9529 results
Cited 12 times since 2009 (0.7 per year)
source: EuropePMC
Journal of biomedicine & biotechnology,
Volume 2009, 14 2 2009, Pages 361795
Herpesvirus-mediated delivery of a genetically encoded fluorescent Ca(2+) sensor to canine cardiomyocytes.
Prorok J, Kovács PP, Kristóf AA, Nagy N, Tombácz D, Tóth JS, Ordög B, Jost N, Virág L, Papp JG, Varró A, Tóth A, Boldogkoi Z
We report the development and application of a pseudorabies virus-based system for delivery of troponeon, a fluorescent Ca(2+) sensor to adult canine cardiomyocytes. The efficacy of transduction was assessed by calculating the ratio of fluorescently labelled and nonlabelled cells in cell culture. Interaction of the virus vector with electrophysiological properties of cardiomyocytes was evaluated by the analysis of transient outward current (I(to)), kinetics of the intracellular Ca(2+) transients...
Abstract
Cited 24 times since 2009 (1.5 per year)
source: EuropePMC
International journal of primatology,
Volume 30, Issue 4, 14 2 2009, Pages 601-624
Dietary Profile of Rhinopithecus bieti and Its Socioecological Implications.
Grueter CC, Li D, Ren B, Wei F, van Schaik CP
To enhance our understanding of dietary adaptations and socioecological correlates in colobines, we conducted a 20-mo study of a wild group of Rhinopithecus bieti (Yunnan snub-nosed monkeys) in the montane Samage Forest. This forest supports a patchwork of evergreen broadleaved, evergreen coniferous, and mixed deciduous broadleaved/coniferous forest assemblages with a total of 80 tree species in 23 families. The most common plant families by basal area are the predominantly evergreen Pinaceae an...
Abstract
Cited 21 times since 2009 (1.3 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 2, Issue 5, 7 1 2009, Pages 524-530
New ECG criteria in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Cox MG, van der Smagt JJ, Wilde AA, Wiesfeld AC, Atsma DE, Nelen MR, Rodriguez LM, Loh P, Cramer MJ, Doevendans PA, van Tintelen JP, de Bakker JM, Hauer RN
Background: Desmosomal changes, electric uncoupling, and surviving myocardial bundles in fibrofatty tissue characterize arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). Resultant activation delay is pivotal for reentry and thereby ventricular tachycardia (VT). Current task force criteria (TFC) for diagnosis have limited sensitivity. The aim of this study was to assess the diagnostic value of additional criteria on activation delay and VT to improve identification of affected i...
Abstract
Cited 34 times since 2009 (2.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 95, Issue 19, 5 1 2009, Pages 1607-1611
Multislice computed tomography coronary angiography for risk stratification in patients with an intermediate pretest likelihood.
van Werkhoven JM, Gaemperli O, Schuijf JD, Jukema JW, Kroft LJ, Leschka S, Alkadhi H, Valenta I, Pundziute G, de Roos A, van der Wall EE, Kaufmann PA, Bax JJ
Objectives: To assess whether multislice computed tomography coronary angiography (MSCTA) may be useful for risk stratification of patients with suspected coronary artery disease (CAD) at intermediate pretest likelihood according to Diamond and Forrester. Design and patients: MSCTA images were evaluated for the presence of significant CAD in 316 patients with suspected CAD (60% male, average (SD) age 57 (11) years) and an intermediate pretest likelihood according to Diamond and Forrester. Patien...
Abstract
Cited 110 times since 2009 (6.7 per year)
source: EuropePMC
Human molecular genetics,
Volume 18, Issue 19, 4 1 2009, Pages 3758-3768
A genome-wide association study of acenocoumarol maintenance dosage.
Teichert M, Eijgelsheim M, Rivadeneira F, Uitterlinden AG, van Schaik RH, Hofman A, De Smet PA, van Gelder T, Visser LE, Stricker BH
Several genome-wide association studies have been performed on warfarin. For acenocoumarol, the most frequently used coumarin in many countries worldwide, pharmacodynamic influences are expected to be comparable. Pharmacokinetics however might differ. We aimed to confirm known or identify new genetic variants contributing to interindividual variation on stabilized acenocoumarol dosage by a GWAS. The index population consisted of 1451 Caucasian subjects from the Rotterdam study and results were r...
