7401 results
Applied and environmental microbiology,
Volume 91, Issue 3, 12 2 2025, Pages e0179424
Microfluidic droplets with amended culture media cultivate a greater diversity of soil microorganisms.
Dai J, Ouyang Y, Gupte R, Liu XJA, Li Y, Yang F, Chen S, Provin T, Van Schaik E, Samuel JE, Jayaraman A, Zhou A, de Figueiredo P, Zhou J, Han A
Uncultivated but abundant soil microorganisms have untapped potential for producing broad ranges of natural products, as well as for bioremediation. However, cultivating soil microorganisms while maintaining a broad microorganism diversity to enable phenotyping and functional analysis of as diverse individual isolates as possible remains challenging. In this study, we developed and tested the ability of several culture media formulations that contain defined soil metabolites or soil extracts to...
Abstract
Cited 3 times since 2025 (5 per year)
source: EuropePMC
Lupus science & medicine,
Volume 12, Issue 1, 12 2 2025, Pages e001424
Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report.
van Schaik M, Arends EJ, Wetzels MJAL, Kraaij T, Verbruggen SH, van der Kooij SW, Kamerling SWA, Huizinga T, Goekoop RJ, van Kooten C, Rabelink T, Teng YKO
Objective: Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking. To address this, we analysed outcomes of patients with severe treatment-refractory SLE who previously participated in the phase II Synbiose Study, with a particular focus on immunological parameters. Methods: Eight patients continued belimumab treatment beyond the 2-year duration...
Abstract
Cited 6 times since 2025 (9.9 per year)
source: EuropePMC
Nature communications,
Volume 16, Issue 1, 11 2 2025, Pages 1545
The neurobench framework for benchmarking neuromorphic computing algorithms and systems.
Yik J, Van den Berghe K, den Blanken D, Bouhadjar Y, Fabre M, Hueber P, Ke W, Khoei MA, Kleyko D, Pacik-Nelson N, Pierro A, Stratmann P, Sun PV, Tang G, Wang S, Zhou B, Ahmed SH, Vathakkattil Joseph G, Leto B, Micheli A, Mishra AK, Lenz G, Sun T, Ahmed Z, Akl M, Anderson B, Andreou AG, Bartolozzi C, Basu A, Bogdan P, Bohte S, Buckley S, Cauwenberghs G, Chicca E, Corradi F, de Croon G, Danielescu A, Daram A, Davies M, Demirag Y, Eshraghian J, Fischer T, Forest J, Fra V, Furber S, Furlong PM, Gilpin W, Gilra A, Gonzalez HA, Indiveri G, Joshi S, Karia V, Khacef L, Knight JC, Kriener L, Kubendran R, Kudithipudi D, Liu SC, Liu YH, Ma H, Manohar R, Margarit-Taulé JM, Mayr C, Michmizos K, Muir DR, Neftci E, Nowotny T, Ottati F, Ozcelikkale A, Panda P, Park J, Payvand M, Pehle C, Petrovici MA, Posch C, Renner A, Sandamirskaya Y, Schaefer CJS, van Schaik A, Schemmel J, Schmidgall S, Schuman C, Seo JS, Sheik S, Shrestha SB, Sifalakis M, Sironi A, Stewart K, Stewart M, Stewart TC, Timcheck J, Tömen N, Urgese G, Verhelst
Neuromorphic computing shows promise for advancing computing efficiency and capabilities of AI applications using brain-inspired principles. However, the neuromorphic research field currently lacks standardized benchmarks, making it difficult to accurately measure technological advancements, compare performance with conventional methods, and identify promising future research directions. This article presents NeuroBench, a benchmark framework for neuromorphic algorithms and systems, which is col...
Abstract
BMC public health,
Volume 25, Issue 1, 10 2 2025, Pages 551
The relationship between environmental literacy, ecological footprint awareness, and environmental behavior in adults.
