8853 results
The international journal of cardiovascular imaging,
5 1 2025
Incremental prognostic value of left atrial reservoir strain after ST-segment elevation myocardial infarction for the prediction of new-onset atrial fibrillation.
Caunite L, Myagmardorj R, Galloo X, Laenens D, Stassen J, Nabeta T, Yedidya I, Meucci MC, Kuneman JH, van den Hoogen IJ, van Rosendael SE, Wu HW, van den Brand VM, Giuca A, Trusinskis K, Marsan NA, Bax JJ, van der Bijl P
New-onset atrial fibrillation (AF) affects up to 21% of ST-segment elevation myocardial infarction (STEMI) patients. The value of LA reservoir strain to predict new-onset AF in a STEMI population has not been thoroughly investigated. We aimed to explore the incremental value of LA reservoir strain for predicting new-onset AF post-STEMI. Data were analyzed retrospectively from an ongoing STEMI registry. LA reservoir strain
Abstract
Waste management (New York, N.Y.),
Volume 205, 4 1 2025, Pages 115003
Coupling of chemical deconstruction and pyrolysis to upcycle metallized multilayer plastic films.
Kulas D, Aloba S, Noecker A, Putman L, Meinholz C, Garland K, Henry J, Flores H, Chipkar S, Zolghadr A, Techtmann S, Ong R, Shonnard D
Multilayer metallized plastic films are popular packaging materials that are not currently recycled due to their complex multi-material make-up. In this study, a sequential pathway combining chemical, thermal and biological techniques was introduced to recycle military multilayer packaging made up of Polyethylene Terephthalate (PET), Polyethylene (PE), and aluminum. Chemical deconstruction using 10 wt% aqueous ammonia was able to selectively depolymerize the PET layer at a conversion close to 10...
Abstract
EClinicalMedicine,
Volume 85, 4 1 2025, Pages 103342
Intravascular lithotripsy for the treatment of calcified coronary lesions in individuals of advanced age: a post-hoc analysis of the multicentre, prospective BENELUX-IVL study.
Oliveri F, García PV, van Oort MJH, Phagu A, Al Amri I, Bingen BO, Paradies V, Mincione G, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Mandurino-Mirizzi A, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Patients of advanced age are frequently underrepresented or excluded from major clinical trials, leading to limited evidence in this population and a reliance on data extrapolated from younger populations. The present study aims to compare and evaluate the safety and efficacy of intravascular lithotripsy (IVL) for the treatment of calcified coronary lesions in individuals of advanced age and in younger populations. Methods: In this post-hoc analysis, from the ongoing prospective, mul...
Abstract
International journal of radiation oncology, biology, physics,
3 1 2025, Pages S0360-3016(25)04509-2
Health-Related Quality of Life in Patients Treated for Nonmetastatic Muscle-Invasive Bladder Cancer: Radical Cystectomy Versus Bladder-Preserving Therapy.
Brück K, Atema V, Leliveld AM, Franckena M, Meijer RP, van der Heijden MS, Donders AR, Witjes JA, Uyl-de Groot CA, van Hoogstraten LMC, Kiemeney LA, Boormans JL, Aben KKH, Hulshof MCCM, CRAC study group and the BlaZIB study group
Purpose: Patients with nonmetastatic muscle-invasive bladder cancer (MIBC) can be treated with either radical cystectomy (RC) or bladder-preserving therapy (BPT). Contemporary data on the impact of these treatments on health-related quality of life (HRQOL) are lacking. Methods and materials: In our prospective national cohort study, patients were invited to complete HRQOL questionnaires at baseline, 12 and 24 months after diagnosis. We included patients with nonmetastatic MIBC, treated with eith...
Abstract
The Prostate,
Volume 85, Issue 13, 2 1 2025, Pages 1168-1180
Transcriptomic Signatures of Monocyte-Derived Macrophages Associate With Androgen Receptor Pathway Inhibitor Progression in Prostate Cancer.
Sharifi MN, Heninger E, Bootsma ML, Recchia EE, Breneman MT, Taylor AK, Zhao SG, LeBeau AM, Kosoff D
Background: Androgen receptor pathway inhibitors (ARPIs) have significantly improved clinical outcomes for patients with metastatic prostate cancer (PC) but acquired ARPI resistance remains universal. Maximizing ARPI treatment duration is crucial to optimal clinical outcomes, but current clinical tools to detect acquired ARPI resistance, including serum Prostate Specific Antigen (PSA) and radiographic disease monitoring, are limited in both sensitivity and specificity. Since prostate cancer dise...
Abstract
JAMA cardiology,
2 1 2025
Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy.
Bhaskaran A, Ben Yaou R, Helms AS, Fayssoil A, Richard P, Stojkovic T, Anselme F, Labombarda F, Chikhaoui C, De Sandre-Giovannoli A, Jeru I, Leturcq F, Vigouroux C, Dembele M, Elliott P, Savvatis K, Zeppenfeld K, Bouguerra H, Charron P, Kumar S, Bonne G, Wahbi K, Lakdawala NK
Importance: Prior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood. Objective: To determine the association of the spatial distribution of missense and truncating LMNA variants with cardiac outcomes. Design, setting, and participants: Th...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 8, 1 1 2025, Pages 1466-1474
Left ventricular dilatation in patients with significant aortic regurgitation: association with outcome.