Abstract
Cited 81 times since 2009 (5 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 19, 4 1 2009, Pages 2360-2367
Magnetic resonance imaging and response to cardiac resynchronization therapy: relative merits of left ventricular dyssynchrony and scar tissue.
Marsan NA, Westenberg JJ, Ypenburg C, van Bommel RJ, Roes S, Delgado V, Tops LF, van der Geest RJ, Boersma E, de Roos A, Schalij MJ, Bax JJ
Aim: To assess the relative value of a novel measure of left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and the extent of scar tissue for prediction of response to cardiac resynchronization therapy (CRT). Methods and results: Thirty-five heart failure patients scheduled for CRT were included. Left ventricular dyssynchrony was defined as the standard deviation of 16 segment time-to-maximum radial wall thickness (SDt-16) obtained from a cine-set of short-axis slice...
Abstract
Cited 18 times since 2009 (1.1 per year)
source: EuropePMC
American journal of primatology,
Volume 71, Issue 7, 1 1 2009, Pages 609-616
Sexual size dimorphism in Asian colobines revisited.
Grueter CC, Van Schaik CP
Asian colobines exhibit a wide range of sexual dimorphism in body mass. Some species are monomorphic, whereas others are strongly dimorphic. Strong sexual dimorphism is generally viewed as the consequence of intense male contest competition over access to mates, but this idea appears not to explain variation in sexual dimorphism in Asian colobines. Our results show that modular colobines, i.e. species in which social units aggregate into higher-level bands or often associate, have significantly...
Abstract
Cited 240 times since 2009 (14.7 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 5, 1 1 2009, Pages 402-409
Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.
Phan TT, Abozguia K, Nallur Shivu G, Mahadevan G, Ahmed I, Williams L, Dwivedi G, Patel K, Steendijk P, Ashrafian H, Henning A, Frenneaux M
Objectives: We sought to evaluate the role of exercise-related changes in left ventricular (LV) relaxation and of LV contractile function and vasculoventricular coupling (VVC) in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and to assess myocardial energetic status in these patients. Background: To date, no studies have investigated exercise-related changes in LV relaxation and VVC as well as in vivo myocardial energetic status in patients with HFpEF. Methods: We...
Abstract
Cited 28 times since 2009 (1.7 per year)
source: EuropePMC
Pediatric research,
Volume 66, Issue 1, 1 1 2009, Pages 74-79
Histopathological changes of the heart after neonatal dexamethasone treatment: studies in 4-, 8-, and 50-week-old rats.
Bal MP, de Vries WB, Steendijk P, Homoet-van der Kraak P, van der Leij FR, Baan J, van Oosterhout MF, van Bel F
Dexamethasone (Dex), for prevention of chronic lung disease in preterm infants, showed potential negative long-term effects. Studies regarding long-term cardiovascular effects are lacking. We investigated possible histopathological myocardial changes after neonatal Dex in the young and adult rat heart. Rats were treated with Dex on d 1, 2, and 3 (0.5, 0.3, and 0.1 mg/kg) of life. Control-pups received saline. At 4, 8, and 50 wk after birth rats were killed and anatomic data collected. Heart tiss...
Abstract
Cited 200 times since 2009 (12.2 per year)
source: EuropePMC
The Journal of clinical psychiatry,
Volume 70, Issue 7, 1 1 2009, Pages 983-989
The importance of childhood trauma and childhood life events for chronicity of depression in adults.
Wiersma JE, Hovens JG, van Oppen P, Giltay EJ, van Schaik DJ, Beekman AT, Penninx BW
Background: Childhood trauma is linked to adult depression and might be a risk factor for a more chronic course of depression. However, the link between childhood trauma and chronicity of depression has not been investigated using a large and representative sample in which other depression characteristics, such as severity, age at onset, and comorbid psychopathology, were taken into account. Method: Baseline data, collected during 2004 through 2007, were drawn from the Netherlands Study of Depre...
