6173 results
Cited 97 times since 2020 (22 per year)
source: EuropePMC
Nature genetics,
Volume 52, Issue 12, 23 4 2020, Pages 1314-1332
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E,
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P
Abstract
Cited 25 times since 2020 (5.7 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 1, 23 4 2020, Pages 566-576
Meta-analysis of echocardiographic quantification of left ventricular filling pressure.
Jones R, Varian F, Alabed S, Morris P, Rothman A, Swift AJ, Lewis N, Kyriacou A, Wild JM, Al-Mohammad A, Zhong L, Dastidar A, Storey RF, Swoboda PP, Bax JJ, Garg P
Aims: The clinical reliability of echocardiographic surrogate markers of left ventricular filling pressures (LVFPs) across different cardiovascular pathologies remains unanswered. The main objective was to evaluate the evidence of how effectively different echocardiographic indices estimate true LVFP. Methods and results: Design: this is a systematic review and meta-analysis. Data source: Scopus, PubMed and Embase. Eligibility criteria for selecting studies were those that used echocardiography...
Abstract
Cited 26 times since 2020 (5.9 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 112, Issue 4, 19 3 2020, Pages 1150-1159
Multiinstitutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer.
Gangadharan S, Sarkaria IN, Rice D, Murthy S, Braun J, Kucharczuk J, Predina J, Singhal S
Background: Intraoperative molecular imaging (IMI) may improve surgical outcomes during pulmonary resection for lung cancer. A multiinstitutional phase 2 IMI clinical trial was conducted using a near-infrared, folate receptor-targeted contrast agent for lung adenocarcinomas, OTL38. The primary goal was to determine whether OTL38 improved surgeons' ability to identify difficult to find nodules, occult cancers, and positive margins. Methods: Patients with lung nodules received OTL38 (0.025 mg...
Abstract
Cited 47 times since 2020 (10.6 per year)
source: EuropePMC
Frontiers in nutrition,
Volume 7, 19 3 2020, Pages 597600
The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19.
de Frel DL, Atsma DE, Pijl H, Seidell JC, Leenen PJM, Dik WA, van Rossum EFC
Background: COVID-19 is a global challenge to healthcare. Obesity is common in patients with COVID-19 and seems to aggravate disease prognosis. In this review we explore the link between obesity, chronic disease, lifestyle factors and the immune system, and propose societal interventions to enhance global immunity. Search Strategy and Selection Criteria: We performed three literature searches using the keywords (1) coronavirus AND comorbidities, (2) comorbidities AND immune system, and (3) lifes...
Abstract
Cited 38 times since 2020 (8.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 1, 18 3 2020, Pages 233-242
The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease.
Jin HY, Weir-McCall JR, Leipsic JA, Son JW, Sellers SL, Shao M, Blanke P, Ahmadi A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araujo Goncalves P, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Chinnaiyan K, Raff G, Al-Mallah MH, Lin FY, Min JK, Sung JM, Lee SE, Chang HJ
Objectives: The aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease. Background: Coronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in respo...
Abstract
Cited 17 times since 2020 (3.8 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 9, Issue 23, 16 3 2020, Pages e017094
Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.
Bruijn LE, van den Akker BEWM, van Rhijn CM, Hamming JF, Lindeman JHN
Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as "fibroblasts," "myofibroblasts," "smooth muscle cells," "fibrocytes," "mesangial cells," and "pericytes." However, a discriminative marker-based subclassification has to date not been established. Methods and Results As a fir...
Abstract
Cited 142 times since 2020 (32 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 18, Issue 4, 13 2 2020, Pages 291-304
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging.
Ng ACT, Delgado V, Borlaug BA, Bax JJ
Diabesity is a term used to describe the combined adverse health effects of obesity and diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an important public health issue. Projections estimate a sixfold increase in the number of adults with obesity in 40 years and an increase in the number of individuals with diabetes to 642 million by 2040. Increased adiposity is the strongest risk factor for developing diabetes. Early detection of the effects of diabesity on the...
Abstract
Cited 3 times since 2020 (0.7 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 44, Issue 1, 12 2 2020, Pages 120-128
Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach.
Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L
The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile range...
