7401 results
Cited 32 times since 2023 (14.1 per year)
source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology,
Volume 34, Issue 9, 16 3 2023, Pages 813-825
Fragmentomic analysis of circulating tumor DNA-targeted cancer panels.
Helzer KT, Sharifi MN, Sperger JM, Shi Y, Annala M, Bootsma ML, Reese SR, Taylor A, Kaufmann KR, Krause HK, Schehr JL, Sethakorn N, Kosoff D, Kyriakopoulos C, Burkard ME, Rydzewski NR, Yu M, Harari PM, Bassetti M, Blitzer G, Floberg J, Sjöström M, Quigley DA, Dehm SM, Armstrong AJ, Beltran H, McKay RR, Feng FY, O'Regan R, Wisinski KB, Emamekhoo H, Wyatt AW, Lang JM, Zhao SG
Background: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to infer epigenomic and transcriptomic information. However, most of these analyses used whole-genome sequ...
Abstract
Cited 19 times since 2023 (8.4 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 380, Issue 6650, 15 3 2023, Pages 1155-1160
Widespread diversity deficits of coral reef sharks and rays.
Simpfendorfer CA, Heithaus MR, Heupel MR, MacNeil MA, Meekan M, Harvey E, Sherman CS, Currey-Randall LM, Goetze JS, Kiszka JJ, Rees MJ, Speed CW, Udyawer V, Bond ME, Flowers KI, Clementi GM, Valentin-Albanese J, Adam MS, Ali K, Asher J, Aylagas E, Beaufort O, Benjamin C, Bernard ATF, Berumen ML, Bierwagen S, Birrell C, Bonnema E, Bown RMK, Brooks EJ, Brown JJ, Buddo D, Burke PJ, Cáceres C, Cambra M, Cardeñosa D, Carrier JC, Casareto S, Caselle JE, Charloo V, Cinner JE, Claverie T, Clua EEG, Cochran JEM, Cook N, Cramp JE, D'Alberto BM, de Graaf M, Dornhege MC, Espinoza M, Estep A, Fanovich L, Farabaugh NF, Fernando D, Ferreira CEL, Fields CYA, Flam AL, Floros C, Fourqurean V, Gajdzik L, Barcia LG, Garla R, Gastrich K, George L, Giarrizzo T, Graham R, Guttridge TL, Hagan V, Hardenstine RS, Heck SM, Henderson AC, Heithaus P, Hertler H, Padilla MH, Hueter RE, Jabado RW, Joyeux JC, Jaiteh V, Johnson M, Jupiter SD, Kaimuddin M, Kasana D, Kelley M, Kessel ST, Kiilu B, Kirata T, Kuguru B, Kyne F, Langlois T, Lara F,
A global survey of coral reefs reveals that overfishing is driving resident shark species toward extinction, causing diversity deficits in reef elasmobranch (shark and ray) assemblages. Our species-level analysis revealed global declines of 60 to 73% for five common resident reef shark species and that individual shark species were not detected at 34 to 47% of surveyed reefs. As reefs become more shark-depleted, rays begin to dominate assemblages. Shark-dominated assemblages persist in wealthy n...
Abstract
Cited 4 times since 2023 (1.8 per year)
source: EuropePMC
Clinical pharmacokinetics,
Volume 62, Issue 8, 13 2 2023, Pages 1129-1139
CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer Patients.
van Eerden RAG, IJzerman NS, van Meekeren M, Oomen-de Hoop E, Guchelaar NAD, Visser AMW, Matic M, van Schaik RHN, de Bruijn P, Moes DAR, Jobse PA, Gelderblom H, Huitema ADR, Steeghs N, Mathijssen RHJ, Koolen SLW, Dutch Pharmacology Oncology Group
Introduction: A genetic variant explaining a part of the exposure of many kinase inhibitors (KIs) is the single nucleotide polymorphism (SNP) CYP3A4*22, resulting in less CYP3A4 enzyme activity. The primary aim of this study was to investigate if the systemic exposure is non-inferior after a dose reduction of KIs metabolized by CYP3A4 in CYP3A4*22 carriers compared to patients without this SNP (i.e., wildtype patients) receiving the standard dose. Methods: In this multicenter, prospective, non-i...
Abstract
Cited 4 times since 2023 (1.8 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 89, Issue 10, 13 2 2023, Pages 3026-3036
Towards precision dosing of aripiprazole in children and adolescents with autism spectrum disorder: Linking blood levels to weight gain and effectiveness.
