Research

Publications

Below you can find a list of our published research.

6143 results

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 453-459 Predictive power of T-wave alternans and of ventricular gradient hysteresis for the occurrence of ventricular arrhythmias in primary prevention cardioverter-defibrillator patients. Man S, De Winter PV, Maan AC, Thijssen J, Borleffs CJ, van Meerwijk WP, Bootsma M, van Erven L, van der Wall EE, Schalij MJ, Burattini L, Burattini R, Swenne CA

Background and purpose: Left ventricular ejection fraction lacks specificity to predict sudden cardiac death in heart failure. T-wave alternans (TWA; beat-to-beat T-wave instability, often measured during exercise) is deemed a promising noninvasive predictor of major cardiac arrhythmic event. Recently, it was demonstrated that TWA during recovery from exercise has additional predictive value. Another mechanism that potentially contributes to arrhythmogeneity is exercise-recovery hysteresis in ac... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, Volume 19, Issue 7, 1 1 2011, Pages 678-679 Successful electroconvulsive therapy in a 95-year-old man with a cardiac pacemaker--a case report. Gosselink MJ, Schenkeveld KW, Trines SA, van Vliet IM

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Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Pediatric research, Volume 70, Issue 1, 1 1 2011, Pages 37-43 Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias. Hahurij ND, Kolditz DP, Bökenkamp R, Markwald RR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Blom NA

Atrioventricular reentry tachycardia (AVRT) requiring an accessory atrioventricular pathway (AP) is the most common type of arrhythmia in the perinatal period. The etiology of these arrhythmias is not fully understood as well as their capability to dissipate spontaneously in the first year of life. Temporary presence of APs during annulus fibrosus development might cause this specific type of arrhythmias. To study the presence of APs, electrophysiological recordings of ventricular activation pat... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 410-415 Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction. Man S, Algra AM, Schreurs CA, Borleffs CJ, Scherptong RW, van Erven L, van der Wall EE, Cannegieter SC, Schalij MJ, Swenne CA

Background and purpose: Several studies have demonstrated that the spatial mean QRS-T angle (SA) predicts cardiac events and mortality. Spatial mean QRS-T angle is a vectorcardiographic variable. Because in clinical practice, 12-lead standard electrocardiograms (ECGs) are recorded rather than vectorcardiograms (VCGs) according to Frank, VCGs are commonly obtained by synthesizing them from 12-lead ECGs, by using a VCG synthesis matrix. Hence, the thus computed SA is an estimate of the real SA mea... Abstract

The Annals of thoracic surgery, Volume 92, Issue 1, 1 1 2011, Pages 166 Invited commentary. Hazekamp MG

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Cited 39 times since 2011 (2.8 per year) source: EuropePMC

Journal of dairy science, Volume 94, Issue 7, 1 1 2011, Pages 3213-3228 Invited review: associations between variables of routine herd data and dairy cattle welfare indicators. de Vries M, Bokkers EA, Dijkstra T, van Schaik G, de Boer IJ

As farm animal welfare is high on the political and societal agendas of many countries, considerable pressure exists to establish audit programs in which farm animal welfare is routinely monitored. On-farm assessment of animal welfare, however, is time-consuming and costly. A promising strategy to monitor animal welfare more efficiently is to first estimate the level of animal welfare on a farm based on routine herd data that are available in national databases. It is not currently known which v... Abstract

Cited 52 times since 2011 (3.8 per year) source: EuropePMC

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, Volume 47, Issue 2, 30 5 2011, Pages 90-97 Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy. Hutteman M, van der Vorst JR, Mieog JS, Bonsing BA, Hartgrink HH, Kuppen PJ, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Background: Intraoperative visualization of pancreatic tumors has the potential to improve radical resection rates. Intraoperative visualization of the common bile duct and bile duct anastomoses could be of added value. In this study, we explored the use of indocyanine green (ICG) for these applications and attempted to optimize injection timing and dose. Methods: Eight patients undergoing a pancreaticoduodenectomy were injected intravenously with 5 or 10 mg ICG. During and after injection, the... Abstract

Cited 27 times since 2011 (2 per year) source: EuropePMC

Stroke research and treatment, Volume 2011, 30 5 2011, Pages 424759 Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality. Trompet S, Pons D, Kanse SM, de Craen AJ, Ikram MA, Verschuren JJ, Zwinderman AH, Doevendans PA, Tio RA, de Winter RJ, Slagboom PE, Westendorp RG, Jukema JW

