6143 results
Cited 15 times since 2018 (2.3 per year)
source: EuropePMC
European journal of heart failure,
Volume 20, Issue 11, 17 3 2018, Pages 1601-1610
Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1-receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction.
Voors AA, Shah SJ, Bax JJ, Butler J, Gheorghiade M, Hernandez AF, Kitzman DW, McMurray JJV, Wirtz AB, Lanius V, van der Laan M, Solomon SD
Despite major advances in the treatment of chronic heart failure (HF) with reduced ejection fraction (HFrEF), morbidity and mortality associated with the condition remain high, suggesting the need for additional treatment options, particularly haemodynamically neutral treatments that do not alter blood pressure, heart rate, or renal function. HF with preserved ejection fraction (HFpEF) is also associated with high morbidity and mortality and adequate treatment options are limited; thus there is...
Abstract
Cited 694 times since 2018 (106.6 per year)
source: EuropePMC
Nature genetics,
Volume 50, Issue 10, 17 3 2018, Pages 1412-1425
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, El
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 12, Issue 7 Pt 1, 12 2 2018, Pages 1188-1198
Effect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC Trial.
Podlesnikar T, Pizarro G, Fernández-Jiménez R, Montero-Cabezas JM, Sánchez-González J, Bucciarelli-Ducci C, Ajmone Marsan N, Fras Z, Bax JJ, Fuster V, Ibáñez B, Delgado V
Objectives: This study sought to evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature-tracking cardiovascular magnetic resonance (CMR). Background: Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial. Methods: A total of 197 pa...
Abstract
Cited 3 times since 2018 (0.5 per year)
source: EuropePMC
International journal of cardiology,
Volume 274, 12 2 2018, Pages 113-116
Aortic dissection and prophylactic surgery in congenital heart disease.
Kuijpers JM, Koolbergen DR, Groenink M, Boekholdt SM, Meijboom FJ, Jongbloed MRM, Hoendermis ES, Duijnhouwer AL, Mulder BJM, Bouma BJ
Background: Proximal aortic dilatation in certain congenital heart diseases (CHD) prompts concerns about dissection and consideration of prophylactic surgery. To evaluate contemporary prophylactic practice, we determined incidence of aortic dissection and prophylactic surgery in aortopathy-associated CHD, compared to Marfan syndrom (MFS) and controls. Methods and results: We followed patients from the CONCOR adult CHD registry (2002-2015), with a native proximal aorta and aortopathy-associated C...
Abstract
Cited 32 times since 2018 (4.9 per year)
source: EuropePMC
Journal of internal medicine,
Volume 285, Issue 1, 7 1 2018, Pages 59-74
Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels.
de Vries MR, Parma L, Peters HAB, Schepers A, Hamming JF, Jukema JW, Goumans MJTH, Guo L, Finn AV, Virmani R, Ozaki CK, Quax PHA
Background: Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a natural occurring process to fulfil the increasing demand of oxygen and nourishment of the vessel wall. However, inadequate formed, immature plaque neovessels are leaky and cause intraplaque haemorrhage. Objective: Blockade of VEGFR2 normalizes the unbridled process of plaque neovessel formation and induces maturation of nascent vessels resu...
Abstract
Cited 55 times since 2018 (8.4 per year)
source: EuropePMC
JAMA cardiology,
Volume 3, Issue 9, 1 1 2018, Pages 839-847
Association of Left Ventricular Global Longitudinal Strain With Asymptomatic Severe Aortic Stenosis: Natural Course and Prognostic Value.
Vollema EM, Sugimoto T, Shen M, Tastet L, Ng ACT, Abou R, Marsan NA, Mertens B, Dulgheru R, Lancellotti P, Clavel MA, Pibarot P, Genereux P, Leon MB, Delgado V, Bax JJ
Importance: The optimal timing to operate in patients with asymptomatic severe aortic stenosis (AS) remains controversial. Left ventricular global longitudinal strain (LV GLS) may help to identify patients who might benefit from undergoing earlier aortic valve replacement. Objective: To investigate the prevalence of impaired LV GLS, the natural course of LV GLS, and its prognostic implications in patients with asymptomatic severe AS with preserved left ventricular ejection fraction (LVEF). Desig...