Yildirim MS, Elkoca A, Gökçay G, Yilmaz DA, Yıldız M
Background: Environmental literacy and ecological footprint awareness encouraging them to consume less energy, reduce waste and use natural resources more sustainably. Aim: In this study, the aim was to determine and compare the relationship between environmental literacy, ecological footprint awareness, and environmental behaviors of adults. Methods: The research was conducted in a descriptive and cross-sectional type. The universe of the research was individuals aged 18 and over in a province...
Abstract
Cited 3 times since 2025 (4.9 per year)
source: EuropePMC
BMC nursing,
Volume 24, Issue 1, 10 2 2025, Pages 151
Psychometrics of the Attitude Scale towards the use of Artificial Intelligence Technologies in Nursing.
Yılmaz D, Uzelli D, Dikmen Y
Background: It is clear that nursing practice is directly affected by artificial intelligence (AI), and in this regard, a need is felt for more information on the knowledge and attitudes of nurses to the use of AI technology in nursing care practice. However, no inclusive measurement instrument tested for validity and reliability evaluating the attitudes of nurses to the use of AI technology was found. The aim of this research was to develop and test the validity of the Attitude Scale Towards th...
Abstract
Cureus,
Volume 17, Issue 2, 9 2 2025, Pages e78781
Patients' Perceptions and Experiences With Outpatient Hip and Knee Arthroplasty: A Qualitative Study.
Keulen MH, Boonen B, Leenders AM, Van Haaren EH, Schotanus MG, Bemelmans YF
Background Outpatient joint arthroplasty (OJA) of the hip and knee is becoming increasingly popular within the orthopedic community. Most evidence regarding the safety and feasibility of OJA has been gathered from the perspectives of surgeons and healthcare organizations. However, the success of these pathways also hinges on patients feeling safe and adequately prepared to return home. This study aimed to explore patients' perspectives, experiences, and challenges during the preoperative ph...
Abstract
Cited 3 times since 2025 (4.9 per year)
source: EuropePMC
European journal of preventive cardiology,
8 2 2025, Pages zwaf067
Apolipoprotein C3 and risk of cardiovascular events and death in patients on optimized statin treatment after recent acute coronary syndrome.
Schwartz GG, Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Ruhaak LR, Stevanovic I, Cobbaert CM, Steg PG
Aims: Apolipoprotein (Apo) C3 has been associated with incident coronary heart disease and major adverse cardiovascular events (MACE). Whether ApoC3 levels predict risk in patients with acute coronary syndrome (ACS) on optimized statin treatment is unknown. Methods: ApoC3 was measured by mass spectrometry at baseline (n=11,956) and after 4 months' treatment (M4; n=11 176) with alirocumab or placebo in the ODYSSEY OUTCOMES trial. Patients with fasting triglycerides >400 mg/dL were exclude...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
PharmacoEconomics,
Volume 43, Issue 5, 8 2 2025, Pages 483-497
Towards Recommendations for Cost-Effectiveness Analysis of Predictive, Prognostic, and Serial Biomarker Tests in Oncology.
Kramer A, van Schaik LF, van den Broek D, Meijer GA, Gutierrez Ibarluzea I, Galnares Cordero L, Fijneman RJA, Ligtenberg MJL, Schuuring E, van Harten WH, Coupé VMH, Retèl VP, COIN Consortium
Background: Cost-effectiveness analysis (CEA) of biomarkers is challenging due to the indirect impact on health outcomes and the lack of sufficient fit-for-purpose data. Hands-on guidance is lacking. Objective: We aimed firstly to explore how CEAs in the context of three different types of biomarker applications have addressed these challenges, and secondly to develop recommendations for future CEAs. Methods: A scoping review was performed for three biomarker applications: predictive, prognostic...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Environmental monitoring and assessment,
Volume 197, Issue 3, 7 1 2025, Pages 252
Investigating the effects of local climate zones on land surface temperature using spectral indices via linear regression model: a seasonal study of Sapanca Lake.
