6136 results
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Journal of cardiovascular medicine (Hagerstown, Md.),
Volume 16, Issue 6, 1 1 2015, Pages 465-471
B-type natriuretic peptide vs. cardiac risk scores for prediction of outcome following major orthopedic surgery.
Katsanos S, Babalis D, Kafkas N, Mavrogenis A, Leong D, Parissis J, Varounis C, Makris K, van der Heijden A, Anastasiou-Nana M, Filippatos G
Aims: The clinical role of B-type natriuretic peptide (BNP) in preoperative evaluation is not clear. We designed a prospective study to investigate the predictive value of BNP in comparison with established clinical risk scores for the outcome of major orthopedic surgery. Methods: Overall 242 elderly patients [80 (74-85) years] undergoing orthopedic surgery were included. Inhospital cardiovascular events and 1-year mortality were the main endpoints. Results: In total 20 (8.3%) patients had major...
Abstract
Cited 16 times since 2015 (1.6 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 56 Suppl 4, 1 1 2015, Pages 25S-30S
123I-MIBG SPECT for Evaluation of Patients with Heart Failure.
Dimitriu-Leen AC, Scholte AJ, Jacobson AF
Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The condition of cardiac sympathetic nerves can be evaluated by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. Most cardiac (123)I-MIBG studies have relied on measurements from anterior planar images of the chest. However, it has become progressively more common to include SPECT imaging in clinical and research protocols. This review examines recent trends in (123)I-MIBG SPECT imaging and evidence that pr...
Abstract
Cited 6 times since 2015 (0.6 per year)
source: EuropePMC
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 24, Issue 2, 1 1 2015, Pages 127-132
Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction.
Dharma S, Hapsari R, Siswanto BB, van der Laarse A, Jukema JW
We aim to test the hypothesis that blood leukocyte count adds prognostic information in patients with acute non-ST-elevation myocardial infarction (non-STEMI). A total of 585 patients with acute non-STEMI (thrombolysis in myocardial infarction risk score ≥ 3) were enrolled in this cohort retrospective study. Blood leukocyte count was measured immediately after admission in the emergency department. The composite of death, reinfarction, urgent revascularization, and stroke during hospitalization...
Abstract
Cited 27 times since 2015 (2.8 per year)
source: EuropePMC
Protein science : a publication of the Protein Society,
Volume 24, Issue 8, 29 5 2015, Pages 1292-1300
Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment.
Konijnenberg A, Bannwarth L, Yilmaz D, Koçer A, Venien-Bryan C, Sobott F
Here we study the intact stoichiometry and top-down fragmentation behavior of three integral membrane proteins which were natively reconstituted into detergent micelles: the mechano-sensitive ion channel of large conductance (MscL), the Kirbac potassium channel and the p7 viroporin from the hepatitis C virus. By releasing the proteins under nondenaturing conditions inside the mass spectrometer, we obtained their oligomeric sizes. Increasing the ion activation (collision energy) causes unfolding...
Abstract
Cited 32 times since 2015 (3.3 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 30, 25 4 2015, Pages 1983-1989
The effect of QRS duration on cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial.
Steffel J, Robertson M, Singh JP, Abraham WT, Bax JJ, Borer JS, Dickstein K, Ford I, Gorcsan J, Gras D, Krum H, Sogaard P, Holzmeister J, Brugada J, Ruschitzka F
Aims: In EchoCRT, a randomized trial evaluating the effect of cardiac resynchronization therapy (CRT) in patients with a QRS duration of
Abstract
Cited 40 times since 2015 (4.1 per year)
source: EuropePMC
Heart rhythm,
Volume 12, Issue 10, 22 4 2015, Pages 2106-2114
Myocardial scar predicts monomorphic ventricular tachycardia but not polymorphic ventricular tachycardia or ventricular fibrillation in nonischemic dilated cardiomyopathy.
Piers SR, Everaerts K, van der Geest RJ, Hazebroek MR, Siebelink HM, Pison LA, Schalij MJ, Bekkers SC, Heymans S, Zeppenfeld K
Background: The relation between myocardial scar and different types of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy (NIDCM) is unknown. Objectives: The purpose of this study was to analyze the effect of myocardial scar, assessed by late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR), on the occurrence and type of ventricular arrhythmia in patients with NIDCM. Methods: Consecutive patients with NIDCM who underwent LGE-CMR and implantable cardio...
