9294 results
Cited 55 times since 2014 (4.9 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 96, Issue 1, 24 4 2014, Pages 81-89
Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662.
Diekstra MH, Klümpen HJ, Lolkema MP, Yu H, Kloth JS, Gelderblom H, van Schaik RH, Gurney H, Swen JJ, Huitema AD, Steeghs N, Mathijssen RH
Interpatient variability in the pharmacokinetics (PK) of sunitinib is high. Single nucleotide polymorphisms (SNPs) in PK candidate genes have been associated with the efficacy and toxicity of sunitinib, but whether these SNPs truly affect the PK of sunitinib remains to be elucidated. This multicenter study involving 114 patients investigated whether these SNPs and haplotypes in genes encoding metabolizing enzymes or efflux transporters are associated with the clearance of sunitinib and its activ...
Abstract
Cited 24 times since 2014 (2.1 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 46, Issue 3, 23 4 2014, Pages 474-9; discussion 479
Reoperation for neoaortic root pathology after the arterial switch operation.
Koolbergen DR, Manshanden JS, Yazdanbakhsh AP, Bouma BJ, Blom NA, de Mol BA, Mulder BJ, Hazekamp MG
Objectives: To evaluate incidence and results of surgical intervention for neoaortic root pathology following arterial switch operation (ASO) for transposition of the great arteries (TGA). Methods: Between April 1996 and August 2013, 12 patients underwent reoperation for neoaortic root dilatation (ARD) and/or neoaortic valve regurgitation (AR). Maximal aortic sinus and annulus diameter Z-scores were recorded. Original diagnoses were TGA/IVS (6), TGA/ventricular septal defect (VSD) (4) and Taussi...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
TheScientificWorldJournal,
Volume 2014, 23 4 2014, Pages 531324
Echocardiographic assessment of embryonic and fetal mouse heart development: a focus on haemodynamics and morphology.
Hahurij ND, Calkoen EE, Jongbloed MR, Roest AA, Gittenberger-de Groot AC, Poelmann RE, De Ruiter MC, van Munsteren CJ, Steendijk P, Blom NA
Background: Heart development is a complex process, and abnormal development may result in congenital heart disease (CHD). Currently, studies on animal models mainly focus on cardiac morphology and the availability of hemodynamic data, especially of the right heart half, is limited. Here we aimed to assess the morphological and hemodynamic parameters of normal developing mouse embryos/fetuses by using a high-frequency ultrasound system. Methods: A timed breeding program was initiated with a WT m...
Abstract
Cited 85 times since 2014 (7.5 per year)
source: EuropePMC
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 40, Issue 7, 22 4 2014, Pages 850-858
Real-time intraoperative detection of breast cancer using near-infrared fluorescence imaging and Methylene Blue.
Tummers QR, Verbeek FP, Schaafsma BE, Boonstra MC, van der Vorst JR, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: Despite recent developments in preoperative breast cancer imaging, intraoperative localization of tumor tissue can be challenging, resulting in tumor-positive resection margins during breast conserving surgery. Based on certain physicochemical similarities between Technetium((99m)Tc)-sestamibi (MIBI), an SPECT radiodiagnostic with a sensitivity of 83-90% to detect breast cancer preoperatively, and the near-infrared (NIR) fluorophore Methylene Blue (MB), we hypothesized that MB might...
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 2, 21 3 2014, Pages e88984
Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
Willems S, van der Velden D, Quax PH, de Borst GJ, de Vries JP, Moll FL, Kuiper J, Toes RE, de Jager SC, de Kleijn DP, Hoefer IE, Pasterkamp G, Bot I
Background: Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activate mast cells during the progression and destabilization of atherosclerotic lesions remain unidentified. Mast cells can be activated by immunoglobulins and in the present study, we aimed to...
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 47, Issue 5, 20 3 2014, Pages 479-486
Differences in mortality, risk factors, and complications after open and endovascular repair of ruptured abdominal aortic aneurysms.
von Meijenfeldt GC, Ultee KH, Eefting D, Hoeks SE, ten Raa S, Rouwet EV, Hendriks JM, Verhagen HJ, Bastos Goncalves FM
Objective/background: Endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysm (rAAA) has faced resistance owing to the marginal evidence of benefit over open surgical repair (OSR). This study aims to determine the impact of treatment modality on early mortality after rAAA, and to assess differences in postoperative complications and long-term survival. Methods: Patients treated between January 2000 and June 2013 were identified. The primary endpoint was early mortality. Second...
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 111, Issue 9, 18 3 2014, Pages 3556-3560
Small distances can keep bacteria at bay for days.
van Bunnik BA, Ssematimba A, Hagenaars TJ, Nodelijk G, Haverkate MR, Bonten MJ, Hayden MK, Weinstein RA, Bootsma MC, De Jong MC
Transmission of pathogens between spatially separated hosts, i.e., indirect transmission, is a commonly encountered phenomenon important for epidemic pathogen spread. The routes of indirect transmission often remain untraced, making it difficult to develop control strategies. Here we used a tailor-made design to study indirect transmission experimentally, using two different zoonotic bacteria in broilers. Previous experiments using a single bacterial species yielded a delay in the onset of trans...