Lopez Santi P, Bernard J, Fortuni F, Butcher SC, Meucci MC, Sarrazyn C, Chua AP, Nabeta T, Zhang J, Popescu BA, Tay ELW, Yiu KH, Clavel MA, Pibarot P, Bax JJ, Ajmone Marsan N
Aims: Left ventricular (LV) dilatation is an important prognostic factor in patients with aortic regurgitation (AR). Although current guidelines recommend the use of LV end-systolic diameter index (LVESDi) to indicate the need for intervention, recent studies suggested that LV end-systolic volume index (LVESVi) may more accurately characterize LV remodelling.The present study aims to evaluate, in a multi-centre setting, whether combining LV linear and volumetric measures could improve risk strat...
Abstract
Cited 1 times since 2025 (6 per year)
source: EuropePMC
Cardiovascular research,
Volume 121, Issue 8, 1 1 2025, Pages 1215-1227
Sex and sex hormonal regulation of the atrial inward rectifier potassium current (IK1): insights into potential pro-arrhythmic mechanisms.
Giammarino L, Matas L, Alerni N, Horváth A, Vashanthakumar V, Nimani S, Barbieri M, Bains S, Lopez R, Louradour J, Ördög B, Hof T, Maguy A, Conte G, Auricchio A, Schotten U, Odening KE
Aims: Pronounced sex-differences are known in the incidence of atrial fibrillation (AF). In this study, we aimed to investigate the atrial electrophysiological properties that may underlie sex-differences in AF incidence in the younger population, focusing on IK1, a cardiac ion current important for action potential (AP) stability and triggered activity. Methods and results: We assessed sex-differences in P-wave morphology in 12-lead ECG in healthy young New Zealand White rabbits. Males presente...
Abstract
Frontiers in physiology,
Volume 16, 1 1 2025, Pages 1631426
Functional conduction system mapping in sheep reveals Purkinje spikes in the free wall of the right ventricular outflow tract.
Blok M, den Ouden BL, Kuiper M, Ophelders DRMG, Jongbloed MRM, Zeemering S, Jensen B, van Hunnik A, Boukens BJ
Ablation of sites displaying Purkinje activity is highly effective against idiopathic ventricular fibrillation which often originates in the right ventricular outflow tract. However, during endocardial mapping Purkinje potentials are rarely, if never, detected in the right ventricular outflow tract. In the present study, we aimed to determine whether the Purkinje system extends into the right ventricular outflow tract. Hearts of five female sheep were blood-perfused in a Langendorff setup in whi...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 7, 1 1 2025, Pages ezaf137
Reply to Xiao et al.
Sabik JF, Rao V, Dagenais F, Reardon MJ, PERIGON Investigators
Abstract
Scientific reports,
Volume 15, Issue 1, 1 1 2025, Pages 21482
Systematic assessment of bone and soft tissue tumors on whole-body CTs of 45 mummies from ancient Egypt.
Panzer S, Wörtler K, Paladin A, Zesch S, Rosendahl W, van Schaik KD, Sutherland ML, Sutherland JD, Hergan K, Thompson RC, Zink AR
There is a growing interest in the antiquity of cancer and ongoing discussion of the apparent scarcity of malignant tumors in ancient human remains, especially those of soft tissues. We systematically assessed bone and soft tissue tumors on 45 whole-body computed tomography (CT) scans of ancient Egyptian mummies. In one of 45 cases (2%), malignant skeletal disease (probably skeletal metastases) was detected. In five of 45 cases (11%), probably malignant soft tissue masses were identified. The so...
Abstract
Cited 1 times since 2025 (6 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 31, Issue 13, 1 1 2025, Pages 2793-2813
Antitumor Immunity Mediated by Engineered Stem Cells Exploiting TRAIL-Induced Cell Death and FLT3L Immunomodulation.
van Schaik TA, Chen KS, Kanaya N, Moreno-Lama L, Freeman NW, Wang M, Li W, Zhang YS, Vrbanac V, Huang R, Wakimoto H, Reardon D, Shah K
Purpose: Death receptor (DR)-targeted therapies offer a promising tumor cell-specific therapeutic strategy for highly malignant brain tumors, such as glioblastoma (GBM). However, whether DR-mediated cell death leads to activation of the adaptive immune system and impacts the tumor immune microenvironment (TIME) remains unknown. In this study, we explored the (i) immunomodulatory role of secretable human DR4/5 ligand, TNF-related apoptosis-inducing ligand (S-TRAIL) and (ii) the therapeutic potent...
Abstract
Heart rhythm,
Volume 22, Issue 7, 1 1 2025, Pages 1877-1879
Top stories on proactive ventricular arrhythmia assessment in repaired tetralogy of Fallot.