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
World journal of experimental medicine,
Volume 5, Issue 2, 20 3 2015, Pages 140-153
Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration.
de la Garza-Rodea AS, Boersma H, Dambrot C, de Vries AA, van Bekkum DW, Knaän-Shanzer S
Aim: To study regeneration of damaged human and murine muscle implants and the contribution of added xenogeneic mesenchymal stem cells (MSCs). Methods: Minced human or mouse skeletal muscle tissues were implanted together with human or mouse MSCs subcutaneously on the back of non-obese diabetic/severe combined immunodeficient mice. The muscle tissues (both human and murine) were minced with scalpels into small pieces (< 1 mm(3)) and aliquoted in portions of 200 mm(3). These portions were eith...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 16, 18 3 2015, Pages 1263-1264
Diastolic dysfunction and atrial fibrillation.
Delgado V, Bax JJ
Abstract
Cited 24 times since 2015 (2.4 per year)
source: EuropePMC
European journal of pharmacology,
Volume 763, Issue Pt A, 16 3 2015, Pages 48-63
Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials.
Kühnast S, Fiocco M, van der Hoorn JW, Princen HM, Jukema JW
Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This systematic review and meta-analysis investigated the effects of established and novel treatment strategies, specifically targeting HDL, on inhibition of atheroscl...
Abstract
Cited 42 times since 2015 (4.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 194, 15 3 2015, Pages 7-12
Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome.
Franken R, El Morabit A, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Marquering H, Planken NR, Zwinderman AH, Mulder BJ, Groenink M
Background: Patients with Marfan syndrome (MFS) have a highly variable occurrence of aortic complications. Aortic tortuosity is often present in MFS and may help to identify patients at risk for aortic complications. Methods: 3D-visualization of the total aorta by MR imaging was performed in 211 adult MFS patients (28% with prior aortic root replacement) and 20 controls. A method to assess aortic tortuosity (aortic tortuosity index: ATI) was developed and reproducibility was tested. The relation...
Abstract
Cited 25 times since 2015 (2.5 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 8, Issue 6, 14 2 2015, Pages 697-704
The Functional Effects of Intramural Course of Coronary Arteries and its Relation to Coronary Atherosclerosis.
Uusitalo V, Saraste A, Pietilä M, Kajander S, Bax JJ, Knuuti J
Objectives: This study observed hemodynamic consequences of myocardial bridging and its relation to coronary atherosclerosis. Background: Myocardial bridging is seen as intramural course by computed tomography angiography (CTA) or systolic compression by invasive coronary angiography. Segments with myocardial bridging are in previous studies closely associated with proximal atherosclerotic plaques. Methods: We prospectively studied 100 patients 63 ± 7 years of age with intermediate likelihood of...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Korean journal of radiology,
Volume 16, Issue 3, 13 2 2015, Pages 668-672
Right ventricular cardiomyopathy meeting the arrhythmogenic right ventricular dysplasia revised criteria? Don't forget sarcoidosis!
Vasaturo S, Ploeg DE, Buitrago G, Zeppenfeld K, Veselic-Charvat M, Kroft LJ
A 53-year-old woman was referred for ventricular fibrillation with resuscitation. A CT-angiography showed signs of a right ventricular enlargement without obvious cause. A cardiac MRI demonstrated a dilated and hypokinetic right ventricle with extensive late gadolinium enhancement. Arrhythmogenic right ventricular dysplasia (ARVD) was suspected according to the "revised ARVD task force criteria". An endomyocardial biopsy was inconclusive. The patient developed purulent pericarditis aft...
Abstract
Cited 15 times since 2015 (1.5 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 4, 12 2 2015, Pages 853-862
Reassessing noninducibility as ablation endpoint of post-infarction ventricular tachycardia: the impact of left ventricular function.
de Riva M, Piers SR, Kapel GF, Watanabe M, Venlet J, Trines SA, Schalij MJ, Zeppenfeld K
Background: Noninducibility is frequently used as procedural end point of ventricular tachycardia (VT) ablation after myocardial infarction. We investigated the influence of left ventricular (LV) function on the predictive value of noninducibility for VT recurrence and cardiac mortality. Methods and results: Ninety-one patients (82 men, 67±10 years) with post-myocardial infarction VT underwent ablation between 2009 and 2012. Fifty-nine (65%) had an LV ejection fraction (EF) >30% (mean 41±7) a...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 1, Issue 4, 12 2 2015, Pages 232-244
Contemporary registries on P2Y12 inhibitors in patients with acute coronary syndromes in Europe: overview and methodological considerations.
