Research

Publications

Below you can find a list of our published research.

7154 results

Cited 5 times since 2021 (1.5 per year) source: EuropePMC

Peptides, Volume 146, 28 4 2021, Pages 170664 Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox. Christen T, de Mutsert R, Lamb HJ, van Dijk KW, le Cessie S, Rosendaal FR, Jukema JW, Trompet S

High adiponectin concentrations are generally regarded as beneficial with regard to cardiometabolic health, but have been paradoxically associated with increased cardiovascular disease risk, specifically heart failure, in individuals at high cardiovascular risk. We aimed to investigate the association between adiponectin and heart function parameters, and inversely, we estimated the effect of genetically-determined heart function and NT-proBNP as the main marker of heart failure on adiponectin u... Abstract

Cited 23 times since 2021 (6.7 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 374, 28 4 2021, Pages n2134 Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study. Slieker RC, van der Heijden AAWA, Siddiqui MK, Langendoen-Gort M, Nijpels G, Herings R, Feenstra TL, Moons KGM, Bell S, Elders PJ, 't Hart LM, Beulens JWJ

Objectives: To identify and assess the quality and accuracy of prognostic models for nephropathy and to validate these models in external cohorts of people with type 2 diabetes. Design: Systematic review and external validation. Data sources: PubMed and Embase. Eligibility criteria: Studies describing the development of a model to predict the risk of nephropathy, applicable to people with type 2 diabetes. Methods: Screening, data extraction, and risk of bias assessment were done in duplicate. El... Abstract

Cited 11 times since 2021 (3.2 per year) source: EuropePMC

Scientific reports, Volume 11, Issue 1, 22 4 2021, Pages 18797 Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension. Tura-Ceide O, Smolders VFED, Aventin N, Morén C, Guitart-Mampel M, Blanco I, Piccari L, Osorio J, Rodríguez C, Rigol M, Solanes N, Malandrino A, Kurakula K, Goumans MJ, Quax PHA, Peinado VI, Castellà M, Barberà JA

Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to comprehensively analyze the endothelial function, molecular signature, and mitochondrial profile of CTEPH-derived endothelial cells to better understand the pathophysiological mechanisms of endothelial dysfunction behind CTEPH, and to identify potential novel targets for the prevention and treatment of the... Abstract

Cited 11 times since 2021 (3.2 per year) source: EuropePMC

NPJ genomic medicine, Volume 6, Issue 1, 21 3 2021, Pages 76 Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures. Rydzewski NR, Peterson E, Lang JM, Yu M, Laura Chang S, Sjöström M, Bakhtiar H, Song G, Helzer KT, Bootsma ML, Chen WS, Shrestha RM, Zhang M, Quigley DA, Aggarwal R, Small EJ, Wahl DR, Feng FY, Zhao SG

We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGETS). We trained TARGETS drug response models using Elastic-Net regression in the publicly available G... Abstract

Cited 4 times since 2021 (1.2 per year) source: EuropePMC

International journal of cardiology, Volume 344, 21 3 2021, Pages 1-7 Comparison of guidelines for diagnosing suspected stable angina and the additional value of the calcium score. Rijlaarsdam-Hermsen D, van Domburg RT, Deckers JW, Kuijpers D, van Dijkman PRM

Background The performance of current diagnostic algorithms of the American College of Cardiology/American Heart Association (ACC/AHA), National Institute for Health and Care Excellence (NICE) and European Society of Cardiology (ESC) in patients with stable chest pain and coronary artery calcium (CAC) remains a matter of debate. We compared their merits in patients with CAC and investigated the additional value of the CAC score to improve diagnostic accuracy and risk stratification. Methods and... Abstract

Cited 14 times since 2021 (4.1 per year) source: EuropePMC

Frontiers in immunology, Volume 12, 20 3 2021, Pages 754712 <i>Coxiella burnetii</i> Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model. Fratzke AP, Gregory AE, van Schaik EJ, Samuel JE

Q-VAX®, a whole cell, formalin-inactivated vaccine, is the only vaccine licensed for human use to protect against Coxiella burnetii, the cause of Q fever. Although this vaccine provides long-term protection, local and systemic reactogenic responses are common in previously sensitized individuals which prevents its use outside of Australia. Despite the importance of preventing these adverse reactions to develop widely accepted, novel vaccines against C. burnetii, little is understood about the un... Abstract