Introduction. The FSAP-Marburg I polymorphism (1704G > A), which reduces FSAP activity, is associated with late complications of carotid stenosis in humans. Therefore, this study examines the influence of the Marburg I polymorphism and the closely linked Marburg II polymorphism (1280G > C) on various cardiovascular outcomes in two large independent study populations. Methods. The two Marburg polymorphisms in the HABP2 gene encoding FSAP were genotyped in a large population of elderly patie... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 5, 28 4 2011, Pages 711-717 Prediction of response to cardiac resynchronization therapy combining two different three-dimensional analyses of left ventricular dyssynchrony. Auger D, Bertini M, Marsan NA, Hoke U, Ewe SH, Thijssen J, Witkowski TG, Yiu KH, Ng AC, van der Wall EE, Schalij MJ, Bax JJ, Delgado V

Triplane tissue synchronization imaging (TSI) and real-time 3-dimensional echocardiography (RT3DE) provide different characterizations of left ventricular (LV) mechanics and dyssynchrony. Triplane TSI assesses differences in time to peak systolic segmental myocardial tissue velocities, whereas RT3DE evaluates differences in time to minimum end-systolic regional volumes. Whether an approach using the 2 3D techniques predicts better significant reverse remodeling after cardiac resynchronization th... Abstract

Cited 51 times since 2011 (3.7 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 11, 28 4 2011, Pages 1533-1540 Prognostic value of total atrial conduction time estimated with tissue Doppler imaging to predict the recurrence of atrial fibrillation after radiofrequency catheter ablation. den Uijl DW, Gawrysiak M, Tops LF, Trines SA, Zeppenfeld K, Schalij MJ, Bax JJ, Delgado V

Aims: Total atrial activation time has been identified as an independent predictor of new-onset atrial fibrillation (AF). Echocardiographic assessment of PA-TDI duration provides an estimation of total atrial conduction time. The aim of this study was to investigate the prognostic value of total atrial conduction time to predict AF recurrence after radiofrequency catheter ablation (RFCA). Methods and results: In 213 patients undergoing RFCA for symptomatic drug-refractory paroxysmal AF, the tota... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Acta physiologica (Oxford, England), Volume 203, Issue 4, 27 4 2011, Pages 409-418 The induction of mild hypothermia improves systolic function of the resuscitated porcine heart at no further sympathetic activation. Schwarzl M, Steendijk P, Huber S, Truschnig-Wilders M, Obermayer-Pietsch B, Maechler H, Pieske B, Post H

Aim: Mild hypothermia (MH) after cardiac arrest attenuates hypoxic brain injury and improves survival. As MH increases contractility in normal hearts, we hypothesized that MH improves cardiovascular function after cardiac arrest. Methods: In 16 anaesthetized pigs (64 ± 2 kg), ventricular fibrillation was induced electrically for 5 min. At 10 min after resuscitation and return of spontaneous circulation (ROSC), pigs were assigned to normothermia (NT, 38°C, n = 8) or MH (33°C, n = 8, intravascular... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 5, 22 4 2011, Pages 658-664 Comparison of the relation between the calcium score and plaque characteristics in patients with acute coronary syndrome versus patients with stable coronary artery disease, assessed by computed tomography angiography and virtual histology intravascular ultrasound. van Velzen JE, de Graaf FR, Jukema JW, de Grooth GJ, Pundziute G, Kroft LJ, de Roos A, Reiber JH, Bax JJ, Schalij MJ, Schuijf JD, van der Wall EE

A considerable number of patients with an acute coronary syndrome (ACS) who present with a 0 or low calcium score (CS) still demonstrate coronary artery disease (CAD) and significant stenosis. The aim of the present study was to evaluate the relation between the CS and the degree and character of atherosclerosis in patients with suspected ACS versus patients with stable CAD obtained by computed tomography angiography and virtual histology intravascular ultrasound (VH IVUS). Overall 112 patients... Abstract

Cited 9 times since 2011 (0.7 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 38, Issue 10, 21 3 2011, Pages 1899-1907 Impaired cardiac sympathetic innervation in symptomatic patients with long QT syndrome. Kies P, Paul M, Gerss J, Stegger L, Mönnig G, Schober O, Wichter T, Schäfers M, Schulze-Bahr E

Purpose: Increased sympathetic activation is a key modifier for arrhythmogenesis in patients with long QT syndrome (LQTS), a congenital channelopathy. Therefore, we investigated cardiac sympathetic function using 123I-metaiodobenzylguanidine (MIBG) single photon emission computed tomography (SPECT) in a cohort of symptomatic LQTS patients and correlated these findings with the underlying genotype. Methods: [123I]MIBG SPECT was performed in 28 LQTS patients. Among these, 18 patients (64%) had a p... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Nurse education today, Volume 32, Issue 4, 17 3 2011, Pages 373-377 Student nurses' perceptions of mental health care: validation of a questionnaire. van der Heijden A, van der Bijl J, Latour CH, Hoekstra H, van Meijel B

Aim: This article describes the results of a study into the psychometric properties of a questionnaire about student nurses' perceptions of mental health care. The questionnaire was constructed in 2008, but has not yet been tested in terms of construct validity and reliability. A validated questionnaire is essential as a standardized method of analyzing student nurses' perceptions of mental health care. Method: To investigate the construct validity, an exploratory factor analysis was p... Abstract