Abstract
Cited 30 times since 2009 (1.8 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 1, 1 1 2009, Pages 40-46
Delayed improvement of right ventricular diastolic function and regression of right ventricular mass after percutaneous pulmonary valve implantation in patients with congenital heart disease.
Romeih S, Kroft LJ, Bokenkamp R, Schalij MJ, Grotenhuis H, Hazekamp MG, Groenink M, de Roos A, Blom NA
Background: Percutaneous pulmonary valve implantation (PPVI) has been introduced as therapy for right ventricular (RV) to pulmonary artery conduit dysfunction in patients with congenital heart disease. It has been shown that RV systolic function improved early after PPVI. The effects of PPVI on RV diastolic function and RV hypertrophy have not yet been studied. Purpose: The objective of this study is to assess early and late changes in systolic and diastolic RV function and RV mass after PPVI. M...
Abstract
Cited 1 times since 2009 (0.1 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 32, Issue 7, 1 1 2009, Pages 913-917
Left ventricular ejection fraction as criterion for implantation of an implantable cardioverter-defibrillator in heart failure patients undergoing surgical left ventricular reconstruction.
Mollema SA, Klein P, Heersche J, Schalij MJ, Van der Wall EE, Versteegh MI, Klautz RJ, Van Erven L, Bax JJ
Background: Besides implantation of an implantable cardioverter-defibrillator (ICD), a proportion of patients with left ventricular (LV) dysfunction due to ischemic cardiomyopathy are potential candidates for surgical LV reconstruction (Dor procedure), which changes LV ejection fraction (LVEF) considerably. In these patients, LVEF as selection criterium for ICD implantation may be difficult. This study aimed to determine the value of LVEF as criterium for ICD implantation in heart failure patien...
Abstract
Cited 3 times since 2009 (0.2 per year)
source: EuropePMC
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese,
Volume 50, Issue 4, 1 1 2009, Pages 245-263
Imaging of atherosclerosis: invasive and noninvasive techniques.
Van Velzen JE, Schuijf JD, De Graaf FR, Jukema JW, Roos AD, Kroft LJ, Schalij MJ, Reiber JH, Van Der Wall EE, Bax JJ
Abstract
Cited 17 times since 2009 (1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 5, 1 1 2009, Pages 445-451
Prevalence and pathophysiologic attributes of ventricular dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Tops LF, Prakasa K, Tandri H, Dalal D, Jain R, Dimaano VL, Dombroski D, James C, Tichnell C, Daly A, Marcus F, Schalij MJ, Bax JJ, Bluemke D, Calkins H, Abraham TP
Objectives: This study sought to investigate the prevalence and mechanisms underlying right ventricular (RV) dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) using tissue Doppler echocardiography (TDE). Background: An ARVD/C is characterized by fibrofatty replacement of RV myocardium and RV dilation. These pathologic changes may result in electromechanical dyssynchrony. Methods: Echocardiography, both conventional and TDE, was performed in 52 ARVD/C patients ful...
Abstract
Cited 30 times since 2009 (1.8 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 50, Issue 1, 1 1 2009, Pages 152-160
Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice.
Eefting D, Bot I, de Vries MR, Schepers A, van Bockel JH, Van Berkel TJ, Biessen EA, Quax PH
Objective: Inflammatory responses to vascular injury are key events in vein graft disease and accelerated atherosclerosis, which may result in bypass failure. The monocyte chemoattractant protein-1 (MCP-1)/CC-chemokine receptor (CCR)-2 pathway is hypothesized to play a central role. A murine model for vein graft disease was used to study the effect of local application of lentiviral short hairpin RNA (shRNA) targeted against CCR2. Methods: A venous interposition was placed into the carotid arter...
Abstract
Cited 71 times since 2009 (4.3 per year)
source: EuropePMC
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation,
Volume 15, Issue 7, 1 1 2009, Pages 817-826
Lung function, pulmonary complications, and mortality after allogeneic blood and marrow transplantation in children.