Abstract
Cited 30 times since 2018 (4.6 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 26, Issue 9, 1 1 2018, Pages 417-421
2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: comments from the Dutch ACS working group.
Arslan F, Bongartz L, Ten Berg JM, Jukema JW, Appelman Y, Liem AH, de Winter RJ, van 't Hof AWJ, Damman P
On behalf of the Dutch ACS working group, we discuss the most important changes in recommendations in the 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation relevant for both the general and interventional cardiologist.
Abstract
Cited 168 times since 2018 (25.6 per year)
source: EuropePMC
European heart journal,
Volume 39, Issue 35, 1 1 2018, Pages 3322-3330
The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability.
Knuuti J, Ballo H, Juarez-Orozco LE, Saraste A, Kolh P, Rutjes AWS, Jüni P, Windecker S, Bax JJ, Wijns W
Aims: To determine the ranges of pre-test probability (PTP) of coronary artery disease (CAD) in which stress electrocardiogram (ECG), stress echocardiography, coronary computed tomography angiography (CCTA), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance (CMR) can reclassify patients into a post-test probability that defines (>85%) or excludes (100 patients with stable CAD that utilized either ICA or ICA with FFR measurem...
Abstract
JACC. Clinical electrophysiology,
Volume 4, Issue 9, 1 1 2018, Pages 1211-1213
Imaging to Evaluate the Substrate Underlying Sudden Cardiac Death.
Bax JJ, Delgado V
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Current opinion in cardiology,
Volume 33, Issue 5, 1 1 2018, Pages 470-478
Application of left ventricular strain in patients with aortic and mitral valve disease.
Ng ACT, Delgado V, Bax JJ
Purpose of review: Left ventricular (LV) global longitudinal strain (GLS) is widely recognized as a more sensitive measure of LV systolic function compared with LV ejection fraction (LVEF). In addition, the measurement of LVGLS is more reproducible than two-dimensional LVEF. Current guidelines for diagnosis and treatment of valvular heart disease include LVEF as one of the parameters to take into consideration in the clinical decision-making. However, a large body of evidence is showing that LVG...
Abstract
JACC. Clinical electrophysiology,
Volume 4, Issue 9, 1 1 2018, Pages 1163-1165
Characterization of Septal Scars in Nonischemic Left Ventricular Cardiomyopathy by Cardiac Magnetic Resonance Imaging Versus Electroanatomical Mapping: Superior, Inferior, or Complementary?
Zeppenfeld K, Piers SRD
Abstract
Cited 68 times since 2018 (10.4 per year)
source: EuropePMC
JAMA cardiology,
Volume 3, Issue 9, 1 1 2018, Pages 806-814
Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial: A Randomized Clinical Trial.
Nicholls SJ, Puri R, Ballantyne CM, Jukema JW, Kastelein JJP, Koenig W, Wright RS, Kallend D, Wijngaard P, Borgman M, Wolski K, Nissen SE
Importance: Infusing a high-density lipoprotein mimetic containing apolipoprotein A-I Milano demonstrated potential atheroma regression in patients following an acute coronary syndrome. To our knowledge, the effect of infusing a new mimetic preparation (MDCO-216) with contemporary statin therapy is unknown. Objective: To determine the effect of infusing MDCO-216 on coronary atherosclerosis progression. Design, setting, and participants: This double-blind, randomized clinical trial conducted in 2...
Abstract
Cited 10 times since 2018 (1.5 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 54, Issue 3, 1 1 2018, Pages 585-592
Aortopexy for the treatment of tracheobronchomalacia in 100 children: a 10-year single-centre experience.
Rijnberg FM, Butler CR, Bieli C, Kumar S, Nouraei R, Asto J, McKavanagh E, de Coppi P, Muthialu N, Elliott MJ, Hewitt RJ
Objectives: Our study describes and analyses the results from aortopexy for the treatment of airway malacia in children. Methods: Demographic data, characteristics and preoperative, operative and outcome details, including the need for reintervention, were collected for children undergoing aortopexy between 2006 and 2016. Results: One hundred patients [median age 8.2 months, interquartile range (IQR) 3.3-26.0 months] underwent aortopexy. Sixty-four (64%) patients had tracheomalacia (TM) only, 24...