Cited 1 times since 2021 (0.3 per year) source: EuropePMC

Journal of visualized experiments : JoVE, Issue 175, 17 3 2021 Automated, High-Throughput Detection of Bacterial Adherence to Host Cells. Yang J, Qin QM, Van Schaik E, Samuel JE, de Figueiredo P

Identification of emerging bacterial pathogens is critical for human health and security. Bacterial adherence to host cells is an essential step in bacterial infections and constitutes a hallmark of potential threat. Therefore, examining the adherence of bacteria to host cells can be used as a component of bacterial threat assessment. A standard method for enumerating bacterial adherence to host cells is to co-incubate bacteria with host cells, harvest the adherent bacteria, plate the harvested... Abstract

Cited 31 times since 2021 (8.9 per year) source: EuropePMC

Frontiers in physiology, Volume 12, 16 3 2021, Pages 665298 Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function. Zandstra TE, Notenboom RGE, Wink J, Kiès P, Vliegen HW, Egorova AD, Schalij MJ, De Ruiter MC, Jongbloed MRM

The cardiac autonomic nervous system (cANS) regulates cardiac adaptation to different demands. The heart is an asymmetrical organ, and in the selection of adequate treatment of cardiac diseases it may be relevant to take into account that the cANS also has sidedness as well as regional differences in anatomical, functional, and molecular characteristics. The left and right ventricles respond differently to adrenergic stimulation. Isoforms of nitric oxide synthase, which plays an important role i... Abstract

Cited 4 times since 2021 (1.2 per year) source: EuropePMC

European heart journal. Case reports, Volume 5, Issue 10, 15 3 2021, Pages ytab333 Case series, chemotherapy-induced cardiomyopathy: mind the family history! Moghadasi S, Fijn R, Beeres SLMA, Bikker H, Jongbloed JDH, Josephus Jitta D, Kroep JR, Lekanne Deprez RH, Vos YJ, de Vreede MJM, Antoni ML, Barge-Schaapveld DQCM

Background: Cardiotoxicity presenting as cardiomyopathy is a common side effect in cancer treatment especially with anthracyclines. The role of genetic predisposition is still being investigated. Case summary: Four unrelated patients with a familial burden for cardiac disease, who developed cardiomyopathy after anthracycline treatment are presented. Case 1 received chemotherapy for breast cancer and developed a dilated left ventricle just after treatment. Her father had died unexpectedly while b... Abstract

Cited 10 times since 2021 (2.9 per year) source: EuropePMC

European urology focus, Volume 8, Issue 4, 15 3 2021, Pages 995-1002 Overall Survival of Patients Receiving Cisplatin or Carboplatin for Primary Metastatic Urothelial Carcinoma of the Bladder: A Contemporary Dutch Nationwide Cohort Study. Richters A, Boormans JL, van der Heijden MS, van der Heijden AG, Meijer RP, Mehra N, Kiemeney LALM, Aben KKH

Background: Cisplatin is preferred to carboplatin when treating metastatic urothelial carcinoma of the bladder (mUCB), despite its greater toxicity. Randomised studies underpinning this have been performed in noncontemporary populations with limitations in sample sizes and analyses, affecting their validity in current clinical practice. Objective: To estimate overall survival (OS) and assess the benefit of cisplatin-based regimens over carboplatin-based regimens in a contemporary cohort of patie... Abstract

Cited 12 times since 2021 (3.5 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 14, Issue 9, 15 3 2021, Pages e012142 Prognostic Implications of Left Ventricular Myocardial Work Indices in Patients With Secondary Mitral Regurgitation. Yedidya I, Lustosa RP, Fortuni F, van der Bijl P, Namazi F, Vo NM, Meucci MC, Ajmone Marsan N, Bax JJ, Delgado V

Background: Assessment of left ventricular (LV) function in patients with secondary mitral regurgitation (SMR) remains challenging but is an important parameter for risk stratification. The association of LV myocardial work components (work index [GWI], constructive [GCW] and wasted [GWW] work, and work efficiency) derived from pressure-strain loops obtained with speckle tracking echocardiography, and all-cause mortality in patients with SMR was investigated. Methods: LV myocardial GWI, GCW, GWW... Abstract

