8853 results
Biological reviews of the Cambridge Philosophical Society,
23 4 2025
Assessing flexibility in meaning and context in non-human communication.
Fröhlich M, Aychet J, Clark PR, Crockford C, Dezecache G, Rebout N, van Schaik CP, Graham KE
The concept of flexibility in communication is central to reconstructing the evolutionary history of language, and grappling with "contextual flexibility" in particular is pivotal to address implications for pragmatics-first accounts of language evolution. Despite significant advances in the field, research is hindered by definitional inconsistencies and methodological gaps across modalities. We build on recent frameworks to propose further, detailed methods for studying contextual and...
Abstract
Frontiers in medicine,
Volume 12, 23 4 2025, Pages 1587912
Immersion to impact: does one or three years of rural immersion influence graduate clinical practice intentions and locations?
Harvey W, Ali Z, Van Schaik L, Develyn T, Wright J
Background: Addressing rural healthcare workforce shortages requires evidence-based strategies in medical education. Extended rural immersion programs offer a potential solution, but the optimal duration for fostering long-term regional and rural practice remains unclear. Methods: This retrospective study evaluates the impact of one-year versus three-year rural immersion experiences at the University of Melbourne's Rural Clinical School (RCS) on graduate clinical practice locations of the 2...
Abstract
British journal of anaesthesia,
22 4 2025, Pages S0007-0912(25)00404-0
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial.
Miggelbrink LA, van Klei WA, Verhaar MC, Asselbergs FW, Spiering W, Buhre WFFA, Hollmann MW, van Lier F, van Dongen EHPA, Schober P, Rettig TCD, Reitsma HJB, van Schaik EPC, Vernooij LM, van Waes JAR
Abstract
The American journal of cardiology,
Volume 256, 22 4 2025, Pages 72-80
Procedural and Clinical Outcomes of Coronary Intravascular Lithotripsy in Patients With Impaired Renal Function: A Multicenter Retrospective Study.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Chronic kidney disease (CKD) is a prevalent comorbidity in patients undergoing percutaneous coronary intervention (PCI), yet its impact on outcomes following intravascular lithotripsy (IVL) remains insufficiently studied. This study evaluated procedural and long-term outcomes of IVL-assisted PCI in patients with renal insufficiency compared to those with normal renal function. From the BENELUX-IVL registry (May 2019-September 2024), 558 patients were included in a retrospective multicenter analy...
Abstract
Cited 2 times since 2025 (17.8 per year)
source: EuropePMC
Nature medicine,
21 3 2025
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, G
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry...
Abstract
Frontiers in medicine,
Volume 12, 21 3 2025, Pages 1585017
Support from start to finish-a collaborative primary medical program in rural Victoria, Australia.
Harvey W, Van Schaik L, Develyn T, Ali Z, Hogarth C, Wright J
Australia faces a persistent shortage of doctors in rural and regional areas, exacerbating health disparities between urban and rural communities. Traditional medical education models, which have been largely centralized in metropolitan areas, often result in rural-origin students needing to relocate to cities for training, thus disrupting community connections and reducing the likelihood of their return to rural practice. To address this challenge, the University of Melbourne and La Trobe Unive...
Abstract
Open heart,
Volume 12, Issue 2, 21 3 2025, Pages e003445
Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure.
Neijenhuis RM, Regeer MV, Walker NL, Mertens BJ, Hunter A, Kiès P, Swan L, Vliegen HW, MacDonald ST, Zemrak F, Zaidi AN, Cedars AM, Jongbloed MR, Jukema JW, Veldtman GR, Egorova AD
Background: Systemic right ventricle (sRV) patients are at an increased risk of developing heart failure. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) could be a valuable treatment option. This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i. Methods: Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram...
Abstract
Water research,
Volume 287, Issue Pt A, 18 3 2025, Pages 124257
Tracking norovirus diversity at a global scale through wastewater metagenomics.
Izquierdo-Lara RW, Worp N, Olthof M, Oude Munnink BB, Schapendonk CME, Prasad DK, Aarestrup FM, Koopmans MPG, de Graaf M
Norovirus is a leading cause of gastroenteritis globally. Understanding the emergence, evolution, and trends in norovirus genotype/strain diversity is essential to develop sustainable strategies to guide the development of interventions. Here, we used urban wastewater samples to assess and compare the diversity of noroviruses worldwide. By using a metagenomics approach, we analyzed 327 sewage samples, collected from 62 cities across 6 continents, collected over the course of two years between 20...
Abstract
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
18 3 2025, Pages S1078-5884(25)00690-2
Activated Clotting Time Guided Heparinisation during Open Abdominal Aortic Aneurysm Repair (ACTION-1): A Randomised, Multicentre, Single Blind, Superiority Trial.
