Research

Publications

Below you can find a list of our published research.

6143 results

Cited 64 times since 2011 (4.8 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 12, 21 3 2011, Pages 262 Outcome in hip fracture patients related to anemia at admission and allogeneic blood transfusion: an analysis of 1262 surgically treated patients. Vochteloo AJ, Borger van der Burg BL, Mertens B, Niggebrugge AH, de Vries MR, Tuinebreijer WE, Bloem RM, Nelissen RG, Pilot P

Background: Anemia is more often seen in older patients. As the mean age of hip fracture patients is rising, anemia is common in this population. Allogeneic blood transfusion (ABT) and anemia have been pointed out as possible risk factors for poorer outcome in hip fracture patients. Methods: In the timeframe 2005-2010, 1262 admissions for surgical treatment of a hip fracture in patients aged 65 years and older were recorded. Registration was prospective from 2008 on. Anemic and non-anemic patien... Abstract

Cited 29 times since 2011 (2.2 per year) source: EuropePMC

In vitro cellular & developmental biology. Animal, Volume 48, Issue 1, 20 3 2011, Pages 21-29 Endothelial colony-forming cells show a mature transcriptional response to shear stress. Egorova AD, DeRuiter MC, de Boer HC, van de Pas S, Gittenberger-de Groot AC, van Zonneveld AJ, Poelmann RE, Hierck BP

Endothelial progenitor cells (EPC) play a central role in endothelial maintenance and repair. Endothelial colony-forming cells (ECFC) form a subpopulation of EPC. ECFC are readily attainable, can be easily isolated, possess a high proliferation potential, and are therefore a promising source of endothelial cells (EC) for future cardiovascular therapeutic applications. The extent to which these cells respond to shear stress as adult vascular EC remains to be elucidated. Here, we study the transcr... Abstract

Cited 46 times since 2011 (3.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 5, Issue 1, 17 3 2011, Pages 101-110 Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks? Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, van Erven L, van Dijk AP, Wilde AA, Pieper PG, Sieswerda GT, Mulder BJ

Background: The value of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (CHD) is unknown. We investigated the long-term outcome after ICD implantation and developed a simple risk stratification score for ICD therapy. Methods and results: A total of 136 adults with CHD and ICD (mean age±SD, 41±13 years; 67% male) were identified from 10 tertiary referral centers in the Netherlands and Belgium. The indication for ICD implantation was primary prevention in 50... Abstract

Cited 48 times since 2011 (3.6 per year) source: EuropePMC

International journal of epidemiology, Volume 41, Issue 1, 17 3 2011, Pages 106-115 Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Talens RP, Jukema JW, Trompet S, Kremer D, Westendorp RG, Lumey LH, Sattar N, Putter H, Slagboom PE, Heijmans BT, PROSPER Group

Background: Human epidemiological studies suggest that small size at birth and food deprivation during gestation confer an excess risk of coronary heart diseases (CHD) in adulthood, frequently in a sex-specific manner. Prior epigenetic studies indicate that such prenatal conditions are marked by persistent and sometimes sex-specific changes in DNA methylation. Here, we have investigated the association between DNA methylation and myocardial infarction (MI) at six loci sensitive to prenatal nutri... Abstract

Cited 31 times since 2011 (2.3 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 14, Issue 1, 16 3 2011, Pages 17-21 Vacuum-assisted closure of post-sternotomy mediastinitis as compared to open packing. Vos RJ, Yilmaz A, Sonker U, Kelder JC, Kloppenburg GT

Post-sternotomy mediastinitis is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. The aim of this study is to describe clinical outcomes of VAC as compared to open packing and to predict risk factors for mortality. We performed a retrospective analysis of 113 patients with mediastinitis undergoing... Abstract

Cited 38 times since 2011 (2.8 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 4, 15 3 2011, Pages 513-519 Implantable cardioverter-defibrillator longevity under clinical circumstances: an analysis according to device type, generation, and manufacturer. Thijssen J, Borleffs CJ, van Rees JB, Man S, de Bie MK, Venlet J, van der Velde ET, van Erven L, Schalij MJ

Background: One of the major drawbacks of implantable cardioverter-defibrillator (ICD) treatment is the limited device service life. Thus far, data concerning ICD longevity under clinical circumstances are scarce. In this study, the ICD service life was assessed in a large cohort of ICD recipients. Objective: To assess the battery longevity of ICDs under clinical circumstances. Methods: All patients receiving an ICD in the Leiden University Medical Center were included in the analysis. During pr... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Contemporary clinical trials, Volume 33, Issue 2, 13 2 2011, Pages 410-416 Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair. Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Veen G, Zwinderman AH, Mulder BJ

Background: HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular risk in adults after successful coarctation repair has not yet been established. Methods: We designed a multicentre, prospective, randomised,... Abstract