Cited 6 times since 2021 (1.7 per year) source: EuropePMC

ESC heart failure, Volume 8, Issue 6, 14 2 2021, Pages 4394-4408 HFA of the ESC Position paper on the management of LVAD supported patients for the non LVAD specialist healthcare provider Part 1: Introduction and at the non-hospital settings in the community. Ben Avraham B, Crespo-Leiro MG, Filippatos G, Gotsman I, Seferovic P, Hasin T, Potena L, Milicic D, Coats AJS, Rosano G, Ruschitzka F, Metra M, Anker S, Altenberger J, Adamopoulos S, Barac YD, Chioncel O, De Jonge N, Elliston J, Frigeiro M, Goncalvesova E, Grupper A, Hamdan R, Hammer Y, Hill L, Itzhaki Ben Zadok O, Abuhazira M, Lavee J, Mullens W, Nalbantgil S, Piepoli MF, Ponikowski P, Ristic A, Ruhparwar A, Shaul A, Tops LF, Tsui S, Winnik S, Jaarsma T, Gustafsson F, Ben Gal T

The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD-supported patients on the device and the scarcity of donor hearts has significantly increased the population of LVAD-supported patients. The expected and non-expected device-related and patient-device interaction complications impose a significant burden on the medical system exceeding the capacity of... Abstract

Cited 6 times since 2021 (1.7 per year) source: EuropePMC

ESC heart failure, Volume 8, Issue 6, 14 2 2021, Pages 4409-4424 Heart Failure Association of the European Society of Cardiology position paper on the management of left ventricular assist device-supported patients for the non-left ventricular assist device specialist healthcare provider: Part 2: at the emergency department. Milicic D, Ben Avraham B, Chioncel O, Barac YD, Goncalvesova E, Grupper A, Altenberger J, Frigeiro M, Ristic A, De Jonge N, Tsui S, Lavee J, Rosano G, Crespo-Leiro MG, Coats AJS, Seferovic P, Ruschitzka F, Metra M, Anker S, Filippatos G, Adamopoulos S, Abuhazira M, Elliston J, Gotsman I, Hamdan R, Hammer Y, Hasin T, Hill L, Itzhaki Ben Zadok O, Mullens W, Nalbantgil S, Piepoli MF, Ponikowski P, Potena L, Ruhparwar A, Shaul A, Tops LF, Winnik S, Jaarsma T, Gustafsson F, Ben Gal T

The improvement in left ventricular assist device (LVAD) technology and scarcity of donor hearts have increased dramatically the population of the LVAD-supported patients and the probability of those patients to present to the emergency department with expected and non-expected device-related and patient-device interaction complications. The ageing of the LVAD-supported patients, mainly those supported with the 'destination therapy' indication, increases the risk for those patients to... Abstract

Cited 9 times since 2021 (2.6 per year) source: EuropePMC

mSystems, Volume 6, Issue 5, 14 2 2021, Pages e0030021 Microbial Communities in a Serpentinizing Aquifer Are Assembled through Strong Concurrent Dispersal Limitation and Selection. Putman LI, Sabuda MC, Brazelton WJ, Kubo MD, Hoehler TM, McCollom TM, Cardace D, Schrenk MO

In recent years, our appreciation of the extent of habitable environments in Earth's subsurface has greatly expanded, as has our understanding of the biodiversity contained within. Most studies have relied on single sampling points, rather than considering the long-term dynamics of subsurface environments and their microbial populations. One such habitat are aquifers associated with the aqueous alteration of ultramafic rocks through a process known as serpentinization. Ecological modeling p... Abstract

Cited 10 times since 2021 (2.9 per year) source: EuropePMC

Cancers, Volume 13, Issue 18, 13 2 2021, Pages 4598 Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study. van der Perk MEM, Broer L, Yasui Y, Robison LL, Hudson MM, Laven JSE, van der Pal HJ, Tissing WJE, Versluys B, Bresters D, Kaspers GJL, de Vries ACH, Lambalk CB, Overbeek A, Loonen JJ, Beerendonk CCM, Byrne J, Berger C, Clemens E, Dirksen U, Winther JF, Fosså SD, Grabow D, Muraca M, Kaiser M, Kepák T, Kruseova J, Modan-Moses D, Spix C, Zolk O, Kaatsch P, Krijthe JH, Kremer LCM, Brooke RJ, Baedke JL, van Schaik RHN, van den Anker JN, Uitterlinden AG, Bos AME, van Leeuwen FE, van Dulmen-den Broeder E, van der Kooi ALF, van den Heuvel-Eibrink MM, On Behalf Of The PanCareLIFE Consortium