Hermans RA, Sassen SDT, Kloosterboer SM, Reichart CG, Kouijzer MEJ, de Kroon MMJ, Bastiaansen D, van Altena D, van Schaik RHN, Nasserinejad K, Hillegers MHJ, Koch BCP, Dierckx B, de Winter BCM
Aims: Aripiprazole is one of the most commonly prescribed antipsychotic drugs to children and adolescents worldwide, but it is associated with serious side-effects, including weight gain. This study assessed the population pharmacokinetics of aripiprazole and its active metabolite and investigated the relationship between pharmacokinetic parameters and body mass index (BMI) in children and adolescents with autism spectrum disorder (ASD) and behavioural problems. Secondary outcomes were metabolic...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 80, 13 2 2023, Pages 133-138
Prolongation of the QTc interval is associated with an increased risk of cardiovascular diseases: The Hoorn study.
Welten SJGC, van der Heijden AA, Remmelzwaal S, Blom MT, Nijpels G, Rutters F, Beulens JWJ, Elders PJM, ESCAPE-NET investigators
Background/objective: Prolonged heart rate-corrected QT interval (QTc) on the electrocardiogram (ECG) is maybe associated with the occurrence of cardiovascular diseases (CVD), but the evidence is inconsistent. Therefore, we investigated whether baseline prolongation of the QTc interval is associated with CVD morbidity and mortality and its subtypes and whether glucose tolerance modifies this association in a population-based cohort study with a mean follow-up of 10.8 years. Methods: We analyzed...
Abstract
The Journal of cardiovascular surgery,
Volume 64, Issue 6, 12 2 2023, Pages 634-644
Outcomes of Omniflow® II prosthesis used for revascularization in the femoral tract both in infected and non-infected setting.
Liesker DJ, Gareb B, Speijers MJ, VAN DER Vorst JR, Salemans PB, Tutein Nolthenius RP, Zeebregts CJ, Saleem BR
Background: Evidence regarding the outcomes of Omniflow® II prosthesis in peripheral arterial revascularization at different anatomical sites and for different indications is scarce. Therefore, the aim of this study was to evaluate the outcomes of the Omniflow® II used at various positions within the femoral tract both in infected and non-infected setting. Methods: Patients who underwent reconstructive lower leg vascular surgery with implantation of an Omniflow® II from 2014 until 2021 at five m...
Abstract
Cited 8 times since 2023 (3.5 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 12, Issue 12, 10 2 2023, Pages e027657
Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies.
Tschiderer L, Seekircher L, Izzo R, Mancusi C, Manzi MV, Baldassarre D, Amato M, Tremoli E, Veglia F, Tuomainen TP, Kauhanen J, Voutilainen A, Iglseder B, Lind L, Rundek T, Desvarieux M, Kato A, de Groot E, Aşçi G, Ok E, Agewall S, Beulens JWJ, Byrne CD, Calder PC, Gerstein HC, Gresele P, Klingenschmid G, Nagai M, Olsen MH, Parraga G, Safarova MS, Sattar N, Skilton M, Stehouwer CDA, Uthoff H, van Agtmael MA, van der Heijden AA, Zozulińska-Ziółkiewicz DA, Park HW, Lee MS, Bae JH, Beloqui O, Landecho MF, Plichart M, Ducimetiere P, Empana JP, Bokemark L, Bergström G, Schmidt C, Castelnuovo S, Calabresi L, Norata GD, Grigore L, Catapano A, Zhao D, Wang M, Liu J, Ikram MA, Kavousi M, Bots ML, Sweeting MJ, Lorenz MW, Willeit P, Proof‐ATHERO Study Group
Background The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque invol...
Abstract
Cited 5 times since 2023 (2.2 per year)
source: EuropePMC
BMJ open,
Volume 13, Issue 6, 8 2 2023, Pages e071822
Ruling out acute coronary syndrome in primary care with a clinical decision rule and a capillary, high-sensitive troponin I point of care test: study protocol of a diagnostic RCT in the Netherlands (POB HELP).
van den Bulk S, Petrus AHJ, Willemsen RTA, Boogers MJ, Meeder JG, Rahel BM, van den Akker-van Marle ME, Numans ME, Dinant GJ, Bonten TN
Introduction: Chest pain is a common reason for consultation in primary care. To rule out acute coronary syndrome (ACS), general practitioners (GP) refer 40%-70% of patients with chest pain to the emergency department (ED). Only 10%-20% of those referred, are diagnosed with ACS. A clinical decision rule, including a high-sensitive cardiac troponin-I point-of-care test (hs-cTnI-POCT), may safely rule out ACS in primary care. Being able to safely rule out ACS at the GP level reduces referrals and...