Kaya Z, Weiner DJ, Yilmaz D, Rowan J, Goyal RK
Pulmonary complications (PC) remain a significant barrier to the success of allogeneic blood and marrow transplantation (BMT). Pretransplant pulmonary function tests (PFTs) have been correlated with risk of early respiratory failure and mortality in adult BMT recipients. There is limited data on their relationship to posttransplant outcomes in pediatric patients. We sought, in pediatric allo-BMT recipients (1) to analyze the spectrum of infectious and noninfectious PCs, (2) to evaluate the preva...
Abstract
Cited 24 times since 2009 (1.5 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 1, 1 1 2009, Pages 71-77
Cardiac structures track during the first 2 years of life and are associated with fetal growth and hemodynamics: the Generation R Study.
Geelhoed JJ, Steegers EA, van Osch-Gevers L, Verburg BO, Hofman A, Witteman JC, van der Heijden AJ, Helbing WA, Jaddoe VW
Background: The aim of this study is to examine whether cardiac size and function track in early childhood and are associated with fetal and early postnatal growth and blood flow characteristics. Methods: This study was embedded in a population-based prospective cohort study from fetal life onward. Fetal growth and fetal and placental blood flow parameters in second and third trimester of pregnancy were measured by ultrasound and Doppler. Left cardiac structures and shortening fraction were meas...
Abstract
Cited 123 times since 2009 (7.5 per year)
source: EuropePMC
European heart journal,
Volume 30, Issue 21, 29 5 2009, Pages 2622-2629
Incremental prognostic value of multi-slice computed tomography coronary angiography over coronary artery calcium scoring in patients with suspected coronary artery disease.
van Werkhoven JM, Schuijf JD, Gaemperli O, Jukema JW, Kroft LJ, Boersma E, Pazhenkottil A, Valenta I, Pundziute G, de Roos A, van der Wall EE, Kaufmann PA, Bax JJ
Aims: The purpose of this study was to assess the relationship between calcium scoring (CS) and multi-slice computed tomography coronary angiography (MSCTA) and to determine if MSCTA has an incremental prognostic value to CS. Methods and results: In 432 patients (59% male, age 58 +/- 11 years) referred for cardiac evaluation owing to suspected coronary artery disease (CAD), CS and 64-slice MSCTA were performed. The following events were combined in a composite endpoint: all-cause mortality, non-...
Abstract
Cited 22 times since 2009 (1.3 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 50, Issue 4, 27 4 2009, Pages 749-54; discussion 754
Perioperative asymptomatic cardiac damage after endovascular abdominal aneurysm repair is associated with poor long-term outcome.
Winkel TA, Schouten O, van Kuijk JP, Verhagen HJ, Bax JJ, Poldermans D
Background: Endovascular abdominal aortic aneurysm (AAA) repair (EVAR) is associated with a decreased incidence of perioperative cardiac complications compared with open repair. However, EVAR is not associated with long-term survival benefit. This study assessed the effect of perioperative asymptomatic cardiac damage after EVAR on long-term prognosis. Methods: In 220 patients undergoing elective EVAR, routine sampling for levels of cardiac troponin T and electrocardiography (ECG) were performed...
Abstract
Cited 13 times since 2009 (0.8 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 138, Issue 5, 26 4 2009, Pages 1167-1171
Results of surgical repair of atrioventricular septal defect with double-orifice left atrioventricular valve.
Hoohenkerk GJ, Wenink AC, Schoof PH, Koolbergen DR, Bruggemans EF, Rijlaarsdam M, Hazekamp MG
Objective: The outcome of surgical correction of atrioventricular septal defect with double-orifice left atrioventricular valve has improved in recent years but is still reported to be associated with high mortality and reoperation rates. Controversy exists about the management of the accessory orifice. We evaluated our results with correction of atrioventricular septal defect with double-orifice left atrioventricular valve. Methods: Between 1975 and 2006, 21 patients underwent correction of atr...
Abstract