Abstract
Trends in cardiovascular medicine,
Volume 31, Issue 8, 11 2 2020, Pages 495-496
Editorial commentary: Future of transcatheter mitral valve interventions for secondary mitral regurgitation.
Vo NM, Bax JJ, Delgado V
Abstract
Cited 8 times since 2020 (1.8 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 48, Issue 5, 11 2 2020, Pages 1434-1444
Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [<sup>15</sup>O] water positron emission tomography study.
Harjulahti E, Maaniitty T, Nammas W, Stenström I, Biancari F, Bax JJ, Knuuti J, Saraste A
Purpose: We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods: Global and segmental sMBF during adenosine stress were retrospectively quantified in 530 symptomatic patients who underwent [15O] water PET for evaluation of coronary stenosis detected by coronary computed tomography angi...
Abstract
Cited 24 times since 2020 (5.4 per year)
source: EuropePMC
Cell reports. Medicine,
Volume 1, Issue 9, 10 2 2020, Pages 100146
Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons.
Rother N, Yanginlar C, Lindeboom RGH, Bekkering S, van Leent MMT, Buijsers B, Jonkman I, de Graaf M, Baltissen M, Lamers LA, Riksen NP, Fayad ZA, Mulder WJM, Hilbrands LB, Joosten LAB, Netea MG, Vermeulen M, van der Vlag J, Duivenvoorden R
Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Can...
Abstract
Cited 20 times since 2020 (4.5 per year)
source: Scopus
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 3, 9 2 2020, Pages 257-266
Left Ventricular Myocardial Work in Patients with Severe Aortic Stenosis.
Fortuni F, Butcher SC, van der Kley F, Lustosa RP, Karalis I, de Weger A, Priori SG, van der Bijl P, Bax JJ, Delgado V, Ajmone Marsan N
Background: Left ventricular myocardial work (LVMW) is a novel method to assess left ventricular (LV) function using pressure-strain loops that takes into consideration LV afterload. The estimation of LV afterload in patients with severe aortic stenosis (AS) may be challenging, and no study so far has investigated LVMW in this setting. The aim of this study was to develop a method to calculate LVMW in patients with severe AS and to analyze its relationship with heart failure symptoms. Methods: I...
Abstract
Cited 91 times since 2020 (20.5 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 2, 9 2 2020, Pages 93-109
Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging - Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque.
Shaw LJ, Blankstein R, Bax JJ, Ferencik M, Bittencourt MS, Min JK, Berman DS, Leipsic J, Villines TC, Dey D, Al'Aref S, Williams MC, Lin F, Baskaran L, Litt H, Litmanovich D, Cury R, Gianni U, van den Hoogen I, R van Rosendael A, Budoff M, Chang HJ, E Hecht H, Feuchtner G, Ahmadi A, Ghoshajra BB, Newby D, Chandrashekhar YS, Narula J
Coronary computed tomographic angiography (CCTA) provides a wealth of clinically meaningful information beyond anatomic stenosis alone, including the presence or absence of nonobstructive atherosclerosis and high-risk plaque features as precursors for incident coronary events. There is, however, no uniform agreement on how to identify and quantify these features or their use in evidence-based clinical decision-making. This statement from the Society of Cardiovascular Computed Tomography and Nort...
Abstract
Cited 13 times since 2020 (2.9 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 5 1 2020, Pages 19111
An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms.
Wildisen L, Del Giovane C, Moutzouri E, Beglinger S, Syrogiannouli L, Collet TH, Cappola AR, Åsvold BO, Bakker SJL, Yeap BB, Almeida OP, Ceresini G, Dullaart RPF, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp R, Gussekloo J, Klöppel S, Aujesky D, Bauer D, Peeters R, Feller M, Rodondi N
In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and depressive symptoms. We aimed to examine the association between subclinical thyroid dysfunction and depressive symptoms in all prospective cohorts with relevant data available. We performed a systematic review of the literature from Medline, Embase, Cumulative Index to Nursing and A...
Abstract
Cited 6 times since 2020 (1.3 per year)
source: EuropePMC
Cells,
Volume 9, Issue 11, 4 1 2020, Pages E2412
Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review.