Abstract
Cited 15 times since 2023 (6.5 per year)
source: EuropePMC
Surgical endoscopy,
Volume 37, Issue 9, 7 1 2023, Pages 6824-6833
Quantification of indocyanine green near-infrared fluorescence bowel perfusion assessment in colorectal surgery.
Faber RA, Tange FP, Galema HA, Zwaan TC, Holman FA, Peeters KCMJ, Tanis PJ, Verhoef C, Burggraaf J, Mieog JSD, Hutteman M, Keereweer S, Vahrmeijer AL, van der Vorst JR, Hilling DE
Background: Indocyanine green near-infrared fluorescence bowel perfusion assessment has shown its potential benefit in preventing anastomotic leakage. However, the surgeon's subjective visual interpretation of the fluorescence signal limits the validity and reproducibility of the technique. Therefore, this study aimed to identify objective quantified bowel perfusion patterns in patients undergoing colorectal surgery using a standardized imaging protocol. Method: A standardized fluorescence...
Abstract
European heart journal. Digital health,
Volume 4, Issue 4, 7 1 2023, Pages 347-356
Mobile health for cardiovascular risk management after cardiac surgery: results of a sub-analysis of The Box 2.0 study.
Biersteker TE, Boogers MJ, Schalij MJ, Braun J, Groenwold RHH, Atsma DE, Treskes RW
Aims: Lowering low-density lipoprotein (LDL-C) and blood pressure (BP) levels to guideline recommended values reduces the risk of major adverse cardiac events in patients who underwent coronary artery bypass grafting (CABG). To improve cardiovascular risk management, this study evaluated the effects of mobile health (mHealth) on BP and cholesterol levels in patients after standalone CABG. Methods and results: This study is a post hoc analysis of an observational cohort study among 228 adult pati...
Abstract
European heart journal. Case reports,
Volume 7, Issue 6, 7 1 2023, Pages ytad269
Atrioventricular nodal reentry tachycardia in pregnancy: 'I have ice for you'.
Abou R, Louwe LA, Jukema JW, Kortekaas KA
Background: Pregnancy is a known trigger of novel and pre-existing supraventricular tachyarrhythmias. We present a case of a stable pregnant patient presenting with atrioventricular nodal reentry tachycardia (AVNRT) and application of the 'facial ice immersion technique'. Case summary: A 37-year-old pregnant woman presented with recurrent AVNRT. Due to unsuccessful attempts of conventional vagal manoeuvres (VMs) and refusal of pharmacological agents, we successfully performed a non-con...
Abstract
Indian journal of thoracic and cardiovascular surgery,
Volume 39, Issue Suppl 2, 5 1 2023, Pages 233-238
Is the intimal thickness a key contributor to thoracic aortopathy?
Grewal N, Poelmann R
Background: An aortic dissection is the most devastating complication of thoracic aortic disease. Several non- and syndromic conditions such as a bicuspid aortic valve (BAV) and Marfan syndrome (MFS) have a severely increased risk to develop a thoracic aortic aneurysm and dissection. To date, the medial layer has been extensively studied in search of the pathogenetic mechanisms leading to aortic complications. Objective: We aim to determine whether intimal layer pathology is characteristic in al...
Abstract
Cited 1 times since 2023 (0.4 per year)
source: EuropePMC
Journal of visualized experiments : JoVE,
Issue 196, 2 1 2023
Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans.
Van Schaik L, Kettle C, Green RA, Irving HR, Rathner JA
In mammals, brown adipose tissue (BAT) is activated rapidly in response to cold in order to maintain body temperature. Although BAT has been studied greatly in small animals, it is difficult to measure the activity of BAT in humans. Therefore, little is known about the heat-generating capacity and physiological significance of BAT in humans, including the degree to which components of the diet can activate BAT. This is due to the limitations in the currently most used method to assess the activa...
Abstract
Cited 3 times since 2023 (1.3 per year)
source: EuropePMC
Heart rhythm,
Volume 20, Issue 8, 2 1 2023, Pages 1128-1135
Five-year safety and efficacy of leadless pacemakers in a Dutch cohort.
Breeman KTN, Oosterwerff EFJ, de Graaf MA, Juffer A, Saleem-Talib S, Maass AH, Wilde AAM, Boersma LVA, Ramanna H, van Dijk VF, van Erven L, Delnoy PHM, Tjong FVY, Knops RE
Background: Adequate real-world safety and efficacy of leadless pacemakers (LPs) have been demonstrated up to 3 years after implantation. Longer-term data are warranted to assess the net clinical benefit of leadless pacing. Objective: The purpose of this study was to evaluate the long-term safety and efficacy of LP therapy in a real-world cohort. Methods: In this retrospective cohort study, all consecutive patients with a first LP implantation from December 21, 2012, to December 13, 2016, in 6 D...
