Research

Publications

Below you can find a list of our published research.

7724 results

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 9 2 2012, Pages 2841-2845 Rates and determinants of progressive aortic valve dysfunction in aortic coarctation. Luijendijk P, Stevens AW, de Bruin-Bon RH, Boekholdt SM, Vriend JW, Vliegen HW, Bouma BJ, Mulder BJ

Purpose: Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunction in CoA. Methods: 96 CoA patients prospectively underwent echocardiography twice between 2001 and 2010. AS was defined as an aortic valve gradient ≥ 20 mmHg, AR as none/minor, or... Abstract

Cited 132 times since 2012 (10.5 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 5, Issue 5, 8 2 2012, Pages 628-636 Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Haeck ML, Scherptong RW, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V

Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluat... Abstract

Cited 13 times since 2012 (1 per year) source: EuropePMC

PloS one, Volume 7, Issue 8, 3 1 2012, Pages e42401 Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study. Verschuren JJ, Trompet S, Postmus I, Sampietro ML, Heijmans BT, Houwing-Duistermaat JJ, Slagboom PE, Jukema JW

Background: Coronary restenosis after percutaneous coronary intervention still remains a significant problem, despite all medical advances. Unraveling the mechanisms leading to restenosis development remains challenging. Many studies have identified genetic markers associated with restenosis, but consistent replication of the reported markers is scarce. The aim of the current study was to analyze the joined effect of previously in literature reported candidate genes for restenosis in the GENetic... Abstract

Cited 12 times since 2012 (1 per year) source: EuropePMC

Optics express, Volume 20, Issue 18, 1 1 2012, Pages 20635-20646 Asymmetric light propagation in chirped photonic crystal waveguides. Kurt H, Yilmaz D, Akosman AE, Ozbay E

We report numerical and experimental investigations of asymmetric light propagation in a newly designed photonic structure that is formed by creating a chirped photonic crystal (PC) waveguide. The use of a non-symmetric distribution of unit cells of PC ensures the obtaining of asymmetric light propagation. Properly designing the spatial modulation of a PC waveguide inherently modifies the band structure. That in turn induces asymmetry for the light's followed path. The investigation of the... Abstract

Cited 68 times since 2012 (5.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 98, Issue 16, 1 1 2012, Pages 1229-1236 Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation. Gripari P, Ewe SH, Fusini L, Muratori M, Ng AC, Cefalù C, Delgado V, Schalij MJ, Bax JJ, Marsan NA, Tamborini G, Pepi M

Background: Post-procedural aortic regurgitation (AR) has been described in a large number of patients receiving transcatheter aortic valve implantation (TAVI). Objective: The aim of this study was to examine the intraoperative 2-dimensional (2D) and 3-dimensional (3D) echocardiographic features of the aortic valve associated with significant post-procedural paravalvular AR. Methods: A total of 135 patients (81±7 years) with severe symptomatic aortic stenosis, who underwent TAVI, were imaged wit... Abstract

Cited 20 times since 2012 (1.6 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 16, Issue 8, 1 1 2012, Pages 1866-1877 Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors. Wierda RJ, Kuipers HF, van Eggermond MC, Benard A, van Leeuwen JC, Carluccio S, Geutskens SB, Jukema JW, Marquez VE, Quax PH, van den Elsen PJ

Previously, we have shown that CCR5 transcription is regulated by CREB-1. However, the ubiquitous pattern of CREB-1 expression suggests the involvement of an additional level of transcriptional control in the cell type-specific expression of CCR5. In this study, we show that epigenetic changes (i.e. DNA methylation and histone modifications) within the context of the CCR5 P1 promoter region correlate with transcript levels of CCR5 in healthy and in malignant CD4(+) T lymphocytes as well as in C... Abstract

Cited 1733 times since 2012 (137.7 per year) source: EuropePMC

European journal of heart failure, Volume 14, Issue 8, 1 1 2012, Pages 803-869 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P, ESC Committee for Practice Guidelines

Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

The Eurasian journal of medicine, Volume 44, Issue 2, 1 1 2012, Pages 94-98 Obesity and its diagnostic methods in Turkish children. Yilmaz D, Inan G, Karakas S, Buyukozturk-Karul A, Sonmez F

Objective: The application of body mass index (BMI) for obesity classification in all population studies has been questioned by the scientific community. It has been found that the bioelectrical impedance analysis (BIA) is an accurate method for screening obesity. This study was conducted to evaluate the accuracies of BMI, skinfold thickness (SFT), leptin and BIA measurements in obesity classification and to find correlations between BIA and the other indicators for obesity. Materials and method... Abstract