Abstract
International journal of cardiology,
Volume 274, 1 1 2018, Pages 331-336
Borderline Q-waves in individuals without overt cardiovascular disease: Relations with adiposity, subclinical atherosclerosis and vascular stiffness.
Elffers TW, Trompet S, de Mutsert R, Maan AC, Lamb HJ, Macfarlane PW, Rosendaal FR, Jukema JW
Background: Characteristics and risk factors associated with electrocardiographic borderline Q-waves are not fully elucidated, especially in individuals without overt cardiovascular disease (CVD). Also, the relation of isolated and non-isolated borderline Q-waves with subclinical atherosclerosis and vascular stiffness is unknown. Methods and results: We included 5746 Netherlands Epidemiology of Obesity study participants without overt CVD. Participants were divided in three groups: no Q-waves (9...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 19, Issue 9, 1 1 2018, Pages 975-976
The effect of blood pressure on left atrial size and function assessed by 3-dimensional echocardiography.
Abou R, Delgado V
Abstract
Cited 18 times since 2018 (2.7 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 4, Issue 9, 29 5 2018, Pages 1123-1140
Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy.
Zeppenfeld K
Catheter ablation is being increasingly performed as adjunctive treatment to prevent recurrent implantable cardioverter-defibrillator therapies in patients with nonischemic cardiomyopathy and ventricular tachycardia (VT). In the context of VT ablation, nonischemic cardiomyopathy usually refers to dilated cardiomyopathy (DCM) as one morphological phenotype. Over the past decades, progress has been made to better characterize distinct subtypes and to differentiate between causes of DCM, which has...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 60, Issue 1, 29 5 2018, Pages 111-118
Excessive leaflet tissue in mitral valve repair for isolated posterior leaflet prolapse-leaflet resection or shortening neochords? A propensity score adjusted comparison.
Tomšič A, Hiemstra YL, van Brakel TJ, Versteegh MI, Ajmone Marsan N, Klautz RJ, Palmen M
Background: Chordal replacement techniques are progressively used to treat posterior mitral valve leaflet (PMVL) prolapse while leaflet resection remains commonly in use to address excessive leaflet tissue. For excessive tissue in height, shortening neochords can be used alternatively. Use of chordal replacement techniques has been suggested to result in lower diastolic transvalvular gradients, higher freedom from reoperation and improved left ventricular function. Methods: From 1/2005 to 12/201...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 4, Issue 10, 29 5 2018, Pages 1308-1318
Noninvasive Identification of Ventricular Tachycardia-Related Anatomical Isthmuses in Repaired Tetralogy of Fallot: What Is the Role of the 12-Lead Ventricular Tachycardia Electrocardiogram.
Brouwer C, Kapel GFL, Jongbloed MRM, Schalij MJ, de Riva Silva M, Zeppenfeld K
Objectives: This study sought to evaluate the relation between 12-lead ventricular tachycardia (VT) electrocardiography (ECG) and VT-related anatomical isthmuses (AIs) in repaired tetralogy of Fallot (rTOF). Background: Slow-conducting AIs are the dominant VT substrate in rTOF. Whether an AI is considered critical relies on pace mapping (PM) guided by the VT ECG. Methods: VT ECGs, electroanatomical mapping data and PM results were analyzed in 25 rTOF patients (group 1) (age 57 ± 13 years). Selec...
Abstract
Cited 97 times since 2018 (14.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 72, Issue 18, 27 4 2018, Pages 2152-2163
Pathology of Peripheral Artery Disease in Patients With Critical Limb Ischemia.
Narula N, Dannenberg AJ, Olin JW, Bhatt DL, Johnson KW, Nadkarni G, Min J, Torii S, Poojary P, Anand SS, Bax JJ, Yusuf S, Virmani R, Narula J
Background: Critical limb ischemia (CLI) is the most serious complication of peripheral artery disease (PAD). Objectives: The purpose of this study was to characterize pathology of PAD in below- and above-knee amputation specimens in patients presenting with CLI. Methods: Peripheral arteries from 95 patients (121 amputation specimens) were examined; 75 patients had presented with CLI, and the remaining 20 had amputations performed for other reasons. The pathological characteristics were separate...
Abstract
Cited 1407 times since 2018 (214.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 72, Issue 18, 25 4 2018, Pages 2231-2264
Fourth Universal Definition of Myocardial Infarction (2018).
Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction
Abstract