Jongkind V, Steunenberg TAH, Roosendaal LC, Hoebink M, Blankensteijn JD, Koelemay MJW, Kropman RHJ, Zeebregts CJ, van Schaik J, Heyligers JMM, Geelkerken RH, Pierie MEN, Reijnen MMPJ, Lemson SM, Hoencamp R, Teijink JAW, Steinbauer MG, Hissink RJ, Debus S, Buscher HCJL, Fioole B, van Dieren S, Wiersema AM, ACTION-1 Investigators
Objective: The optimal dosage of intravenous unfractionated heparin and the role of monitoring its effect using activated clotting time (ACT) to prevent thromboembolic complications (TECs) during open abdominal aortic aneurysm (AAA) repair are uncertain. This trial aimed to compare ACT guided heparinisation with a single dose of 5 000 international units (IU) of heparin. Methods: This was a multicentre, randomised controlled, single blinded, superiority trial (NCT04061798). Patients undergoing e...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 15, 17 3 2025, Pages e040868
Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse: Prevalence, Predictors, and Association With Outcomes.
Topilsky Y, Essayagh B, Benfari G, Le Tourneau T, Antoine C, Grigioni F, Roussel JC, Bax JJ, Marsan NA, van Wijngaarden A, Tribouilloy C, Loewenstein I, Hochstadt A, Thapa P, Michelena HI, Enriquez-Sarano M
Background: Left ventricular (LV) end-systolic enlargement in severe degenerative mitral-regurgitation (MR) is a class I surgical trigger. Whether it occurs disproportionately to less-than-severe MR due to mitral valve prolapse and is associated with mortality are unknown. We aimed to analyze prevalence and association with survival of disproportionate LV enlargement in less-than-severe MR. Methods: A multicenter cohort international study enrolled 2848 consecutive patients (52% women, 69±16 yea...
Abstract
American heart journal,
Volume 290, 16 3 2025, Pages 359-370
Design and rationale of the HARTc 2.0 trial: A multicenter randomized controlled study on the impact of point-of-care high-sensitivity cardiac troponin-I testing in prehospital acute coronary syndrome triage on diagnosis and cost-effectiveness.
van der Lande ACMH, Diederiks NM, de Koning ER, Bosch J, Romijn FPHTM, van der Loo WPM, van den Akker-van Marle ME, Dehnavi RA, Tietge WJ, Mertens BJA, Jukema JW, Cobbaert CM, Schalij MJ, Boogers MJ
Introduction: Chest pain accounts for ∼10% of emergency department visits, though most cases are not acute coronary syndrome (ACS), underscoring the need for effective prehospital triage. The HARTc 2.0 study evaluates the modified History, Electrocardiogram, Age, Risk Factors, and Troponin (HEART) score incorporating point-of-care (POC) high-sensitivity cardiac troponin-I (hs-cTnI) capillary fingerprick testing with sex-specific cut-offs to improve ACS risk stratification. The randomized control...
Abstract
Molecular therapy. Methods & clinical development,
Volume 33, Issue 3, 15 3 2025, Pages 101532
AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration.
Wang J, Jonker T, Cervera-Barea A, Dong Z, Visser RN, Birza EE, Boender AR, Klerk M, Yang Y, Visser J, Jansen MS, Grootswagers TC, Bart CI, de Jager SCA, Schrödel S, Thirion C, Kirzner OF, Tan HL, de Vries AAF, Sluijter JPG, Neef K, de Groot JR, Christoffels VM, Boink GJJ
Cardiac gene therapy using adeno-associated viral (AAV) vectors holds great promise for treating heart diseases but would benefit from more potent AAV vectors. Vectors based on the AAV serotypes 6 and 9 have been used in pre-clinical gene therapy studies, yet the therapeutic outcomes varied depending on the experimental model and delivery route used. Here, we evaluated the transduction efficiency of AAV6, AAV9, and AAV9-derived MyoAAVs for local cardiac delivery. Vectors were tested in neonatal...
Abstract
BMC nursing,
Volume 24, Issue 1, 15 3 2025, Pages 918
Development and validation of paternal breastfeeding attitude scale.
Buldum A, Alıcı D, Yılmaz DV
Objective: The aim of this study is to develop a valid and reliable instrument for the measurement of fathers' attitudes towards breastfeeding. Methods: This basic research-designed study included two independent participant groups of fathers who resided with their wives and had children aged 0-24 months who were exclusively breastfed. The final draft of the Paternal Breastfeeding Attitude Scale consisted of 32 items, which were scored on a five-point Likert scale. Results: Exploratory Fact...
Abstract
American journal of physiology. Renal physiology,
Volume 329, Issue 2, 15 3 2025, Pages F300-F310
Valosin-containing protein in ciliary morphology: a novel target in ADPKD.
Pioppini C, Bhardwaj R, Schönauer R, Halbritter J, Hassan F, Eckardt KU, Fedeles SV, Yilmaz DE, Krappitz M
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder leading to kidney cyst formation and loss of kidney function. The major causative genes Pkd1 and Pkd2 encode for the ciliary proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively, which are involved in ciliary functions. Within PKD1-defective cells, the accumulation of misfolded PC1 proteins triggers the unfolded protein response (UPR). Among the pathways activated, the ER-associated degradation (ERAD), medi...