Cited 16 times since 2012 (1.3 per year) source: EuropePMC

American heart journal, Volume 164, Issue 2, 1 1 2012, Pages 146-152 The rationale and design of the Shockless IMPLant Evaluation (SIMPLE) trial: a randomized, controlled trial of defibrillation testing at the time of defibrillator implantation. Healey JS, Hohnloser SH, Glikson M, Neuzner J, Viñolas X, Mabo P, Kautzner J, O'Hara G, Van Erven L, Gadler F, Appl U, Connolly SJ

Defibrillation testing (DT) has been an integral part of defibrillator (implantable cardioverter defibrillator [ICD]) implantation; however, there is little evidence that it improves outcomes. Surveys show a trend toward ICD implantation without DT, which now exceeds 30% to 60% in some regions. Because there is no evidence to support dramatic shift in practice, a randomized trial is urgently needed. The SIMPLE trial will determine if ICD implantation without any DT is noninferior to implantation... Abstract

Cited 26 times since 2012 (2.1 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 241, Issue 9, 30 5 2012, Pages 1413-1422 Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept. Scherptong RW, Jongbloed MR, Wisse LJ, Vicente-Steijn R, Bartelings MM, Poelmann RE, Schalij MJ, Gittenberger-De Groot AC

Background: Understanding of cardiac outflow tract (OFT) remodeling is essential to explain repositioning of the aorta and pulmonary orifice. In wild type embryos (E9.5-14.5), second heart field contribution (SHF) to the OFT was studied using expression patterns of Islet 1, Nkx2.5, MLC-2a, WT-1, and 3D-reconstructions. Abnormal remodeling was studied in VEGF120/120 embryos. Results: In wild type, Islet 1 and Nkx2.5 positive myocardial precursors formed an asymmetric elongated column almost exclu... Abstract

Cited 105 times since 2012 (8.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 14, Issue 1, 29 5 2012, Pages 69-76 Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair. Witkowski TG, Thomas JD, Debonnaire PJ, Delgado V, Hoke U, Ewe SH, Versteegh MI, Holman ER, Schalij MJ, Bax JJ, Klautz RJ, Marsan NA

Aims: Despite a successful surgical procedure and adherence to current recommendations, postoperative left ventricular (LV) dysfunction after mitral valve repair (MVr) for organic mitral regurgitation (MR) may still occur. New approaches are therefore needed to detect subclinical preoperative LV dysfunction. LV global longitudinal strain (GLS), assessed with speckle-tracking echocardiographic analysis, has been proposed as a novel measure to better depict latent LV dysfunction. The aim of this s... Abstract

Cited 30 times since 2012 (2.4 per year) source: EuropePMC

Frontiers in oncology, Volume 2, 25 4 2012, Pages 77 The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae. Van Rossom S, Op de Beeck K, Franssens V, Swinnen E, Schepers A, Ghillebert R, Caldara M, Van Camp G, Winderickx J

DFNA5 was first identified as a gene responsible for autosomal dominant deafness. Different mutations were found, but they all resulted in exon 8 skipping during splicing and premature termination of the protein. Later, it became clear that the protein also has a tumor suppression function and that it can induce apoptosis. Epigenetic silencing of the DFNA5 gene is associated with different types of cancers, including gastric and colorectal cancers as well as breast tumors. We introduced the wild... Abstract

Cited 92 times since 2012 (7.3 per year) source: EuropePMC

European heart journal, Volume 34, Issue 36, 24 4 2012, Pages 2839-2849 Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. Reil JC, Hohl M, Reil GH, Granzier HL, Kratz MT, Kazakov A, Fries P, Müller A, Lenski M, Custodis F, Gräber S, Fröhlig G, Steendijk P, Neuberger HR, Böhm M

Aims: In diabetes mellitus, heart failure with preserved ejection fraction (HFPEF) is a significant comorbidity. No therapy is available that improves cardiovascular outcomes. The aim of this study was to characterize myocardial function and ventricular-arterial coupling in a mouse model of diabetes and to analyse the effect of selective heart rate (HR) reduction by If-inhibition in this HFPEF-model. Methods and results: Control mice, diabetic mice (db/db), and db/db mice treated for 4 weeks wit... Abstract

Cited 7 times since 2012 (0.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 14, Issue 3, 19 3 2012, Pages 247-252 Impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Boogers MJ, Compier M, Trines SA, Scholte AJ, Zeppenfeld K, Schalij MJ, Bax JJ, Delgado V