Cited 441 times since 2011 (33 per year) source: EuropePMC

The New England journal of medicine, Volume 366, Issue 1, 13 2 2011, Pages 20-33 Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. Tricoci P, Huang Z, Held C, Moliterno DJ, Armstrong PW, Van de Werf F, White HD, Aylward PE, Wallentin L, Chen E, Lokhnygina Y, Pei J, Leonardi S, Rorick TL, Kilian AM, Jennings LH, Ambrosio G, Bode C, Cequier A, Cornel JH, Diaz R, Erkan A, Huber K, Hudson MP, Jiang L, Jukema JW, Lewis BS, Lincoff AM, Montalescot G, Nicolau JC, Ogawa H, Pfisterer M, Prieto JC, Ruzyllo W, Sinnaeve PR, Storey RF, Valgimigli M, Whellan DJ, Widimsky P, Strony J, Harrington RA, Mahaffey KW, TRACER Investigators

Background: Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. Methods: In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, stroke, recurrent ischemia with rehospitalization, or urgent coronary revascularizat... Abstract

Cited 13 times since 2011 (1 per year) source: EuropePMC

Nucleic acids research, Volume 40, Issue 5, 12 2 2011, Pages 1984-1999 Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells. Holkers M, de Vries AA, Gonçalves MA

DNA repeats constitute potential sites for the nucleation of secondary structures such as hairpins and cruciforms. Studies performed mostly in bacteria and yeast showed that these noncanonical DNA structures are breakage-prone, making them candidate targets for cellular DNA repair pathways. Possible culprits for fragility at repetitive DNA sequences include replication and transcription as well as the action of structure-specific nucleases. Despite their patent biological relevance, the paramete... Abstract

Cited 10 times since 2011 (0.7 per year) source: EuropePMC

Journal of electrocardiology, Volume 45, Issue 2, 9 2 2011, Pages 154-160 Role of the vectorcardiogram-derived spatial QRS-T angle in diagnosing left ventricular hypertrophy. Man S, Rahmattulla C, Maan AC, Holman E, Bax JJ, van der Wall EE, Schalij MJ, Swenne CA

Introduction: Current criteria for electrocardiographic (ECG) diagnosis of left ventricular hypertrophy (LVH) have a low diagnostic accuracy. Addition of demographic, anthropomorphic, and additional ECG variables may improve accuracy. As hypertrophy affects action potential morphology and intraventricular conduction, QRS prolongation and T-wave morphology may occur and become manifest in the vectorcardiographic variables spatial QRS-T angle (SA) and spatial ventricular gradient. In this study, w... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Journal of interventional cardiology, Volume 25, Issue 1, 8 2 2011, Pages 1-9 Aspiration thrombectomy during primary percutaneous coronary intervention as adjunctive therapy to early (in-ambulance) abciximab administration in patients with acute ST elevation myocardial infarction: an analysis from Leiden MISSION! acute myocardial infarction treatment optimization program. Ahmed TA, Atary JZ, Wolterbeek R, Hasan-Ali H, Abdel-Kader SS, Schalij MJ, Jukema JW

Background: The benefits of early abciximab administration and thrombus aspiration in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) have previously been elaborated. However, whether there is an adjunctive effect of thrombus aspiration among STEMI patients, with angiographic evidence of thrombus, receiving early prehospital abciximab remains unclear. Methods: In the context of a fixed protocol for PPCI, 158 consecutive patients w... Abstract

Cited 40 times since 2011 (3 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 4, 3 1 2011, Pages 494-498 Cardiac device infections are associated with a significant mortality risk. de Bie MK, van Rees JB, Thijssen J, Borleffs CJ, Trines SA, Cannegieter SC, Schalij MJ, van Erven L

Background: Cardiac device infections (CDIs) are a serious complication associated with the implantation of cardiac rhythm devices. However, the effect of CDI on the subsequent risk of mortality is unknown. Objective: To assess the prognostic importance of CDI in recipients of implantable cardioverter-defibrillator and cardiac resynchronization therapy - defibrillator. Methods: All patients who received their initial implantable cardioverter-defibrillator/cardiac resynchronization therapy - defi... Abstract

Cited 49 times since 2011 (3.7 per year) source: EuropePMC

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Volume 21, Issue 8, 1 1 2011, Pages 1472-1478 Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients. van der Vorst JR, Hutteman M, Gaarenstroom KN, Peters AA, Mieog JS, Schaafsma BE, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objective: In early cervical cancer, a total pelvic lymphadenectomy is the standard of care, even though most patients have negative nodes and thus undergo lymphadenectomy unnecessarily. Although the value of sentinel lymph node (SLN) mapping in early-stage cervical cancer has not yet been established, near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. Near-infrared fluorescence imaging is based on invisible NIR light and can provide high sensitivity, hi... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

Journal of nephrology, Volume 24, Issue 6, 1 1 2011, Pages 764-770 Preoperative left ventricular dysfunction predisposes to postoperative acute kidney injury and long-term mortality. van Kuijk JP, Flu WJ, Valentijn TM, Chonchol M, Voûte MT, Kuiper RJ, Verhagen HJ, Bax JJ, Poldermans D