Abstract
Cited 27 times since 2014 (2.4 per year)
source: EuropePMC
Obesity (Silver Spring, Md.),
Volume 22, Issue 6, 18 3 2014, Pages 1553-1559
Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation.
Hillebrand S, de Mutsert R, Christen T, Maan AC, Jukema JW, Lamb HJ, de Roos A, Rosendaal FR, den Heijer M, Swenne CA, NEO Study Group
Objective: Obesity is associated with sympathetic activation, but the role of different fat depots is unclear. The association between body fat, specifically visceral fat, and electrocardiographic measures of sympathetic activation in a population with structurally normal hearts was investigated. Methods: In this cross-sectional baseline analysis of the Netherlands Epidemiology of Obesity study, body fat percentage was assessed with BIA and abdominal subcutaneous (SAT) and visceral adipose tissu...
Abstract
Cited 37 times since 2014 (3.3 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 22, 16 3 2014, Pages 1479-1485
Radio-frequency ablation as primary management of well-tolerated sustained monomorphic ventricular tachycardia in patients with structural heart disease and left ventricular ejection fraction over 30%.
Maury P, Baratto F, Zeppenfeld K, Klein G, Delacretaz E, Sacher F, Pruvot E, Brigadeau F, Rollin A, Andronache M, Maccabelli G, Gawrysiak M, Brenner R, Forclaz A, Schlaepfer J, Lacroix D, Duparc A, Mondoly P, Bouisset F, Delay M, Hocini M, Derval N, Sadoul N, Magnin-Poull I, Klug D, Haïssaguerre M, Jaïs P, Della Bella P, De Chillou C
Aims: Patients with well-tolerated sustained monomorphic ventricular tachycardia (SMVT) and left ventricular ejection fraction (LVEF) over 30% may benefit from a primary strategy of VT ablation without immediate need for a 'back-up' implantable cardioverter-defibrillator (ICD). Methods and results: One hundred and sixty-six patients with structural heart disease (SHD), LVEF over 30%, and well-tolerated SMVT (no syncope) underwent primary radiofrequency ablation without ICD implantation...
Abstract
Cited 41 times since 2014 (3.6 per year)
source: EuropePMC
Injury,
Volume 45, Issue 7, 15 3 2014, Pages 1028-1034
Systematic review of the prevalence and characteristics of battle casualties from NATO coalition forces in Iraq and Afghanistan.
Hoencamp R, Vermetten E, Tan EC, Putter H, Leenen LP, Hamming JF
Background: The North Atlantic Treaty Organization (NATO) coalition forces remain heavily committed on combat operations overseas. Understanding the prevalence and characteristics of battlefield injury of coalition partners is vital to combat casualty care performance improvement. The aim of this systematic review was to evaluate the prevalence and characteristics of battle casualties from NATO coalition partners in Iraq and Afghanistan. The primary outcome was mechanism of injury and the second...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Journal of child neurology,
Volume 30, Issue 1, 13 2 2014, Pages 129-132
Strokelike episodes and cutis marmorata telangiectatica congenita.
Van Schaik SM, Reneman L, Engelen M, Roos YB, Poll-The BT
We report the case of a boy with cutis marmorata telangiectatica congenita, strokelike episodes, and a pinpoint stenosis of the left internal carotid artery. To our knowledge, this is the first report of a stenosis of an intracranial artery in a patient with cutis marmorata telangiectatica congenita.
Abstract
Cited 43 times since 2014 (3.8 per year)
source: EuropePMC
Intensive care medicine,
Volume 40, Issue 4, 13 2 2014, Pages 564-571
Duration of colonization with antimicrobial-resistant bacteria after ICU discharge.
Haverkate MR, Derde LP, Brun-Buisson C, Bonten MJ, Bootsma MC
Purpose: Readmission of patients colonized with antimicrobial-resistant bacteria (AMRB) is important in the nosocomial dynamics of AMRB. We assessed the duration of colonization after discharge from the intensive care unit (ICU) with highly resistant Enterobacteriaceae (HRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VRE). Methods: Data were obtained from a cluster-randomized trial in 13 ICUs in 8 European countries (MOSAR-ICU trial, 2008-2011). Al...
Abstract
Cited 36 times since 2014 (3.2 per year)
source: EuropePMC
Annals of surgical oncology,
Volume 21 Suppl 4, 11 2 2014, Pages S528-37
Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe.
Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL
Background: Irradical tumor resections and iatrogenic ureteral injury remain a significant problem during lower abdominal surgery. The aim of the current study was to intraoperatively identify both colorectal tumors and ureters in subcutaneous and orthotopic animal models using cRGD-ZW800-1 and near-infrared (NIR) fluorescence. Methods: The zwitterionic fluorophore ZW800-1 was conjugated to the tumor specific peptide cRGD (targeting integrins) and to the a-specific peptide cRAD. One nmol cRGD-ZW...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
Journal of the American Academy of Dermatology,
Volume 70, Issue 5, 10 2 2014, Pages 893-898
E-learning enables parents to assess an infantile hemangioma.
de Graaf M, Knol MJ, Totté JE, van Os-Medendorp H, Breugem CC, Pasmans SG
Background: Infantile hemangiomas (IH) at risk for complications need to be recognized early. Objective: We sought to determine if parents are able to assess, after e-learning, whether their child has an IH, is at risk for complications, and needs to be seen (urgently) by a specialist. Methods: This was a prospective study of 158 parents participating in an IH e-learning module. Parents were asked to assess their child's skin abnormality. A dermatologist answered the same questions (by e-co...
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 2, 10 2 2014, Pages e86665
Temporal trends of system of care for STEMI: insights from the Jakarta Cardiovascular Care Unit Network System.
Dharma S, Siswanto BB, Firdaus I, Dakota I, Andriantoro H, Wardeh AJ, van der Laarse A, Jukema JW
Aim: Guideline implementation programs are of paramount importance in optimizing acute ST-elevation myocardial infarction (STEMI) care. Assessment of performance indicators from a local STEMI network will provide knowledge of how to improve the system of care. Methods and results: Between 2008-2011, 1505 STEMI patients were enrolled. We compared the performance indicators before (n = 869) and after implementation (n = 636) of a local STEMI network. In 2011 (after introduction of STEMI networking...
Abstract
,
8 2 2014
Enterococcal Genomics
Palmer KL, van Schaik W, Willems RJL, Gilmore MS
Enterococcal genomics is a rapidly growing area of study. The first enterococcal genome sequence—that of Enterococcus faecalis V583—was published ten years ago (McShan & Shankar, 2002; Paulsen, et al., 2003), and complete or draft genome sequences of various enterococcal strains and species now number in the hundreds (http://www.ncbi.nlm.nih.gov/genome). Concurrent with rapid advances in genome sequencing, the sequencing-based classification scheme of multilocus sequence typing (MLST) has be...
Abstract
Cited 37 times since 2014 (3.3 per year)
source: EuropePMC
Circulation research,
Volume 114, Issue 6, 7 1 2014, Pages 993-1003
Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts.
Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S
Rationale: β-Adrenoceptor activation contributes to sudden death risk in heart failure. Chronic β-adrenergic stimulation, as occurs in patients with heart failure, causes potentially arrhythmogenic reductions in slow delayed-rectifier K(+) current (IKs). Objective: To assess the molecular mechanisms of IKs downregulation caused by chronic β-adrenergic activation, particularly the role of exchange protein directly activated by cAMP (Epac). Methods and results: Isolated guinea pig left ventricular...
Abstract
Cited 40 times since 2014 (3.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 30, Issue 3, 6 1 2014, Pages 549-558
Global longitudinal strain and left atrial volume index improve prediction of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy patients.
Debonnaire P, Thijssen J, Leong DP, Joyce E, Katsanos S, Hoogslag GE, Schalij MJ, Atsma DE, Bax JJ, Delgado V, Marsan NA
Accurate predictors of appropriate implantable cardioverter defibrillator (ICD) therapy in hypertrophic cardiomyopathy (HCM) patients are lacking. Both left atrial volume index (LAVI) and global longitudinal strain (GLS) have been proposed as prognostic markers in HCM patients. The specific value of LAVI and GLS to predict appropriate ICD therapy in high-risk HCM patients was studied. LAVI and 2-dimensional speckle tracking-derived GLS were assessed in 92 HCM patients undergoing ICD implantation...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 15, Issue 7, 4 1 2014, Pages 832
CoreValve stent frame misdeployment and increased transvalvular gradient.
Kamperidis V, van der Kley F, Katsanos S, Delgado V
Abstract
Cited 113 times since 2014 (9.9 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 16, Issue 5, 4 1 2014, Pages 681-688
Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the wireless stimulation endocardially for CRT (WiSE-CRT) study.
Auricchio A, Delnoy PP, Butter C, Brachmann J, Van Erven L, Spitzer S, Moccetti T, Seifert M, Markou T, Laszo K, Regoli F, Collaborative Study Group
Aims: Left ventricular (LV) endocardial pacing may address the limitations in the selection of an LV pacing site and provide improvements in cardiac resynchronization therapy (CRT) effectiveness. We report on the feasibility, the safety, and the short-term outcome of a leadless ultrasound-based technology for LV endocardial resynchronization in heart failure (HF) patients enroled into the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study. Methods and results: Seventeen HF patients were...
Abstract
