Research

Publications

Below you can find a list of our published research.

6152 results

Cited 72 times since 2009 (4.6 per year) source: EuropePMC

European heart journal, Volume 30, Issue 19, 4 1 2009, Pages 2360-2367 Magnetic resonance imaging and response to cardiac resynchronization therapy: relative merits of left ventricular dyssynchrony and scar tissue. Marsan NA, Westenberg JJ, Ypenburg C, van Bommel RJ, Roes S, Delgado V, Tops LF, van der Geest RJ, Boersma E, de Roos A, Schalij MJ, Bax JJ

Aim: To assess the relative value of a novel measure of left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and the extent of scar tissue for prediction of response to cardiac resynchronization therapy (CRT). Methods and results: Thirty-five heart failure patients scheduled for CRT were included. Left ventricular dyssynchrony was defined as the standard deviation of 16 segment time-to-maximum radial wall thickness (SDt-16) obtained from a cine-set of short-axis slice... Abstract

Cited 187 times since 2009 (11.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 5, 1 1 2009, Pages 402-409 Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. Phan TT, Abozguia K, Nallur Shivu G, Mahadevan G, Ahmed I, Williams L, Dwivedi G, Patel K, Steendijk P, Ashrafian H, Henning A, Frenneaux M

Objectives: We sought to evaluate the role of exercise-related changes in left ventricular (LV) relaxation and of LV contractile function and vasculoventricular coupling (VVC) in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and to assess myocardial energetic status in these patients. Background: To date, no studies have investigated exercise-related changes in LV relaxation and VVC as well as in vivo myocardial energetic status in patients with HFpEF. Methods: We... Abstract

Cited 23 times since 2009 (1.5 per year) source: EuropePMC

Pediatric research, Volume 66, Issue 1, 1 1 2009, Pages 74-79 Histopathological changes of the heart after neonatal dexamethasone treatment: studies in 4-, 8-, and 50-week-old rats. Bal MP, de Vries WB, Steendijk P, Homoet-van der Kraak P, van der Leij FR, Baan J, van Oosterhout MF, van Bel F

Dexamethasone (Dex), for prevention of chronic lung disease in preterm infants, showed potential negative long-term effects. Studies regarding long-term cardiovascular effects are lacking. We investigated possible histopathological myocardial changes after neonatal Dex in the young and adult rat heart. Rats were treated with Dex on d 1, 2, and 3 (0.5, 0.3, and 0.1 mg/kg) of life. Control-pups received saline. At 4, 8, and 50 wk after birth rats were killed and anatomic data collected. Heart tiss... Abstract

Cited 26 times since 2009 (1.7 per year) source: EuropePMC

American heart journal, Volume 158, Issue 1, 1 1 2009, Pages 40-46 Delayed improvement of right ventricular diastolic function and regression of right ventricular mass after percutaneous pulmonary valve implantation in patients with congenital heart disease. Romeih S, Kroft LJ, Bokenkamp R, Schalij MJ, Grotenhuis H, Hazekamp MG, Groenink M, de Roos A, Blom NA

Background: Percutaneous pulmonary valve implantation (PPVI) has been introduced as therapy for right ventricular (RV) to pulmonary artery conduit dysfunction in patients with congenital heart disease. It has been shown that RV systolic function improved early after PPVI. The effects of PPVI on RV diastolic function and RV hypertrophy have not yet been studied. Purpose: The objective of this study is to assess early and late changes in systolic and diastolic RV function and RV mass after PPVI. M... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 32, Issue 7, 1 1 2009, Pages 913-917 Left ventricular ejection fraction as criterion for implantation of an implantable cardioverter-defibrillator in heart failure patients undergoing surgical left ventricular reconstruction. Mollema SA, Klein P, Heersche J, Schalij MJ, Van der Wall EE, Versteegh MI, Klautz RJ, Van Erven L, Bax JJ