Abstract
Cited 5 times since 2023 (2.2 per year)
source: EuropePMC
Microbiology spectrum,
Volume 11, Issue 4, 1 1 2023, Pages e0036223
Deconstructed Plastic Substrate Preferences of Microbial Populations from the Natural Environment.
Putman LI, Schaerer LG, Wu R, Kulas DG, Zolghadr A, Ong RG, Shonnard DR, Techtmann SM
Over half of the world's plastic waste is landfilled, where it is estimated to take hundreds of years to degrade. Given the continued use and disposal of plastic products, it is vital that we develop fast and effective ways to utilize plastic waste. Here, we explore the potential of tandem chemical and biological processing to process various plastics quickly and effectively. Four samples of compost or sediment were used to set up enrichment cultures grown on mixtures of compounds, includin...
Abstract
Cited 5 times since 2023 (2.2 per year)
source: EuropePMC
Microbial genomics,
Volume 9, Issue 6, 1 1 2023
Noise reduction strategies in metagenomic chromosome confirmation capture to link antibiotic resistance genes to microbial hosts.
McCallum GE, Rossiter AE, Quraishi MN, Iqbal TH, Kuehne SA, van Schaik W
The gut microbiota is a reservoir for antimicrobial resistance genes (ARGs). With current sequencing methods, it is difficult to assign ARGs to their microbial hosts, particularly if these ARGs are located on plasmids. Metagenomic chromosome conformation capture approaches (meta3C and Hi-C) have recently been developed to link bacterial genes to phylogenetic markers, thus potentially allowing the assignment of ARGs to their hosts on a microbiome-wide scale. Here, we generated a meta3C dataset of...
Abstract
Cited 5 times since 2023 (2.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 25, Issue 6, 1 1 2023, Pages euad139
The R″ wave in V1 and the negative terminal QRS vector in aVF combine to a novel 12-lead ECG algorithm to identify slow conducting anatomical isthmus 3 in patients with tetralogy of Fallot.
Wallet J, Kimura Y, Blom NA, Man S, Jongbloed MRM, Zeppenfeld K, Zeppenfeld K
Aims: Patients with repaired tetralogy of Fallot (rTOF) have an increased risk of ventricular tachycardia (VT), with slow conducting anatomical isthmus (SCAI) 3 as dominant VT substrate. In patients with right bundle branch block (RBBB), SCAI 3 leads to local activation delay with a shift of terminal RV activation towards the lateral RV outflow tract which may be detected by terminal QRS vector changes on sinus rhythm electrocardiogram (ECG). Methods and results: Consecutive rTOF patients aged ≥...
Abstract
Cited 7 times since 2023 (3 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 30, Issue 8, 1 1 2023, Pages 624-633
Longitudinal association of electrocardiogram abnormalities with major adverse cardiac events in people with Type 2 diabetes: the Hoorn Diabetes Care System cohort.
Harms PP, Elders PPJM, Rutters F, Lissenberg-Witte BI, Tan HL, Beulens JWJ, Nijpels G, van der Heijden AA, for ESCAPE-NET
Aims: To investigate the association of (changes in) electrocardiogram (ECG) abnormalities with incident major adverse cardiac events (MACE) in people with Type 2 diabetes (T2D) without pre-existing cardiovascular disease (CVD). Methods and results: A prospective longitudinal study of 11 993 people with T2D without known CVD from the Hoorn Diabetes Care System cohort. Annually repeated measurements (1998-2018), included cardiovascular risk factors, over 70 000 ECG, and self-reported cardiovascul...
Abstract
Cited 4 times since 2023 (1.7 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 63, Issue 6, 1 1 2023, Pages ezad114
Extensive aortic root endocarditis with extension into the intervalvular fibrous body: an updated report of a mitral valve sparing approach.
Tomšič A, Palmen M, de Jong ML, Hjortnaes J, Driessen AGH, Braun J, Marsan NA, Klautz RJM
Objectives: Aortic root abscess can spread to include adjacent cardiac structures, including the central or intervalvular fibrous body and mitral valve. After radical debridement, complex surgical correction is needed. We describe the results of our mitral valve sparing approach. Methods: Between January 2004 and December 2020, 60 patients underwent operation for infective endocarditis of the aortic root with extension towards the mitral valve at 2 centres in the Netherlands. Early and late clin...
Abstract
Cited 8 times since 2023 (3.5 per year)
source: EuropePMC
Nature,
Volume 618, Issue 7965, 1 1 2023, Pages E19-E20
Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McD
Abstract