Isinkaralar O, Yeboah E, Isinkaralar K, Sarfo I, Öztürk S, Yilmaz D, Bojago E
The formation of urban heat islands is a widespread issue in cities. However, the impact of spectral indices on land surface temperature (LST) with various urban forms, climates, and functions has not been sufficiently examined. Currently, the prevalent method for analyzing complex urban areas is the classification of local climate zones (LCZs). In this study, we aim to explore the urban thermal environment by utilizing GIS-based spatial analyses and statistical methods. We also examine LCZs and...
Abstract
Cited 3 times since 2025 (4.8 per year)
source: EuropePMC
Cancer discovery,
Volume 15, Issue 5, 6 1 2025, Pages 969-987
High-purity CTC RNA sequencing identifies prostate cancer lineage phenotypes prognostic for clinical outcomes.
Sharifi MN, Sperger JM, Taylor AK, Tippins KE, Reese SR, Carreno V, Kaufmann KR, Chang AH, Nunamaker LA, Linebarger C, Mora-Rodriguez L, Schehr JL, Krause HM, Helzer KT, Bootsma ML, Blitzer GC, Floberg JM, Kyriakopoulos CE, Emamekhoo H, Heath EI, Wells M, Tagawa ST, Sjöström M, Choudhury AD, Yu M, Armstrong AJ, Rathkopf DE, Beltran H, Nelson PS, Feng FY, Dehm SM, Kosoff D, Wei XX, McKay RR, Zhao SG, Lang JM
The development of treatment resistance remains universal for patients with metastatic prostate cancer, driven by AR alterations and lineage state transitions. Identifying the evolution of lineage transitions in treatment resistance has been limited by the challenges of collecting serial tissue biopsies on treatment, which can be overcome using blood-based liquid biopsies. Utilizing a novel circulating tumor cell (CTC) isolation approach, we collected 273 CTC samples from 117 patients with metas...
Abstract
The Pediatric infectious disease journal,
Volume 44, Issue 5, 5 1 2025, Pages e189-e190
Is Rhinovirus More Aggressive in Children This Season?
Özdem Alataş Ş, Elvan Tüz A, Kuş S, Aslan Saritaş Ü, Koçar S, Yilmaz D
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 55, Issue 3, 4 1 2025, Pages 260-263
Increased Levels of Inflammatory Proteins, Including TARC/CCL17, in Skin of AD Patients During JAK Inhibitor Treatment.
Boesjes CM, van der Gang LF, Bakker DS, den Hartog Jager CF, de Graaf M, de Bruin-Weller MS, van Wijk F, Knol EF
Abstract
Frontiers in neuroscience,
Volume 19, 4 1 2025, Pages 1493623
Low-latency hierarchical routing of reconfigurable neuromorphic systems.
Perera S, Xu Y, van Schaik A, Wang R
A reconfigurable hardware accelerator implementation for spiking neural network (SNN) simulation using field-programmable gate arrays (FPGAs) is promising and attractive research because massive parallelism results in better execution speed. For large-scale SNN simulations, a large number of FPGAs are needed. However, inter-FPGA communication bottlenecks cause congestion, data losses, and latency inefficiencies. In this work, we employed a hierarchical tree-based interconnection architecture for...
Abstract
Journal of lipid research,
Volume 66, Issue 3, 3 1 2025, Pages 100753
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis.
Inia JA, van Nieuwkoop-van Straalen A, Jukema JW, Rolin B, Staarup EM, Mogensen CK, Princen HMG, van den Hoek AM
Atherosclerosis is the major cause of cardiovascular disease. This study evaluated the effect of lipid lowering using a novel peptide inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) and a monoclonal antibody against angiopoietin-like 3 (evinacumab), either alone or in combination in APOE∗3-Leiden.CETP mice fed a Western diet. Effects on body weight, plasma lipids, atherosclerotic lesion size, severity, composition, and morphology were assessed. Treatment with PCSK9 inhibitory pe...