Background: Besides implantation of an implantable cardioverter-defibrillator (ICD), a proportion of patients with left ventricular (LV) dysfunction due to ischemic cardiomyopathy are potential candidates for surgical LV reconstruction (Dor procedure), which changes LV ejection fraction (LVEF) considerably. In these patients, LVEF as selection criterium for ICD implantation may be difficult. This study aimed to determine the value of LVEF as criterium for ICD implantation in heart failure patien... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese, Volume 50, Issue 4, 1 1 2009, Pages 245-263 Imaging of atherosclerosis: invasive and noninvasive techniques. Van Velzen JE, Schuijf JD, De Graaf FR, Jukema JW, Roos AD, Kroft LJ, Schalij MJ, Reiber JH, Van Der Wall EE, Bax JJ

Abstract

Cited 16 times since 2009 (1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 5, 1 1 2009, Pages 445-451 Prevalence and pathophysiologic attributes of ventricular dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Tops LF, Prakasa K, Tandri H, Dalal D, Jain R, Dimaano VL, Dombroski D, James C, Tichnell C, Daly A, Marcus F, Schalij MJ, Bax JJ, Bluemke D, Calkins H, Abraham TP

Objectives: This study sought to investigate the prevalence and mechanisms underlying right ventricular (RV) dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) using tissue Doppler echocardiography (TDE). Background: An ARVD/C is characterized by fibrofatty replacement of RV myocardium and RV dilation. These pathologic changes may result in electromechanical dyssynchrony. Methods: Echocardiography, both conventional and TDE, was performed in 52 ARVD/C patients ful... Abstract

Cited 29 times since 2009 (1.8 per year) source: EuropePMC

Journal of vascular surgery, Volume 50, Issue 1, 1 1 2009, Pages 152-160 Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice. Eefting D, Bot I, de Vries MR, Schepers A, van Bockel JH, Van Berkel TJ, Biessen EA, Quax PH

Objective: Inflammatory responses to vascular injury are key events in vein graft disease and accelerated atherosclerosis, which may result in bypass failure. The monocyte chemoattractant protein-1 (MCP-1)/CC-chemokine receptor (CCR)-2 pathway is hypothesized to play a central role. A murine model for vein graft disease was used to study the effect of local application of lentiviral short hairpin RNA (shRNA) targeted against CCR2. Methods: A venous interposition was placed into the carotid arter... Abstract

Cited 57 times since 2009 (3.6 per year) source: EuropePMC

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Volume 15, Issue 7, 1 1 2009, Pages 817-826 Lung function, pulmonary complications, and mortality after allogeneic blood and marrow transplantation in children. Kaya Z, Weiner DJ, Yilmaz D, Rowan J, Goyal RK

Pulmonary complications (PC) remain a significant barrier to the success of allogeneic blood and marrow transplantation (BMT). Pretransplant pulmonary function tests (PFTs) have been correlated with risk of early respiratory failure and mortality in adult BMT recipients. There is limited data on their relationship to posttransplant outcomes in pediatric patients. We sought, in pediatric allo-BMT recipients (1) to analyze the spectrum of infectious and noninfectious PCs, (2) to evaluate the preva... Abstract

Cited 110 times since 2009 (7 per year) source: EuropePMC

European heart journal, Volume 30, Issue 21, 29 5 2009, Pages 2622-2629 Incremental prognostic value of multi-slice computed tomography coronary angiography over coronary artery calcium scoring in patients with suspected coronary artery disease. van Werkhoven JM, Schuijf JD, Gaemperli O, Jukema JW, Kroft LJ, Boersma E, Pazhenkottil A, Valenta I, Pundziute G, de Roos A, van der Wall EE, Kaufmann PA, Bax JJ

Aims: The purpose of this study was to assess the relationship between calcium scoring (CS) and multi-slice computed tomography coronary angiography (MSCTA) and to determine if MSCTA has an incremental prognostic value to CS. Methods and results: In 432 patients (59% male, age 58 +/- 11 years) referred for cardiac evaluation owing to suspected coronary artery disease (CAD), CS and 64-slice MSCTA were performed. The following events were combined in a composite endpoint: all-cause mortality, non-... Abstract

