Research

Publications

Below you can find a list of our published research.

8892 results

Cited 21 times since 2018 (2.8 per year) source: EuropePMC

Veterinary microbiology, Volume 221, 24 4 2018, Pages 13-18 Porcine epidemic diarrhea virus (PEDV) introduction into a naive Dutch pig population in 2014. Dortmans JCFM, Li W, van der Wolf PJ, Buter GJ, Franssen PJM, van Schaik G, Houben M, Bosch BJ

Porcine epidemic diarrhea virus (PEDV) is the highly contagious, causative agent of an economically important acute enteric disease in pigs of all ages. The disease is characterized by diarrhea and dehydration causing mortality and growth retardation. In the last few decades, only classical PEDV was reported sporadically in Europe, but in 2014 outbreaks of PEDV were described in Germany. Phylogenetic analysis showed a very high nucleotide similarity with a variant of PEDV that was isolated in th... Abstract

PloS one, Volume 13, Issue 5, 24 4 2018, Pages e0198376 Correction: Latent tuberculosis infection in foreign-born communities: Import vs. transmission in The Netherlands derived through mathematical modelling. Korthals Altes H, Kloet S, Cobelens F, Bootsma M

[This corrects the article DOI: 10.1371/journal.pone.0192282.]. Abstract

Cited 20 times since 2018 (2.7 per year) source: EuropePMC

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, Volume 105, 24 4 2018, Pages 1-10 Chronic sequelae and severe complications of norovirus infection: A systematic review of literature. Petrignani M, Verhoef L, de Graaf M, Richardus JH, Koopmans M

Norovirus causes an estimated 18% of all cases of acute gastroenteritis worldwide and is found to be associated with mortality. To create a first overview of severe complications and chronic sequelae of norovirus infections, a systematic review of literature was performed. Of 3928 individual hits, 176 publications remained for data extraction. Study periods varied between 1974 and 2017, though strongly skewed towards the last decade (n = 122, 70%). Countries of studies were worldwide, though Afr... Abstract

Cited 10 times since 2018 (1.3 per year) source: EuropePMC

Pharmacogenomics, Volume 19, Issue 8, 23 4 2018, Pages 715-726 A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT. Out M, Becker ML, van Schaik RH, Lehert P, Stehouwer CD, Kooy A

Aim: To determine the influence of polymorphisms on the effects of metformin on HbA1c, daily dose of insulin and metformin plasma concentration. Methods: In a post hoc analysis of a 4.3 year placebo-controlled randomized trial with 390 patients with Type 2 diabetes already on insulin, we analyzed the influence of polymorphisms in genes coding for ATM and the transporters OCT1 and MATE1. Outcome measures were a combined HbA1c + daily dose of insulin Z score and metformin plasma concentrations. Re... Abstract

Cited 10 times since 2018 (1.3 per year) source: EuropePMC

International journal of cardiology, Volume 268, 23 4 2018, Pages 106-112 Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. Lameijer H, van Slooten YJ, Jongbloed MRM, Oudijk MA, Kampman MAM, van Dijk AP, Post MC, Mulder BJ, Sollie KM, van Veldhuisen DJ, Ebels T, van Melle JP, Pieper PG

Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation... Abstract

Cited 12 times since 2018 (1.6 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 12, Issue 3, 19 3 2018, Pages 231-237 Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy. Weir-McCall JR, Blanke P, Sellers SL, Ahmadi AA, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Lee SE, Maffei E, Marques H, Pontone G, Raff GL, Shin S, Sung JM, Stone P, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ, Leipsic JA

Background: The aim of the study is examine the impact of non-obstructive ( Abstract

Cited 28 times since 2018 (3.8 per year) source: EuropePMC

BMC surgery, Volume 18, Issue 1, 18 3 2018, Pages 27 MEDIASTinal staging of non-small cell lung cancer by endobronchial and endoscopic ultrasonography with or without additional surgical mediastinoscopy (MEDIASTrial): study protocol of a multicenter randomised controlled trial. Bousema JE, Dijkgraaf MGW, Papen-Botterhuis NE, Schreurs HW, Maessen JG, van der Heijden EH, Steup WH, Braun J, Noyez VJJM, Hoeijmakers F, Beck N, van Dorp M, Claessens NJM, Hiddinga BI, Daniels JMA, Heineman DJ, Zandbergen HR, Verhagen AFTM, van Schil PE, Annema JT, van den Broek FJC, MEDIASTrial study group