Abstract
European journal of pediatrics,
Volume 184, Issue 8, 14 2 2025, Pages 481
''Unraveling the effects of smoking in asthmatic adolescents: clinical outcomes, spirometry findings, and risk analysis''.
Genis C, Tas D, Yılmaz D, Kuzucu FN, Selmanoglu A, Sengul Emeksiz Z, Dibek Mısırlıoglu E
Adolescent smoking and asthma are major global public health concerns. This study aims to comprehensively assess the impact of smoking on asthma control, pulmonary function, and risk factors for uncontrolled asthma in adolescents. A total of 126 adolescents aged 10 to 18 years were categorized into three groups: (1) smoking asthmatics, (2) non-smoking asthmatics, and (3) smoking non-asthmatics. Asthma symptom control was determined according to the Global Initiative for Asthma (GINA). Demographi...
Abstract
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
12 2 2025, Pages S1078-5884(25)00678-1
Factors Influencing Vascular Surgeons' Compliance with Elective Repair Guidelines for Abdominal Aortic Aneurysm: A Qualitative Study.
Brust M, van Gestel LC, Vriens PWHE, Hamming JF, Adriaanse MA, Lindeman JH
Objective: Despite guideline recommendations to delay elective abdominal aortic aneurysm (AAA) repair until the diameter exceeds the intervention threshold, a notable proportion of repairs occur earlier. This study aimed to explore factors influencing vascular surgeons' compliance with the intervention threshold regarding AAA repair, adopting a behavioural science perspective. Methods: This qualitative study employed semi-structured interviews with vascular surgeons. Twelve vascular surgeon...
Abstract
Scientific reports,
Volume 15, Issue 1, 11 2 2025, Pages 25022
Joint contact forces during barefoot, minimal and conventional shod running are highly individual.
Kloock L, Arensmann A, de Graaf ML, Gerlach M, Boström KJ, Wagner H
The supposed benefits of barefoot running are an often debated topic, with many studies investigating footwear influences on the kinematics and kinetics of running. Few studies, however, have analysed the effect on joint contact forces (JCFs). In this study, we investigated the influence of different footwear on the JCFs of the hip, knee, and ankle during running using a 3D musculoskeletal model. Kinematics were recorded from 16 volunteers while running on a treadmill at two speeds (2.0 m/s and...
Abstract
Cited 1 times since 2025 (6.9 per year)
source: EuropePMC
Royal Society open science,
Volume 12, Issue 7, 9 2 2025, Pages 241754
An integrated baseline assessment of reef-associated sharks around Saba (Dutch Caribbean), combining three methods: stereo-BRUVs, telemetry and citizen science.
Leurs G, de Graaf M, Hassell-Knijff D, Izioka LAK, van Looijengoed W, Meijer Zu Schlochtern MP, Bervoets T, Nagelkerke LAJ, Winter HV
The Exclusive Economic Zone of Saba (Dutch Windward Islands) has been designated Yarari Marine Mammal and Shark Sanctuary. However, to effectively conserve sharks, a baseline on their diversity and spatiotemporal distribution is required. We used three methods: telemetry, stereo-baited remote underwater video systems (stereo-BRUVs) and a citizen science program to study reef-associated sharks, mainly Caribbean reef sharks (Carcharhinus perezi) and nurse sharks (Ginglymostoma cirratum) around Sab...
Abstract
Heart (British Cardiac Society),
8 2 2025, Pages heartjnl-2025-326162
Representativeness of surgical controls in aortic valve replacement trials: comparison with routine surgical cohorts.
Tomsic A, Velders BJJ, Kawczynski MJ, Schoones JW, Klautz RJM, Palmen M, Sardari Nia P, Owais T, Girdauskas E, Heuts S
Background: Randomised controlled trials (RCTs) comparing transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) have significantly influenced treatment guidelines for aortic stenosis, expanding the use of TAVI into lower risk populations. However, the patients enrolled in the SAVR arms of these trials may differ from those typically undergoing SAVR in routine clinical practice. This study aims to critically assess the representativeness of SAVR patients in t...
Abstract
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland,
8 2 2025, Pages S1479-666X(25)00123-4
Bridging generational gaps in Surgery: A narrative review on values, well-being, and training preferences.
Huizing F, Sier VQ, Sark AD, Snijders HS, van der Vorst JR, Schmitz RF, Schepers A, Blok JJ, Future Surgeon Initiative
Background and purpose: Intergenerational differences in surgery create both challenges and opportunities. While differening perspectives and expectations may deter younger generations from pursuing surgical careers, it is crucial to balance these with the core values that define the surgical profession. This narrative review was conducted to better understand how the profession needs to evolve. Methods: A structured literature search on generational changes in surgery was conducted using PubMed...
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