Jukema JW, Lettino M, Widimský P, Danchin N, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Lopez-Sendón J, Tousek P, Weidinger F, Weston CF, Zaman A, Zeymer U, PIRAEUS group
Patient registries that document real-world clinical experience play an important role in cardiology as they complement the data from randomized controlled trials, provide valuable information on drug use and clinical outcomes, and evaluate to what extent guidelines are followed in practice. The Platelet Inhibition Registry in ACS EvalUation Study (PIRAEUS) project is an initiative of registry holders who are managing national or international registries observing patients with acute coronary sy...
Abstract
Cited 48 times since 2015 (4.9 per year)
source: EuropePMC
Nature communications,
Volume 6, 8 2 2015, Pages 7030
Expression of the vault RNA protects cells from undergoing apoptosis.
Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N
Non-protein-coding RNAs are a functionally versatile class of transcripts exerting their biological roles on the RNA level. Recently, we demonstrated that the vault complex-associated RNAs (vtRNAs) are significantly upregulated in Epstein-Barr virus (EBV)-infected human B cells. Very little is known about the function(s) of the vtRNAs or the vault complex. Here, we individually express latent EBV-encoded proteins in B cells and identify the latent membrane protein 1 (LMP1) as trigger for vtRNA u...
Abstract
Cited 16 times since 2015 (1.6 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 48, Issue 4, 8 2 2015, Pages 463-475
Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective.
Man S, Maan AC, Schalij MJ, Swenne CA
In the course of time, electrocardiography has assumed several modalities with varying electrode numbers, electrode positions and lead systems. 12-lead electrocardiography and 3-lead vectorcardiography have become particularly popular. These modalities developed in parallel through the mid-twentieth century. In the same time interval, the physical concepts underlying electrocardiography were defined and worked out. In particular, the vector concept (heart vector, lead vector, volume conductor) a...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 6, 7 1 2015, Pages 541-543
Proximal Left Anterior Descending Artery Acute Occlusion With an Unusual Electrocardiographic Pattern: Not Everything Is ST Elevation.
Montero-Cabezas JM, van-der-Kley F, Karalis I, Schalij MJ
Abstract
Cited 40 times since 2015 (4.1 per year)
source: EuropePMC
Surgery,
Volume 158, Issue 5, 6 1 2015, Pages 1323-1330
Intraoperative guidance in parathyroid surgery using near-infrared fluorescence imaging and low-dose Methylene Blue.
Tummers QR, Schepers A, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Background: Identification of diseased and normal parathyroid glands during parathyroid surgery can be challenging. The aim of this study was to assess whether near-infrared (NIR) fluorescence imaging using administration of a low-dose Methylene Blue (MB) at the start of the operation could provide optical guidance during parathyroid surgery and assist in the detection of parathyroid adenomas. Methods: Patients diagnosed with primary hyperparathyroidism planned for parathyroidectomy were include...
Abstract
Cited 30 times since 2015 (3 per year)
source: EuropePMC
Clinical and vaccine immunology : CVI,
Volume 22, Issue 7, 6 1 2015, Pages 778-788
Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults.
Boer MC, Prins C, van Meijgaarden KE, van Dissel JT, Ottenhoff TH, Joosten SA
Mycobacterium bovis bacillus Calmette-Guérin (BCG), the only currently available vaccine against tuberculosis, induces variable protection in adults. Immune correlates of protection are lacking, and analyses on cytokine-producing T cell subsets in protected versus unprotected cohorts have yielded inconsistent results. We studied the primary T cell response, both proinflammatory and regulatory T cell responses, induced by BCG vaccination in adults. Twelve healthy adult volunteers who were tubercu...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
Drug and chemical toxicology,
Volume 39, Issue 2, 5 1 2015, Pages 119-123
Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro.
Yilmaz D, Teksoy O, Bilaloglu R, Çinkilic N
Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 µg/mL) and a single dose of BLM (20 µg/mL). BLM significantly increased the total CAs...
Abstract