Background: In case of suspicious lymph nodes on computed tomography (CT) or fluorodeoxyglucose positron emission tomography (FDG-PET), advanced tumour size or central tumour location in patients with suspected non-small cell lung cancer (NSCLC), Dutch and European guidelines recommend mediastinal staging by endosonography (endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS)) with sampling of mediastinal lymph nodes. If biopsy results from endosonography turn out negative, additional... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume 72, 17 3 2018, Pages 63-68 A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer. Bilsen MP, van Meijgaarden KE, de Jong HK, Joosten SA, Prins C, Kroft LJM, Jonker JT, Crobach S, Pelger RC, Ottenhoff THM, Arend SM

Intravesical bacillus Calmette-Guérin (BCG) is widely used for high-risk, non-muscle-invasive bladder cancer. This report describes four cases that illustrate the spectrum of BCG-induced complications, varying from granulomatous prostatitis to sepsis. There is considerable debate regarding whether inflammation or infection is the predominant mechanism in the pathogenesis of BCG disease. In two patients with a systemic illness, the symptoms first resolved after adding prednisone, indicating a pri... Abstract

Cited 62 times since 2018 (8.3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 10, 16 3 2018, Pages 1461-1471 Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography: Results of the PARADIGM Study. Kim U, Leipsic JA, Sellers SL, Shao M, Blanke P, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ

Objectives: This study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM). Background: The natural history of coronary PP in patients with DM is not well established. Methods: A total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and an... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 104, Issue 2, 15 3 2018, Pages 311-316 A Rapid (Differential) Effect of Rosuvastatin and Atorvastatin on High-Sensitivity Cardiac Troponin-I in Subjects With Stable Cardiovascular Disease. Bodde MC, Welsh P, Bergheanu SC, Lijfering WM, Mertens B, Liem AH, van der Laarse A, Sattar N, Jukema JW

Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high-sensitivity troponin-I (hs-cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up-titrated at 6-week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs-cTnI concentrations were measured at basel... Abstract

Cited 11 times since 2018 (1.5 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 11, 9 2 2018, Pages 1683-1689 Reduced left ventricular mechanical dispersion at 6 months follow-up after cardiac resynchronization therapy is associated with superior long-term outcome. van der Bijl P, Khidir MJH, Leung M, Yilmaz D, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Background: In heart failure (HF) patients, left ventricular mechanical dispersion (LVMD) reflects heterogeneous mechanical activation of the left ventricle. In HF patients, LVMD can be reduced after CRT. Whether lesser LVMD is associated with improved outcome is unknown. Objective: The purpose of this study was to relate LVMD to long-term prognosis in a large cohort of HF patients after 6 months of cardiac resynchronization therapy (CRT). Methods: Clinical, echocardiographic, and ventricular ar... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Heart, lung & circulation, Volume 28, Issue 6, 8 2 2018, Pages 893-900 Prognostic Importance of Increased Right Ventricular Afterload in Orthotopic Liver Transplantation Recipients With Endstage Cirrhosis. Couperus LE, Vliegen HW, Sorgdrager BJ, den Dulk AC, Beeres SLMA, Sarton EY, Dubbeld J, Schalij MJ, Jukema JW, van Hoek B, Scherptong RWC

Background: Severely increased right ventricular (RV) afterload is considered a contra-indication for orthotopic liver transplantation (OLT). This study assesses the effects of mildly increased RV afterload on long-term outcome after OLT in relation to RV function. Methods: 139 OLT recipients (53±12years, 76% male) were included. Preoperative RV afterload was assessed invasively or, if not available, echocardiographically and categorised as normal, high-normal (mean pulmonary artery pressure [PA... Abstract

Cited 6 times since 2018 (0.8 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 315, Issue 3, 4 1 2018, Pages H669-H680 Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo. Alogna A, Schwarzl M, Manninger M, Hamdani N, Zirngast B, Kloth B, Steendijk P, Verderber J, Zweiker D, Westermann D, Blankenberg S, Maechler H, Tschöpe C, Linke WA, Marsche G, Pieske BM, Post H

Experimental data indicate that stimulation of the nitric oxide-soluble guanylate cyclase(sGC)-cGMP-PKG pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. We aimed to test whether acute pharmacological sGC stimulation with BAY 41-8543 would increase LV capacitance via titin phosphorylation in healthy and deoxycorticosteroneacetate (DOCA)-induced hypertensive pigs. Nine healthy Landrace pigs and 7 pigs with DOCA-induced hypertension and... Abstract

