparathyroidism and kidney transplantation: a propensity-matched analysis. Koh EY, van der Plas WY, Dulfer RR, Pol RA, Kruijff S, Rotmans JI, Appelman-Dijkstra N, Schepers A, de Borst MH, Hoorn EJ, van Ginhoven TM, Nieveen van Dijkum EJM, Vogt L, Engelsman AF, Dutch Hyperparathyroidism Study Group

Purpose: Calcimimetics are currently indicated for severe secondary hyperparathyroidism (SHPT). However, the role of parathyroidectomy (PTX) for these patients is still under debate, and its impact on subsequent kidney transplantation (KTX) is unclear. In this study, we compare the outcomes of kidney transplantation after PTX or medical treatment. Methods: Patients who underwent KTX and had SHPT were analyzed retrospectively. Two groups were selected (patients who had either PTX or calcimimetics... Abstract

Cited 6 times since 2020 (1.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 36, Issue 12, 10 2 2020, Pages 2357-2364 Per-lesion versus per-patient analysis of coronary artery disease in predicting the development of obstructive lesions: the Progression of AtheRosclerotic PlAque DetermIned by Computed TmoGraphic Angiography Imaging (PARADIGM) study. Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ

To determine whether the assessment of individual plaques is superior in predicting the progression to obstructive coronary artery disease (CAD) on serial coronary computed tomography angiography (CCTA) than per-patient assessment. From a multinational registry of 2252 patients who underwent serial CCTA at a ≥ 2-year inter-scan interval, patients with only non-obstructive lesions at baseline were enrolled. CCTA was quantitatively analyzed at both the per-patient and per-lesion level. Models pred... Abstract

Cited 5 times since 2020 (1 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 60, Issue 4, 10 2 2020, Pages 632-633 Imaging Assessment of Carotid Artery Stenosis Varies in Clinical Practice. Brouwers JJWM, Versluijs Y, van Walderveen MAA, Hamming JF, Schepers A

Abstract