Aims: Coronary atherosclerosis has been associated with the development of atrial fibrillation (AF). However, little is known about the impact of coronary atherosclerosis on the outcome treatment of AF. The aim of this study was to investigate the impact of coronary atherosclerosis on the efficacy of radiofrequency catheter ablation (RFCA) for AF using multi-detector row computed tomography (MDCT). Methods: In 125 consecutive patients undergoing RFCA for AF, a pre-procedural MDCT examination (co... Abstract

Cited 249 times since 2012 (19.7 per year) source: EuropePMC

Circulation, Volume 126, Issue 9, 19 3 2012, Pages 1040-1049 Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Gencer B, Collet TH, Virgini V, Bauer DC, Gussekloo J, Cappola AR, Nanchen D, den Elzen WP, Balmer P, Luben RN, Iacoviello M, Triggiani V, Cornuz J, Newman AB, Khaw KT, Jukema JW, Westendorp RG, Vittinghoff E, Aujesky D, Rodondi N, Thyroid Studies Collaboration

Background: American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events. Methods and results: We performed a pooled analysis of individual participant data usin... Abstract

Cited 284 times since 2012 (22.5 per year) source: EuropePMC

International journal of proteomics, Volume 2012, 18 3 2012, Pages 971907 Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome. Lai RC, Tan SS, Teh BJ, Sze SK, Arslan F, de Kleijn DP, Choo A, Lim SK

Mesenchymal stem cells (MSCs) are used in many of the current stem cell-based clinical trials and their therapeutic efficacy has increasingly been attributed to secretion of paracrine factors. We have previously demonstrated that a therapeutic constituent of this secretion is exosome, a secreted bilipid membrane vesicle of ~50-100 nm with a complex cargo that is readily internalized by H9C2 cardiomyocytes. It reduces infarct size in a mouse model of myocardial ischemia/reperfusion (MI/R) injury.... Abstract

Cited 34 times since 2012 (2.7 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 10, 13 2 2012, Pages 1599-1608 Reproducibility of planar (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure. Veltman CE, Boogers MJ, Meinardi JE, Al Younis I, Dibbets-Schneider P, Van der Wall EE, Bax JJ, Scholte AJ

Purpose: Despite its high prognostic value, widespread clinical implementation of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is hampered by a lack of validation and standardization. The purpose of this study was to assess the reliability of planar (123)I-MIBG myocardial scintigraphy in patients with heart failure (HF). Methods: Planar myocardial MIBG images of 70 HF patients were analysed by two experienced and one inexperienced observer. The reproducibility of early and dela... Abstract

Cited 24 times since 2012 (1.9 per year) source: EuropePMC

Atherosclerosis, Volume 224, Issue 1, 13 2 2012, Pages 150-153 A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: the Lipid Treatment Assessment Project 2. Santos RD, Waters DD, Tarasenko L, Messig M, Jukema JW, Chiang CW, Ferrieres J, Foody JM

Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/... Abstract

Cited 144 times since 2012 (11.4 per year) source: EuropePMC

Circulation, Volume 126, Issue 6, 12 2 2012, Pages 720-728 Left bundle-branch block induced by transcatheter aortic valve implantation increases risk of death. Houthuizen P, Van Garsse LA, Poels TT, de Jaegere P, van der Boon RM, Swinkels BM, Ten Berg JM, van der Kley F, Schalij MJ, Baan J, Cocchieri R, Brueren GR, van Straten AH, den Heijer P, Bentala M, van Ommen V, Kluin J, Stella PR, Prins MH, Maessen JG, Prinzen FW

Background: Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and results: Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did and did not develop new LBBB. Of 679 patients analyzed, 387 (57.0... Abstract

Cited 6 times since 2012 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 2, 12 2 2012, Pages 343-354 23Na chemical shift imaging and Gd enhancement of myocardial edema. Aguor EN, van de Kolk CW, Arslan F, Nederhoff MG, Doevendans PA, Pasterkamp G, Strijkers GJ, van Echteld CJ

Myocardial edema can arise in several disease states. MRI contrast agent can accumulate in edematous tissue, which complicates differential diagnosis with contrast-enhanced (CE)-MRI and might lead to overestimation of infarct size. Sodium Chemical Shift Imaging ((23)Na-CSI) may provide an alternative for edema imaging. We have developed a non-infarct, isolated rat heart model with two levels of edema, which was studied with (23)Na-CSI and CE-MRI. In edematous, but viable tissue the extracellular... Abstract