Cited 17 times since 2018 (2.3 per year) source: EuropePMC

Journal of medical Internet research, Volume 20, Issue 5, 3 1 2018, Pages e174 Behind the Scenes of Online Therapeutic Feedback in Blended Therapy for Depression: Mixed-Methods Observational Study. Mol M, Dozeman E, Provoost S, van Schaik A, Riper H, Smit JH

Background: In Internet-delivered cognitive behavioral therapies (iCBT), written feedback by therapists is a substantial part of therapy. However, it is not yet known how this feedback should be given best and which specific therapist behaviors and content are most beneficial for patients. General instructions for written feedback are available, but the uptake and effectiveness of these instructions in iCBT have not been studied yet. Objective: This study aimed to identify therapist behaviors in... Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

Journal of the European Academy of Dermatology and Venereology : JEADV, Volume 32, Issue 12, 3 1 2018, Pages e436-e437 A breathtaking DRESS due to amoxicillin-clavulanate presenting as polymorphic eruption of the pregnancy. van Kester MS, Langeveld TJC, Bouwsma H, van Rees JB, Holman ER, Teng YKO, van Zuuren EJ

Abstract

Cited 61 times since 2018 (8.2 per year) source: EuropePMC

Nanomaterials (Basel, Switzerland), Volume 8, Issue 5, 3 1 2018, Pages E296 Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E

In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and... Abstract

Cited 13 times since 2018 (1.7 per year) source: EuropePMC

Journal of the American Heart Association, Volume 7, Issue 10, 2 1 2018, Pages e008609 Evaluation of the Impact of a Chronic Total Coronary Occlusion on Ventricular Arrhythmias and Long-Term Mortality in Patients With Ischemic Cardiomyopathy and an Implantable Cardioverter-Defibrillator (the eCTOpy-in-ICD Study). van Dongen IM, Yilmaz D, Elias J, Claessen BEPM, Delewi R, Knops RE, Wilde AAM, van Erven L, Schalij MJ, Henriques JPS

Background: Previous studies report conflicting results about a higher incidence of ventricular arrhythmias in patients with a chronic total coronary occlusion (CTO). We aimed to investigate this association in a large cohort of implantable cardioverter defibrillator patients with long-term follow-up. Methods and results: All consecutive patients from 1992 onwards who underwent implantable cardioverter defibrillator implantation for ischemic cardiomyopathy at the Leiden University Medical Center... Abstract

Cited 84 times since 2018 (11.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 19, Issue 5, 1 1 2018, Pages 475-481 Focus cardiac ultrasound core curriculum and core syllabus of the European Association of Cardiovascular Imaging. Neskovic AN, Skinner H, Price S, Via G, De Hert S, Stankovic I, Galderisi M, Donal E, Muraru D, Sloth E, Gargani L, Cardim N, Stefanidis A, Cameli M, Habib G, Cosyns B, Lancellotti P, Edvardsen T, Popescu BA, Reviewers: This document was reviewed by members of the 2016–2018 EACVI Scientific Documents Committee

There is a growing trend of using ultrasound examination of the heart as a first-line diagnostic tool for initial patient evaluation in acute settings. Focus cardiac ultrasound (FoCUS) is a standardized but restricted cardiac ultrasound examination that may be undertaken by a range of medical professionals with diverse backgrounds. The intention of this core curriculum and syllabus is to define a unifying framework for educational and training processes/programmes that should result in competenc... Abstract

The Lancet. Neurology, Volume 17, Issue 5, 1 1 2018, Pages 393-394 Intravenous versus subcutaneous immunoglobulin - Authors' reply. van Schaik IN, Mielke O, PATH study group

Abstract

Cited 18 times since 2018 (2.4 per year) source: EuropePMC

Journal of intensive care medicine, Volume 35, Issue 6, 1 1 2018, Pages 595-605 Early Prediction of Intensive Care Unit-Acquired Weakness: A Multicenter External Validation Study. Witteveen E, Wieske L, Sommers J, Spijkstra JJ, de Waard MC, Endeman H, Rijkenberg S, de Ruijter W, Sleeswijk M, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Objectives: An early diagnosis of intensive care unit-acquired weakness (ICU-AW) is often not possible due to impaired consciousness. To avoid a diagnostic delay, we previously developed a prediction model, based on single-center data from 212 patients (development cohort), to predict ICU-AW at 2 days after ICU admission. The objective of this study was to investigate the external validity of the original prediction model in a new, multicenter cohort and, if necessary, to update the model. Metho... Abstract