Cited 14 times since 2009 (0.9 per year) source: EuropePMC

Journal of vascular surgery, Volume 50, Issue 4, 27 4 2009, Pages 749-54; discussion 754 Perioperative asymptomatic cardiac damage after endovascular abdominal aneurysm repair is associated with poor long-term outcome. Winkel TA, Schouten O, van Kuijk JP, Verhagen HJ, Bax JJ, Poldermans D

Background: Endovascular abdominal aortic aneurysm (AAA) repair (EVAR) is associated with a decreased incidence of perioperative cardiac complications compared with open repair. However, EVAR is not associated with long-term survival benefit. This study assessed the effect of perioperative asymptomatic cardiac damage after EVAR on long-term prognosis. Methods: In 220 patients undergoing elective EVAR, routine sampling for levels of cardiac troponin T and electrocardiography (ECG) were performed... Abstract

Cited 11 times since 2009 (0.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 138, Issue 5, 26 4 2009, Pages 1167-1171 Results of surgical repair of atrioventricular septal defect with double-orifice left atrioventricular valve. Hoohenkerk GJ, Wenink AC, Schoof PH, Koolbergen DR, Bruggemans EF, Rijlaarsdam M, Hazekamp MG

Objective: The outcome of surgical correction of atrioventricular septal defect with double-orifice left atrioventricular valve has improved in recent years but is still reported to be associated with high mortality and reoperation rates. Controversy exists about the management of the accessory orifice. We evaluated our results with correction of atrioventricular septal defect with double-orifice left atrioventricular valve. Methods: Between 1975 and 2006, 21 patients underwent correction of atr... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 20, Issue 10, 26 4 2009, Pages 1119-1127 Patients with scar-related right ventricular tachycardia: determinants of long-term outcome. Wijnmaalen AP, Schalij MJ, Bootsma M, Kies P, DE Roos A, Putter H, Bax JJ, Zeppenfeld K

Introduction: Patients with established arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) based on task force (TF) criteria and ventricular tachycardia (VT) are at risk of VT recurrence and sudden death. Data on patients with VT due to right ventricular (RV) scar not fulfilling TF criteria are lacking. The purpose of this study was to assess the long-term arrhythmia recurrence rate and outcome in patients with scar-related right VT with and without a diagnosis of ARVC/D. Methods... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

Annals of biomedical engineering, Volume 37, Issue 9, 25 4 2009, Pages 1710-1726 Modeling the instantaneous pressure-volume relation of the left ventricle: a comparison of six models. Lankhaar JW, Rövekamp FA, Steendijk P, Faes TJ, Westerhof BE, Kind T, Vonk-Noordegraaf A, Westerhof N

Simulations are useful to study the heart's ability to generate flow and the interaction between contractility and loading conditions. The left ventricular pressure-volume (PV) relation has been shown to be nonlinear, but it is unknown whether a linear model is accurate enough for simulations. Six models were fitted to the PV-data measured in five sheep and the estimated parameters were used to simulate PV-loops. Simulated and measured PV-loops were compared with the Akaike information crit... Abstract

Cited 10 times since 2009 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 104, Issue 5, 24 4 2009, Pages 653-656 Comparison of non-invasive multi-slice computed tomography coronary angiography versus invasive coronary angiography and fractional flow reserve for the evaluation of men with known coronary artery disease. van Werkhoven JM, Schuijf JD, Jukema JW, Pundziute G, de Roos A, Schalij MJ, van der Wall EE, Bax JJ

Multislice computed tomographic coronary angiography (MSCT) can accurately detect the presence of atherosclerosis noninvasively. However, a discrepancy has been observed between MSCT and noninvasive functional imaging. The purpose of the present study was to evaluate the correlation between MSCT and invasive fractional flow reserve (FFR) in men with known coronary artery disease. Thirty-three patients (mean age 57 +/- 11 years) clinically referred for coronary angiography underwent MSCT and FFR... Abstract