Cited 33 times since 2011 (2.4 per year) source: EuropePMC

Metabolic engineering, Volume 13, Issue 5, 17 3 2011, Pages 518-526 Increasing free-energy (ATP) conservation in maltose-grown Saccharomyces cerevisiae by expression of a heterologous maltose phosphorylase. de Kok S, Yilmaz D, Suir E, Pronk JT, Daran JM, van Maris AJ

Increasing free-energy conservation from the conversion of substrate into product is crucial for further development of many biotechnological processes. In theory, replacing the hydrolysis of disaccharides by a phosphorolytic cleavage reaction provides an opportunity to increase the ATP yield on the disaccharide. To test this concept, we first deleted the native maltose metabolism genes in Saccharomyces cerevisiae. The knockout strain showed no maltose-transport activity and a very low residual... Abstract

Cited 52 times since 2011 (3.8 per year) source: EuropePMC

American journal of hypertension, Volume 24, Issue 9, 16 3 2011, Pages 999-1006 SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction. Nossent AY, Hansen JL, Doggen C, Quax PH, Sheikh SP, Rosendaal FR

Background: We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction. Methods: Using online databases dbSNP and TargetScan, we identified 10 SNPs in potential miR binding sites in eight RAAS-related genes, common in Caucasians. We genotyped a large case-control study on myocardial infarctions, the Study of Myocardial Infarctions LEi... Abstract

Cited 83 times since 2011 (6 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 106, Issue 1, 14 2 2011, Pages 1-19 Stabilisation of atherosclerotic plaques. Position paper of the European Society of Cardiology (ESC) Working Group on atherosclerosis and vascular biology. Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgözoglu L

Plaque rupture and subsequent thrombotic occlusion of the coronary artery account for as many as three quarters of myocardial infarctions. The concept of plaque stabilisation emerged about 20 years ago to explain the discrepancy between the reduction of cardiovascular events in patients receiving lipid lowering therapy and the small decrease seen in angiographic evaluation of atherosclerosis. Since then, the concept of a vulnerable plaque has received a lot of attention in basic and clinical res... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

American journal of medical genetics. Part A, Volume 155A, Issue 7, 10 2 2011, Pages 1661-1667 Adults with congenital heart disease: patients' knowledge and concerns about inheritance. van Engelen K, Baars MJ, van Rongen LT, van der Velde ET, Mulder BJ, Smets EM

With recent advances in medical and surgical management, most patients with congenital heart disease (CHD) survive to reproductive age. Current guidelines recommend counseling about inheritance and transmission of CHD to offspring. We evaluated whether adult CHD patients recalled having received information about the inheritance of their CHD, patients' knowledge about inheritance and their concerns in this regard. A questionnaire was sent to 486 non-syndromic CHD patients aged 20-45 years.... Abstract

Cited 18 times since 2011 (1.3 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 12, 9 2 2011, Pages 130 A hinged external fixator for complex elbow dislocations: a multicenter prospective cohort study. Schep NW, De Haan J, Iordens GI, Tuinebreijer WE, Bronkhorst MW, De Vries MR, Goslings JC, Ham SJ, Rhemrev S, Roukema GR, Schipper IB, Sintenie JB, Van der Meulen HG, Van Thiel TP, Van Vugt AB, Verleisdonk EJ, Vroemen JP, Wittich P, Patka P, Van Lieshout EM, Den Hartog D

Background: Elbow dislocations can be classified as simple or complex. Simple dislocations are characterized by the absence of fractures, while complex dislocations are associated with fractures of the radial head, olecranon, or coronoid process. The majority of patients with these complex dislocations are treated with open reduction and internal fixation (ORIF), or arthroplasty in case of a non-reconstructable radial head fracture. If the elbow joint remains unstable after fracture fixation, a... Abstract

Cited 48 times since 2011 (3.5 per year) source: EuropePMC

Cell transplantation, Volume 21, Issue 1, 7 1 2011, Pages 153-173 Myogenic properties of human mesenchymal stem cells derived from three different sources. de la Garza-Rodea AS, van der Velde-van Dijke I, Boersma H, Gonçalves MA, van Bekkum DW, de Vries AA, Knaän-Shanzer S

Mesenchymal stem cells (MSCs) of mammals have been isolated from many tissues and are characterized by their aptitude to differentiate into bone, cartilage, and fat. Differentiation into cells of other lineages like skeletal muscle, tendon/ligament, nervous tissue, and epithelium has been attained with MSCs derived from some tissues. Whether such abilities are shared by MSCs of all tissues is unknown. We therefore compared for three human donors the myogenic properties of MSCs from adipose tiss... Abstract