Background: Female childhood cancer survivors (CCSs) carry a risk of therapy-related gonadal dysfunction. Alkylating agents (AA) are well-established risk factors, yet inter-individual variability in ovarian function is observed. Polymorphisms in CYP450 enzymes may explain this variability in AA-induced ovarian damage. We aimed to evaluate associations between previously identified genetic polymorphisms in CYP450 enzymes and AA-related ovarian function among adult CCSs. Methods: Anti-Müllerian h... Abstract

Journal of environmental management, Volume 300, 9 2 2021, Pages 113608 A conceptual framework for a multi-criteria decision support tool to select technologies for resource recovery from urban wastewater. Sucu S, van Schaik MO, Esmeli R, Ouelhadj D, Holloway T, Williams JB, Cruddas P, Martinson DB, Chen WS, Cappon HJ

In the context of circular economy, wastewater can be used to address some of the 21st century's challenges regarding the transition to renewable resources for water, energy, and nutrients. Despite all the research, development, and experience with resource recovery from urban wastewater, its implementation is still limited. The transition from treatment to resource recovery is complex due to the difficulty of selecting unit processes from a large number of candidate processes considering t... Abstract

Cited 3 times since 2021 (0.9 per year) source: EuropePMC

European journal of medical genetics, Volume 64, Issue 11, 9 2 2021, Pages 104340 Biallelic mutations in ELFN1 gene associated with developmental and epileptic encephalopathy and joint laxity. Dursun A, Yalnizoglu D, Yilmaz DY, Oguz KK, Gülbakan B, Koşukcu C, Akar HT, Kahraman AB, Acar NV, Günbey C, Yildiz Y, Ozgul RK

ELFN1, a transmembrane leucine rich repeat protein, is involved in signal transduction in both neural cells and ROD ON-bipolar synaptogenesis. We present three siblings with developmental and epileptic encephalopathy and co-morbidities due to ELFN1 gene mutation; this is the first report in literature defining the human phenotype of ELFN1 gene mutation. Clinical, electrophysiological, and radiological findings along with comprehensive genetic studies of the patients and their family members are... Abstract

Cited 4 times since 2021 (1.1 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 161, 7 1 2021, Pages 42-48 A nationwide population-based cohort study of surgical care for patients with superior sulcus tumors: Results from the Dutch Lung Cancer Audit for Surgery (DLCA-S). Winkelman JA, van der Woude L, Heineman DJ, Bahce I, Damhuis RA, Mahtab EAF, Hartemink KJ, Senan S, Maat APWM, Braun J, Paul MA, Dahele M, Dickhoff C

Objectives: Data on national patterns of care for patients with superior sulcus tumors (SST) is currently lacking. We investigated the distribution of surgical care and outcome for patients with SST in the Netherlands. Material and methods: Data was retrieved from the Dutch Lung Cancer Audit for Surgery (DLCA-S) for all patients undergoing resection for clinical stage IIB-IV SST from 2012 to 2019. Because DLCA-S is not linked to survival data, survival for a separate cohort (2015-2017) was obtai... Abstract

Cited 90 times since 2021 (25.8 per year) source: EuropePMC

Nature reviews. Clinical oncology, Volume 19, Issue 1, 7 1 2021, Pages 9-22 Fundamentals and developments in fluorescence-guided cancer surgery. Mieog JSD, Achterberg FB, Zlitni A, Hutteman M, Burggraaf J, Swijnenburg RJ, Gioux S, Vahrmeijer AL

Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the past decade as a promising and effective method of intraoperative cancer detection. An impressive number of fluorescently labelled antibodies, peptides, particles and other molecules related to cancer hallmarks have been developed for the illumination of target lesions. New approaches are being implemented to translate these imaging agents into the clinic, although only a few have made it past early-phase clini... Abstract

Journal of cardiothoracic and vascular anesthesia, Volume 36, Issue 1, 5 1 2021, Pages 109-117 Perioperative Care Standards in Cardiac Surgery Patients Aiming at Enhancing Recovery: A Nationwide Survey in the Netherlands and Belgium. Damstra J, Geerts BF, Rex S, Vlaar APJ, Driessen AHG, Engelman DT, Klautz RJM, Eberl S

Objective: The aim of this survey was to describe existing perioperative care standards and best practices in the Netherlands and Belgium. Design: An online survey was followed up by an in-depth personal interview. The main outcomes were the existing standards of perioperative care for patients undergoing cardiac surgery. Setting: The online survey and subsequent interviews were targeted to one representative in the intensive care unit (ICU), cardiac surgery, and anesthesiology department from e... Abstract