Cited 63 times since 2009 (4 per year) source: EuropePMC

PLoS medicine, Volume 6, Issue 6, 23 4 2009, Pages e1000099 Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? Sattar N, Murray HM, Welsh P, Blauw GJ, Buckley BM, Cobbe S, de Craen AJ, Lowe GD, Jukema JW, Macfarlane PW, Murphy MB, Stott DJ, Westendorp RG, Shepherd J, Ford I, Packard CJ, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Study Group

Background: Circulating inflammatory markers may more strongly relate to risk of fatal versus nonfatal cardiovascular disease (CVD) events, but robust prospective evidence is lacking. We tested whether interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen more strongly associate with fatal compared to nonfatal myocardial infarction (MI) and stroke. Methods and findings: In the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), baseline inflammatory markers in up to 5,680 m... Abstract

Cited 201 times since 2009 (12.7 per year) source: EuropePMC

Circulation, Volume 120, Issue 1, 22 4 2009, Pages 28-34 Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. Waters DD, Brotons C, Chiang CW, Ferrières J, Foody J, Jukema JW, Santos RD, Verdejo J, Messig M, McPherson R, Seung KB, Tarasenko L, Lipid Treatment Assessment Project 2 Investigators

Background: Information about physicians' adherence to cholesterol management guidelines remains scant. The present survey updates our knowledge of lipid management worldwide. Methods and results: Lipid levels were determined at enrollment in dyslipidemic adult patients on stable lipid-lowering therapy in 9 countries. The primary end point was the success rate, defined as the proportion of patients achieving appropriate low-density lipoprotein cholesterol (LDL-C) goals for their given risk.... Abstract

Cited 15 times since 2009 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 104, Issue 4, 17 3 2009, Pages 480-485 Impact of time to reperfusion after acute myocardial infarction on myocardial damage assessed by left ventricular longitudinal strain. Bertini M, Mollema SA, Delgado V, Antoni ML, Ng AC, Holman ER, Boriani G, Schalij MJ, Bax JJ

The relation between cardiac troponin T (cTnT) and regional strain in patients with acute myocardial infarction (AMI) was investigated. Furthermore, the effect of symptoms-to-balloon time on impairment in regional strain after AMI was evaluated. A total of 157 consecutive patients with AMI who underwent primary percutaneous coronary intervention were included. Two-dimensional echocardiography soon after percutaneous coronary intervention was performed. Speckle-tracking analysis was applied to as... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 10, Issue 5, 13 2 2009, Pages 602-606 Screening for abdominal aortic aneurysms using a dedicated portable ultrasound system: early results. Flu WJ, van Kuijk JP, Merks EJ, Kuiper R, Verhagen HJ, Bosch JG, Bom N, Bax JJ, Poldermans D

Aims: Abdominal aortic aneurysms (AAA) are often diagnosed at time of (impending) rupture leading to a dramatic increase of morbidity and mortality. A simple screening device might be the key solution for widespread AAA screening. This study evaluated the diagnostic accuracy of a new portable ultrasound scanner (Aortascan BVI 9600) developed for automatic AAA detection. Methods and results: A total of 150 patients with presumed aneurysmatic peripheral atherosclerotic disease were included in the... Abstract

Cited 25 times since 2009 (1.6 per year) source: EuropePMC

Pituitary, Volume 12, Issue 4, 12 2 2009, Pages 339-346 Limited effects of growth hormone replacement in patients with GH deficiency during long-term cure of acromegaly. van der Klaauw AA, Bax JJ, Roelfsema F, Stokkel MP, Bleeker GB, Biermasz NR, Smit JW, Romijn JA, Pereira AM

The aim of this study was to assess the effects of replacement with recombinant human growth hormone (rhGH) in patients with GH deficiency (GHD) after treatment of acromegaly. Intervention study. Sixteen patients (8 men, age 56 years), treated for acromegaly by surgery and radiotherapy, with an insufficient GH response to insulin-induced hypoglycaemia, were treated with 1 year of rhGH replacement. Study parameters were assessed at baseline and after 1 year of rhGH replacement. Study parameters w... Abstract