Zeppenfeld K, Kimura Y
Abstract
Current heart failure reports,
Volume 22, Issue 1, 1 1 2025, Pages 21
Impact of Multisensor CIED-based Heart Failure Monitoring on Mortality, Heart Failure Hospitalizations and Outpatient Visits: A Systematic Review.
Zwaenepoel BAC, Kluft A, Feijen M, Schoones JW, Heggermont WA, Egorova AD, Beeres SLMA
Purpose of review: Cardiac Implantable Electronic Device (CIED)-based remote monitoring has been proposed to improve heart failure (HF) management by enabling early detection of decompensation. This systematic review evaluates the effectiveness of multisensor CIED-based monitoring in reducing mortality, HF hospitalizations, and unplanned HF outpatient visits. Recent findings: Earlier CIED-based remote monitoring strategies were mainly based on single-sensor impedance-based algorithms, and showed...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf122
Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software.
Rademaker R, Cirkel S, Omara S, Dankers FJWM, Sramko M, Solana Munoz J, Kaya YS, Ter Bekke RMA, Schiappacasse L, Teres C, Verhoeven K, Pruvot E, Rasch CRN, Zeppenfeld K
Aims: Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages. Methods and results: In patients considered for STAR, CardTV-E...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 7, 1 1 2025, Pages euaf134
Regionalization of the atria for 3D electroanatomical mapping, cardiac imaging, and computational modelling: a clinical consensus statement of the European Heart Rhythm Association and the European Association of Cardiovascular Imaging of the ESC.
Althoff TF, Anderson RH, Goetz C, Petersen SE, Díaz PM, Nijveldt R, Maurovich-Horvat P, Bax J, Hussain S, Schmidt C, Spicer DE, Sanchez-Quintana D, Corsi C, Dössel O, Climent AM, Rodriguez B, Schotten U, Loewe A, Guillem MS, Cabrera JÁ, Merino JL, Wijnmaalen AP, Bertrand PB, de Groot N, Derval N, Didenko M, Donal E, Dweck MR, Ho SY
This clinical consensus document proposes standardized atrial segments for 3D imaging, electroanatomical mapping and computational modelling, based on anatomical, electrophysiological and clinical considerations, with precise definitions of regional borders allowing for reproducible and automated regionalization. 3D imaging and high-resolution electroanatomical mapping have become an integral part of cardiac electrophysiology and the management of patients with arrhythmias. However, to perform r...
Abstract
Journal of magnetic resonance imaging : JMRI,
30 5 2025
Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.
Bosshardt D, van Andel MM, Schrauben EM, van Kimmenade RRJ, Scholte AJ, Cox MGJP, Robbers-Visser D, Zwinderman AH, Mulder BJM, Nederveen AJ, de Waard V, Groenink M, van Ooij P
Background: New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients. Purpose: To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS. Study type: Prospective single-arm open-label multicenter trial. Population: 46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of ao...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 169, 30 5 2025, Pages D8346
[Unfounded objections against the use of salbutamol/ipratropium].
Lucassen EA, Rood R, Tibboel J, Piers SRD
In acute bronchospasm due to asthma/COPD exacerbations two bronchodilators are frequently used: ipratropium, an acetylcholine antagonist, and salbutamol, a β2-agonist. The combination ipratropium/salbutamol gives more bronchodilation than ipratropium monotherapy in asthma/COPD exacerbations, but there are concerns about cardiac safety of salbutamol. Salbutamol in regular dosage does not affect heart rate in diverse populations (ED, ICU and children). Only a dosage 5-10x the standard dosage of 2,...
Abstract
mBio,
Volume 16, Issue 8, 30 5 2025, Pages e0035325
A redundant isoprenoid biosynthetic pathway supports <i>Staphylococcus aureus</i> metabolic versatility.
Burtchett TA, Ottosen EN, Jitsukawa T, Kaneko M, Yasui M, Lysne JA, Kies PJ, Bailey JA, Thomas SM, Fujisaki S, Hammer ND
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesis initiates via condensation of the five-carbon (C5) precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This initial reaction condenses one DMAPP and two IPPs, resulting in C15 farnesyl diphosphate (FPP), an intermediate...
Abstract
International journal of cancer,
30 5 2025
Physical activity and risks of recurrence and progression among patients with non-muscle invasive bladder cancer.
Beeren I, Kiebach J, Hof JP, Buffart LM, Aben KKH, Witjes JA, van der Heijden AG, Kiemeney LALM, Vrieling A
Previous studies in solid tumors link high physical activity (PA) levels to lower cancer recurrence risk, but evidence is lacking for patients with non-muscle invasive bladder cancer (NMIBC). We evaluated the association between (changes in) PA (total, moderate-to-vigorous PA, leisure-time PA, and Dutch PA guideline adherence) and risks of NMIBC recurrence and progression. Patients diagnosed between 2014 and 2021 were recruited for the multi-center prospective cohort UroLife. Participants report...
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