Kaykı-Mutlu G, Papazisi O, Palmen M, Danser AHJ, Michel MC, Arioglu-Inan E
As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limit...
Abstract
Cited 11 times since 2020 (2.5 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 9, Issue 22, 4 1 2020, Pages e016391
Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease.
Kip P, Tao M, Trocha KM, MacArthur MR, Peters HAB, Mitchell SJ, Mann CG, Sluiter TJ, Jung J, Patterson S, Quax PHA, de Vries MR, Mitchell JR, Keith Ozaki C
Background Failure rates after revascularization surgery remain high, both in vein grafts (VG) and arterial interventions. One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-term dietary restriction. However, strict patient compliance stands as a potential translational barrier in the vascular surgery patient population. Here we present a new therapeutic approach, via a locally applicable gel containing the hydrog...
Abstract
Cited 3 times since 2020 (0.7 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 22, Issue 11, 1 1 2020, Pages 1680-1687
Arrhythmia exacerbation after post-infarction ventricular tachycardia ablation: prevalence and prognostic significance.
Siontis KC, Kim HM, Vergara P, Peretto G, Do DH, de Riva M, Lam A, Qian P, Yokokawa M, Jongnarangsin K, Latchamsetty R, Jais P, Sacher F, Tedrow U, Shivkumar K, Zeppenfeld K, Della Bella P, Stevenson WG, Morady F, Bogun FM
Aims: Catheter ablation is an effective treatment for post-infarction ventricular tachycardia (VT). However, some patients may experience a worsened arrhythmia phenotype after ablation. We aimed to determine the prevalence and prognostic impact of arrhythmia exacerbation (AE) after post-infarction VT ablation. Methods and results: A total of 1187 consecutive patients (93% men, median age 68 years, median ejection fraction 30%) who underwent post-infarction VT ablation at six centres were include...
Abstract
Cited 19 times since 2020 (4.3 per year)
source: EuropePMC
Arrhythmia & electrophysiology review,
Volume 9, Issue 3, 1 1 2020, Pages 128-135
Impact of Micro-, Mini- and Multi-Electrode Mapping on Ventricular Substrate Characterisation.
Berte B, Zeppenfeld K, Tung R
Accurate substrate characterisation may improve the evolving understanding and treatment of cardiac arrhythmias. During substrate-based ablation techniques, wide practice variations exist with mapping via dedicated multi-electrode catheter or conventional ablation catheters. Recently, newer ablation catheter technology with embedded mapping electrodes have been introduced. This article focuses on the general misconceptions of voltage mapping and more specific differences in unipolar and bipolar...
Abstract
Cited 10 times since 2020 (2.2 per year)
source: EuropePMC
Annals of surgery,
Volume 272, Issue 5, 1 1 2020, Pages 678-683
Taking Morbidity and Mortality Conferences to a Next Level: The Resilience Engineering Concept.
Verhagen MJ, de Vos MS, Hamming JF
Objective: To explore possibilities to improve morbidity and mortality conferences using advancing insights in safety science. Summary background data: Mortality and Morbidity conferences (M&M) are the golden practice for case-based learning. While learning from complications is useful, M&M does not meet expectations for system-wide improvement. Resilience engineering principles may be used to improve M&M. Methods: After a review of the shortcomings of traditional M&M, resilience...
Abstract
Cited 15 times since 2020 (3.4 per year)
source: EuropePMC
Annals of surgery,
Volume 272, Issue 5, 1 1 2020, Pages 773-778
Long-term Prognosis After Elective Abdominal Aortic Aneurysm Repair is Poor in Women and Men: The Challenges Remain.
Bulder RMA, Talvitie M, Bastiaannet E, Hamming JF, Hultgren R, Lindeman JHN
Objective: To evaluate the impact of changes in elective Abdominal Aortic Aneurysm (AAA) management on life-expectancy of AAA patients. Background: Over the past decades AAA repair underwent substantial changes, that is, the introduction of EVAR and implementation of intensified cardiovascular risk management. The question rises to what extent these changes improved longevity of AAA patients. Methods: National evaluation including all 12.907 (82.7% male) patients who underwent elective AAA repai...
Abstract