Background: Both preoperative left ventricular dysfunction (LVD) and acute kidney injury (AKI) in the postoperative period are independently associated with mortality. We evaluated the prevalence and prognostic implications of AKI in a cohort of vascular surgery patients. Methods: Before vascular surgery, 1,158 patients were screened for LVD. Development of AKI, defined by RIFLE classification, was detected by serial serum creatinine measurements at days 1 to 3 after surgery. Primary end point w... Abstract

Cited 32 times since 2011 (2.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 58, Issue 22, 1 1 2011, Pages 2282-2289 Implantable cardioverter-defibrillator patients who are upgraded and respond to cardiac resynchronization therapy have less ventricular arrhythmias compared with nonresponders. Thijssen J, Borleffs CJ, Delgado V, van Rees JB, Mooyaart EA, van Bommel RJ, van Erven L, Boersma E, Bax JJ, Schalij MJ

Objectives: The purpose of this study was to evaluate the impact of upgrading implantable cardioverter-defibrillator (ICD) therapy to cardiac resynchronization therapy (CRT) combined with defibrillator (CRT-D) on the occurrence of ventricular arrhythmia (VA) and appropriate ICD therapies. Background: CRT has been shown to improve left ventricular (LV) systolic function and induce reverse LV remodeling. In addition, it has been hypothesized that CRT may reduce the incidence of VA. Methods: Heart... Abstract

Cited 13 times since 2011 (1 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 240, Issue 11, 1 1 2011, Pages 2561-2577 Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC

The inhibitor of differentiation Id2 is expressed in mesoderm of the second heart field, which contributes myocardial and mesenchymal cells to the primary heart tube. The role of Id2 in cardiac development is insufficiently known. Heart development was studied in sequential developmental stages in Id2 wildtype and knockout mouse embryos. Expression patterns of Id2, MLC-2a, Nkx2.5, HCN4, and WT-1 were analyzed. Id2 is expressed in myocardial progenitor cells at the inflow and outflow tract, in th... Abstract

Cited 65 times since 2011 (4.9 per year) source: EuropePMC

Foot & ankle international, Volume 32, Issue 11, 1 1 2011, Pages 1040-1044 Complications of syndesmotic screw removal. Schepers T, Van Lieshout EM, de Vries MR, Van der Elst M

Background: Currently, the metallic syndesmotic screw is the gold standard in the treatment of syndesmotic disruption. Whether or not this screw needs to be removed remains debatable. The aim of the current study was to determine the complications which occur following routine removal of the syndesmotic screw following operative treatment of unstable ankle fractures. Methods: This was a retrospective study with consecutive cases in a Level-2 Trauma center. All patients with routine removal of a... Abstract

Cited 180 times since 2011 (13.4 per year) source: EuropePMC

Science (New York, N.Y.), Volume 334, Issue 6056, 1 1 2011, Pages 686-690 Drosophila CENH3 is sufficient for centromere formation. Mendiburo MJ, Padeken J, Fülöp S, Schepers A, Heun P

CENH3 is a centromere-specific histone H3 variant essential for kinetochore assembly. Despite its central role in centromere function, there has been no conclusive evidence supporting CENH3 as sufficient to determine centromere identity. To address this question, we artificially targeted Drosophila CENH3 (CENP-A/CID) as a CID-GFP-LacI fusion protein to stably integrated lac operator (lacO) arrays. This ectopic CID focus assembles a functional kinetochore and directs incorporation of CID molecule... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Journal of affective disorders, Volume 136, Issue 3, 26 4 2011, Pages 751-757 Beta blocker therapy is associated with reduced depressive symptoms 12 months post percutaneous coronary intervention. Battes LC, Pedersen SS, Oemrawsingh RM, van Geuns RJ, Al Amri I, Regar E, de Jaegere PP, Serruys P, van Domburg RT

Background: Beta blocker therapy may induce depressive symptoms, although current evidence is conflicting. We examined the association between beta blocker therapy and depressive symptoms in percutaneous coronary intervention (PCI) patients and the extent to which there is a dose-response relationship between beta blocker dose and depressive symptoms. Methods: Patients treated with PCI (N=685) completed the depression scale of the Hospital Anxiety and Depression Scale 1 and 12 months post PCI. I... Abstract

Cited 10 times since 2011 (0.7 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 1, 25 4 2011, Pages 86-92 C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure. Krijnen PA, Kupreishvili K, de Vries MR, Schepers A, Stooker W, Vonk AB, Eijsman L, Van Hinsbergh VW, Zeerleder S, Wouters D, van Ham M, Quax PH, Niessen HW

Objectives: Arterial pressure induced vein graft injury can result in endothelial loss, accelerated atherosclerosis and vein graft failure. Inflammation, including complement activation, is assumed to play a pivotal role herein. Here, we analyzed the effects of C1-esterase inhibitor (C1inh) on early vein graft remodeling. Methods: Human saphenous vein graft segments (n=8) were perfused in vitro with autologous blood either supplemented or not with purified human C1inh at arterial pressure for 6h... Abstract