Abstract
Family practice,
Volume 42, Issue 2, 1 1 2025, Pages cmae045
The effect and implementation of the COVID Box, a remote patient monitoring system for patients with a COVID-19 infection in primary care: a matched cohort study.
van Hattem NE, Mijnsbergen NJ, van Os HJA, Mertens BA, Eekhof JAH, Chavannes NH, Atsma DE, Bonten TN
At the onset of the COVID-19 pandemic, the pressure on hospitals increased tremendously. To alleviate this pressure, a remote patient monitoring system called the COVID Box was developed and implemented in primary care. The aim was to assess whether the COVID Box in primary care could reduce emergency department (ED) referrals due to a COVID-19 infection. A matched cohort study was performed between December 2020 and June 2021. Patients with a COVID-19 infection in need of intensive monitoring b...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
European journal of endocrinology,
Volume 192, Issue 2, 1 1 2025, Pages S1-S14
The effect of first intervention on cardiac parameters in patients with acromegaly: a systematic review.
Huynh KA, Al-Gully J, Montero-Cabezas JM, Scheffers LE, Verstegen MJT, Biermasz NR, Coopmans EC
Objective: Cardiovascular disease in acromegaly patients remains a major cause of morbidity and all-cause mortality. This systematic review investigates the effect of the first growth hormone-lowering intervention on cardiac parameters. Design: Systematic review. Methods: Studies evaluating cardiac parameters following the first intervention in acromegaly published up to February, 25, 2022 were included in this systematic review. Risk of bias was assessed using a modified Newcastle-Ottawa Scale...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 2, 1 1 2025, Pages euaf003
Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia: results from a large prospective multicentre study.
de Riva M, Evertz R, Lukac P, Dekker LRC, Blaauw Y, Ter Bekke RMA, Kimura Y, Beukema RJ, Ouss A, Mulder BA, Vernooy K, Wijnmaalen AP, Zeppenfeld K
Aims: The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed ablation targets are prone to individual interpretation making the ablation outcome potentially operator dependent. Evoked delayed potentials (EDPs) are a well-defined target. Evoked delayed potential ablation was effective in preventing post-MI VT recurrence in a prior study. The aims of this study were to assess long-term outcomes of EDP ablation in a large multic...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Family practice,
Volume 42, Issue 2, 1 1 2025, Pages cmae050
Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment.
Versloot AHC, Veldwijk J, Ottenheijm RPG, de Graaf M, van der Windt DA, Koes BW, Runhaar J, Schiphof D
Background: Shoulder pain is common amongst adults, but little is known about patients' preferences. Objective: The aim of this study was to determine patients' preferences for treatment options offered for shoulder pain in primary care. Methods: A discrete choice experiment was used to investigate these preferences. Adults with shoulder pain were asked to make 12 choices between two treatment options, or to opt-out. The attributes of the 12 treatment options were presented as varying...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 36, Issue 2, 1 1 2025, Pages e70040
Ocular surface disease in pediatric patients with moderate-to-severe atopic dermatitis.
van der Rijst LP, Veldhuis N, van der Kamp S, Achten RE, van Luijk CM, Voskuil-Kerkhof ESM, Haeck IM, de Bruin-Weller MS, de Graaf M
Abstract
Health education research,
Volume 40, Issue 2, 1 1 2025, Pages cyaf001
Implementation of a complex eHealth intervention by a public-private partnership in clinical practice: a qualitative multicentre analysis using CFIR.
IJzerman RVH, van der Vaart R, Breeman LD, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Complex eHealth interventions-featuring multiple components within dynamic systems-are used for healthcare improvement. Public-private partnerships (PPPs), combining resources, expertise, and technology, are crucial in this context. Yet, integrating these interventions into practice remains challenging. This study identifies barriers and facilitators affecting implementation of the BENEFIT programme, a complex eHealth intervention targeting cardiovascular disease patients, by PPP within practice...
Abstract
